RING-type E3 ubiquitin transferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger - C3HC4 type (RING finger) containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HXY9_LEIIN

TriTrypDb:

LINF_180017000

Length:

366

Annotations

Annotations by Jardim et al.

Metal Binding, Zinc finger, C3HC4 type (RING finger), putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HXY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXY9

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0061630	ubiquitin protein ligase activity	5	12
GO:0061659	ubiquitin-like protein ligase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.683
CLV_NRD_NRD_1	179	181	PF00675	0.632
CLV_NRD_NRD_1	254	256	PF00675	0.518
CLV_PCSK_KEX2_1	221	223	PF00082	0.781
CLV_PCSK_KEX2_1	253	255	PF00082	0.554
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.781
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.576
CLV_PCSK_SKI1_1	180	184	PF00082	0.606
DEG_APCC_DBOX_1	162	170	PF00400	0.692
DOC_MAPK_gen_1	180	188	PF00069	0.642
DOC_MAPK_MEF2A_6	180	188	PF00069	0.585
DOC_MAPK_MEF2A_6	204	211	PF00069	0.451
DOC_MAPK_NFAT4_5	181	189	PF00069	0.644
DOC_PP2B_LxvP_1	352	355	PF13499	0.506
DOC_USP7_MATH_1	361	365	PF00917	0.740
DOC_USP7_MATH_1	94	98	PF00917	0.817
DOC_USP7_UBL2_3	181	185	PF12436	0.588
DOC_USP7_UBL2_3	196	200	PF12436	0.506
DOC_WW_Pin1_4	57	62	PF00397	0.800
LIG_14-3-3_CanoR_1	180	185	PF00244	0.585
LIG_14-3-3_CanoR_1	345	355	PF00244	0.403
LIG_FHA_1	124	130	PF00498	0.519
LIG_FHA_1	139	145	PF00498	0.431
LIG_FHA_1	181	187	PF00498	0.586
LIG_FHA_1	214	220	PF00498	0.660
LIG_FHA_2	230	236	PF00498	0.676
LIG_FHA_2	242	248	PF00498	0.444
LIG_FHA_2	295	301	PF00498	0.754
LIG_MYND_1	164	168	PF01753	0.680
LIG_PDZ_Class_1	361	366	PF00595	0.747
LIG_SH2_GRB2like	41	44	PF00017	0.806
LIG_SH2_SRC	142	145	PF00017	0.487
LIG_SH2_STAT3	202	205	PF00017	0.513
LIG_SH2_STAT5	132	135	PF00017	0.575
LIG_SH2_STAT5	268	271	PF00017	0.535
LIG_SH3_1	336	342	PF00018	0.419
LIG_SH3_3	158	164	PF00018	0.539
LIG_SH3_3	336	342	PF00018	0.403
LIG_SH3_3	64	70	PF00018	0.821
LIG_TRAF2_1	190	193	PF00917	0.579
LIG_TRAF2_1	232	235	PF00917	0.631
LIG_WRC_WIRS_1	128	133	PF05994	0.525
MOD_CK1_1	118	124	PF00069	0.567
MOD_CK2_1	132	138	PF00069	0.524
MOD_CK2_1	187	193	PF00069	0.591
MOD_CK2_1	229	235	PF00069	0.752
MOD_CK2_1	293	299	PF00069	0.775
MOD_GlcNHglycan	284	287	PF01048	0.713
MOD_GlcNHglycan	84	87	PF01048	0.822
MOD_GSK3_1	111	118	PF00069	0.518
MOD_GSK3_1	123	130	PF00069	0.460
MOD_GSK3_1	132	139	PF00069	0.498
MOD_GSK3_1	238	245	PF00069	0.554
MOD_GSK3_1	255	262	PF00069	0.466
MOD_GSK3_1	278	285	PF00069	0.821
MOD_N-GLC_1	153	158	PF02516	0.601
MOD_N-GLC_1	229	234	PF02516	0.742
MOD_N-GLC_1	4	9	PF02516	0.857
MOD_N-GLC_1	42	47	PF02516	0.831
MOD_N-GLC_1	56	61	PF02516	0.857
MOD_N-GLC_1	82	87	PF02516	0.902
MOD_N-GLC_1	94	99	PF02516	0.729
MOD_NEK2_1	131	136	PF00069	0.473
MOD_NEK2_1	293	298	PF00069	0.688
MOD_NMyristoyl	1	7	PF02799	0.729
MOD_PIKK_1	123	129	PF00454	0.617
MOD_PIKK_1	255	261	PF00454	0.498
MOD_PIKK_1	4	10	PF00454	0.831
MOD_PKA_1	180	186	PF00069	0.642
MOD_Plk_1	115	121	PF00069	0.537
MOD_Plk_1	194	200	PF00069	0.667
MOD_Plk_1	241	247	PF00069	0.481
MOD_Plk_2-3	138	144	PF00069	0.579
MOD_Plk_2-3	187	193	PF00069	0.646
MOD_Plk_2-3	242	248	PF00069	0.544
MOD_Plk_4	118	124	PF00069	0.590
MOD_Plk_4	127	133	PF00069	0.550
MOD_Plk_4	347	353	PF00069	0.417
MOD_ProDKin_1	57	63	PF00069	0.800
MOD_SUMO_for_1	164	167	PF00179	0.597
MOD_SUMO_for_1	169	172	PF00179	0.582
TRG_ER_diArg_1	254	256	PF00400	0.522
TRG_NLS_MonoExtN_4	251	257	PF00514	0.559
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI8	Leptomonas seymouri	74%	99%
A0A0S4JNW6	Bodo saltans	32%	96%
A0A1X0P805	Trypanosomatidae	50%	98%
A0A3S7WV37	Leishmania donovani	99%	100%
A0A422P0Q0	Trypanosoma rangeli	54%	100%
A4H9M5	Leishmania braziliensis	79%	97%
D0A5B8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ARQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	98%
Q4QDS7	Leishmania major	93%	98%
V5BNN3	Trypanosoma cruzi	57%	100%