LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HXY8_LEIIN
TriTrypDb:
LINF_180016900
Length:
947

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HXY8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXY8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 127 131 PF00656 0.573
CLV_C14_Caspase3-7 500 504 PF00656 0.572
CLV_NRD_NRD_1 365 367 PF00675 0.573
CLV_NRD_NRD_1 376 378 PF00675 0.499
CLV_NRD_NRD_1 485 487 PF00675 0.611
CLV_NRD_NRD_1 59 61 PF00675 0.534
CLV_NRD_NRD_1 662 664 PF00675 0.669
CLV_NRD_NRD_1 666 668 PF00675 0.729
CLV_NRD_NRD_1 693 695 PF00675 0.720
CLV_NRD_NRD_1 855 857 PF00675 0.695
CLV_NRD_NRD_1 934 936 PF00675 0.753
CLV_PCSK_FUR_1 374 378 PF00082 0.641
CLV_PCSK_FUR_1 656 660 PF00082 0.649
CLV_PCSK_KEX2_1 262 264 PF00082 0.667
CLV_PCSK_KEX2_1 278 280 PF00082 0.520
CLV_PCSK_KEX2_1 358 360 PF00082 0.588
CLV_PCSK_KEX2_1 365 367 PF00082 0.550
CLV_PCSK_KEX2_1 376 378 PF00082 0.492
CLV_PCSK_KEX2_1 485 487 PF00082 0.611
CLV_PCSK_KEX2_1 517 519 PF00082 0.574
CLV_PCSK_KEX2_1 658 660 PF00082 0.622
CLV_PCSK_KEX2_1 661 663 PF00082 0.665
CLV_PCSK_KEX2_1 666 668 PF00082 0.729
CLV_PCSK_KEX2_1 695 697 PF00082 0.747
CLV_PCSK_KEX2_1 854 856 PF00082 0.839
CLV_PCSK_KEX2_1 934 936 PF00082 0.710
CLV_PCSK_KEX2_1 95 97 PF00082 0.458
CLV_PCSK_PC1ET2_1 262 264 PF00082 0.662
CLV_PCSK_PC1ET2_1 278 280 PF00082 0.456
CLV_PCSK_PC1ET2_1 358 360 PF00082 0.642
CLV_PCSK_PC1ET2_1 517 519 PF00082 0.602
CLV_PCSK_PC1ET2_1 695 697 PF00082 0.799
CLV_PCSK_PC1ET2_1 95 97 PF00082 0.489
CLV_PCSK_PC7_1 656 662 PF00082 0.703
CLV_PCSK_SKI1_1 186 190 PF00082 0.607
CLV_PCSK_SKI1_1 278 282 PF00082 0.667
CLV_PCSK_SKI1_1 485 489 PF00082 0.566
CLV_PCSK_SKI1_1 547 551 PF00082 0.519
CLV_PCSK_SKI1_1 92 96 PF00082 0.578
CLV_Separin_Metazoa 590 594 PF03568 0.505
CLV_Separin_Metazoa 649 653 PF03568 0.608
DEG_APCC_DBOX_1 300 308 PF00400 0.661
DEG_APCC_DBOX_1 501 509 PF00400 0.651
DEG_SPOP_SBC_1 345 349 PF00917 0.649
DEG_SPOP_SBC_1 673 677 PF00917 0.775
DOC_CYCLIN_RxL_1 275 284 PF00134 0.499
DOC_CYCLIN_RxL_1 37 51 PF00134 0.575
DOC_CYCLIN_RxL_1 746 759 PF00134 0.583
DOC_CYCLIN_yClb5_NLxxxL_5 260 269 PF00134 0.613
DOC_MAPK_gen_1 438 446 PF00069 0.543
DOC_MAPK_gen_1 746 755 PF00069 0.580
DOC_MAPK_MEF2A_6 440 448 PF00069 0.543
DOC_USP7_MATH_1 181 185 PF00917 0.529
DOC_USP7_MATH_1 188 192 PF00917 0.511
DOC_USP7_MATH_1 346 350 PF00917 0.650
DOC_USP7_MATH_1 665 669 PF00917 0.784
DOC_USP7_MATH_1 673 677 PF00917 0.746
DOC_USP7_MATH_1 705 709 PF00917 0.817
DOC_USP7_MATH_1 803 807 PF00917 0.771
DOC_USP7_MATH_1 886 890 PF00917 0.769
DOC_USP7_MATH_1 916 920 PF00917 0.582
DOC_USP7_UBL2_3 170 174 PF12436 0.633
DOC_WW_Pin1_4 10 15 PF00397 0.644
DOC_WW_Pin1_4 812 817 PF00397 0.624
DOC_WW_Pin1_4 865 870 PF00397 0.741
DOC_WW_Pin1_4 878 883 PF00397 0.761
LIG_14-3-3_CanoR_1 180 190 PF00244 0.606
LIG_14-3-3_CanoR_1 204 212 PF00244 0.606
LIG_14-3-3_CanoR_1 303 308 PF00244 0.635
LIG_14-3-3_CanoR_1 586 594 PF00244 0.546
LIG_14-3-3_CanoR_1 875 880 PF00244 0.712
LIG_14-3-3_CanoR_1 900 905 PF00244 0.665
LIG_14-3-3_CanoR_1 96 104 PF00244 0.478
LIG_Actin_WH2_2 202 219 PF00022 0.601
LIG_Actin_WH2_2 766 784 PF00022 0.479
LIG_CaM_IQ_9 209 225 PF13499 0.611
LIG_FHA_1 13 19 PF00498 0.693
LIG_FHA_1 473 479 PF00498 0.564
LIG_FHA_1 587 593 PF00498 0.547
LIG_FHA_1 716 722 PF00498 0.678
LIG_FHA_2 100 106 PF00498 0.626
LIG_FHA_2 190 196 PF00498 0.522
LIG_FHA_2 284 290 PF00498 0.619
LIG_FHA_2 318 324 PF00498 0.633
LIG_FHA_2 346 352 PF00498 0.564
LIG_FHA_2 355 361 PF00498 0.501
LIG_FHA_2 387 393 PF00498 0.589
LIG_FHA_2 523 529 PF00498 0.576
LIG_FHA_2 597 603 PF00498 0.705
LIG_FHA_2 862 868 PF00498 0.583
LIG_FHA_2 900 906 PF00498 0.667
LIG_LIR_Apic_2 874 880 PF02991 0.740
LIG_LIR_Gen_1 17 24 PF02991 0.553
LIG_LIR_Gen_1 638 647 PF02991 0.567
LIG_LIR_Nem_3 17 23 PF02991 0.580
LIG_NRBOX 772 778 PF00104 0.471
LIG_RPA_C_Fungi 562 574 PF08784 0.510
LIG_SH2_CRK 70 74 PF00017 0.511
LIG_SH2_CRK 877 881 PF00017 0.738
LIG_SH2_NCK_1 70 74 PF00017 0.554
LIG_SH2_NCK_1 877 881 PF00017 0.738
LIG_SH2_PTP2 20 23 PF00017 0.591
LIG_SH2_SRC 20 23 PF00017 0.535
LIG_SH2_STAP1 322 326 PF00017 0.641
LIG_SH2_STAP1 647 651 PF00017 0.607
LIG_SH2_STAT5 140 143 PF00017 0.600
LIG_SH2_STAT5 146 149 PF00017 0.504
LIG_SH2_STAT5 20 23 PF00017 0.591
LIG_SH3_2 3 8 PF14604 0.627
LIG_SH3_3 3 9 PF00018 0.737
LIG_SH3_3 708 714 PF00018 0.762
LIG_SUMO_SIM_par_1 392 399 PF11976 0.549
LIG_SUMO_SIM_par_1 769 775 PF11976 0.490
LIG_TRAF2_1 175 178 PF00917 0.624
LIG_TRAF2_1 232 235 PF00917 0.668
LIG_TRAF2_1 287 290 PF00917 0.700
LIG_TRAF2_1 368 371 PF00917 0.629
LIG_TRAF2_1 434 437 PF00917 0.503
LIG_TRAF2_1 646 649 PF00917 0.607
LIG_TRAF2_1 79 82 PF00917 0.508
LIG_TYR_ITIM 18 23 PF00017 0.644
LIG_UBA3_1 507 512 PF00899 0.530
MOD_CDK_SPxxK_3 865 872 PF00069 0.681
MOD_CK1_1 13 19 PF00069 0.604
MOD_CK1_1 184 190 PF00069 0.622
MOD_CK1_1 191 197 PF00069 0.574
MOD_CK1_1 386 392 PF00069 0.466
MOD_CK1_1 600 606 PF00069 0.665
MOD_CK1_1 638 644 PF00069 0.590
MOD_CK1_1 672 678 PF00069 0.726
MOD_CK1_1 681 687 PF00069 0.688
MOD_CK1_1 716 722 PF00069 0.600
MOD_CK1_1 878 884 PF00069 0.760
MOD_CK2_1 189 195 PF00069 0.524
MOD_CK2_1 283 289 PF00069 0.650
MOD_CK2_1 292 298 PF00069 0.605
MOD_CK2_1 336 342 PF00069 0.613
MOD_CK2_1 345 351 PF00069 0.548
MOD_CK2_1 354 360 PF00069 0.401
MOD_CK2_1 386 392 PF00069 0.572
MOD_CK2_1 430 436 PF00069 0.544
MOD_CK2_1 522 528 PF00069 0.579
MOD_CK2_1 596 602 PF00069 0.656
MOD_CK2_1 643 649 PF00069 0.548
MOD_CK2_1 680 686 PF00069 0.763
MOD_CK2_1 861 867 PF00069 0.746
MOD_CK2_1 899 905 PF00069 0.669
MOD_CK2_1 99 105 PF00069 0.620
MOD_DYRK1A_RPxSP_1 10 14 PF00069 0.714
MOD_GlcNHglycan 10 13 PF01048 0.744
MOD_GlcNHglycan 185 189 PF01048 0.651
MOD_GlcNHglycan 243 246 PF01048 0.636
MOD_GlcNHglycan 348 351 PF01048 0.555
MOD_GlcNHglycan 426 429 PF01048 0.559
MOD_GlcNHglycan 431 435 PF01048 0.546
MOD_GlcNHglycan 671 674 PF01048 0.769
MOD_GlcNHglycan 805 808 PF01048 0.734
MOD_GlcNHglycan 81 86 PF01048 0.569
MOD_GlcNHglycan 843 846 PF01048 0.697
MOD_GlcNHglycan 877 880 PF01048 0.684
MOD_GlcNHglycan 892 895 PF01048 0.608
MOD_GSK3_1 184 191 PF00069 0.558
MOD_GSK3_1 299 306 PF00069 0.657
MOD_GSK3_1 37 44 PF00069 0.502
MOD_GSK3_1 382 389 PF00069 0.590
MOD_GSK3_1 392 399 PF00069 0.486
MOD_GSK3_1 596 603 PF00069 0.727
MOD_GSK3_1 619 626 PF00069 0.657
MOD_GSK3_1 665 672 PF00069 0.768
MOD_GSK3_1 674 681 PF00069 0.715
MOD_GSK3_1 799 806 PF00069 0.758
MOD_GSK3_1 8 15 PF00069 0.678
MOD_GSK3_1 850 857 PF00069 0.746
MOD_GSK3_1 861 868 PF00069 0.530
MOD_GSK3_1 871 878 PF00069 0.799
MOD_GSK3_1 882 889 PF00069 0.739
MOD_GSK3_1 914 921 PF00069 0.551
MOD_GSK3_1 95 102 PF00069 0.558
MOD_N-GLC_1 679 684 PF02516 0.815
MOD_N-GLC_1 850 855 PF02516 0.745
MOD_NEK2_1 299 304 PF00069 0.615
MOD_NEK2_1 344 349 PF00069 0.573
MOD_NEK2_1 354 359 PF00069 0.512
MOD_NEK2_1 41 46 PF00069 0.500
MOD_NEK2_1 430 435 PF00069 0.538
MOD_NEK2_1 522 527 PF00069 0.576
MOD_NEK2_1 573 578 PF00069 0.532
MOD_PIKK_1 549 555 PF00454 0.554
MOD_PIKK_1 886 892 PF00454 0.729
MOD_PKA_1 854 860 PF00069 0.698
MOD_PKA_1 95 101 PF00069 0.501
MOD_PKA_2 292 298 PF00069 0.663
MOD_PKA_2 327 333 PF00069 0.566
MOD_PKA_2 472 478 PF00069 0.509
MOD_PKA_2 643 649 PF00069 0.605
MOD_PKA_2 665 671 PF00069 0.733
MOD_PKA_2 716 722 PF00069 0.600
MOD_PKA_2 807 813 PF00069 0.632
MOD_PKA_2 854 860 PF00069 0.698
MOD_PKA_2 871 877 PF00069 0.563
MOD_PKA_2 899 905 PF00069 0.652
MOD_PKA_2 95 101 PF00069 0.499
MOD_PKB_1 301 309 PF00069 0.656
MOD_PKB_1 667 675 PF00069 0.740
MOD_PKB_1 839 847 PF00069 0.700
MOD_Plk_1 184 190 PF00069 0.622
MOD_Plk_1 299 305 PF00069 0.611
MOD_Plk_1 370 376 PF00069 0.630
MOD_Plk_1 41 47 PF00069 0.500
MOD_Plk_1 430 436 PF00069 0.560
MOD_Plk_1 638 644 PF00069 0.664
MOD_Plk_1 860 866 PF00069 0.741
MOD_Plk_1 99 105 PF00069 0.581
MOD_Plk_2-3 392 398 PF00069 0.553
MOD_Plk_2-3 766 772 PF00069 0.486
MOD_Plk_2-3 861 867 PF00069 0.583
MOD_Plk_4 303 309 PF00069 0.651
MOD_Plk_4 738 744 PF00069 0.559
MOD_Plk_4 766 772 PF00069 0.486
MOD_ProDKin_1 10 16 PF00069 0.638
MOD_ProDKin_1 812 818 PF00069 0.616
MOD_ProDKin_1 865 871 PF00069 0.742
MOD_ProDKin_1 878 884 PF00069 0.761
MOD_SUMO_for_1 749 752 PF00179 0.598
MOD_SUMO_rev_2 109 118 PF00179 0.548
MOD_SUMO_rev_2 420 425 PF00179 0.539
TRG_DiLeu_BaEn_1 332 337 PF01217 0.582
TRG_DiLeu_BaEn_1 766 771 PF01217 0.486
TRG_DiLeu_BaEn_4 370 376 PF01217 0.630
TRG_DiLeu_BaEn_4 50 56 PF01217 0.492
TRG_DiLeu_BaEn_4 582 588 PF01217 0.562
TRG_DiLeu_BaLyEn_6 276 281 PF01217 0.498
TRG_ENDOCYTIC_2 20 23 PF00928 0.535
TRG_ENDOCYTIC_2 640 643 PF00928 0.558
TRG_ENDOCYTIC_2 647 650 PF00928 0.518
TRG_ENDOCYTIC_2 70 73 PF00928 0.455
TRG_ENDOCYTIC_2 91 94 PF00928 0.481
TRG_ER_diArg_1 119 122 PF00400 0.558
TRG_ER_diArg_1 301 304 PF00400 0.627
TRG_ER_diArg_1 365 367 PF00400 0.594
TRG_ER_diArg_1 374 377 PF00400 0.598
TRG_ER_diArg_1 656 659 PF00400 0.626
TRG_ER_diArg_1 660 663 PF00400 0.667
TRG_ER_diArg_1 666 669 PF00400 0.707
TRG_ER_diArg_1 728 731 PF00400 0.482
TRG_ER_diArg_1 785 788 PF00400 0.595
TRG_ER_diArg_1 840 843 PF00400 0.678
TRG_ER_diArg_1 854 856 PF00400 0.608
TRG_ER_diArg_1 933 935 PF00400 0.752
TRG_NLS_MonoExtC_3 693 699 PF00514 0.748
TRG_NLS_MonoExtN_4 692 698 PF00514 0.747
TRG_Pf-PMV_PEXEL_1 145 149 PF00026 0.509
TRG_Pf-PMV_PEXEL_1 174 178 PF00026 0.571
TRG_Pf-PMV_PEXEL_1 263 267 PF00026 0.661
TRG_Pf-PMV_PEXEL_1 279 284 PF00026 0.460
TRG_Pf-PMV_PEXEL_1 359 363 PF00026 0.518
TRG_Pf-PMV_PEXEL_1 365 370 PF00026 0.529
TRG_Pf-PMV_PEXEL_1 486 490 PF00026 0.590
TRG_Pf-PMV_PEXEL_1 60 64 PF00026 0.563
TRG_Pf-PMV_PEXEL_1 627 632 PF00026 0.612
TRG_Pf-PMV_PEXEL_1 652 657 PF00026 0.575
TRG_Pf-PMV_PEXEL_1 95 99 PF00026 0.550

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IBB1 Leptomonas seymouri 61% 80%
A0A3R7MU41 Trypanosoma rangeli 39% 96%
A0A3S5H739 Leishmania donovani 100% 100%
A4H9M4 Leishmania braziliensis 83% 100%
D0A5B9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 99%
E9ARQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QDS8 Leishmania major 94% 100%
V5BEK2 Trypanosoma cruzi 40% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS