Putative ras-related protein rab-5

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ras-related protein Rab5A - putative

Species:

Leishmania infantum

UniProt:

A4HXY7_LEIIN

TriTrypDb:

LINF_180016700

Length:

236

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, ras-related rab-5

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0030139	endocytic vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HXY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXY7

PDB structure(s): 5yoz_A

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0003924	GTPase activity	7	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0017076	purine nucleotide binding	4	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.365
CLV_PCSK_SKI1_1	81	85	PF00082	0.408
DEG_Nend_UBRbox_3	1	3	PF02207	0.702
DOC_MAPK_MEF2A_6	133	142	PF00069	0.333
DOC_MAPK_MEF2A_6	26	33	PF00069	0.308
DOC_MAPK_NFAT4_5	26	34	PF00069	0.308
DOC_PP1_RVXF_1	153	160	PF00149	0.393
DOC_PP4_MxPP_1	56	59	PF00568	0.408
DOC_USP7_MATH_1	136	140	PF00917	0.408
DOC_USP7_MATH_1	24	28	PF00917	0.401

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z9	Leptomonas seymouri	31%	100%
A0A0N0P3A0	Leptomonas seymouri	39%	87%
A0A0N0P6K4	Leptomonas seymouri	29%	100%
A0A0N0P6P8	Leptomonas seymouri	41%	100%
A0A0N0P8G7	Leptomonas seymouri	34%	100%
A0A0N0P8I1	Leptomonas seymouri	36%	100%
A0A0N0P971	Leptomonas seymouri	27%	100%
A0A0N1HYV5	Leptomonas seymouri	31%	100%
A0A0N1I011	Leptomonas seymouri	34%	100%
A0A0N1I5E3	Leptomonas seymouri	28%	100%

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