LeishMANIAdb
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Putative methyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative methyltransferase
Gene product:
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4HXY5_LEIIN
TriTrypDb:
LINF_180016500
Length:
847

Annotations

Annotations by Jardim et al.

tRNA synthetase, Multisite-specific tRNA:(cytosine-C(5))-methyltransferase methyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HXY5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXY5

Function

Biological processes
Term Name Level Count
GO:0001510 RNA methylation 4 13
GO:0006139 nucleobase-containing compound metabolic process 3 13
GO:0006725 cellular aromatic compound metabolic process 3 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0009451 RNA modification 5 13
GO:0009987 cellular process 1 13
GO:0016070 RNA metabolic process 5 13
GO:0032259 methylation 2 13
GO:0034641 cellular nitrogen compound metabolic process 3 13
GO:0043170 macromolecule metabolic process 3 13
GO:0043412 macromolecule modification 4 13
GO:0043414 macromolecule methylation 3 13
GO:0044237 cellular metabolic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0044260 obsolete cellular macromolecule metabolic process 3 13
GO:0046483 heterocycle metabolic process 3 13
GO:0071704 organic substance metabolic process 2 13
GO:0090304 nucleic acid metabolic process 4 13
GO:1901360 organic cyclic compound metabolic process 3 13
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 13
GO:0003723 RNA binding 4 13
GO:0003824 catalytic activity 1 13
GO:0005488 binding 1 13
GO:0008168 methyltransferase activity 4 13
GO:0016740 transferase activity 2 13
GO:0016741 transferase activity, transferring one-carbon groups 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:1901363 heterocyclic compound binding 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 687 693 PF00089 0.460
CLV_NRD_NRD_1 133 135 PF00675 0.566
CLV_NRD_NRD_1 196 198 PF00675 0.693
CLV_NRD_NRD_1 3 5 PF00675 0.597
CLV_NRD_NRD_1 409 411 PF00675 0.261
CLV_NRD_NRD_1 537 539 PF00675 0.280
CLV_NRD_NRD_1 585 587 PF00675 0.426
CLV_NRD_NRD_1 619 621 PF00675 0.413
CLV_NRD_NRD_1 685 687 PF00675 0.380
CLV_NRD_NRD_1 7 9 PF00675 0.536
CLV_NRD_NRD_1 99 101 PF00675 0.476
CLV_PCSK_FUR_1 355 359 PF00082 0.291
CLV_PCSK_KEX2_1 132 134 PF00082 0.564
CLV_PCSK_KEX2_1 2 4 PF00082 0.615
CLV_PCSK_KEX2_1 269 271 PF00082 0.502
CLV_PCSK_KEX2_1 357 359 PF00082 0.286
CLV_PCSK_KEX2_1 585 587 PF00082 0.501
CLV_PCSK_KEX2_1 619 621 PF00082 0.404
CLV_PCSK_KEX2_1 685 687 PF00082 0.429
CLV_PCSK_KEX2_1 7 9 PF00082 0.515
CLV_PCSK_KEX2_1 99 101 PF00082 0.476
CLV_PCSK_PC1ET2_1 2 4 PF00082 0.634
CLV_PCSK_PC1ET2_1 269 271 PF00082 0.535
CLV_PCSK_PC1ET2_1 357 359 PF00082 0.286
CLV_PCSK_PC7_1 3 9 PF00082 0.604
CLV_PCSK_PC7_1 681 687 PF00082 0.502
CLV_PCSK_SKI1_1 234 238 PF00082 0.499
CLV_PCSK_SKI1_1 335 339 PF00082 0.362
CLV_PCSK_SKI1_1 432 436 PF00082 0.300
CLV_PCSK_SKI1_1 538 542 PF00082 0.520
CLV_PCSK_SKI1_1 620 624 PF00082 0.393
CLV_PCSK_SKI1_1 695 699 PF00082 0.442
CLV_PCSK_SKI1_1 714 718 PF00082 0.450
DEG_Nend_UBRbox_1 1 4 PF02207 0.668
DEG_ODPH_VHL_1 678 691 PF01847 0.480
DEG_SIAH_1 729 737 PF03145 0.520
DEG_SPOP_SBC_1 596 600 PF00917 0.538
DOC_CKS1_1 211 216 PF01111 0.501
DOC_CKS1_1 236 241 PF01111 0.560
DOC_CKS1_1 623 628 PF01111 0.488
DOC_CYCLIN_RxL_1 432 444 PF00134 0.504
DOC_CYCLIN_RxL_1 681 692 PF00134 0.504
DOC_CYCLIN_yCln2_LP_2 563 569 PF00134 0.521
DOC_CYCLIN_yCln2_LP_2 623 629 PF00134 0.489
DOC_MAPK_gen_1 560 569 PF00069 0.547
DOC_MAPK_gen_1 636 645 PF00069 0.423
DOC_MAPK_HePTP_8 633 645 PF00069 0.531
DOC_MAPK_MEF2A_6 636 645 PF00069 0.423
DOC_PP1_RVXF_1 683 690 PF00149 0.518
DOC_PP2B_LxvP_1 50 53 PF13499 0.569
DOC_PP2B_LxvP_1 563 566 PF13499 0.482
DOC_PP4_FxxP_1 677 680 PF00568 0.521
DOC_USP7_MATH_1 137 141 PF00917 0.532
DOC_USP7_MATH_1 250 254 PF00917 0.520
DOC_USP7_MATH_1 382 386 PF00917 0.424
DOC_USP7_MATH_1 56 60 PF00917 0.781
DOC_USP7_MATH_1 596 600 PF00917 0.580
DOC_USP7_UBL2_3 343 347 PF12436 0.480
DOC_USP7_UBL2_3 731 735 PF12436 0.556
DOC_WW_Pin1_4 210 215 PF00397 0.420
DOC_WW_Pin1_4 235 240 PF00397 0.536
DOC_WW_Pin1_4 496 501 PF00397 0.480
DOC_WW_Pin1_4 622 627 PF00397 0.490
LIG_14-3-3_CanoR_1 100 109 PF00244 0.450
LIG_14-3-3_CanoR_1 220 228 PF00244 0.478
LIG_14-3-3_CanoR_1 234 239 PF00244 0.500
LIG_14-3-3_CanoR_1 345 353 PF00244 0.480
LIG_14-3-3_CanoR_1 413 423 PF00244 0.508
LIG_14-3-3_CanoR_1 620 626 PF00244 0.474
LIG_14-3-3_CanoR_1 681 689 PF00244 0.528
LIG_14-3-3_CanoR_1 823 827 PF00244 0.604
LIG_APCC_ABBA_1 522 527 PF00400 0.480
LIG_BRCT_BRCA1_1 673 677 PF00533 0.494
LIG_deltaCOP1_diTrp_1 201 207 PF00928 0.436
LIG_deltaCOP1_diTrp_1 570 580 PF00928 0.397
LIG_Dynein_DLC8_1 345 351 PF01221 0.520
LIG_FAT_LD_1 75 83 PF03623 0.527
LIG_FHA_1 144 150 PF00498 0.563
LIG_FHA_1 18 24 PF00498 0.540
LIG_FHA_1 216 222 PF00498 0.399
LIG_FHA_1 231 237 PF00498 0.420
LIG_FHA_1 252 258 PF00498 0.516
LIG_FHA_1 347 353 PF00498 0.489
LIG_FHA_1 442 448 PF00498 0.547
LIG_FHA_1 623 629 PF00498 0.446
LIG_FHA_1 761 767 PF00498 0.424
LIG_FHA_1 96 102 PF00498 0.563
LIG_FHA_2 235 241 PF00498 0.545
LIG_FHA_2 303 309 PF00498 0.539
LIG_FHA_2 365 371 PF00498 0.491
LIG_FHA_2 42 48 PF00498 0.688
LIG_FHA_2 750 756 PF00498 0.617
LIG_LIR_Apic_2 544 548 PF02991 0.483
LIG_LIR_Apic_2 635 641 PF02991 0.432
LIG_LIR_Apic_2 674 680 PF02991 0.466
LIG_LIR_Gen_1 156 162 PF02991 0.454
LIG_LIR_Gen_1 201 211 PF02991 0.410
LIG_LIR_Gen_1 285 294 PF02991 0.429
LIG_LIR_Gen_1 39 48 PF02991 0.595
LIG_LIR_Gen_1 391 402 PF02991 0.471
LIG_LIR_Gen_1 571 581 PF02991 0.423
LIG_LIR_Gen_1 89 97 PF02991 0.568
LIG_LIR_Nem_3 156 161 PF02991 0.444
LIG_LIR_Nem_3 201 207 PF02991 0.448
LIG_LIR_Nem_3 285 289 PF02991 0.438
LIG_LIR_Nem_3 39 43 PF02991 0.524
LIG_LIR_Nem_3 391 397 PF02991 0.471
LIG_LIR_Nem_3 571 577 PF02991 0.390
LIG_LIR_Nem_3 578 583 PF02991 0.385
LIG_LIR_Nem_3 588 594 PF02991 0.419
LIG_LIR_Nem_3 711 716 PF02991 0.446
LIG_LIR_Nem_3 814 818 PF02991 0.537
LIG_LIR_Nem_3 89 95 PF02991 0.564
LIG_MYND_1 508 512 PF01753 0.577
LIG_NRBOX 697 703 PF00104 0.521
LIG_NRBOX 739 745 PF00104 0.557
LIG_NRBOX 74 80 PF00104 0.521
LIG_Pex14_1 374 378 PF04695 0.504
LIG_Pex14_1 419 423 PF04695 0.480
LIG_Pex14_2 533 537 PF04695 0.475
LIG_SH2_CRK 359 363 PF00017 0.504
LIG_SH2_CRK 638 642 PF00017 0.468
LIG_SH2_STAT5 273 276 PF00017 0.432
LIG_SH2_STAT5 35 38 PF00017 0.479
LIG_SH2_STAT5 378 381 PF00017 0.562
LIG_SH2_STAT5 423 426 PF00017 0.480
LIG_SH2_STAT5 708 711 PF00017 0.579
LIG_SH3_3 241 247 PF00018 0.461
LIG_SH3_3 369 375 PF00018 0.502
LIG_SH3_3 505 511 PF00018 0.532
LIG_SH3_3 537 543 PF00018 0.534
LIG_SUMO_SIM_anti_2 473 479 PF11976 0.480
LIG_SUMO_SIM_anti_2 754 764 PF11976 0.539
LIG_SUMO_SIM_par_1 124 131 PF11976 0.557
LIG_TRAF2_1 285 288 PF00917 0.370
LIG_TRAF2_1 754 757 PF00917 0.589
LIG_TRAF2_1 839 842 PF00917 0.795
LIG_TRFH_1 609 613 PF08558 0.447
LIG_WRC_WIRS_1 577 582 PF05994 0.497
LIG_WRC_WIRS_1 812 817 PF05994 0.500
LIG_WW_1 511 514 PF00397 0.472
MOD_CK1_1 104 110 PF00069 0.430
MOD_CK1_1 121 127 PF00069 0.460
MOD_CK1_1 202 208 PF00069 0.490
MOD_CK1_1 210 216 PF00069 0.474
MOD_CK1_1 282 288 PF00069 0.382
MOD_CK1_1 414 420 PF00069 0.373
MOD_CK1_1 451 457 PF00069 0.323
MOD_CK1_1 598 604 PF00069 0.585
MOD_CK1_1 748 754 PF00069 0.620
MOD_CK2_1 182 188 PF00069 0.725
MOD_CK2_1 282 288 PF00069 0.374
MOD_CK2_1 382 388 PF00069 0.315
MOD_CK2_1 41 47 PF00069 0.649
MOD_CK2_1 70 76 PF00069 0.537
MOD_CK2_1 735 741 PF00069 0.575
MOD_CK2_1 751 757 PF00069 0.483
MOD_CK2_1 761 767 PF00069 0.424
MOD_GlcNHglycan 123 126 PF01048 0.564
MOD_GlcNHglycan 139 142 PF01048 0.547
MOD_GlcNHglycan 168 171 PF01048 0.597
MOD_GlcNHglycan 190 193 PF01048 0.760
MOD_GlcNHglycan 203 207 PF01048 0.455
MOD_GlcNHglycan 254 257 PF01048 0.524
MOD_GlcNHglycan 281 284 PF01048 0.405
MOD_GlcNHglycan 290 293 PF01048 0.362
MOD_GlcNHglycan 325 328 PF01048 0.415
MOD_GlcNHglycan 329 332 PF01048 0.383
MOD_GlcNHglycan 403 406 PF01048 0.323
MOD_GlcNHglycan 419 422 PF01048 0.323
MOD_GlcNHglycan 492 495 PF01048 0.396
MOD_GlcNHglycan 54 57 PF01048 0.756
MOD_GlcNHglycan 58 61 PF01048 0.718
MOD_GlcNHglycan 600 603 PF01048 0.569
MOD_GlcNHglycan 673 676 PF01048 0.376
MOD_GlcNHglycan 72 75 PF01048 0.357
MOD_GlcNHglycan 720 723 PF01048 0.398
MOD_GlcNHglycan 790 793 PF01048 0.398
MOD_GlcNHglycan 794 797 PF01048 0.410
MOD_GlcNHglycan 832 835 PF01048 0.741
MOD_GSK3_1 132 139 PF00069 0.665
MOD_GSK3_1 230 237 PF00069 0.517
MOD_GSK3_1 252 259 PF00069 0.532
MOD_GSK3_1 260 267 PF00069 0.510
MOD_GSK3_1 323 330 PF00069 0.411
MOD_GSK3_1 380 387 PF00069 0.452
MOD_GSK3_1 401 408 PF00069 0.323
MOD_GSK3_1 411 418 PF00069 0.323
MOD_GSK3_1 419 426 PF00069 0.323
MOD_GSK3_1 52 59 PF00069 0.753
MOD_GSK3_1 594 601 PF00069 0.543
MOD_GSK3_1 745 752 PF00069 0.587
MOD_GSK3_1 774 781 PF00069 0.500
MOD_GSK3_1 788 795 PF00069 0.367
MOD_LATS_1 130 136 PF00433 0.674
MOD_N-GLC_1 182 187 PF02516 0.677
MOD_N-GLC_1 193 198 PF02516 0.503
MOD_N-GLC_1 383 388 PF02516 0.258
MOD_N-GLC_1 575 580 PF02516 0.418
MOD_N-GLC_1 828 833 PF02516 0.731
MOD_NEK2_1 118 123 PF00069 0.537
MOD_NEK2_1 143 148 PF00069 0.579
MOD_NEK2_1 207 212 PF00069 0.482
MOD_NEK2_1 441 446 PF00069 0.379
MOD_NEK2_1 448 453 PF00069 0.299
MOD_NEK2_1 689 694 PF00069 0.524
MOD_NEK2_1 761 766 PF00069 0.453
MOD_NEK2_1 790 795 PF00069 0.382
MOD_NEK2_2 405 410 PF00069 0.323
MOD_NEK2_2 811 816 PF00069 0.542
MOD_PIKK_1 101 107 PF00454 0.476
MOD_PIKK_1 118 124 PF00454 0.464
MOD_PIKK_1 346 352 PF00454 0.336
MOD_PIKK_1 41 47 PF00454 0.636
MOD_PIKK_1 427 433 PF00454 0.336
MOD_PIKK_1 761 767 PF00454 0.490
MOD_PK_1 411 417 PF00069 0.418
MOD_PK_1 77 83 PF00069 0.517
MOD_PKA_1 132 138 PF00069 0.690
MOD_PKA_2 132 138 PF00069 0.684
MOD_PKA_2 153 159 PF00069 0.560
MOD_PKA_2 680 686 PF00069 0.506
MOD_PKA_2 689 695 PF00069 0.456
MOD_PKA_2 822 828 PF00069 0.695
MOD_PKA_2 95 101 PF00069 0.550
MOD_Plk_1 143 149 PF00069 0.561
MOD_Plk_1 202 208 PF00069 0.438
MOD_Plk_1 411 417 PF00069 0.418
MOD_Plk_1 575 581 PF00069 0.430
MOD_Plk_1 749 755 PF00069 0.560
MOD_Plk_4 104 110 PF00069 0.534
MOD_Plk_4 302 308 PF00069 0.344
MOD_Plk_4 320 326 PF00069 0.370
MOD_Plk_4 419 425 PF00069 0.352
MOD_Plk_4 546 552 PF00069 0.570
MOD_Plk_4 576 582 PF00069 0.461
MOD_Plk_4 673 679 PF00069 0.409
MOD_Plk_4 77 83 PF00069 0.509
MOD_Plk_4 811 817 PF00069 0.520
MOD_Plk_4 822 828 PF00069 0.648
MOD_ProDKin_1 210 216 PF00069 0.420
MOD_ProDKin_1 235 241 PF00069 0.529
MOD_ProDKin_1 496 502 PF00069 0.335
MOD_ProDKin_1 622 628 PF00069 0.489
MOD_SUMO_rev_2 654 661 PF00179 0.438
TRG_DiLeu_BaEn_1 757 762 PF01217 0.555
TRG_DiLeu_BaEn_1 822 827 PF01217 0.516
TRG_DiLeu_BaEn_2 202 208 PF01217 0.467
TRG_DiLeu_BaEn_2 672 678 PF01217 0.494
TRG_DiLeu_LyEn_5 145 150 PF01217 0.456
TRG_ER_diArg_1 132 134 PF00400 0.566
TRG_ER_diArg_1 618 620 PF00400 0.435
TRG_ER_diArg_1 633 636 PF00400 0.515
TRG_ER_diArg_1 685 687 PF00400 0.434
TRG_ER_diArg_1 7 10 PF00400 0.549
TRG_ER_diArg_1 99 101 PF00400 0.495
TRG_NES_CRM1_1 13 29 PF08389 0.475
TRG_Pf-PMV_PEXEL_1 396 400 PF00026 0.370
TRG_Pf-PMV_PEXEL_1 695 699 PF00026 0.515

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8H1 Leptomonas seymouri 71% 98%
A0A0S4KJ12 Bodo saltans 43% 100%
A0A1X0P6Y3 Trypanosomatidae 54% 100%
A0A3R7M922 Trypanosoma rangeli 52% 100%
A0A3S7WV22 Leishmania donovani 99% 100%
A4H9M1 Leishmania braziliensis 84% 99%
D0A386 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A5C2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9ARP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QDT1 Leishmania major 94% 100%
V5DFH6 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS