ANK_REP_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (many copies)/Ankyrin repeats (3 copies)/Ankyrin repeat - putative

Species:

Leishmania infantum

UniProt:

A4HXY4_LEIIN

TriTrypDb:

LINF_180016400

Length:

231

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0000502	proteasome complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905368	peptidase complex	3	2
GO:1905369	endopeptidase complex	4	2

Expansion

Sequence features

A4HXY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.421
CLV_PCSK_KEX2_1	145	147	PF00082	0.328
CLV_PCSK_SKI1_1	131	135	PF00082	0.352
CLV_PCSK_SKI1_1	209	213	PF00082	0.418
CLV_PCSK_SKI1_1	34	38	PF00082	0.517
DEG_APCC_DBOX_1	123	131	PF00400	0.328
DEG_Nend_UBRbox_3	1	3	PF02207	0.631
DOC_CKS1_1	16	21	PF01111	0.538
DOC_CYCLIN_RxL_1	126	135	PF00134	0.453
DOC_USP7_MATH_1	73	77	PF00917	0.720
DOC_USP7_UBL2_3	172	176	PF12436	0.616
DOC_WW_Pin1_4	113	118	PF00397	0.243
DOC_WW_Pin1_4	15	20	PF00397	0.388
DOC_WW_Pin1_4	4	9	PF00397	0.592
DOC_WW_Pin1_4	95	100	PF00397	0.626
LIG_14-3-3_CanoR_1	145	155	PF00244	0.372
LIG_BIR_III_2	96	100	PF00653	0.517
LIG_BIR_III_4	111	115	PF00653	0.512
LIG_BRCT_BRCA1_1	16	20	PF00533	0.562
LIG_BRCT_BRCA1_1	193	197	PF00533	0.468
LIG_deltaCOP1_diTrp_1	12	20	PF00928	0.584
LIG_FHA_1	114	120	PF00498	0.349
LIG_FHA_1	4	10	PF00498	0.545
LIG_FHA_1	80	86	PF00498	0.688
LIG_FHA_2	166	172	PF00498	0.494
LIG_FHA_2	56	62	PF00498	0.720
LIG_FHA_2	9	15	PF00498	0.636
LIG_LIR_Apic_2	13	19	PF02991	0.614
LIG_PCNA_APIM_2	207	213	PF02747	0.409
LIG_PCNA_yPIPBox_3	153	166	PF02747	0.382
LIG_PCNA_yPIPBox_3	204	218	PF02747	0.394
LIG_Pex14_1	16	20	PF04695	0.534
LIG_SH2_CRK	5	9	PF00017	0.603
LIG_SH2_STAT5	210	213	PF00017	0.397
LIG_SH2_STAT5	5	8	PF00017	0.456
LIG_SH3_3	23	29	PF00018	0.396
LIG_TRAF2_1	58	61	PF00917	0.739
MOD_CK2_1	165	171	PF00069	0.469
MOD_CK2_1	37	43	PF00069	0.559
MOD_CK2_1	55	61	PF00069	0.506
MOD_CK2_1	8	14	PF00069	0.634
MOD_GlcNHglycan	102	105	PF01048	0.535
MOD_GlcNHglycan	193	196	PF01048	0.453
MOD_GlcNHglycan	65	68	PF01048	0.777
MOD_GlcNHglycan	85	88	PF01048	0.591
MOD_GSK3_1	15	22	PF00069	0.398
MOD_GSK3_1	4	11	PF00069	0.580
MOD_GSK3_1	63	70	PF00069	0.738
MOD_GSK3_1	79	86	PF00069	0.527
MOD_N-GLC_1	62	67	PF02516	0.777
MOD_NEK2_1	165	170	PF00069	0.436
MOD_NEK2_1	37	42	PF00069	0.464
MOD_PIKK_1	89	95	PF00454	0.495
MOD_Plk_1	37	43	PF00069	0.559
MOD_Plk_4	125	131	PF00069	0.389
MOD_ProDKin_1	113	119	PF00069	0.167
MOD_ProDKin_1	15	21	PF00069	0.380
MOD_ProDKin_1	4	10	PF00069	0.589
MOD_ProDKin_1	95	101	PF00069	0.617
MOD_SUMO_rev_2	219	228	PF00179	0.442
MOD_SUMO_rev_2	76	82	PF00179	0.753
TRG_DiLeu_BaEn_2	160	166	PF01217	0.453
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.328
TRG_ENDOCYTIC_2	198	201	PF00928	0.382
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U8	Leptomonas seymouri	57%	75%
A0A1X0P783	Trypanosomatidae	46%	72%
A0A3S7WV17	Leishmania donovani	100%	100%
A0A422P0K3	Trypanosoma rangeli	46%	78%
A4H9M0	Leishmania braziliensis	82%	100%
D0A5C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	78%
E9ARP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q15327	Homo sapiens	26%	72%
Q4QDT2	Leishmania major	94%	100%
Q8N6D5	Homo sapiens	26%	77%
Q9WV06	Mus musculus	28%	70%
V5BJ76	Trypanosoma cruzi	46%	78%