Phosphodiesterase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphodiesterase

Gene product:

cAMP phosphodiesterase A - putative

Species:

Leishmania infantum

UniProt:

A4HXY3_LEIIN

TriTrypDb:

LINF_180016300

Length:

631

Annotations

LeishMANIAdb annotations

Phosphodiesterase, with probable N-terminal lipidation signal. Not embedded in membrane, like its homologs.

Annotations by Jardim et al.

Phosphodiesterase, cAMP phosphodiesterase A PDEA

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A4HXY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXY3

Function

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Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	13
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	13
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	13
GO:0050794	regulation of cellular process	3	13

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	13
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	13
GO:0005488	binding	1	13
GO:0008081	phosphoric diester hydrolase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0042578	phosphoric ester hydrolase activity	4	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.539
CLV_NRD_NRD_1	204	206	PF00675	0.619
CLV_PCSK_KEX2_1	126	128	PF00082	0.485
CLV_PCSK_KEX2_1	177	179	PF00082	0.609
CLV_PCSK_KEX2_1	408	410	PF00082	0.465
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.485
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.617
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.465
CLV_PCSK_SKI1_1	126	130	PF00082	0.556
CLV_PCSK_SKI1_1	141	145	PF00082	0.554

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y4	Leptomonas seymouri	34%	89%
A0A0N1PG81	Leptomonas seymouri	66%	100%
A0A0S4KIW5	Bodo saltans	47%	100%
A0A1X0P701	Trypanosomatidae	50%	100%
A0A3Q8IB14	Leishmania donovani	99%	100%
A0A422P0P1	Trypanosoma rangeli	49%	100%
A4H9L9	Leishmania braziliensis	86%	100%
D0A5C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ARP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q6S998	Leishmania major	96%	100%

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