Putative vacuolar protein sorting complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar protein sorting-associated protein 16 homolog - putative

Species:

Leishmania infantum

UniProt:

A4HXY1_LEIIN

TriTrypDb:

LINF_180016100

Length:

831

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0012505	endomembrane system	2	9
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005768	endosome	7	1
GO:0030897	HOPS complex	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A4HXY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXY1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0006996	organelle organization	4	10
GO:0007033	vacuole organization	5	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016043	cellular component organization	3	10
GO:0033036	macromolecule localization	2	10
GO:0045184	establishment of protein localization	3	10
GO:0046907	intracellular transport	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0042144	vacuole fusion, non-autophagic	7	1
GO:0048284	organelle fusion	5	1
GO:0097576	vacuole fusion	6	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.478
CLV_C14_Caspase3-7	736	740	PF00656	0.461
CLV_NRD_NRD_1	178	180	PF00675	0.421
CLV_PCSK_KEX2_1	100	102	PF00082	0.384
CLV_PCSK_KEX2_1	178	180	PF00082	0.421
CLV_PCSK_KEX2_1	336	338	PF00082	0.321
CLV_PCSK_KEX2_1	362	364	PF00082	0.407
CLV_PCSK_KEX2_1	502	504	PF00082	0.421
CLV_PCSK_KEX2_1	751	753	PF00082	0.421
CLV_PCSK_KEX2_1	787	789	PF00082	0.313
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.384
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.321
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.482
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.421
CLV_PCSK_PC1ET2_1	751	753	PF00082	0.421
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.421
CLV_PCSK_SKI1_1	121	125	PF00082	0.396
CLV_PCSK_SKI1_1	336	340	PF00082	0.421
CLV_PCSK_SKI1_1	448	452	PF00082	0.460
CLV_PCSK_SKI1_1	59	63	PF00082	0.421
CLV_PCSK_SKI1_1	682	686	PF00082	0.414
CLV_PCSK_SKI1_1	697	701	PF00082	0.386
CLV_PCSK_SKI1_1	709	713	PF00082	0.335
CLV_PCSK_SKI1_1	735	739	PF00082	0.397
DEG_APCC_DBOX_1	258	266	PF00400	0.462
DEG_ODPH_VHL_1	267	278	PF01847	0.384
DEG_SPOP_SBC_1	623	627	PF00917	0.603
DOC_CYCLIN_RxL_1	69	81	PF00134	0.365
DOC_MAPK_DCC_7	367	377	PF00069	0.551
DOC_MAPK_gen_1	100	108	PF00069	0.468
DOC_MAPK_gen_1	362	372	PF00069	0.488
DOC_PP1_RVXF_1	151	158	PF00149	0.377
DOC_PP2B_LxvP_1	134	137	PF13499	0.462
DOC_PP2B_LxvP_1	76	79	PF13499	0.377
DOC_PP4_FxxP_1	700	703	PF00568	0.421
DOC_USP7_MATH_1	112	116	PF00917	0.388
DOC_USP7_MATH_1	126	130	PF00917	0.231
DOC_USP7_MATH_1	232	236	PF00917	0.338
DOC_USP7_MATH_1	29	33	PF00917	0.379
DOC_USP7_MATH_1	411	415	PF00917	0.512
DOC_USP7_MATH_1	429	433	PF00917	0.321
DOC_USP7_MATH_1	609	613	PF00917	0.506
DOC_USP7_MATH_1	820	824	PF00917	0.612
DOC_USP7_UBL2_3	444	448	PF12436	0.521
DOC_USP7_UBL2_3	799	803	PF12436	0.321
DOC_WW_Pin1_4	108	113	PF00397	0.457
DOC_WW_Pin1_4	146	151	PF00397	0.321
DOC_WW_Pin1_4	180	185	PF00397	0.384
DOC_WW_Pin1_4	617	622	PF00397	0.613
DOC_WW_Pin1_4	628	633	PF00397	0.634
LIG_14-3-3_CanoR_1	101	110	PF00244	0.357
LIG_14-3-3_CanoR_1	178	184	PF00244	0.395
LIG_14-3-3_CanoR_1	346	352	PF00244	0.418
LIG_14-3-3_CanoR_1	395	399	PF00244	0.520
LIG_14-3-3_CanoR_1	430	434	PF00244	0.546
LIG_14-3-3_CanoR_1	454	461	PF00244	0.537
LIG_14-3-3_CanoR_1	622	632	PF00244	0.695
LIG_14-3-3_CanoR_1	689	693	PF00244	0.444
LIG_Actin_WH2_2	401	419	PF00022	0.416
LIG_Actin_WH2_2	487	504	PF00022	0.421
LIG_BIR_III_2	181	185	PF00653	0.287
LIG_BRCT_BRCA1_1	114	118	PF00533	0.462
LIG_BRCT_BRCA1_1	260	264	PF00533	0.323
LIG_BRCT_BRCA1_1	353	357	PF00533	0.429
LIG_BRCT_BRCA1_1	776	780	PF00533	0.462
LIG_Clathr_ClatBox_1	226	230	PF01394	0.346
LIG_Clathr_ClatBox_1	91	95	PF01394	0.464
LIG_FHA_1	101	107	PF00498	0.214
LIG_FHA_1	14	20	PF00498	0.377
LIG_FHA_1	513	519	PF00498	0.326
LIG_FHA_1	743	749	PF00498	0.451
LIG_FHA_1	86	92	PF00498	0.462
LIG_FHA_2	287	293	PF00498	0.421
LIG_FHA_2	40	46	PF00498	0.418
LIG_FHA_2	52	58	PF00498	0.356
LIG_FHA_2	70	76	PF00498	0.311
LIG_FHA_2	734	740	PF00498	0.421
LIG_FHA_2	766	772	PF00498	0.462
LIG_GBD_Chelix_1	408	416	PF00786	0.419
LIG_GBD_Chelix_1	442	450	PF00786	0.492
LIG_LIR_Apic_2	749	753	PF02991	0.421
LIG_LIR_Gen_1	129	138	PF02991	0.431
LIG_LIR_Gen_1	16	24	PF02991	0.462
LIG_LIR_Gen_1	169	177	PF02991	0.325
LIG_LIR_Gen_1	261	272	PF02991	0.324
LIG_LIR_Gen_1	289	299	PF02991	0.377
LIG_LIR_Gen_1	347	353	PF02991	0.321
LIG_LIR_Gen_1	354	364	PF02991	0.386
LIG_LIR_Gen_1	45	55	PF02991	0.462
LIG_LIR_Gen_1	456	465	PF02991	0.419
LIG_LIR_Gen_1	511	521	PF02991	0.346
LIG_LIR_Gen_1	592	600	PF02991	0.472
LIG_LIR_Gen_1	646	657	PF02991	0.354
LIG_LIR_Gen_1	718	727	PF02991	0.377
LIG_LIR_Gen_1	813	822	PF02991	0.527
LIG_LIR_Nem_3	104	110	PF02991	0.350
LIG_LIR_Nem_3	129	134	PF02991	0.431
LIG_LIR_Nem_3	16	21	PF02991	0.385
LIG_LIR_Nem_3	169	174	PF02991	0.325
LIG_LIR_Nem_3	261	267	PF02991	0.324
LIG_LIR_Nem_3	289	294	PF02991	0.377
LIG_LIR_Nem_3	347	351	PF02991	0.391
LIG_LIR_Nem_3	45	51	PF02991	0.462
LIG_LIR_Nem_3	456	461	PF02991	0.331
LIG_LIR_Nem_3	592	598	PF02991	0.481
LIG_LIR_Nem_3	627	633	PF02991	0.593
LIG_LIR_Nem_3	646	652	PF02991	0.354
LIG_LIR_Nem_3	666	670	PF02991	0.132
LIG_LIR_Nem_3	718	724	PF02991	0.362
LIG_LIR_Nem_3	771	775	PF02991	0.321
LIG_LIR_Nem_3	826	830	PF02991	0.584
LIG_LRP6_Inhibitor_1	516	522	PF00058	0.248
LIG_MAD2	142	150	PF02301	0.462
LIG_MLH1_MIPbox_1	260	264	PF16413	0.406
LIG_PCNA_PIPBox_1	553	562	PF02747	0.406
LIG_PCNA_yPIPBox_3	553	565	PF02747	0.406
LIG_Pex14_2	344	348	PF04695	0.321
LIG_Pex14_2	827	831	PF04695	0.611
LIG_PTB_Apo_2	12	19	PF02174	0.474
LIG_SH2_CRK	670	674	PF00017	0.462
LIG_SH2_CRK	750	754	PF00017	0.421
LIG_SH2_GRB2like	559	562	PF00017	0.338
LIG_SH2_PTP2	545	548	PF00017	0.377
LIG_SH2_STAP1	220	224	PF00017	0.384
LIG_SH2_STAP1	291	295	PF00017	0.377
LIG_SH2_STAT3	263	266	PF00017	0.406
LIG_SH2_STAT5	200	203	PF00017	0.328
LIG_SH2_STAT5	24	27	PF00017	0.471
LIG_SH2_STAT5	263	266	PF00017	0.406
LIG_SH2_STAT5	545	548	PF00017	0.346
LIG_SH2_STAT5	559	562	PF00017	0.281
LIG_SH2_STAT5	569	572	PF00017	0.279
LIG_SH2_STAT5	575	578	PF00017	0.263
LIG_SH2_STAT5	71	74	PF00017	0.365
LIG_SH2_STAT5	715	718	PF00017	0.385
LIG_SH2_STAT5	759	762	PF00017	0.332
LIG_SH2_STAT5	773	776	PF00017	0.321
LIG_SH3_3	226	232	PF00018	0.377
LIG_Sin3_3	48	55	PF02671	0.462
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.395
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.346
LIG_SUMO_SIM_anti_2	88	93	PF11976	0.456
LIG_SUMO_SIM_par_1	417	422	PF11976	0.502
LIG_SUMO_SIM_par_1	474	479	PF11976	0.411
LIG_SUMO_SIM_par_1	490	496	PF11976	0.286
LIG_SUMO_SIM_par_1	8	14	PF11976	0.346
LIG_SUMO_SIM_par_1	90	97	PF11976	0.462
LIG_SxIP_EBH_1	756	765	PF03271	0.462
LIG_TYR_ITIM	543	548	PF00017	0.377
LIG_UBA3_1	794	803	PF00899	0.321
MOD_CDK_SPK_2	617	622	PF00069	0.609
MOD_CDK_SPxxK_3	146	153	PF00069	0.377
MOD_CK1_1	111	117	PF00069	0.447
MOD_CK1_1	127	133	PF00069	0.209
MOD_CK1_1	163	169	PF00069	0.397
MOD_CK1_1	172	178	PF00069	0.384
MOD_CK1_1	258	264	PF00069	0.299
MOD_CK1_1	277	283	PF00069	0.435
MOD_CK1_1	432	438	PF00069	0.494
MOD_CK1_1	523	529	PF00069	0.403
MOD_CK1_1	589	595	PF00069	0.615
MOD_CK1_1	625	631	PF00069	0.594
MOD_CK1_1	728	734	PF00069	0.365
MOD_CK1_1	823	829	PF00069	0.656
MOD_CK2_1	127	133	PF00069	0.442
MOD_CK2_1	225	231	PF00069	0.248
MOD_CK2_1	287	293	PF00069	0.421
MOD_CK2_1	432	438	PF00069	0.474
MOD_CK2_1	490	496	PF00069	0.397
MOD_CK2_1	51	57	PF00069	0.418
MOD_CK2_1	69	75	PF00069	0.311
MOD_CK2_1	765	771	PF00069	0.431
MOD_GlcNHglycan	168	171	PF01048	0.474
MOD_GlcNHglycan	207	210	PF01048	0.385
MOD_GlcNHglycan	298	302	PF01048	0.389
MOD_GlcNHglycan	311	314	PF01048	0.414
MOD_GlcNHglycan	525	528	PF01048	0.463
MOD_GlcNHglycan	591	594	PF01048	0.641
MOD_GlcNHglycan	675	678	PF01048	0.421
MOD_GlcNHglycan	712	715	PF01048	0.355
MOD_GlcNHglycan	725	730	PF01048	0.408
MOD_GlcNHglycan	822	825	PF01048	0.563
MOD_GlcNHglycan	95	99	PF01048	0.398
MOD_GSK3_1	108	115	PF00069	0.383
MOD_GSK3_1	160	167	PF00069	0.379
MOD_GSK3_1	188	195	PF00069	0.427
MOD_GSK3_1	232	239	PF00069	0.439
MOD_GSK3_1	25	32	PF00069	0.381
MOD_GSK3_1	293	300	PF00069	0.393
MOD_GSK3_1	347	354	PF00069	0.377
MOD_GSK3_1	531	538	PF00069	0.359
MOD_GSK3_1	624	631	PF00069	0.583
MOD_GSK3_1	673	680	PF00069	0.321
MOD_GSK3_1	725	732	PF00069	0.404
MOD_GSK3_1	74	81	PF00069	0.462
MOD_GSK3_1	742	749	PF00069	0.281
MOD_N-GLC_1	127	132	PF02516	0.436
MOD_N-GLC_2	23	25	PF02516	0.474
MOD_NEK2_1	124	129	PF00069	0.462
MOD_NEK2_1	160	165	PF00069	0.387
MOD_NEK2_1	286	291	PF00069	0.313
MOD_NEK2_1	308	313	PF00069	0.400
MOD_NEK2_1	344	349	PF00069	0.389
MOD_NEK2_1	351	356	PF00069	0.415
MOD_NEK2_1	490	495	PF00069	0.421
MOD_NEK2_1	51	56	PF00069	0.425
MOD_NEK2_1	512	517	PF00069	0.321
MOD_NEK2_1	520	525	PF00069	0.321
MOD_NEK2_1	652	657	PF00069	0.463
MOD_NEK2_1	673	678	PF00069	0.321
MOD_NEK2_1	716	721	PF00069	0.459
MOD_NEK2_1	85	90	PF00069	0.383
MOD_NEK2_2	220	225	PF00069	0.384
MOD_NEK2_2	429	434	PF00069	0.593
MOD_NEK2_2	677	682	PF00069	0.421
MOD_PIKK_1	482	488	PF00454	0.470
MOD_PIKK_1	584	590	PF00454	0.625
MOD_PIKK_1	658	664	PF00454	0.416
MOD_PIKK_1	716	722	PF00454	0.406
MOD_PIKK_1	793	799	PF00454	0.351
MOD_PKA_1	100	106	PF00069	0.384
MOD_PKA_2	100	106	PF00069	0.418
MOD_PKA_2	177	183	PF00069	0.393
MOD_PKA_2	258	264	PF00069	0.384
MOD_PKA_2	394	400	PF00069	0.532
MOD_PKA_2	429	435	PF00069	0.589
MOD_PKA_2	453	459	PF00069	0.542
MOD_PKA_2	523	529	PF00069	0.377
MOD_PKA_2	688	694	PF00069	0.418
MOD_Plk_1	127	133	PF00069	0.436
MOD_Plk_1	172	178	PF00069	0.321
MOD_Plk_1	297	303	PF00069	0.377
MOD_Plk_1	352	358	PF00069	0.542
MOD_Plk_1	577	583	PF00069	0.460
MOD_Plk_1	658	664	PF00069	0.387
MOD_Plk_1	69	75	PF00069	0.462
MOD_Plk_4	114	120	PF00069	0.326
MOD_Plk_4	127	133	PF00069	0.310
MOD_Plk_4	160	166	PF00069	0.346
MOD_Plk_4	172	178	PF00069	0.327
MOD_Plk_4	183	189	PF00069	0.382
MOD_Plk_4	220	226	PF00069	0.354
MOD_Plk_4	258	264	PF00069	0.374
MOD_Plk_4	353	359	PF00069	0.465
MOD_Plk_4	640	646	PF00069	0.560
MOD_Plk_4	652	658	PF00069	0.421
MOD_Plk_4	733	739	PF00069	0.360
MOD_ProDKin_1	108	114	PF00069	0.457
MOD_ProDKin_1	146	152	PF00069	0.321
MOD_ProDKin_1	180	186	PF00069	0.384
MOD_ProDKin_1	617	623	PF00069	0.620
MOD_ProDKin_1	628	634	PF00069	0.630
MOD_SUMO_for_1	764	767	PF00179	0.462
MOD_SUMO_rev_2	410	419	PF00179	0.502
MOD_SUMO_rev_2	53	61	PF00179	0.451
MOD_SUMO_rev_2	596	604	PF00179	0.464
TRG_DiLeu_BaEn_1	659	664	PF01217	0.321
TRG_DiLeu_BaEn_2	259	265	PF01217	0.462
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.421
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.499
TRG_ENDOCYTIC_2	291	294	PF00928	0.377
TRG_ENDOCYTIC_2	545	548	PF00928	0.346
TRG_ENDOCYTIC_2	569	572	PF00928	0.341
TRG_ENDOCYTIC_2	670	673	PF00928	0.462
TRG_ENDOCYTIC_2	772	775	PF00928	0.346
TRG_ER_diArg_1	177	179	PF00400	0.421
TRG_ER_diArg_1	363	366	PF00400	0.413
TRG_ER_diArg_1	521	524	PF00400	0.416
TRG_NES_CRM1_1	84	96	PF08389	0.462
TRG_Pf-PMV_PEXEL_1	648	653	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	810	814	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I839	Leptomonas seymouri	69%	100%
A0A1X0P6Z7	Trypanosomatidae	39%	90%
A0A3S7WUZ3	Leishmania donovani	100%	100%
A0A422P0I7	Trypanosoma rangeli	38%	91%
A4H9L7	Leishmania braziliensis	88%	100%
D0A5C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	91%
E9ARP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QDT5	Leishmania major	96%	100%
Q55C58	Dictyostelium discoideum	26%	100%
Q93VQ0	Arabidopsis thaliana	26%	97%
Q9H269	Homo sapiens	27%	99%
Q9UT38	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
V5BGG7	Trypanosoma cruzi	22%	83%