Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial carrier protein - putative

Species:

Leishmania infantum

UniProt:

A4HXX3_LEIIN

TriTrypDb:

LINF_180015300

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	33
GO:0110165	cellular anatomical entity	1	33
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HXX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXX3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006862	nucleotide transport	6	7
GO:0009987	cellular process	1	7
GO:0015748	organophosphate ester transport	5	7
GO:0015931	nucleobase-containing compound transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0055085	transmembrane transport	2	7
GO:0071702	organic substance transport	4	7
GO:0071705	nitrogen compound transport	4	7
GO:0035352	NAD transmembrane transport	4	1
GO:0043132	NAD transport	7	1
GO:1901679	nucleotide transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0051724	NAD transmembrane transporter activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.342
CLV_NRD_NRD_1	377	379	PF00675	0.362
CLV_NRD_NRD_1	389	391	PF00675	0.305
CLV_NRD_NRD_1	399	401	PF00675	0.270
CLV_NRD_NRD_1	78	80	PF00675	0.300
CLV_PCSK_KEX2_1	161	163	PF00082	0.526
CLV_PCSK_KEX2_1	389	391	PF00082	0.342
CLV_PCSK_KEX2_1	80	82	PF00082	0.285
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.526
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.295
CLV_PCSK_SKI1_1	198	202	PF00082	0.260
CLV_PCSK_SKI1_1	274	278	PF00082	0.528
CLV_PCSK_SKI1_1	405	409	PF00082	0.240
CLV_PCSK_SKI1_1	66	70	PF00082	0.316
CLV_PCSK_SKI1_1	80	84	PF00082	0.282
DEG_APCC_DBOX_1	242	250	PF00400	0.562
DEG_Nend_Nbox_1	1	3	PF02207	0.485
DEG_SPOP_SBC_1	3	7	PF00917	0.334
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.335
DOC_CYCLIN_yCln2_LP_2	337	343	PF00134	0.327
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.388
DOC_MAPK_gen_1	272	279	PF00069	0.248
DOC_PP2B_LxvP_1	258	261	PF13499	0.430
DOC_PP2B_LxvP_1	50	53	PF13499	0.348
DOC_USP7_MATH_1	168	172	PF00917	0.360
DOC_USP7_MATH_1	22	26	PF00917	0.437
DOC_USP7_MATH_1	297	301	PF00917	0.435
DOC_USP7_MATH_1	3	7	PF00917	0.539
DOC_USP7_MATH_1	324	328	PF00917	0.351
DOC_USP7_MATH_1	34	38	PF00917	0.445
DOC_USP7_MATH_1	369	373	PF00917	0.585
DOC_USP7_MATH_1	413	417	PF00917	0.328
DOC_USP7_UBL2_3	379	383	PF12436	0.591
DOC_WW_Pin1_4	156	161	PF00397	0.348
DOC_WW_Pin1_4	187	192	PF00397	0.335
DOC_WW_Pin1_4	312	317	PF00397	0.344
DOC_WW_Pin1_4	371	376	PF00397	0.590
DOC_WW_Pin1_4	4	9	PF00397	0.551
DOC_WW_Pin1_4	84	89	PF00397	0.617
LIG_14-3-3_CanoR_1	198	206	PF00244	0.464
LIG_14-3-3_CanoR_1	378	383	PF00244	0.536
LIG_14-3-3_CanoR_1	45	53	PF00244	0.272
LIG_BRCT_BRCA1_1	142	146	PF00533	0.234
LIG_BRCT_BRCA1_1	384	388	PF00533	0.530
LIG_Clathr_ClatBox_1	145	149	PF01394	0.390
LIG_FHA_1	140	146	PF00498	0.328
LIG_FHA_1	300	306	PF00498	0.430
LIG_FHA_1	332	338	PF00498	0.299
LIG_FHA_1	368	374	PF00498	0.387
LIG_FHA_1	38	44	PF00498	0.365
LIG_IRF3_LxIS_1	72	78	PF10401	0.491
LIG_LIR_Gen_1	209	219	PF02991	0.552
LIG_LIR_Gen_1	430	438	PF02991	0.329
LIG_LIR_Gen_1	44	53	PF02991	0.337
LIG_LIR_Gen_1	54	63	PF02991	0.300
LIG_LIR_Nem_3	209	215	PF02991	0.551
LIG_LIR_Nem_3	218	222	PF02991	0.524
LIG_LIR_Nem_3	247	253	PF02991	0.460
LIG_LIR_Nem_3	263	269	PF02991	0.332
LIG_LIR_Nem_3	335	341	PF02991	0.285
LIG_LIR_Nem_3	385	391	PF02991	0.515
LIG_LIR_Nem_3	421	427	PF02991	0.346
LIG_LIR_Nem_3	430	434	PF02991	0.248
LIG_LIR_Nem_3	44	50	PF02991	0.333
LIG_LIR_Nem_3	54	59	PF02991	0.276
LIG_LIR_Nem_3	67	73	PF02991	0.373
LIG_NRBOX	134	140	PF00104	0.234
LIG_NRBOX	182	188	PF00104	0.327
LIG_PALB2_WD40_1	51	59	PF16756	0.301
LIG_Pex14_1	266	270	PF04695	0.284
LIG_Pex14_1	288	292	PF04695	0.282
LIG_Pex14_2	219	223	PF04695	0.459
LIG_Pex14_2	425	429	PF04695	0.308
LIG_REV1ctd_RIR_1	405	413	PF16727	0.450
LIG_SH2_CRK	127	131	PF00017	0.496
LIG_SH2_CRK	212	216	PF00017	0.564
LIG_SH2_CRK	250	254	PF00017	0.307
LIG_SH2_GRB2like	212	215	PF00017	0.578
LIG_SH2_NCK_1	204	208	PF00017	0.633
LIG_SH2_NCK_1	212	216	PF00017	0.446
LIG_SH2_SRC	10	13	PF00017	0.380
LIG_SH2_SRC	154	157	PF00017	0.386
LIG_SH2_STAP1	172	176	PF00017	0.341
LIG_SH2_STAT5	144	147	PF00017	0.307
LIG_SH2_STAT5	154	157	PF00017	0.334
LIG_SH2_STAT5	212	215	PF00017	0.495
LIG_SH2_STAT5	270	273	PF00017	0.292
LIG_SH2_STAT5	278	281	PF00017	0.278
LIG_SH3_3	277	283	PF00018	0.422
LIG_SUMO_SIM_anti_2	182	188	PF11976	0.349
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.317
LIG_SUMO_SIM_anti_2	416	421	PF11976	0.354
LIG_SUMO_SIM_par_1	185	190	PF11976	0.316
LIG_UBA3_1	145	152	PF00899	0.476
MOD_CDC14_SPxK_1	159	162	PF00782	0.291
MOD_CDK_SPK_2	156	161	PF00069	0.274
MOD_CDK_SPK_2	4	9	PF00069	0.405
MOD_CDK_SPxK_1	156	162	PF00069	0.273
MOD_CDK_SPxxK_3	371	378	PF00069	0.394
MOD_CK1_1	170	176	PF00069	0.326
MOD_CK1_1	205	211	PF00069	0.612
MOD_CK1_1	331	337	PF00069	0.279
MOD_CK1_1	37	43	PF00069	0.377
MOD_CK1_1	371	377	PF00069	0.567
MOD_CK1_1	4	10	PF00069	0.516
MOD_GlcNHglycan	104	107	PF01048	0.342
MOD_GlcNHglycan	172	175	PF01048	0.486
MOD_GlcNHglycan	18	22	PF01048	0.726
MOD_GlcNHglycan	24	27	PF01048	0.615
MOD_GlcNHglycan	246	249	PF01048	0.329
MOD_GlcNHglycan	253	256	PF01048	0.295
MOD_GlcNHglycan	262	265	PF01048	0.235
MOD_GlcNHglycan	34	37	PF01048	0.648
MOD_GlcNHglycan	59	62	PF01048	0.335
MOD_GSK3_1	140	147	PF00069	0.304
MOD_GSK3_1	17	24	PF00069	0.459
MOD_GSK3_1	198	205	PF00069	0.523
MOD_GSK3_1	206	213	PF00069	0.532
MOD_GSK3_1	297	304	PF00069	0.404
MOD_GSK3_1	32	39	PF00069	0.416
MOD_GSK3_1	324	331	PF00069	0.265
MOD_GSK3_1	367	374	PF00069	0.565
MOD_GSK3_1	378	385	PF00069	0.524
MOD_GSK3_1	41	48	PF00069	0.356
MOD_GSK3_1	429	436	PF00069	0.279
MOD_GSK3_1	80	87	PF00069	0.548
MOD_N-GLC_1	413	418	PF02516	0.327
MOD_N-GLC_1	45	50	PF02516	0.534
MOD_NEK2_1	1	6	PF00069	0.458
MOD_NEK2_1	139	144	PF00069	0.362
MOD_NEK2_1	167	172	PF00069	0.356
MOD_NEK2_1	206	211	PF00069	0.566
MOD_NEK2_1	408	413	PF00069	0.477
MOD_NEK2_1	429	434	PF00069	0.229
MOD_NEK2_1	75	80	PF00069	0.468
MOD_PKA_1	378	384	PF00069	0.413
MOD_PKA_1	80	86	PF00069	0.542
MOD_PKA_2	102	108	PF00069	0.613
MOD_PKA_2	80	86	PF00069	0.542
MOD_Plk_1	140	146	PF00069	0.351
MOD_Plk_1	357	363	PF00069	0.394
MOD_Plk_1	413	419	PF00069	0.351
MOD_Plk_4	140	146	PF00069	0.330
MOD_Plk_4	324	330	PF00069	0.292
MOD_Plk_4	332	338	PF00069	0.271
MOD_Plk_4	357	363	PF00069	0.546
MOD_Plk_4	51	57	PF00069	0.235
MOD_Plk_4	87	93	PF00069	0.542
MOD_ProDKin_1	156	162	PF00069	0.354
MOD_ProDKin_1	187	193	PF00069	0.335
MOD_ProDKin_1	312	318	PF00069	0.340
MOD_ProDKin_1	371	377	PF00069	0.590
MOD_ProDKin_1	4	10	PF00069	0.554
MOD_ProDKin_1	84	90	PF00069	0.620
MOD_SUMO_rev_2	300	305	PF00179	0.316
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.402
TRG_ENDOCYTIC_2	127	130	PF00928	0.463
TRG_ENDOCYTIC_2	212	215	PF00928	0.556
TRG_ENDOCYTIC_2	250	253	PF00928	0.291
TRG_ER_diArg_1	388	390	PF00400	0.477
TRG_ER_diArg_1	79	82	PF00400	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S5	Leptomonas seymouri	25%	100%
A0A0N1IBB8	Leptomonas seymouri	59%	93%
A0A0N1IHK9	Leptomonas seymouri	26%	100%
A0A0S4JF45	Bodo saltans	37%	100%
A0A0S4JH99	Bodo saltans	26%	88%
A0A0S4JIT1	Bodo saltans	24%	100%
A0A1X0NN16	Trypanosomatidae	23%	100%
A0A1X0NQB5	Trypanosomatidae	26%	100%
A0A1X0P6Z0	Trypanosomatidae	45%	100%
A0A3Q8IC78	Leishmania donovani	26%	100%
A0A3Q8IS12	Leishmania donovani	26%	100%
A0A3R7L1P3	Trypanosoma rangeli	24%	100%
A0A3S7WUZ5	Leishmania donovani	100%	100%
A0A422NGL1	Trypanosoma rangeli	25%	100%
A0A422P0Q3	Trypanosoma rangeli	46%	100%
A4H690	Leishmania braziliensis	26%	100%
A4H9K7	Leishmania braziliensis	83%	100%
A4HQI4	Leishmania braziliensis	26%	88%
A4HUL3	Leishmania infantum	24%	98%
C9ZVP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZZS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AHZ3	Leishmania infantum	26%	100%
E9ANB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	97%
E9ARN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AU97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	92%
Q4Q094	Leishmania major	26%	92%
Q4QDU2	Leishmania major	94%	100%
Q4QHB2	Leishmania major	26%	97%
V5BTU3	Trypanosoma cruzi	26%	100%
V5DDT9	Trypanosoma cruzi	24%	100%
V5DN72	Trypanosoma cruzi	45%	100%