Der GTPase-activating protein YihI

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXX1_LEIIN

TriTrypDb:

LINF_180015100

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HXX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.616
CLV_C14_Caspase3-7	24	28	PF00656	0.702
CLV_NRD_NRD_1	102	104	PF00675	0.530
CLV_NRD_NRD_1	111	113	PF00675	0.575
CLV_NRD_NRD_1	13	15	PF00675	0.608
CLV_NRD_NRD_1	4	6	PF00675	0.561
CLV_NRD_NRD_1	96	98	PF00675	0.441
CLV_PCSK_FUR_1	100	104	PF00082	0.624
CLV_PCSK_KEX2_1	102	104	PF00082	0.542
CLV_PCSK_KEX2_1	111	113	PF00082	0.307
CLV_PCSK_KEX2_1	141	143	PF00082	0.589
CLV_PCSK_KEX2_1	4	6	PF00082	0.563
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.587
CLV_PCSK_SKI1_1	119	123	PF00082	0.453
CLV_PCSK_SKI1_1	16	20	PF00082	0.565
CLV_PCSK_SKI1_1	5	9	PF00082	0.680
CLV_PCSK_SKI1_1	75	79	PF00082	0.431
CLV_PCSK_SKI1_1	84	88	PF00082	0.390
DOC_USP7_MATH_1	21	25	PF00917	0.724
DOC_USP7_UBL2_3	15	19	PF12436	0.579
DOC_USP7_UBL2_3	37	41	PF12436	0.632
DOC_USP7_UBL2_3	71	75	PF12436	0.489
LIG_LIR_Gen_1	163	172	PF02991	0.585
LIG_LIR_Nem_3	163	169	PF02991	0.582
LIG_SH2_STAT3	117	120	PF00017	0.401
LIG_SH2_STAT5	117	120	PF00017	0.437
MOD_CK1_1	131	137	PF00069	0.470
MOD_CK2_1	131	137	PF00069	0.515
MOD_GlcNHglycan	24	27	PF01048	0.645
MOD_GSK3_1	128	135	PF00069	0.393
MOD_GSK3_1	17	24	PF00069	0.624
MOD_PKA_1	22	28	PF00069	0.652
MOD_Plk_1	131	137	PF00069	0.333
MOD_Plk_2-3	132	138	PF00069	0.438
MOD_SUMO_for_1	107	110	PF00179	0.417
MOD_SUMO_for_1	121	124	PF00179	0.478
MOD_SUMO_rev_2	134	143	PF00179	0.459
TRG_DiLeu_BaEn_1	139	144	PF01217	0.517
TRG_DiLeu_LyEn_5	139	144	PF01217	0.460
TRG_ER_diArg_1	100	103	PF00400	0.511
TRG_ER_diArg_1	4	6	PF00400	0.575
TRG_ER_diArg_1	48	51	PF00400	0.681
TRG_NLS_Bipartite_1	4	20	PF00514	0.556
TRG_NLS_Bipartite_1	57	74	PF00514	0.443
TRG_NLS_MonoCore_2	13	18	PF00514	0.575
TRG_NLS_MonoExtC_3	14	19	PF00514	0.559
TRG_NLS_MonoExtN_4	11	18	PF00514	0.575
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9L1	Leptomonas seymouri	69%	98%
A0A0S4JFM3	Bodo saltans	41%	100%
A0A1X0P6Y6	Trypanosomatidae	45%	100%
A0A3S7WUY3	Leishmania donovani	100%	100%
A4H9K6	Leishmania braziliensis	85%	100%
C9ZZT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ARN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QDU4	Leishmania major	93%	99%
V5B6M9	Trypanosoma cruzi	44%	100%