LeishMANIAdb
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GPI mannosyltransferase 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GPI mannosyltransferase 2
Gene product:
mannosyltransferase-II - putative
Species:
Leishmania infantum
UniProt:
A4HXW9_LEIIN
TriTrypDb:
LINF_180014900
Length:
704

Annotations

Annotations by Jardim et al.

GPI anchor biosynthesis, mannosyltransferase-II

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 7
GO:0016020 membrane 2 7
GO:0031090 organelle membrane 3 7
GO:0110165 cellular anatomical entity 1 7
GO:0005737 cytoplasm 2 1
GO:0031501 mannosyltransferase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

A4HXW9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXW9

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 7
GO:0006505 GPI anchor metabolic process 6 7
GO:0006506 GPI anchor biosynthetic process 6 7
GO:0006629 lipid metabolic process 3 7
GO:0006643 membrane lipid metabolic process 4 7
GO:0006644 phospholipid metabolic process 4 7
GO:0006650 glycerophospholipid metabolic process 5 7
GO:0006661 phosphatidylinositol biosynthetic process 6 7
GO:0006664 glycolipid metabolic process 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0008610 lipid biosynthetic process 4 7
GO:0008654 phospholipid biosynthetic process 5 7
GO:0009058 biosynthetic process 2 7
GO:0009247 glycolipid biosynthetic process 5 7
GO:0009987 cellular process 1 7
GO:0019538 protein metabolic process 3 7
GO:0019637 organophosphate metabolic process 3 7
GO:0036211 protein modification process 4 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0044249 cellular biosynthetic process 3 7
GO:0044255 cellular lipid metabolic process 3 7
GO:0045017 glycerolipid biosynthetic process 4 7
GO:0046467 membrane lipid biosynthetic process 4 7
GO:0046474 glycerophospholipid biosynthetic process 5 7
GO:0046486 glycerolipid metabolic process 4 7
GO:0046488 phosphatidylinositol metabolic process 6 7
GO:0071704 organic substance metabolic process 2 7
GO:0090407 organophosphate biosynthetic process 4 7
GO:1901135 carbohydrate derivative metabolic process 3 7
GO:1901137 carbohydrate derivative biosynthetic process 4 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:1901576 organic substance biosynthetic process 3 7
GO:1903509 liposaccharide metabolic process 4 7
Molecular functions
Term Name Level Count
GO:0000009 alpha-1,6-mannosyltransferase activity 6 7
GO:0000030 mannosyltransferase activity 5 7
GO:0003824 catalytic activity 1 7
GO:0004376 glycolipid mannosyltransferase activity 6 7
GO:0016740 transferase activity 2 7
GO:0016757 glycosyltransferase activity 3 7
GO:0016758 hexosyltransferase activity 4 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 252 256 PF00656 0.585
CLV_C14_Caspase3-7 373 377 PF00656 0.739
CLV_NRD_NRD_1 151 153 PF00675 0.527
CLV_NRD_NRD_1 183 185 PF00675 0.346
CLV_NRD_NRD_1 217 219 PF00675 0.585
CLV_NRD_NRD_1 278 280 PF00675 0.308
CLV_NRD_NRD_1 3 5 PF00675 0.421
CLV_NRD_NRD_1 529 531 PF00675 0.527
CLV_NRD_NRD_1 613 615 PF00675 0.354
CLV_PCSK_KEX2_1 151 153 PF00082 0.527
CLV_PCSK_KEX2_1 183 185 PF00082 0.346
CLV_PCSK_KEX2_1 2 4 PF00082 0.426
CLV_PCSK_KEX2_1 277 279 PF00082 0.353
CLV_PCSK_KEX2_1 475 477 PF00082 0.447
CLV_PCSK_KEX2_1 529 531 PF00082 0.524
CLV_PCSK_KEX2_1 613 615 PF00082 0.354
CLV_PCSK_PC1ET2_1 475 477 PF00082 0.447
CLV_PCSK_SKI1_1 183 187 PF00082 0.420
CLV_PCSK_SKI1_1 26 30 PF00082 0.293
CLV_PCSK_SKI1_1 400 404 PF00082 0.478
CLV_PCSK_SKI1_1 530 534 PF00082 0.546
CLV_PCSK_SKI1_1 603 607 PF00082 0.314
CLV_PCSK_SKI1_1 69 73 PF00082 0.514
DEG_APCC_DBOX_1 3 11 PF00400 0.690
DEG_APCC_DBOX_1 493 501 PF00400 0.653
DEG_APCC_DBOX_1 68 76 PF00400 0.412
DEG_Nend_UBRbox_1 1 4 PF02207 0.694
DEG_SCF_FBW7_1 392 399 PF00400 0.605
DEG_SCF_FBW7_2 209 215 PF00400 0.792
DOC_AGCK_PIF_1 565 570 PF00069 0.354
DOC_CDC14_PxL_1 136 144 PF14671 0.412
DOC_CKS1_1 209 214 PF01111 0.756
DOC_CKS1_1 289 294 PF01111 0.412
DOC_CYCLIN_yCln2_LP_2 357 360 PF00134 0.680
DOC_CYCLIN_yCln2_LP_2 439 445 PF00134 0.514
DOC_CYCLIN_yCln2_LP_2 578 584 PF00134 0.412
DOC_MAPK_gen_1 183 190 PF00069 0.546
DOC_MAPK_gen_1 2 11 PF00069 0.691
DOC_MAPK_gen_1 557 564 PF00069 0.393
DOC_MAPK_gen_1 613 622 PF00069 0.554
DOC_MAPK_MEF2A_6 2 11 PF00069 0.625
DOC_MAPK_RevD_3 514 530 PF00069 0.397
DOC_PP1_RVXF_1 31 38 PF00149 0.422
DOC_PP2B_LxvP_1 254 257 PF13499 0.664
DOC_PP2B_LxvP_1 357 360 PF13499 0.746
DOC_PP2B_LxvP_1 493 496 PF13499 0.663
DOC_PP2B_LxvP_1 578 581 PF13499 0.412
DOC_PP4_FxxP_1 190 193 PF00568 0.546
DOC_PP4_FxxP_1 87 90 PF00568 0.602
DOC_USP7_MATH_1 379 383 PF00917 0.673
DOC_USP7_MATH_1 396 400 PF00917 0.591
DOC_USP7_MATH_1 43 47 PF00917 0.415
DOC_USP7_MATH_1 455 459 PF00917 0.651
DOC_USP7_MATH_1 462 466 PF00917 0.569
DOC_USP7_MATH_1 468 472 PF00917 0.521
DOC_USP7_MATH_1 479 483 PF00917 0.604
DOC_USP7_MATH_1 626 630 PF00917 0.330
DOC_WW_Pin1_4 205 210 PF00397 0.800
DOC_WW_Pin1_4 288 293 PF00397 0.412
DOC_WW_Pin1_4 336 341 PF00397 0.675
DOC_WW_Pin1_4 392 397 PF00397 0.682
DOC_WW_Pin1_4 570 575 PF00397 0.262
DOC_WW_Pin1_4 656 661 PF00397 0.385
LIG_14-3-3_CanoR_1 107 111 PF00244 0.620
LIG_14-3-3_CanoR_1 197 204 PF00244 0.683
LIG_14-3-3_CanoR_1 231 241 PF00244 0.559
LIG_14-3-3_CanoR_1 26 35 PF00244 0.353
LIG_14-3-3_CanoR_1 330 335 PF00244 0.675
LIG_14-3-3_CanoR_1 400 405 PF00244 0.644
LIG_14-3-3_CanoR_1 409 419 PF00244 0.497
LIG_14-3-3_CanoR_1 654 660 PF00244 0.417
LIG_14-3-3_CanoR_1 680 684 PF00244 0.530
LIG_APCC_ABBA_1 298 303 PF00400 0.429
LIG_APCC_ABBA_1 39 44 PF00400 0.605
LIG_BRCT_BRCA1_1 429 433 PF00533 0.346
LIG_CaM_NSCaTE_8 560 567 PF13499 0.420
LIG_eIF4E_1 559 565 PF01652 0.354
LIG_FHA_1 148 154 PF00498 0.346
LIG_FHA_1 209 215 PF00498 0.756
LIG_FHA_1 248 254 PF00498 0.555
LIG_FHA_1 300 306 PF00498 0.357
LIG_FHA_1 57 63 PF00498 0.420
LIG_FHA_2 250 256 PF00498 0.573
LIG_FHA_2 264 270 PF00498 0.637
LIG_FHA_2 53 59 PF00498 0.456
LIG_FHA_2 96 102 PF00498 0.630
LIG_GBD_Chelix_1 416 424 PF00786 0.514
LIG_GBD_Chelix_1 67 75 PF00786 0.514
LIG_LIR_Apic_2 189 193 PF02991 0.546
LIG_LIR_Gen_1 105 115 PF02991 0.527
LIG_LIR_Gen_1 44 53 PF02991 0.423
LIG_LIR_Gen_1 5 16 PF02991 0.626
LIG_LIR_Gen_1 615 625 PF02991 0.480
LIG_LIR_Gen_1 682 692 PF02991 0.417
LIG_LIR_Nem_3 105 111 PF02991 0.527
LIG_LIR_Nem_3 12 16 PF02991 0.663
LIG_LIR_Nem_3 44 50 PF02991 0.440
LIG_LIR_Nem_3 5 11 PF02991 0.671
LIG_LIR_Nem_3 563 568 PF02991 0.362
LIG_LIR_Nem_3 615 620 PF02991 0.497
LIG_LIR_Nem_3 682 688 PF02991 0.417
LIG_LYPXL_S_1 551 555 PF13949 0.546
LIG_LYPXL_yS_3 552 555 PF13949 0.346
LIG_MYND_1 491 495 PF01753 0.667
LIG_NRBOX 635 641 PF00104 0.385
LIG_NRBOX 661 667 PF00104 0.412
LIG_PCNA_PIPBox_1 328 337 PF02747 0.683
LIG_Pex14_1 406 410 PF04695 0.562
LIG_RPA_C_Fungi 273 285 PF08784 0.514
LIG_SH2_CRK 125 129 PF00017 0.343
LIG_SH2_NCK_1 42 46 PF00017 0.619
LIG_SH2_PTP2 166 169 PF00017 0.514
LIG_SH2_SRC 103 106 PF00017 0.617
LIG_SH2_SRC 42 45 PF00017 0.497
LIG_SH2_STAP1 129 133 PF00017 0.382
LIG_SH2_STAP1 301 305 PF00017 0.378
LIG_SH2_STAT3 129 132 PF00017 0.385
LIG_SH2_STAT3 453 456 PF00017 0.426
LIG_SH2_STAT5 127 130 PF00017 0.412
LIG_SH2_STAT5 166 169 PF00017 0.513
LIG_SH2_STAT5 301 304 PF00017 0.430
LIG_SH2_STAT5 315 318 PF00017 0.412
LIG_SH2_STAT5 334 337 PF00017 0.516
LIG_SH2_STAT5 52 55 PF00017 0.446
LIG_SH2_STAT5 520 523 PF00017 0.412
LIG_SH2_STAT5 525 528 PF00017 0.412
LIG_SH2_STAT5 568 571 PF00017 0.367
LIG_SH2_STAT5 594 597 PF00017 0.402
LIG_SH3_1 206 212 PF00018 0.697
LIG_SH3_1 356 362 PF00018 0.707
LIG_SH3_3 131 137 PF00018 0.410
LIG_SH3_3 206 212 PF00018 0.697
LIG_SH3_3 35 41 PF00018 0.514
LIG_SH3_3 356 362 PF00018 0.707
LIG_SH3_3 444 450 PF00018 0.422
LIG_SH3_3 485 491 PF00018 0.544
LIG_SH3_3 513 519 PF00018 0.514
LIG_SUMO_SIM_anti_2 679 685 PF11976 0.402
LIG_SUMO_SIM_par_1 507 512 PF11976 0.412
LIG_SUMO_SIM_par_1 580 586 PF11976 0.514
LIG_SxIP_EBH_1 381 390 PF03271 0.648
LIG_TRAF2_1 98 101 PF00917 0.522
LIG_TRFH_1 37 41 PF08558 0.422
LIG_ULM_U2AF65_1 613 618 PF00076 0.422
LIG_WRC_WIRS_1 187 192 PF05994 0.412
MOD_CK1_1 205 211 PF00069 0.687
MOD_CK1_1 304 310 PF00069 0.422
MOD_CK1_1 563 569 PF00069 0.514
MOD_CK1_1 672 678 PF00069 0.425
MOD_CK1_1 679 685 PF00069 0.397
MOD_CK2_1 207 213 PF00069 0.791
MOD_CK2_1 232 238 PF00069 0.614
MOD_CK2_1 263 269 PF00069 0.546
MOD_CK2_1 409 415 PF00069 0.412
MOD_CK2_1 95 101 PF00069 0.534
MOD_GlcNHglycan 17 20 PF01048 0.577
MOD_GlcNHglycan 336 339 PF01048 0.518
MOD_GlcNHglycan 342 345 PF01048 0.667
MOD_GlcNHglycan 351 354 PF01048 0.665
MOD_GlcNHglycan 457 460 PF01048 0.447
MOD_GlcNHglycan 464 467 PF01048 0.425
MOD_GlcNHglycan 470 473 PF01048 0.402
MOD_GlcNHglycan 481 484 PF01048 0.486
MOD_GlcNHglycan 565 568 PF01048 0.514
MOD_GSK3_1 229 236 PF00069 0.534
MOD_GSK3_1 330 337 PF00069 0.607
MOD_GSK3_1 386 393 PF00069 0.585
MOD_GSK3_1 396 403 PF00069 0.493
MOD_GSK3_1 420 427 PF00069 0.390
MOD_GSK3_1 52 59 PF00069 0.568
MOD_GSK3_1 566 573 PF00069 0.371
MOD_GSK3_1 669 676 PF00069 0.421
MOD_NEK2_1 128 133 PF00069 0.385
MOD_NEK2_1 15 20 PF00069 0.541
MOD_NEK2_1 169 174 PF00069 0.293
MOD_NEK2_1 249 254 PF00069 0.446
MOD_NEK2_1 420 425 PF00069 0.424
MOD_NEK2_1 627 632 PF00069 0.492
MOD_NEK2_1 642 647 PF00069 0.295
MOD_NEK2_1 655 660 PF00069 0.322
MOD_NEK2_1 76 81 PF00069 0.466
MOD_NEK2_2 301 306 PF00069 0.412
MOD_NEK2_2 560 565 PF00069 0.424
MOD_PIKK_1 128 134 PF00454 0.518
MOD_PKA_1 183 189 PF00069 0.514
MOD_PKA_2 106 112 PF00069 0.514
MOD_PKA_2 183 189 PF00069 0.514
MOD_PKA_2 196 202 PF00069 0.411
MOD_PKA_2 247 253 PF00069 0.472
MOD_PKA_2 479 485 PF00069 0.588
MOD_PKA_2 612 618 PF00069 0.409
MOD_PKA_2 672 678 PF00069 0.412
MOD_PKA_2 679 685 PF00069 0.412
MOD_PKB_1 24 32 PF00069 0.293
MOD_Plk_1 229 235 PF00069 0.573
MOD_Plk_1 237 243 PF00069 0.438
MOD_Plk_4 138 144 PF00069 0.256
MOD_Plk_4 183 189 PF00069 0.424
MOD_Plk_4 249 255 PF00069 0.502
MOD_Plk_4 301 307 PF00069 0.412
MOD_Plk_4 330 336 PF00069 0.599
MOD_Plk_4 386 392 PF00069 0.614
MOD_Plk_4 560 566 PF00069 0.412
MOD_Plk_4 583 589 PF00069 0.385
MOD_Plk_4 642 648 PF00069 0.514
MOD_Plk_4 679 685 PF00069 0.408
MOD_Plk_4 90 96 PF00069 0.470
MOD_ProDKin_1 205 211 PF00069 0.769
MOD_ProDKin_1 288 294 PF00069 0.412
MOD_ProDKin_1 336 342 PF00069 0.604
MOD_ProDKin_1 392 398 PF00069 0.597
MOD_ProDKin_1 570 576 PF00069 0.293
MOD_ProDKin_1 656 662 PF00069 0.385
MOD_SUMO_for_1 404 407 PF00179 0.548
TRG_DiLeu_BaLyEn_6 30 35 PF01217 0.422
TRG_DiLeu_BaLyEn_6 66 71 PF01217 0.514
TRG_ENDOCYTIC_2 125 128 PF00928 0.343
TRG_ENDOCYTIC_2 166 169 PF00928 0.412
TRG_ENDOCYTIC_2 243 246 PF00928 0.389
TRG_ENDOCYTIC_2 520 523 PF00928 0.412
TRG_ENDOCYTIC_2 528 531 PF00928 0.412
TRG_ENDOCYTIC_2 552 555 PF00928 0.378
TRG_ENDOCYTIC_2 559 562 PF00928 0.340
TRG_ENDOCYTIC_2 663 666 PF00928 0.355
TRG_ER_diArg_1 1 4 PF00400 0.618
TRG_ER_diArg_1 151 153 PF00400 0.385
TRG_ER_diArg_1 182 184 PF00400 0.412
TRG_ER_diArg_1 23 26 PF00400 0.488
TRG_ER_diArg_1 276 279 PF00400 0.481
TRG_ER_diArg_1 381 384 PF00400 0.597
TRG_ER_diArg_1 528 530 PF00400 0.385
TRG_ER_diArg_1 613 616 PF00400 0.420

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDL0 Leptomonas seymouri 52% 100%
A0A3S7WV16 Leishmania donovani 99% 100%
A4H9K3 Leishmania braziliensis 75% 100%
E9ARN3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4QDU6 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS