Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXW6_LEIIN

TriTrypDb:

LINF_180014600

Length:

899

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXW6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.724
CLV_C14_Caspase3-7	174	178	PF00656	0.546
CLV_C14_Caspase3-7	228	232	PF00656	0.562
CLV_C14_Caspase3-7	471	475	PF00656	0.743
CLV_C14_Caspase3-7	599	603	PF00656	0.532
CLV_C14_Caspase3-7	879	883	PF00656	0.646
CLV_NRD_NRD_1	142	144	PF00675	0.573
CLV_NRD_NRD_1	239	241	PF00675	0.512
CLV_NRD_NRD_1	293	295	PF00675	0.651
CLV_NRD_NRD_1	347	349	PF00675	0.749
CLV_NRD_NRD_1	422	424	PF00675	0.748
CLV_NRD_NRD_1	525	527	PF00675	0.668
CLV_NRD_NRD_1	639	641	PF00675	0.476
CLV_NRD_NRD_1	654	656	PF00675	0.443
CLV_NRD_NRD_1	697	699	PF00675	0.553
CLV_NRD_NRD_1	721	723	PF00675	0.561
CLV_NRD_NRD_1	739	741	PF00675	0.455
CLV_NRD_NRD_1	78	80	PF00675	0.574
CLV_NRD_NRD_1	780	782	PF00675	0.801
CLV_NRD_NRD_1	858	860	PF00675	0.678
CLV_NRD_NRD_1	895	897	PF00675	0.770
CLV_PCSK_FUR_1	345	349	PF00082	0.669
CLV_PCSK_FUR_1	652	656	PF00082	0.512
CLV_PCSK_FUR_1	695	699	PF00082	0.525
CLV_PCSK_KEX2_1	142	144	PF00082	0.592
CLV_PCSK_KEX2_1	283	285	PF00082	0.786
CLV_PCSK_KEX2_1	347	349	PF00082	0.694
CLV_PCSK_KEX2_1	525	527	PF00082	0.667
CLV_PCSK_KEX2_1	639	641	PF00082	0.476
CLV_PCSK_KEX2_1	654	656	PF00082	0.443
CLV_PCSK_KEX2_1	697	699	PF00082	0.588
CLV_PCSK_KEX2_1	721	723	PF00082	0.561
CLV_PCSK_KEX2_1	738	740	PF00082	0.450
CLV_PCSK_KEX2_1	78	80	PF00082	0.574
CLV_PCSK_KEX2_1	780	782	PF00082	0.801
CLV_PCSK_KEX2_1	858	860	PF00082	0.678
CLV_PCSK_KEX2_1	895	897	PF00082	0.770
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.786
CLV_PCSK_SKI1_1	133	137	PF00082	0.702
CLV_PCSK_SKI1_1	207	211	PF00082	0.573
CLV_PCSK_SKI1_1	280	284	PF00082	0.763
CLV_PCSK_SKI1_1	39	43	PF00082	0.556
CLV_PCSK_SKI1_1	490	494	PF00082	0.588
CLV_PCSK_SKI1_1	526	530	PF00082	0.751
CLV_PCSK_SKI1_1	552	556	PF00082	0.671
CLV_PCSK_SKI1_1	697	701	PF00082	0.580
DEG_APCC_DBOX_1	697	705	PF00400	0.591
DEG_SPOP_SBC_1	172	176	PF00917	0.601
DEG_SPOP_SBC_1	26	30	PF00917	0.571
DEG_SPOP_SBC_1	514	518	PF00917	0.605
DOC_CKS1_1	411	416	PF01111	0.754
DOC_CYCLIN_RxL_1	129	138	PF00134	0.594
DOC_CYCLIN_RxL_1	523	532	PF00134	0.692
DOC_MAPK_gen_1	38	44	PF00069	0.495
DOC_MAPK_gen_1	695	704	PF00069	0.514
DOC_MAPK_gen_1	78	85	PF00069	0.570
DOC_MAPK_MEF2A_6	207	216	PF00069	0.561
DOC_MAPK_MEF2A_6	38	46	PF00069	0.557
DOC_MAPK_MEF2A_6	695	704	PF00069	0.526
DOC_MAPK_NFAT4_5	39	47	PF00069	0.563
DOC_MAPK_NFAT4_5	697	705	PF00069	0.527
DOC_PP1_RVXF_1	488	494	PF00149	0.589
DOC_PP1_SILK_1	635	640	PF00149	0.413
DOC_PP2B_LxvP_1	152	155	PF13499	0.699
DOC_PP2B_LxvP_1	267	270	PF13499	0.549
DOC_PP2B_LxvP_1	309	312	PF13499	0.785
DOC_PP2B_LxvP_1	439	442	PF13499	0.727
DOC_PP2B_LxvP_1	809	812	PF13499	0.626
DOC_PP2B_LxvP_1	868	871	PF13499	0.662
DOC_PP4_FxxP_1	251	254	PF00568	0.589
DOC_USP7_MATH_1	105	109	PF00917	0.686
DOC_USP7_MATH_1	155	159	PF00917	0.802
DOC_USP7_MATH_1	172	176	PF00917	0.546
DOC_USP7_MATH_1	180	184	PF00917	0.752
DOC_USP7_MATH_1	358	362	PF00917	0.662
DOC_USP7_MATH_1	468	472	PF00917	0.802
DOC_USP7_MATH_1	494	498	PF00917	0.688
DOC_USP7_MATH_1	524	528	PF00917	0.704
DOC_USP7_MATH_1	541	545	PF00917	0.579
DOC_USP7_MATH_1	577	581	PF00917	0.565
DOC_USP7_MATH_1	592	596	PF00917	0.398
DOC_USP7_MATH_1	626	630	PF00917	0.505
DOC_USP7_MATH_1	673	677	PF00917	0.578
DOC_USP7_MATH_1	771	775	PF00917	0.723
DOC_USP7_MATH_1	782	786	PF00917	0.616
DOC_USP7_MATH_1	804	808	PF00917	0.704
DOC_USP7_MATH_2	254	260	PF00917	0.397
DOC_USP7_UBL2_3	39	43	PF12436	0.556
DOC_WW_Pin1_4	176	181	PF00397	0.700
DOC_WW_Pin1_4	27	32	PF00397	0.708
DOC_WW_Pin1_4	307	312	PF00397	0.782
DOC_WW_Pin1_4	314	319	PF00397	0.715
DOC_WW_Pin1_4	374	379	PF00397	0.757
DOC_WW_Pin1_4	389	394	PF00397	0.644
DOC_WW_Pin1_4	404	409	PF00397	0.595
DOC_WW_Pin1_4	410	415	PF00397	0.737
DOC_WW_Pin1_4	767	772	PF00397	0.785
DOC_WW_Pin1_4	800	805	PF00397	0.755
DOC_WW_Pin1_4	807	812	PF00397	0.687
DOC_WW_Pin1_4	821	826	PF00397	0.641
DOC_WW_Pin1_4	832	837	PF00397	0.595
DOC_WW_Pin1_4	889	894	PF00397	0.630
LIG_14-3-3_CanoR_1	399	409	PF00244	0.740
LIG_14-3-3_CanoR_1	464	472	PF00244	0.727
LIG_14-3-3_CanoR_1	481	489	PF00244	0.631
LIG_14-3-3_CanoR_1	525	529	PF00244	0.694
LIG_14-3-3_CanoR_1	585	591	PF00244	0.526
LIG_14-3-3_CanoR_1	674	682	PF00244	0.525
LIG_14-3-3_CanoR_1	756	764	PF00244	0.755
LIG_14-3-3_CanoR_1	781	791	PF00244	0.729
LIG_14-3-3_CanoR_1	82	86	PF00244	0.502
LIG_14-3-3_CanoR_1	895	899	PF00244	0.770
LIG_APCC_ABBAyCdc20_2	525	531	PF00400	0.692
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_BIR_III_2	177	181	PF00653	0.629
LIG_BIR_III_4	166	170	PF00653	0.694
LIG_BIR_III_4	261	265	PF00653	0.488
LIG_FHA_1	211	217	PF00498	0.457
LIG_FHA_1	467	473	PF00498	0.741
LIG_FHA_1	533	539	PF00498	0.746
LIG_FHA_1	70	76	PF00498	0.609
LIG_FHA_1	851	857	PF00498	0.779
LIG_FHA_2	3	9	PF00498	0.634
LIG_FHA_2	382	388	PF00498	0.621
LIG_FHA_2	516	522	PF00498	0.775
LIG_FHA_2	611	617	PF00498	0.598
LIG_Integrin_RGD_1	143	145	PF01839	0.602
LIG_LIR_Apic_2	387	393	PF02991	0.715
LIG_LIR_Gen_1	134	140	PF02991	0.698
LIG_LIR_Gen_1	2	8	PF02991	0.554
LIG_LIR_Gen_1	60	71	PF02991	0.559
LIG_LIR_Nem_3	134	139	PF02991	0.700
LIG_LIR_Nem_3	275	281	PF02991	0.529
LIG_LIR_Nem_3	60	66	PF02991	0.530
LIG_MYND_1	328	332	PF01753	0.698
LIG_NBox_RRM_1	235	245	PF00076	0.498
LIG_PDZ_Class_1	894	899	PF00595	0.771
LIG_PTAP_UEV_1	317	322	PF05743	0.805
LIG_RPA_C_Fungi	599	611	PF08784	0.444
LIG_SH2_NCK_1	227	231	PF00017	0.498
LIG_SH2_PTP2	63	66	PF00017	0.529
LIG_SH2_STAP1	671	675	PF00017	0.573
LIG_SH2_STAT3	734	737	PF00017	0.636
LIG_SH2_STAT5	36	39	PF00017	0.573
LIG_SH2_STAT5	4	7	PF00017	0.636
LIG_SH2_STAT5	63	66	PF00017	0.592
LIG_SH2_STAT5	863	866	PF00017	0.750
LIG_SH2_STAT5	891	894	PF00017	0.708
LIG_SH3_1	423	429	PF00018	0.864
LIG_SH3_2	394	399	PF14604	0.634
LIG_SH3_2	811	816	PF14604	0.625
LIG_SH3_3	117	123	PF00018	0.773
LIG_SH3_3	273	279	PF00018	0.602
LIG_SH3_3	309	315	PF00018	0.794
LIG_SH3_3	318	324	PF00018	0.687
LIG_SH3_3	370	376	PF00018	0.762
LIG_SH3_3	377	383	PF00018	0.715
LIG_SH3_3	391	397	PF00018	0.583
LIG_SH3_3	422	428	PF00018	0.867
LIG_SH3_3	503	509	PF00018	0.763
LIG_SH3_3	535	541	PF00018	0.689
LIG_SH3_3	61	67	PF00018	0.534
LIG_SH3_3	738	744	PF00018	0.571
LIG_SH3_3	765	771	PF00018	0.773
LIG_SH3_3	798	804	PF00018	0.691
LIG_SH3_3	808	814	PF00018	0.617
LIG_SH3_3	869	875	PF00018	0.700
LIG_SH3_CIN85_PxpxPR_1	811	816	PF14604	0.625
LIG_SUMO_SIM_par_1	53	60	PF11976	0.453
LIG_SUMO_SIM_par_1	594	602	PF11976	0.521
LIG_TRAF2_1	254	257	PF00917	0.665
LIG_TRAF2_1	303	306	PF00917	0.715
LIG_TRAF2_1	384	387	PF00917	0.769
LIG_TRAF2_1	667	670	PF00917	0.572
LIG_WW_1	871	874	PF00397	0.704
LIG_WW_3	310	314	PF00397	0.794
LIG_WW_3	813	817	PF00397	0.708
MOD_CDC14_SPxK_1	310	313	PF00782	0.792
MOD_CDC14_SPxK_1	415	418	PF00782	0.799
MOD_CDK_SPK_2	311	316	PF00069	0.804
MOD_CDK_SPK_2	767	772	PF00069	0.785
MOD_CDK_SPxK_1	307	313	PF00069	0.787
MOD_CDK_SPxK_1	412	418	PF00069	0.799
MOD_CDK_SPxK_1	889	895	PF00069	0.631
MOD_CDK_SPxxK_3	889	896	PF00069	0.630
MOD_CK1_1	138	144	PF00069	0.685
MOD_CK1_1	2	8	PF00069	0.634
MOD_CK1_1	243	249	PF00069	0.531
MOD_CK1_1	314	320	PF00069	0.847
MOD_CK1_1	338	344	PF00069	0.789
MOD_CK1_1	351	357	PF00069	0.643
MOD_CK1_1	412	418	PF00069	0.604
MOD_CK1_1	431	437	PF00069	0.630
MOD_CK1_1	466	472	PF00069	0.740
MOD_CK1_1	544	550	PF00069	0.691
MOD_CK1_1	774	780	PF00069	0.737
MOD_CK1_1	807	813	PF00069	0.706
MOD_CK1_1	820	826	PF00069	0.595
MOD_CK2_1	2	8	PF00069	0.634
MOD_CK2_1	347	353	PF00069	0.667
MOD_CK2_1	381	387	PF00069	0.621
MOD_CK2_1	515	521	PF00069	0.645
MOD_CK2_1	610	616	PF00069	0.598
MOD_CK2_1	626	632	PF00069	0.369
MOD_CK2_1	782	788	PF00069	0.727
MOD_Cter_Amidation	345	348	PF01082	0.736
MOD_GlcNHglycan	105	108	PF01048	0.799
MOD_GlcNHglycan	116	119	PF01048	0.677
MOD_GlcNHglycan	12	15	PF01048	0.762
MOD_GlcNHglycan	123	126	PF01048	0.592
MOD_GlcNHglycan	161	164	PF01048	0.791
MOD_GlcNHglycan	189	192	PF01048	0.715
MOD_GlcNHglycan	227	230	PF01048	0.587
MOD_GlcNHglycan	245	248	PF01048	0.358
MOD_GlcNHglycan	261	265	PF01048	0.423
MOD_GlcNHglycan	334	338	PF01048	0.793
MOD_GlcNHglycan	439	442	PF01048	0.741
MOD_GlcNHglycan	466	469	PF01048	0.735
MOD_GlcNHglycan	498	501	PF01048	0.746
MOD_GlcNHglycan	546	549	PF01048	0.701
MOD_GlcNHglycan	579	582	PF01048	0.586
MOD_GlcNHglycan	67	70	PF01048	0.562
MOD_GlcNHglycan	675	678	PF01048	0.582
MOD_GlcNHglycan	750	753	PF01048	0.643
MOD_GlcNHglycan	760	763	PF01048	0.766
MOD_GlcNHglycan	773	776	PF01048	0.616
MOD_GlcNHglycan	785	788	PF01048	0.639
MOD_GlcNHglycan	792	795	PF01048	0.579
MOD_GlcNHglycan	826	829	PF01048	0.770
MOD_GSK3_1	114	121	PF00069	0.823
MOD_GSK3_1	131	138	PF00069	0.585
MOD_GSK3_1	155	162	PF00069	0.834
MOD_GSK3_1	172	179	PF00069	0.562
MOD_GSK3_1	25	32	PF00069	0.712
MOD_GSK3_1	256	263	PF00069	0.443
MOD_GSK3_1	307	314	PF00069	0.788
MOD_GSK3_1	322	329	PF00069	0.607
MOD_GSK3_1	347	354	PF00069	0.773
MOD_GSK3_1	381	388	PF00069	0.737
MOD_GSK3_1	400	407	PF00069	0.627
MOD_GSK3_1	412	419	PF00069	0.673
MOD_GSK3_1	464	471	PF00069	0.759
MOD_GSK3_1	477	484	PF00069	0.646
MOD_GSK3_1	492	499	PF00069	0.591
MOD_GSK3_1	65	72	PF00069	0.606
MOD_GSK3_1	767	774	PF00069	0.706
MOD_GSK3_1	800	807	PF00069	0.720
MOD_GSK3_1	817	824	PF00069	0.568
MOD_GSK3_1	850	857	PF00069	0.731
MOD_GSK3_1	887	894	PF00069	0.709
MOD_LATS_1	333	339	PF00433	0.718
MOD_LATS_1	462	468	PF00433	0.711
MOD_N-GLC_1	10	15	PF02516	0.770
MOD_N-GLC_1	832	837	PF02516	0.621
MOD_NEK2_1	135	140	PF00069	0.791
MOD_NEK2_1	171	176	PF00069	0.602
MOD_NEK2_1	409	414	PF00069	0.580
MOD_NEK2_1	437	442	PF00069	0.762
MOD_NEK2_1	46	51	PF00069	0.588
MOD_NEK2_1	586	591	PF00069	0.588
MOD_NEK2_1	610	615	PF00069	0.599
MOD_NEK2_1	7	12	PF00069	0.560
MOD_NEK2_2	444	449	PF00069	0.694
MOD_NEK2_2	468	473	PF00069	0.804
MOD_NEK2_2	524	529	PF00069	0.694
MOD_OFUCOSY	502	508	PF10250	0.667
MOD_PIKK_1	358	364	PF00454	0.626
MOD_PIKK_1	431	437	PF00454	0.741
MOD_PIKK_1	466	472	PF00454	0.696
MOD_PIKK_1	481	487	PF00454	0.693
MOD_PIKK_1	626	632	PF00454	0.586
MOD_PK_1	876	882	PF00069	0.641
MOD_PKA_1	240	246	PF00069	0.517
MOD_PKA_1	347	353	PF00069	0.693
MOD_PKA_2	347	353	PF00069	0.728
MOD_PKA_2	463	469	PF00069	0.744
MOD_PKA_2	480	486	PF00069	0.549
MOD_PKA_2	524	530	PF00069	0.698
MOD_PKA_2	633	639	PF00069	0.525
MOD_PKA_2	673	679	PF00069	0.518
MOD_PKA_2	748	754	PF00069	0.647
MOD_PKA_2	757	763	PF00069	0.760
MOD_PKA_2	771	777	PF00069	0.601
MOD_PKA_2	81	87	PF00069	0.541
MOD_PKB_1	345	353	PF00069	0.747
MOD_PKB_1	756	764	PF00069	0.698
MOD_Plk_1	385	391	PF00069	0.764
MOD_Plk_2-3	256	262	PF00069	0.378
MOD_Plk_4	131	137	PF00069	0.738
MOD_Plk_4	2	8	PF00069	0.602
MOD_Plk_4	207	213	PF00069	0.580
MOD_Plk_4	326	332	PF00069	0.635
MOD_Plk_4	592	598	PF00069	0.582
MOD_Plk_4	633	639	PF00069	0.525
MOD_Plk_4	804	810	PF00069	0.705
MOD_ProDKin_1	176	182	PF00069	0.702
MOD_ProDKin_1	27	33	PF00069	0.698
MOD_ProDKin_1	307	313	PF00069	0.787
MOD_ProDKin_1	314	320	PF00069	0.714
MOD_ProDKin_1	374	380	PF00069	0.758
MOD_ProDKin_1	389	395	PF00069	0.646
MOD_ProDKin_1	404	410	PF00069	0.595
MOD_ProDKin_1	412	418	PF00069	0.710
MOD_ProDKin_1	767	773	PF00069	0.784
MOD_ProDKin_1	800	806	PF00069	0.758
MOD_ProDKin_1	807	813	PF00069	0.686
MOD_ProDKin_1	821	827	PF00069	0.640
MOD_ProDKin_1	832	838	PF00069	0.595
MOD_ProDKin_1	889	895	PF00069	0.631
MOD_SUMO_for_1	282	285	PF00179	0.701
TRG_DiLeu_BaEn_1	696	701	PF01217	0.585
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.708
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.371
TRG_ENDOCYTIC_2	227	230	PF00928	0.587
TRG_ENDOCYTIC_2	4	7	PF00928	0.556
TRG_ENDOCYTIC_2	63	66	PF00928	0.529
TRG_ER_diArg_1	345	348	PF00400	0.673
TRG_ER_diArg_1	524	526	PF00400	0.672
TRG_ER_diArg_1	638	640	PF00400	0.531
TRG_ER_diArg_1	652	655	PF00400	0.465
TRG_ER_diArg_1	697	699	PF00400	0.413
TRG_ER_diArg_1	721	724	PF00400	0.560
TRG_ER_diArg_1	738	740	PF00400	0.450
TRG_ER_diArg_1	77	79	PF00400	0.573
TRG_ER_diArg_1	780	782	PF00400	0.736
TRG_ER_diArg_1	858	860	PF00400	0.674
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.687
TRG_Pf-PMV_PEXEL_1	526	531	PF00026	0.688
TRG_Pf-PMV_PEXEL_1	644	648	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	698	703	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUY5	Leishmania donovani	100%	100%
A4H9K1	Leishmania braziliensis	54%	97%
E9ARN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	95%
Q4QDU9	Leishmania major	82%	97%