Putative ARP2/3 complex subunit

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-related protein 2/3 complex subunit 1 - putative

Species:

Leishmania infantum

UniProt:

A4HXW5_LEIIN

TriTrypDb:

LINF_180014500

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005885	Arp2/3 protein complex	2	7
GO:0032991	protein-containing complex	1	7

Phosphorylation

Promastigote/Amastigote: 358

Expansion

Sequence features

A4HXW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXW5

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	7
GO:0008064	regulation of actin polymerization or depolymerization	6	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0030832	regulation of actin filament length	5	7
GO:0030833	regulation of actin filament polymerization	7	7
GO:0032271	regulation of protein polymerization	6	7
GO:0032535	regulation of cellular component size	4	7
GO:0032956	regulation of actin cytoskeleton organization	5	7
GO:0032970	regulation of actin filament-based process	4	7
GO:0033043	regulation of organelle organization	5	7
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	7
GO:0043254	regulation of protein-containing complex assembly	5	7
GO:0044087	regulation of cellular component biogenesis	4	7
GO:0045010	actin nucleation	6	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0051128	regulation of cellular component organization	4	7
GO:0051493	regulation of cytoskeleton organization	6	7
GO:0065007	biological regulation	1	7
GO:0065008	regulation of biological quality	2	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0090066	regulation of anatomical structure size	3	7
GO:0097435	supramolecular fiber organization	4	7
GO:0110053	regulation of actin filament organization	6	7
GO:1902903	regulation of supramolecular fiber organization	5	7
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0030029	actin filament-based process	2	1
GO:0030036	actin cytoskeleton organization	3	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	7
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0008092	cytoskeletal protein binding	3	7
GO:0005198	structural molecule activity	1	1
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.580
CLV_NRD_NRD_1	228	230	PF00675	0.554
CLV_NRD_NRD_1	444	446	PF00675	0.626
CLV_NRD_NRD_1	50	52	PF00675	0.452
CLV_PCSK_KEX2_1	228	230	PF00082	0.554
CLV_PCSK_KEX2_1	444	446	PF00082	0.626
CLV_PCSK_KEX2_1	50	52	PF00082	0.452
DEG_APCC_DBOX_1	601	609	PF00400	0.459
DEG_SCF_TRCP1_1	336	341	PF00400	0.401
DEG_SIAH_1	85	93	PF03145	0.483
DEG_SPOP_SBC_1	347	351	PF00917	0.558
DEG_SPOP_SBC_1	529	533	PF00917	0.563
DEG_SPOP_SBC_1	542	546	PF00917	0.605
DEG_SPOP_SBC_1	79	83	PF00917	0.591
DOC_ANK_TNKS_1	535	542	PF00023	0.603
DOC_CDC14_PxL_1	169	177	PF14671	0.389
DOC_CDC14_PxL_1	379	387	PF14671	0.462
DOC_MAPK_gen_1	506	515	PF00069	0.547
DOC_MAPK_HePTP_8	503	515	PF00069	0.558
DOC_MAPK_MEF2A_6	506	515	PF00069	0.547
DOC_PP4_FxxP_1	232	235	PF00568	0.505
DOC_USP7_MATH_1	240	244	PF00917	0.618
DOC_USP7_MATH_1	285	289	PF00917	0.540
DOC_USP7_MATH_1	346	350	PF00917	0.598
DOC_USP7_MATH_1	406	410	PF00917	0.485
DOC_USP7_MATH_1	542	546	PF00917	0.760
DOC_USP7_MATH_1	567	571	PF00917	0.609
DOC_WW_Pin1_4	24	29	PF00397	0.604
DOC_WW_Pin1_4	321	326	PF00397	0.367
DOC_WW_Pin1_4	562	567	PF00397	0.591
DOC_WW_Pin1_4	619	624	PF00397	0.577
DOC_WW_Pin1_4	71	76	PF00397	0.442
LIG_14-3-3_CanoR_1	228	233	PF00244	0.510
LIG_14-3-3_CanoR_1	246	251	PF00244	0.476
LIG_14-3-3_CanoR_1	420	425	PF00244	0.547
LIG_14-3-3_CanoR_1	471	479	PF00244	0.600
LIG_14-3-3_CanoR_1	534	540	PF00244	0.723
LIG_14-3-3_CanoR_1	559	567	PF00244	0.620
LIG_14-3-3_CanoR_1	609	614	PF00244	0.507
LIG_CSL_BTD_1	133	136	PF09270	0.447
LIG_CSL_BTD_1	322	325	PF09270	0.440
LIG_FHA_1	117	123	PF00498	0.475
LIG_FHA_1	204	210	PF00498	0.433
LIG_FHA_1	228	234	PF00498	0.580
LIG_FHA_1	269	275	PF00498	0.364
LIG_FHA_1	421	427	PF00498	0.487
LIG_FHA_1	445	451	PF00498	0.790
LIG_FHA_1	567	573	PF00498	0.556
LIG_FHA_2	123	129	PF00498	0.441
LIG_FHA_2	229	235	PF00498	0.555
LIG_FHA_2	583	589	PF00498	0.636
LIG_LIR_Apic_2	230	235	PF02991	0.497
LIG_LIR_Gen_1	166	177	PF02991	0.422
LIG_LIR_Nem_3	166	172	PF02991	0.504
LIG_LIR_Nem_3	341	347	PF02991	0.479
LIG_MYND_1	21	25	PF01753	0.634
LIG_NRBOX	570	576	PF00104	0.359
LIG_REV1ctd_RIR_1	513	522	PF16727	0.553
LIG_SH2_STAT5	199	202	PF00017	0.369
LIG_SH2_STAT5	309	312	PF00017	0.370
LIG_SH3_1	22	28	PF00018	0.519
LIG_SH3_1	617	623	PF00018	0.677
LIG_SH3_3	130	136	PF00018	0.446
LIG_SH3_3	154	160	PF00018	0.541
LIG_SH3_3	22	28	PF00018	0.599
LIG_SH3_3	573	579	PF00018	0.432
LIG_SH3_3	617	623	PF00018	0.675
LIG_SUMO_SIM_anti_2	569	576	PF11976	0.501
LIG_SUMO_SIM_par_1	174	181	PF11976	0.368
LIG_SUMO_SIM_par_1	478	483	PF11976	0.574
LIG_UBA3_1	574	583	PF00899	0.538
MOD_CK1_1	16	22	PF00069	0.556
MOD_CK1_1	203	209	PF00069	0.441
MOD_CK1_1	236	242	PF00069	0.624
MOD_CK1_1	570	576	PF00069	0.603
MOD_CK1_1	71	77	PF00069	0.584
MOD_CK1_1	80	86	PF00069	0.623
MOD_CK2_1	541	547	PF00069	0.721
MOD_CK2_1	582	588	PF00069	0.511
MOD_GlcNHglycan	125	128	PF01048	0.388
MOD_GlcNHglycan	147	150	PF01048	0.619
MOD_GlcNHglycan	15	18	PF01048	0.642
MOD_GlcNHglycan	191	194	PF01048	0.387
MOD_GlcNHglycan	202	205	PF01048	0.324
MOD_GlcNHglycan	243	246	PF01048	0.651
MOD_GlcNHglycan	288	291	PF01048	0.639
MOD_GlcNHglycan	293	296	PF01048	0.558
MOD_GlcNHglycan	325	328	PF01048	0.429
MOD_GlcNHglycan	336	339	PF01048	0.494
MOD_GlcNHglycan	350	353	PF01048	0.653
MOD_GlcNHglycan	360	365	PF01048	0.675
MOD_GlcNHglycan	366	369	PF01048	0.547
MOD_GlcNHglycan	412	415	PF01048	0.551
MOD_GlcNHglycan	437	441	PF01048	0.763
MOD_GlcNHglycan	579	582	PF01048	0.555
MOD_GlcNHglycan	595	598	PF01048	0.488
MOD_GlcNHglycan	83	86	PF01048	0.597
MOD_GSK3_1	189	196	PF00069	0.385
MOD_GSK3_1	199	206	PF00069	0.440
MOD_GSK3_1	236	243	PF00069	0.643
MOD_GSK3_1	274	281	PF00069	0.457
MOD_GSK3_1	286	293	PF00069	0.505
MOD_GSK3_1	334	341	PF00069	0.408
MOD_GSK3_1	36	43	PF00069	0.475
MOD_GSK3_1	360	367	PF00069	0.682
MOD_GSK3_1	406	413	PF00069	0.529
MOD_GSK3_1	466	473	PF00069	0.692
MOD_GSK3_1	5	12	PF00069	0.599
MOD_GSK3_1	530	537	PF00069	0.690
MOD_GSK3_1	562	569	PF00069	0.652
MOD_GSK3_1	577	584	PF00069	0.666
MOD_GSK3_1	609	616	PF00069	0.582
MOD_GSK3_1	77	84	PF00069	0.617
MOD_NEK2_1	122	127	PF00069	0.507
MOD_NEK2_1	268	273	PF00069	0.571
MOD_NEK2_1	286	291	PF00069	0.551
MOD_NEK2_1	407	412	PF00069	0.450
MOD_NEK2_1	613	618	PF00069	0.477
MOD_NEK2_1	68	73	PF00069	0.312
MOD_PIKK_1	430	436	PF00454	0.682
MOD_PIKK_1	466	472	PF00454	0.584
MOD_PIKK_1	492	498	PF00454	0.657
MOD_PK_1	246	252	PF00069	0.469
MOD_PKA_1	228	234	PF00069	0.538
MOD_PKA_1	444	450	PF00069	0.622
MOD_PKA_2	227	233	PF00069	0.528
MOD_PKA_2	347	353	PF00069	0.689
MOD_PKA_2	355	361	PF00069	0.657
MOD_PKA_2	444	450	PF00069	0.749
MOD_PKA_2	470	476	PF00069	0.617
MOD_PKA_2	535	541	PF00069	0.671
MOD_PKA_2	608	614	PF00069	0.494
MOD_PKB_1	607	615	PF00069	0.493
MOD_Plk_1	258	264	PF00069	0.407
MOD_Plk_2-3	388	394	PF00069	0.443
MOD_Plk_4	228	234	PF00069	0.538
MOD_Plk_4	374	380	PF00069	0.437
MOD_Plk_4	567	573	PF00069	0.426
MOD_Plk_4	63	69	PF00069	0.399
MOD_ProDKin_1	24	30	PF00069	0.595
MOD_ProDKin_1	321	327	PF00069	0.367
MOD_ProDKin_1	562	568	PF00069	0.574
MOD_ProDKin_1	619	625	PF00069	0.585
MOD_ProDKin_1	71	77	PF00069	0.461
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.443
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.470
TRG_ER_diArg_1	443	445	PF00400	0.627
TRG_ER_diArg_1	49	51	PF00400	0.425
TRG_ER_diArg_1	606	609	PF00400	0.445
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H8	Leptomonas seymouri	38%	100%
A0A3Q8IA03	Leishmania donovani	100%	100%
A4H9K0	Leishmania braziliensis	60%	89%
E9ARM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QDV0	Leishmania major	89%	100%