Putative dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1 -4-mannosyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4HXW3_LEIIN

TriTrypDb:

LINF_180014300

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HXW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXW3

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043413	macromolecule glycosylation	3	1
GO:0044238	primary metabolic process	2	1
GO:0070085	glycosylation	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000030	mannosyltransferase activity	5	11
GO:0003824	catalytic activity	1	11
GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	6	5
GO:0016740	transferase activity	2	11
GO:0016757	glycosyltransferase activity	3	11
GO:0016758	hexosyltransferase activity	4	11
GO:0004578	chitobiosyldiphosphodolichol beta-mannosyltransferase activity	7	1
GO:0019187	beta-1,4-mannosyltransferase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	824	828	PF00656	0.791
CLV_MEL_PAP_1	29	35	PF00089	0.544
CLV_NRD_NRD_1	150	152	PF00675	0.327
CLV_NRD_NRD_1	380	382	PF00675	0.552
CLV_NRD_NRD_1	39	41	PF00675	0.369
CLV_NRD_NRD_1	398	400	PF00675	0.435
CLV_NRD_NRD_1	44	46	PF00675	0.379
CLV_NRD_NRD_1	452	454	PF00675	0.402
CLV_NRD_NRD_1	611	613	PF00675	0.412
CLV_NRD_NRD_1	80	82	PF00675	0.571
CLV_NRD_NRD_1	845	847	PF00675	0.347
CLV_NRD_NRD_1	862	864	PF00675	0.344
CLV_PCSK_FUR_1	37	41	PF00082	0.427
CLV_PCSK_KEX2_1	150	152	PF00082	0.327
CLV_PCSK_KEX2_1	37	39	PF00082	0.404
CLV_PCSK_KEX2_1	379	381	PF00082	0.480
CLV_PCSK_KEX2_1	397	399	PF00082	0.492
CLV_PCSK_KEX2_1	44	46	PF00082	0.384
CLV_PCSK_KEX2_1	452	454	PF00082	0.406
CLV_PCSK_KEX2_1	611	613	PF00082	0.432
CLV_PCSK_KEX2_1	79	81	PF00082	0.600
CLV_PCSK_KEX2_1	844	846	PF00082	0.335
CLV_PCSK_KEX2_1	862	864	PF00082	0.357
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.432
CLV_PCSK_PC1ET2_1	844	846	PF00082	0.326
CLV_PCSK_PC7_1	146	152	PF00082	0.401
CLV_PCSK_PC7_1	40	46	PF00082	0.391
CLV_PCSK_PC7_1	76	82	PF00082	0.545
CLV_PCSK_SKI1_1	142	146	PF00082	0.339
CLV_PCSK_SKI1_1	277	281	PF00082	0.470
CLV_PCSK_SKI1_1	399	403	PF00082	0.394
CLV_PCSK_SKI1_1	452	456	PF00082	0.364
CLV_PCSK_SKI1_1	49	53	PF00082	0.427
CLV_PCSK_SKI1_1	525	529	PF00082	0.360
CLV_PCSK_SKI1_1	530	534	PF00082	0.387
CLV_PCSK_SKI1_1	685	689	PF00082	0.402
CLV_PCSK_SKI1_1	862	866	PF00082	0.421
DEG_APCC_DBOX_1	379	387	PF00400	0.634
DEG_APCC_DBOX_1	524	532	PF00400	0.626
DEG_APCC_DBOX_1	861	869	PF00400	0.614
DEG_Nend_Nbox_1	1	3	PF02207	0.393
DEG_SPOP_SBC_1	617	621	PF00917	0.583
DOC_CKS1_1	214	219	PF01111	0.734
DOC_CKS1_1	311	316	PF01111	0.405
DOC_CKS1_1	596	601	PF01111	0.652
DOC_CKS1_1	69	74	PF01111	0.797
DOC_CKS1_1	836	841	PF01111	0.616
DOC_CYCLIN_yCln2_LP_2	326	332	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	596	602	PF00134	0.648
DOC_MAPK_DCC_7	324	332	PF00069	0.447
DOC_MAPK_DCC_7	834	842	PF00069	0.677
DOC_MAPK_gen_1	150	156	PF00069	0.516
DOC_MAPK_gen_1	379	385	PF00069	0.634
DOC_MAPK_gen_1	611	617	PF00069	0.614
DOC_MAPK_gen_1	677	686	PF00069	0.608
DOC_MAPK_gen_1	862	868	PF00069	0.581
DOC_MAPK_MEF2A_6	399	408	PF00069	0.520
DOC_MAPK_RevD_3	384	398	PF00069	0.677
DOC_PP1_RVXF_1	205	212	PF00149	0.717
DOC_PP2B_LxvP_1	249	252	PF13499	0.544
DOC_PP2B_LxvP_1	726	729	PF13499	0.517
DOC_PP2B_PxIxI_1	403	409	PF00149	0.553
DOC_PP4_FxxP_1	514	517	PF00568	0.550
DOC_USP7_MATH_1	390	394	PF00917	0.692
DOC_USP7_MATH_1	476	480	PF00917	0.788
DOC_USP7_MATH_1	482	486	PF00917	0.776
DOC_USP7_MATH_1	543	547	PF00917	0.730
DOC_USP7_MATH_1	561	565	PF00917	0.689
DOC_USP7_MATH_1	587	591	PF00917	0.650
DOC_USP7_MATH_1	607	611	PF00917	0.631
DOC_USP7_MATH_1	779	783	PF00917	0.779
DOC_USP7_MATH_1	819	823	PF00917	0.661
DOC_WW_Pin1_4	116	121	PF00397	0.782
DOC_WW_Pin1_4	160	165	PF00397	0.554
DOC_WW_Pin1_4	213	218	PF00397	0.737
DOC_WW_Pin1_4	230	235	PF00397	0.616
DOC_WW_Pin1_4	251	256	PF00397	0.530
DOC_WW_Pin1_4	310	315	PF00397	0.320
DOC_WW_Pin1_4	497	502	PF00397	0.686
DOC_WW_Pin1_4	51	56	PF00397	0.686
DOC_WW_Pin1_4	538	543	PF00397	0.702
DOC_WW_Pin1_4	595	600	PF00397	0.716
DOC_WW_Pin1_4	62	67	PF00397	0.707
DOC_WW_Pin1_4	68	73	PF00397	0.796
DOC_WW_Pin1_4	775	780	PF00397	0.725
DOC_WW_Pin1_4	83	88	PF00397	0.746
DOC_WW_Pin1_4	832	837	PF00397	0.668
LIG_14-3-3_CanoR_1	207	212	PF00244	0.691
LIG_14-3-3_CanoR_1	277	282	PF00244	0.425
LIG_14-3-3_CanoR_1	49	55	PF00244	0.663
LIG_14-3-3_CanoR_1	759	768	PF00244	0.689
LIG_14-3-3_CanoR_1	79	87	PF00244	0.751
LIG_14-3-3_CanoR_1	798	803	PF00244	0.621
LIG_14-3-3_CanoR_1	853	858	PF00244	0.596
LIG_Actin_WH2_2	753	771	PF00022	0.660
LIG_APCC_ABBAyCdc20_2	175	181	PF00400	0.552
LIG_BIR_III_4	370	374	PF00653	0.552
LIG_BRCT_BRCA1_1	175	179	PF00533	0.576
LIG_BRCT_BRCA1_1	364	368	PF00533	0.687
LIG_Clathr_ClatBox_1	184	188	PF01394	0.510
LIG_deltaCOP1_diTrp_1	257	263	PF00928	0.628
LIG_deltaCOP1_diTrp_1	409	413	PF00928	0.518
LIG_deltaCOP1_diTrp_1	5	13	PF00928	0.296
LIG_deltaCOP1_diTrp_1	797	802	PF00928	0.599
LIG_eIF4E_1	703	709	PF01652	0.619
LIG_FHA_1	143	149	PF00498	0.582
LIG_FHA_1	244	250	PF00498	0.519
LIG_FHA_1	304	310	PF00498	0.384
LIG_FHA_1	423	429	PF00498	0.611
LIG_FHA_1	57	63	PF00498	0.703
LIG_FHA_1	756	762	PF00498	0.626
LIG_FHA_2	621	627	PF00498	0.573
LIG_FHA_2	790	796	PF00498	0.638
LIG_FHA_2	854	860	PF00498	0.515
LIG_HCF-1_HBM_1	456	459	PF13415	0.565
LIG_LIR_Apic_2	210	214	PF02991	0.721
LIG_LIR_Apic_2	513	517	PF02991	0.574
LIG_LIR_Gen_1	176	187	PF02991	0.561
LIG_LIR_Gen_1	409	418	PF02991	0.523
LIG_LIR_Gen_1	625	635	PF02991	0.542
LIG_LIR_Gen_1	705	713	PF02991	0.553
LIG_LIR_Nem_3	176	182	PF02991	0.567
LIG_LIR_Nem_3	261	266	PF02991	0.595
LIG_LIR_Nem_3	274	279	PF02991	0.408
LIG_LIR_Nem_3	409	413	PF02991	0.484
LIG_LIR_Nem_3	456	462	PF02991	0.631
LIG_LIR_Nem_3	513	518	PF02991	0.581
LIG_LIR_Nem_3	625	631	PF02991	0.551
LIG_LIR_Nem_3	665	670	PF02991	0.544
LIG_LIR_Nem_3	702	706	PF02991	0.529
LIG_LIR_Nem_3	813	818	PF02991	0.607
LIG_LIR_Nem_3	858	864	PF02991	0.571
LIG_LYPXL_S_1	402	406	PF13949	0.390
LIG_LYPXL_yS_3	403	406	PF13949	0.587
LIG_LYPXL_yS_3	459	462	PF13949	0.630
LIG_LYPXL_yS_3	747	750	PF13949	0.600
LIG_NRBOX	527	533	PF00104	0.637
LIG_NRBOX	807	813	PF00104	0.580
LIG_PCNA_yPIPBox_3	129	142	PF02747	0.666
LIG_PCNA_yPIPBox_3	296	309	PF02747	0.332
LIG_Pex14_1	9	13	PF04695	0.335
LIG_Rb_pABgroove_1	502	510	PF01858	0.533
LIG_REV1ctd_RIR_1	512	516	PF16727	0.623
LIG_SH2_CRK	276	280	PF00017	0.447
LIG_SH2_CRK	334	338	PF00017	0.402
LIG_SH2_CRK	340	344	PF00017	0.249
LIG_SH2_CRK	560	564	PF00017	0.693
LIG_SH2_CRK	628	632	PF00017	0.533
LIG_SH2_CRK	706	710	PF00017	0.554
LIG_SH2_NCK_1	508	512	PF00017	0.541
LIG_SH2_NCK_1	560	564	PF00017	0.693
LIG_SH2_NCK_1	583	587	PF00017	0.621
LIG_SH2_SRC	248	251	PF00017	0.570
LIG_SH2_SRC	583	586	PF00017	0.615
LIG_SH2_STAP1	4	8	PF00017	0.356
LIG_SH2_STAP1	583	587	PF00017	0.621
LIG_SH2_STAP1	628	632	PF00017	0.533
LIG_SH2_STAP1	699	703	PF00017	0.553
LIG_SH2_STAP1	706	710	PF00017	0.468
LIG_SH2_STAP1	785	789	PF00017	0.755
LIG_SH2_STAP1	848	852	PF00017	0.550
LIG_SH2_STAT3	189	192	PF00017	0.615
LIG_SH2_STAT3	698	701	PF00017	0.612
LIG_SH2_STAT5	248	251	PF00017	0.535
LIG_SH2_STAT5	325	328	PF00017	0.335
LIG_SH3_3	132	138	PF00018	0.627
LIG_SH3_3	211	217	PF00018	0.700
LIG_SH3_3	249	255	PF00018	0.522
LIG_SH3_3	312	318	PF00018	0.339
LIG_SH3_3	339	345	PF00018	0.417
LIG_SH3_3	398	404	PF00018	0.562
LIG_SH3_3	537	543	PF00018	0.686
LIG_SH3_3	60	66	PF00018	0.745
LIG_SH3_3	833	839	PF00018	0.635
LIG_SH3_3	861	867	PF00018	0.568
LIG_Sin3_3	559	566	PF02671	0.654
LIG_SUMO_SIM_anti_2	180	186	PF11976	0.503
LIG_SUMO_SIM_anti_2	26	31	PF11976	0.408
LIG_SUMO_SIM_anti_2	306	313	PF11976	0.327
LIG_SUMO_SIM_anti_2	502	509	PF11976	0.564
LIG_SUMO_SIM_anti_2	838	844	PF11976	0.640
LIG_SUMO_SIM_par_1	277	282	PF11976	0.407
LIG_SUMO_SIM_par_1	306	313	PF11976	0.327
LIG_TRAF2_1	702	705	PF00917	0.610
LIG_TRAF2_1	856	859	PF00917	0.555
LIG_TYR_ITIM	337	342	PF00017	0.357
LIG_TYR_ITIM	401	406	PF00017	0.504
LIG_TYR_ITSM	272	279	PF00017	0.447
LIG_UBA3_1	865	870	PF00899	0.513
LIG_WRC_WIRS_1	812	817	PF05994	0.505
MOD_CDK_SPK_2	160	165	PF00069	0.435
MOD_CDK_SPK_2	213	218	PF00069	0.643
MOD_CDK_SPK_2	775	780	PF00069	0.675
MOD_CDK_SPxxK_3	230	237	PF00069	0.543
MOD_CK1_1	466	472	PF00069	0.685
MOD_CK1_1	487	493	PF00069	0.692
MOD_CK1_1	502	508	PF00069	0.456
MOD_CK1_1	647	653	PF00069	0.640
MOD_CK1_1	658	664	PF00069	0.452
MOD_CK1_1	67	73	PF00069	0.783
MOD_CK1_1	83	89	PF00069	0.729
MOD_CK1_1	830	836	PF00069	0.703
MOD_CK2_1	251	257	PF00069	0.536
MOD_CK2_1	618	624	PF00069	0.544
MOD_CK2_1	648	654	PF00069	0.596
MOD_CK2_1	699	705	PF00069	0.486
MOD_CK2_1	789	795	PF00069	0.524
MOD_CK2_1	817	823	PF00069	0.614
MOD_CK2_1	853	859	PF00069	0.399
MOD_CK2_1	96	102	PF00069	0.750
MOD_Cter_Amidation	35	38	PF01082	0.531
MOD_Cter_Amidation	377	380	PF01082	0.568
MOD_Cter_Amidation	395	398	PF01082	0.451
MOD_GlcNHglycan	112	115	PF01048	0.526
MOD_GlcNHglycan	175	178	PF01048	0.449
MOD_GlcNHglycan	199	202	PF01048	0.548
MOD_GlcNHglycan	351	354	PF01048	0.555
MOD_GlcNHglycan	394	397	PF01048	0.650
MOD_GlcNHglycan	465	468	PF01048	0.673
MOD_GlcNHglycan	478	481	PF01048	0.719
MOD_GlcNHglycan	484	487	PF01048	0.720
MOD_GlcNHglycan	501	504	PF01048	0.448
MOD_GlcNHglycan	545	548	PF01048	0.638
MOD_GlcNHglycan	593	596	PF01048	0.630
MOD_GlcNHglycan	657	660	PF01048	0.712
MOD_GlcNHglycan	723	726	PF01048	0.395
MOD_GlcNHglycan	781	784	PF01048	0.743
MOD_GlcNHglycan	83	86	PF01048	0.749
MOD_GlcNHglycan	98	101	PF01048	0.534
MOD_GSK3_1	169	176	PF00069	0.437
MOD_GSK3_1	286	293	PF00069	0.454
MOD_GSK3_1	362	369	PF00069	0.619
MOD_GSK3_1	463	470	PF00069	0.630
MOD_GSK3_1	478	485	PF00069	0.693
MOD_GSK3_1	51	58	PF00069	0.547
MOD_GSK3_1	587	594	PF00069	0.480
MOD_GSK3_1	616	623	PF00069	0.438
MOD_GSK3_1	64	71	PF00069	0.626
MOD_GSK3_1	644	651	PF00069	0.606
MOD_GSK3_1	653	660	PF00069	0.670
MOD_GSK3_1	75	82	PF00069	0.738
MOD_GSK3_1	775	782	PF00069	0.735
MOD_GSK3_1	817	824	PF00069	0.614
MOD_GSK3_1	828	835	PF00069	0.489
MOD_N-GLC_1	443	448	PF02516	0.383
MOD_NEK2_1	173	178	PF00069	0.445
MOD_NEK2_1	286	291	PF00069	0.452
MOD_NEK2_1	413	418	PF00069	0.393
MOD_NEK2_1	50	55	PF00069	0.580
MOD_NEK2_1	657	662	PF00069	0.593
MOD_NEK2_1	719	724	PF00069	0.403
MOD_NEK2_1	810	815	PF00069	0.428
MOD_NEK2_1	95	100	PF00069	0.691
MOD_NEK2_2	258	263	PF00069	0.543
MOD_PIKK_1	243	249	PF00454	0.476
MOD_PIKK_1	445	451	PF00454	0.506
MOD_PIKK_1	760	766	PF00454	0.605
MOD_PKA_1	79	85	PF00069	0.728
MOD_PKA_2	366	372	PF00069	0.697
MOD_PKA_2	422	428	PF00069	0.462
MOD_PKA_2	75	81	PF00069	0.784
MOD_PKA_2	779	785	PF00069	0.682
MOD_PKB_1	79	87	PF00069	0.753
MOD_PKB_1	851	859	PF00069	0.412
MOD_Plk_1	443	449	PF00069	0.391
MOD_Plk_1	626	632	PF00069	0.421
MOD_Plk_1	644	650	PF00069	0.510
MOD_Plk_1	704	710	PF00069	0.481
MOD_Plk_4	258	264	PF00069	0.481
MOD_Plk_4	271	277	PF00069	0.295
MOD_Plk_4	413	419	PF00069	0.407
MOD_Plk_4	502	508	PF00069	0.407
MOD_Plk_4	510	516	PF00069	0.391
MOD_Plk_4	58	64	PF00069	0.684
MOD_Plk_4	626	632	PF00069	0.412
MOD_Plk_4	694	700	PF00069	0.378
MOD_Plk_4	704	710	PF00069	0.383
MOD_Plk_4	811	817	PF00069	0.467
MOD_Plk_4	838	844	PF00069	0.589
MOD_ProDKin_1	116	122	PF00069	0.757
MOD_ProDKin_1	160	166	PF00069	0.430
MOD_ProDKin_1	213	219	PF00069	0.687
MOD_ProDKin_1	230	236	PF00069	0.523
MOD_ProDKin_1	251	257	PF00069	0.408
MOD_ProDKin_1	310	316	PF00069	0.389
MOD_ProDKin_1	497	503	PF00069	0.601
MOD_ProDKin_1	51	57	PF00069	0.628
MOD_ProDKin_1	538	544	PF00069	0.649
MOD_ProDKin_1	595	601	PF00069	0.657
MOD_ProDKin_1	62	68	PF00069	0.653
MOD_ProDKin_1	775	781	PF00069	0.676
MOD_ProDKin_1	83	89	PF00069	0.704
MOD_ProDKin_1	832	838	PF00069	0.584
TRG_DiLeu_BaEn_1	299	304	PF01217	0.516
TRG_DiLeu_BaEn_1	705	710	PF01217	0.437
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.544
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.566
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.542
TRG_ENDOCYTIC_2	276	279	PF00928	0.379
TRG_ENDOCYTIC_2	334	337	PF00928	0.395
TRG_ENDOCYTIC_2	339	342	PF00928	0.259
TRG_ENDOCYTIC_2	4	7	PF00928	0.442
TRG_ENDOCYTIC_2	403	406	PF00928	0.437
TRG_ENDOCYTIC_2	431	434	PF00928	0.412
TRG_ENDOCYTIC_2	459	462	PF00928	0.542
TRG_ENDOCYTIC_2	560	563	PF00928	0.636
TRG_ENDOCYTIC_2	628	631	PF00928	0.409
TRG_ENDOCYTIC_2	706	709	PF00928	0.439
TRG_ENDOCYTIC_2	747	750	PF00928	0.388
TRG_ER_diArg_1	149	151	PF00400	0.401
TRG_ER_diArg_1	37	40	PF00400	0.514
TRG_ER_diArg_1	379	381	PF00400	0.612
TRG_ER_diArg_1	398	400	PF00400	0.595
TRG_ER_diArg_1	451	453	PF00400	0.512
TRG_ER_diArg_1	533	536	PF00400	0.566
TRG_ER_diArg_1	677	680	PF00400	0.504
TRG_ER_diArg_1	766	769	PF00400	0.645
TRG_ER_diArg_1	79	81	PF00400	0.746
TRG_ER_diArg_1	861	863	PF00400	0.572
TRG_NLS_Bipartite_1	379	401	PF00514	0.475
TRG_NLS_MonoExtC_3	843	849	PF00514	0.504
TRG_Pf-PMV_PEXEL_1	759	764	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC1	Leptomonas seymouri	61%	99%
A0A1X0P7S9	Trypanosomatidae	35%	100%
A0A3S5H736	Leishmania donovani	100%	100%
A0A422P1Y6	Trypanosoma rangeli	36%	100%
A4H9J8	Leishmania braziliensis	81%	99%
C9ZZT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ARM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QDV2	Leishmania major	94%	100%
V5B6K9	Trypanosoma cruzi	35%	100%