Putative ethanolamine phosphotransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ethanolamine phosphotransferase - putative

Species:

Leishmania infantum

UniProt:

A4HXV5_LEIIN

TriTrypDb:

LINF_180013300

Length:

410

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, ethanolamine phosphotransferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HXV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXV5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0019637	organophosphate metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006646	phosphatidylethanolamine biosynthetic process	6	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0044249	cellular biosynthetic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046337	phosphatidylethanolamine metabolic process	6	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004307	ethanolaminephosphotransferase activity	6	6
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	11
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.440
CLV_NRD_NRD_1	137	139	PF00675	0.240
CLV_NRD_NRD_1	253	255	PF00675	0.505
CLV_PCSK_KEX2_1	137	139	PF00082	0.240
CLV_PCSK_KEX2_1	253	255	PF00082	0.505
CLV_PCSK_SKI1_1	196	200	PF00082	0.265
CLV_PCSK_SKI1_1	204	208	PF00082	0.280
DEG_Nend_UBRbox_3	1	3	PF02207	0.550
DEG_SCF_FBW7_1	10	17	PF00400	0.586
DEG_SPOP_SBC_1	338	342	PF00917	0.294
DOC_AGCK_PIF_2	29	34	PF00069	0.534
DOC_CKS1_1	11	16	PF01111	0.636
DOC_MAPK_FxFP_2	327	330	PF00069	0.308
DOC_MAPK_gen_1	253	263	PF00069	0.334
DOC_PP2B_LxvP_1	92	95	PF13499	0.332
DOC_PP4_FxxP_1	108	111	PF00568	0.334
DOC_PP4_FxxP_1	327	330	PF00568	0.308
DOC_USP7_MATH_1	18	22	PF00917	0.548
DOC_USP7_MATH_1	226	230	PF00917	0.408
DOC_USP7_MATH_1	244	248	PF00917	0.397
DOC_USP7_MATH_1	315	319	PF00917	0.411
DOC_USP7_MATH_1	338	342	PF00917	0.294
DOC_USP7_MATH_1	373	377	PF00917	0.376
DOC_WW_Pin1_4	10	15	PF00397	0.528
DOC_WW_Pin1_4	100	105	PF00397	0.340
DOC_WW_Pin1_4	107	112	PF00397	0.278
DOC_WW_Pin1_4	3	8	PF00397	0.547
LIG_14-3-3_CanoR_1	204	209	PF00244	0.453
LIG_14-3-3_CanoR_1	278	284	PF00244	0.540
LIG_14-3-3_CanoR_1	355	361	PF00244	0.533
LIG_APCC_ABBA_1	28	33	PF00400	0.507
LIG_APCC_ABBA_1	303	308	PF00400	0.388
LIG_Clathr_ClatBox_1	394	398	PF01394	0.315
LIG_CSL_BTD_1	219	222	PF09270	0.355
LIG_CtBP_PxDLS_1	96	100	PF00389	0.238
LIG_EH1_1	388	396	PF00400	0.233
LIG_FHA_1	101	107	PF00498	0.401
LIG_FHA_1	11	17	PF00498	0.605
LIG_FHA_1	110	116	PF00498	0.326
LIG_FHA_1	140	146	PF00498	0.446
LIG_FHA_1	155	161	PF00498	0.393
LIG_FHA_1	228	234	PF00498	0.364
LIG_FHA_1	247	253	PF00498	0.319
LIG_FHA_1	268	274	PF00498	0.470
LIG_FHA_1	357	363	PF00498	0.541
LIG_FHA_2	205	211	PF00498	0.525
LIG_LIR_Apic_2	3	7	PF02991	0.620
LIG_LIR_Gen_1	25	34	PF02991	0.576
LIG_LIR_Nem_3	245	251	PF02991	0.379
LIG_LIR_Nem_3	25	31	PF02991	0.553
LIG_LIR_Nem_3	272	277	PF02991	0.300
LIG_LIR_Nem_3	328	332	PF02991	0.240
LIG_LYPXL_yS_3	329	332	PF13949	0.296
LIG_NRBOX	297	303	PF00104	0.384
LIG_PTB_Apo_2	393	400	PF02174	0.325
LIG_SH2_CRK	32	36	PF00017	0.527
LIG_SH2_SRC	148	151	PF00017	0.440
LIG_SH2_SRC	32	35	PF00017	0.526
LIG_SH2_STAP1	32	36	PF00017	0.504
LIG_SH2_STAT3	34	37	PF00017	0.532
LIG_SH2_STAT5	125	128	PF00017	0.301
LIG_SH2_STAT5	148	151	PF00017	0.440
LIG_SH2_STAT5	251	254	PF00017	0.332
LIG_SH2_STAT5	26	29	PF00017	0.522
LIG_SH2_STAT5	262	265	PF00017	0.248
LIG_SH2_STAT5	322	325	PF00017	0.305
LIG_SH2_STAT5	34	37	PF00017	0.527
LIG_SH3_3	101	107	PF00018	0.316
LIG_SH3_3	238	244	PF00018	0.431
LIG_SH3_3	24	30	PF00018	0.540
LIG_SH3_3	372	378	PF00018	0.380
LIG_SH3_3	4	10	PF00018	0.556
LIG_SH3_5	30	34	PF00018	0.535
LIG_SUMO_SIM_anti_2	112	117	PF11976	0.391
LIG_SUMO_SIM_anti_2	296	302	PF11976	0.357
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.309
LIG_SUMO_SIM_par_1	60	66	PF11976	0.309
LIG_SUMO_SIM_par_1	95	101	PF11976	0.272
LIG_TRFH_1	322	326	PF08558	0.416
LIG_Vh1_VBS_1	379	397	PF01044	0.367
MOD_CK1_1	158	164	PF00069	0.276
MOD_CK1_1	229	235	PF00069	0.379
MOD_CK1_1	246	252	PF00069	0.500
MOD_CK1_1	3	9	PF00069	0.436
MOD_CK1_1	55	61	PF00069	0.457
MOD_CK2_1	204	210	PF00069	0.276
MOD_CK2_1	81	87	PF00069	0.542
MOD_CK2_1	95	101	PF00069	0.394
MOD_GlcNHglycan	16	19	PF01048	0.463
MOD_GlcNHglycan	295	298	PF01048	0.374
MOD_GlcNHglycan	57	60	PF01048	0.389
MOD_GSK3_1	10	17	PF00069	0.593
MOD_GSK3_1	154	161	PF00069	0.276
MOD_GSK3_1	263	270	PF00069	0.445
MOD_GSK3_1	289	296	PF00069	0.379
MOD_GSK3_1	333	340	PF00069	0.294
MOD_GSK3_1	53	60	PF00069	0.327
MOD_NEK2_1	117	122	PF00069	0.451
MOD_NEK2_1	159	164	PF00069	0.281
MOD_NEK2_1	168	173	PF00069	0.268
MOD_NEK2_1	175	180	PF00069	0.250
MOD_NEK2_1	188	193	PF00069	0.319
MOD_NEK2_1	62	67	PF00069	0.332
MOD_PK_1	140	146	PF00069	0.388
MOD_PKA_1	140	146	PF00069	0.276
MOD_Plk_1	244	250	PF00069	0.423
MOD_Plk_4	109	115	PF00069	0.293
MOD_Plk_4	140	146	PF00069	0.313
MOD_Plk_4	155	161	PF00069	0.241
MOD_Plk_4	18	24	PF00069	0.363
MOD_Plk_4	183	189	PF00069	0.373
MOD_Plk_4	269	275	PF00069	0.311
MOD_Plk_4	340	346	PF00069	0.277
MOD_Plk_4	39	45	PF00069	0.414
MOD_Plk_4	46	52	PF00069	0.303
MOD_Plk_4	57	63	PF00069	0.150
MOD_Plk_4	81	87	PF00069	0.496
MOD_ProDKin_1	10	16	PF00069	0.398
MOD_ProDKin_1	100	106	PF00069	0.416
MOD_ProDKin_1	107	113	PF00069	0.330
MOD_ProDKin_1	3	9	PF00069	0.422
TRG_DiLeu_BaEn_2	194	200	PF01217	0.294
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.376
TRG_ENDOCYTIC_2	26	29	PF00928	0.410
TRG_ENDOCYTIC_2	32	35	PF00928	0.337
TRG_ENDOCYTIC_2	329	332	PF00928	0.291
TRG_ER_diArg_1	252	254	PF00400	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V7	Leptomonas seymouri	65%	94%
A0A0S4J4C6	Bodo saltans	39%	100%
A0A1X0P7R6	Trypanosomatidae	47%	98%
A0A3Q8IJQ4	Leishmania donovani	100%	100%
A0A3R7N2B7	Trypanosoma rangeli	47%	99%
A4H9J2	Leishmania braziliensis	78%	100%
C9ZZU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ARL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QDW1	Leishmania major	93%	100%