Ribosomal_S8 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosomal protein S8 - putative

Species:

Leishmania infantum

UniProt:

A4HXV4_LEIIN

TriTrypDb:

LINF_180013200

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HXV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXV4

PDB structure(s): 7ane_c

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	189	191	PF00675	0.242
CLV_NRD_NRD_1	262	264	PF00675	0.242
CLV_NRD_NRD_1	50	52	PF00675	0.619
CLV_NRD_NRD_1	91	93	PF00675	0.630
CLV_PCSK_KEX2_1	162	164	PF00082	0.411
CLV_PCSK_KEX2_1	191	193	PF00082	0.242
CLV_PCSK_KEX2_1	262	264	PF00082	0.242
CLV_PCSK_KEX2_1	70	72	PF00082	0.576
CLV_PCSK_KEX2_1	91	93	PF00082	0.630
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.411
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.242
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.598
CLV_PCSK_SKI1_1	131	135	PF00082	0.400
CLV_PCSK_SKI1_1	207	211	PF00082	0.298
CLV_PCSK_SKI1_1	4	8	PF00082	0.623
CLV_PCSK_SKI1_1	46	50	PF00082	0.602
DEG_APCC_DBOX_1	72	80	PF00400	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.509
DEG_SPOP_SBC_1	23	27	PF00917	0.577
DOC_CKS1_1	172	177	PF01111	0.338
DOC_CYCLIN_RxL_1	203	211	PF00134	0.496
DOC_MAPK_gen_1	190	196	PF00069	0.469
DOC_PP1_RVXF_1	129	135	PF00149	0.397
DOC_PP2B_PxIxI_1	237	243	PF00149	0.536
DOC_SPAK_OSR1_1	192	196	PF12202	0.455
DOC_USP7_MATH_1	100	104	PF00917	0.616
DOC_USP7_MATH_1	23	27	PF00917	0.708
DOC_USP7_UBL2_3	162	166	PF12436	0.555
DOC_WW_Pin1_4	171	176	PF00397	0.347
DOC_WW_Pin1_4	254	259	PF00397	0.442
LIG_deltaCOP1_diTrp_1	167	170	PF00928	0.487
LIG_FHA_1	167	173	PF00498	0.410
LIG_FHA_1	17	23	PF00498	0.544
LIG_FHA_1	237	243	PF00498	0.442
LIG_FHA_1	265	271	PF00498	0.435
LIG_FHA_2	144	150	PF00498	0.424
LIG_FHA_2	250	256	PF00498	0.442
LIG_FHA_2	64	70	PF00498	0.428
LIG_LIR_Apic_2	146	150	PF02991	0.399
LIG_LIR_Gen_1	167	177	PF02991	0.455
LIG_LIR_Nem_3	167	173	PF02991	0.420
LIG_NRBOX	75	81	PF00104	0.456
LIG_SH2_NCK_1	147	151	PF00017	0.409
LIG_SH2_SRC	147	150	PF00017	0.416
LIG_SH2_STAT5	233	236	PF00017	0.442
LIG_SH2_STAT5	277	280	PF00017	0.457
LIG_SH3_1	105	111	PF00018	0.505
LIG_SH3_1	122	128	PF00018	0.427
LIG_SH3_3	105	111	PF00018	0.509
LIG_SH3_3	122	128	PF00018	0.478
LIG_SH3_3	169	175	PF00018	0.386
LIG_SH3_3	191	197	PF00018	0.442
LIG_SH3_3	239	245	PF00018	0.435
LIG_UBA3_1	286	294	PF00899	0.473
MOD_CDK_SPK_2	254	259	PF00069	0.442
MOD_CK1_1	25	31	PF00069	0.664
MOD_CK2_1	143	149	PF00069	0.521
MOD_CK2_1	195	201	PF00069	0.442
MOD_CK2_1	249	255	PF00069	0.442
MOD_CK2_1	63	69	PF00069	0.532
MOD_Cter_Amidation	49	52	PF01082	0.457
MOD_GlcNHglycan	102	105	PF01048	0.639
MOD_GlcNHglycan	29	32	PF01048	0.686
MOD_GlcNHglycan	4	7	PF01048	0.559
MOD_GlcNHglycan	94	97	PF01048	0.636
MOD_GSK3_1	195	202	PF00069	0.442
MOD_GSK3_1	22	29	PF00069	0.622
MOD_NEK2_1	2	7	PF00069	0.475
MOD_NEK2_1	264	269	PF00069	0.423
MOD_PKA_1	91	97	PF00069	0.591
MOD_PKA_2	91	97	PF00069	0.591
MOD_PKB_1	182	190	PF00069	0.455
MOD_Plk_1	166	172	PF00069	0.481
MOD_Plk_1	63	69	PF00069	0.532
MOD_Plk_2-3	244	250	PF00069	0.451
MOD_Plk_4	54	60	PF00069	0.435
MOD_ProDKin_1	171	177	PF00069	0.344
MOD_ProDKin_1	254	260	PF00069	0.442
MOD_SUMO_rev_2	224	234	PF00179	0.460
MOD_SUMO_rev_2	244	252	PF00179	0.384
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.519
TRG_ER_diArg_1	190	193	PF00400	0.442
TRG_ER_diArg_1	261	263	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I854	Leptomonas seymouri	82%	99%
A0A1X0P6W5	Trypanosomatidae	70%	100%
A0A3S7WUX4	Leishmania donovani	100%	100%
A0A422P1R7	Trypanosoma rangeli	75%	100%
A4H9J1	Leishmania braziliensis	86%	100%
C9ZZU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9ARL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QDW2	Leishmania major	94%	100%
V5DN42	Trypanosoma cruzi	67%	100%