Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXU9_LEIIN

TriTrypDb:

LINF_180012700

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXU9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.466
CLV_C14_Caspase3-7	92	96	PF00656	0.580
CLV_NRD_NRD_1	141	143	PF00675	0.748
CLV_NRD_NRD_1	183	185	PF00675	0.698
CLV_NRD_NRD_1	230	232	PF00675	0.691
CLV_NRD_NRD_1	233	235	PF00675	0.667
CLV_NRD_NRD_1	420	422	PF00675	0.727
CLV_NRD_NRD_1	472	474	PF00675	0.664
CLV_NRD_NRD_1	538	540	PF00675	0.724
CLV_PCSK_FUR_1	231	235	PF00082	0.614
CLV_PCSK_KEX2_1	141	143	PF00082	0.748
CLV_PCSK_KEX2_1	183	185	PF00082	0.698
CLV_PCSK_KEX2_1	230	232	PF00082	0.691
CLV_PCSK_KEX2_1	233	235	PF00082	0.667
CLV_PCSK_KEX2_1	420	422	PF00082	0.727
CLV_PCSK_KEX2_1	472	474	PF00082	0.664
CLV_PCSK_KEX2_1	538	540	PF00082	0.724
CLV_PCSK_SKI1_1	265	269	PF00082	0.536
CLV_PCSK_SKI1_1	276	280	PF00082	0.481
CLV_PCSK_SKI1_1	473	477	PF00082	0.661
DEG_SPOP_SBC_1	60	64	PF00917	0.619
DEG_SPOP_SBC_1	86	90	PF00917	0.578
DOC_CYCLIN_RxL_1	241	252	PF00134	0.613
DOC_MAPK_gen_1	141	149	PF00069	0.688
DOC_MAPK_gen_1	33	41	PF00069	0.621
DOC_MAPK_MEF2A_6	141	149	PF00069	0.688
DOC_PP2B_LxvP_1	291	294	PF13499	0.611
DOC_PP4_FxxP_1	383	386	PF00568	0.652
DOC_PP4_FxxP_1	475	478	PF00568	0.684
DOC_PP4_FxxP_1	485	488	PF00568	0.615
DOC_PP4_FxxP_1	494	497	PF00568	0.511
DOC_PP4_FxxP_1	9	12	PF00568	0.626
DOC_USP7_MATH_1	100	104	PF00917	0.492
DOC_USP7_MATH_1	12	16	PF00917	0.652
DOC_USP7_MATH_1	148	152	PF00917	0.710
DOC_USP7_MATH_1	267	271	PF00917	0.498
DOC_USP7_MATH_1	386	390	PF00917	0.674
DOC_USP7_MATH_1	422	426	PF00917	0.670
DOC_USP7_MATH_1	503	507	PF00917	0.744
DOC_USP7_MATH_1	85	89	PF00917	0.698
DOC_WW_Pin1_4	14	19	PF00397	0.636
DOC_WW_Pin1_4	141	146	PF00397	0.774
DOC_WW_Pin1_4	213	218	PF00397	0.757
DOC_WW_Pin1_4	413	418	PF00397	0.704
DOC_WW_Pin1_4	431	436	PF00397	0.562
DOC_WW_Pin1_4	501	506	PF00397	0.741
LIG_14-3-3_CanoR_1	105	113	PF00244	0.730
LIG_14-3-3_CanoR_1	141	145	PF00244	0.767
LIG_14-3-3_CanoR_1	162	168	PF00244	0.638
LIG_14-3-3_CanoR_1	189	197	PF00244	0.596
LIG_14-3-3_CanoR_1	269	275	PF00244	0.533
LIG_14-3-3_CanoR_1	282	288	PF00244	0.444
LIG_14-3-3_CanoR_1	421	429	PF00244	0.636
LIG_14-3-3_CanoR_1	439	445	PF00244	0.504
LIG_14-3-3_CanoR_1	472	478	PF00244	0.719
LIG_14-3-3_CanoR_1	538	544	PF00244	0.670
LIG_Actin_WH2_2	254	271	PF00022	0.553
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_BIR_III_4	321	325	PF00653	0.656
LIG_BRCT_BRCA1_1	114	118	PF00533	0.561
LIG_deltaCOP1_diTrp_1	361	369	PF00928	0.536
LIG_deltaCOP1_diTrp_1	460	469	PF00928	0.701
LIG_EH1_1	47	55	PF00400	0.625
LIG_FHA_1	142	148	PF00498	0.630
LIG_FHA_1	23	29	PF00498	0.645
LIG_FHA_1	295	301	PF00498	0.610
LIG_FHA_1	49	55	PF00498	0.600
LIG_FHA_1	525	531	PF00498	0.651
LIG_FHA_2	162	168	PF00498	0.602
LIG_FHA_2	194	200	PF00498	0.606
LIG_FHA_2	342	348	PF00498	0.474
LIG_FHA_2	477	483	PF00498	0.709
LIG_FXI_DFP_1	466	470	PF00024	0.713
LIG_LIR_Apic_2	382	386	PF02991	0.654
LIG_LIR_Apic_2	482	488	PF02991	0.709
LIG_LIR_Apic_2	492	497	PF02991	0.593
LIG_LIR_Apic_2	531	536	PF02991	0.659
LIG_LIR_Apic_2	8	12	PF02991	0.622
LIG_LIR_Gen_1	150	159	PF02991	0.631
LIG_LIR_Gen_1	340	349	PF02991	0.541
LIG_LIR_Gen_1	361	372	PF02991	0.617
LIG_LIR_Gen_1	479	488	PF02991	0.707
LIG_LIR_Nem_3	150	156	PF02991	0.685
LIG_LIR_Nem_3	165	171	PF02991	0.488
LIG_LIR_Nem_3	340	345	PF02991	0.521
LIG_LIR_Nem_3	361	367	PF02991	0.541
LIG_LIR_Nem_3	382	387	PF02991	0.659
LIG_LIR_Nem_3	479	484	PF02991	0.702
LIG_LIR_Nem_3	68	73	PF02991	0.675
LIG_NRBOX	203	209	PF00104	0.562
LIG_NRBOX	286	292	PF00104	0.594
LIG_PDZ_Class_1	539	544	PF00595	0.670
LIG_SH2_CRK	500	504	PF00017	0.646
LIG_SH2_CRK	533	537	PF00017	0.729
LIG_SH2_NCK_1	500	504	PF00017	0.707
LIG_SH2_STAP1	339	343	PF00017	0.531
LIG_SH2_STAP1	481	485	PF00017	0.701
LIG_SH2_STAT5	339	342	PF00017	0.556
LIG_SH2_STAT5	500	503	PF00017	0.707
LIG_SH2_STAT5	533	536	PF00017	0.730
LIG_SH2_STAT5	58	61	PF00017	0.632
LIG_SH3_1	142	148	PF00018	0.687
LIG_SH3_3	142	148	PF00018	0.687
LIG_SH3_3	182	188	PF00018	0.623
LIG_SH3_3	308	314	PF00018	0.712
LIG_SH3_3	446	452	PF00018	0.534
LIG_SH3_3	492	498	PF00018	0.662
LIG_SH3_3	499	505	PF00018	0.609
LIG_SUMO_SIM_anti_2	198	206	PF11976	0.574
LIG_SUMO_SIM_par_1	19	25	PF11976	0.629
LIG_SUMO_SIM_par_1	283	289	PF11976	0.567
LIG_TRAF2_1	209	212	PF00917	0.638
LIG_TRAF2_1	238	241	PF00917	0.690
LIG_TRAF2_1	29	32	PF00917	0.618
LIG_TRAF2_1	520	523	PF00917	0.684
LIG_UBA3_1	257	263	PF00899	0.480
LIG_WRC_WIRS_1	149	154	PF05994	0.606
LIG_WRC_WIRS_1	352	357	PF05994	0.411
LIG_WRC_WIRS_1	6	11	PF05994	0.621
LIG_WW_1	497	500	PF00397	0.698
MOD_CDK_SPxxK_3	413	420	PF00069	0.676
MOD_CK1_1	112	118	PF00069	0.602
MOD_CK1_1	126	132	PF00069	0.728
MOD_CK1_1	176	182	PF00069	0.689
MOD_CK1_1	193	199	PF00069	0.425
MOD_CK1_1	239	245	PF00069	0.749
MOD_CK1_1	286	292	PF00069	0.594
MOD_CK1_1	323	329	PF00069	0.621
MOD_CK1_1	334	340	PF00069	0.416
MOD_CK1_1	506	512	PF00069	0.579
MOD_CK1_1	89	95	PF00069	0.688
MOD_CK2_1	105	111	PF00069	0.769
MOD_CK2_1	140	146	PF00069	0.702
MOD_CK2_1	161	167	PF00069	0.601
MOD_CK2_1	422	428	PF00069	0.750
MOD_CK2_1	431	437	PF00069	0.646
MOD_CK2_1	76	82	PF00069	0.670
MOD_CK2_1	87	93	PF00069	0.572
MOD_GlcNHglycan	1	4	PF01048	0.640
MOD_GlcNHglycan	125	128	PF01048	0.686
MOD_GlcNHglycan	321	325	PF01048	0.714
MOD_GlcNHglycan	375	378	PF01048	0.499
MOD_GlcNHglycan	388	391	PF01048	0.681
MOD_GlcNHglycan	413	416	PF01048	0.734
MOD_GlcNHglycan	491	494	PF01048	0.721
MOD_GlcNHglycan	512	515	PF01048	0.737
MOD_GSK3_1	105	112	PF00069	0.768
MOD_GSK3_1	126	133	PF00069	0.645
MOD_GSK3_1	137	144	PF00069	0.702
MOD_GSK3_1	189	196	PF00069	0.714
MOD_GSK3_1	203	210	PF00069	0.389
MOD_GSK3_1	267	274	PF00069	0.566
MOD_GSK3_1	333	340	PF00069	0.525
MOD_GSK3_1	409	416	PF00069	0.684
MOD_GSK3_1	48	55	PF00069	0.498
MOD_GSK3_1	506	513	PF00069	0.626
MOD_GSK3_1	61	68	PF00069	0.578
MOD_GSK3_1	85	92	PF00069	0.749
MOD_N-GLC_1	137	142	PF02516	0.688
MOD_N-GLC_1	190	195	PF02516	0.562
MOD_NEK2_1	113	118	PF00069	0.662
MOD_NEK2_1	203	208	PF00069	0.568
MOD_NEK2_1	268	273	PF00069	0.572
MOD_NEK2_1	332	337	PF00069	0.531
MOD_NEK2_1	341	346	PF00069	0.418
MOD_NEK2_1	54	59	PF00069	0.646
MOD_NEK2_1	61	66	PF00069	0.597
MOD_NEK2_2	100	105	PF00069	0.585
MOD_NEK2_2	379	384	PF00069	0.539
MOD_OFUCOSY	104	109	PF10250	0.649
MOD_PIKK_1	173	179	PF00454	0.682
MOD_PIKK_1	207	213	PF00454	0.568
MOD_PIKK_1	236	242	PF00454	0.698
MOD_PIKK_1	268	274	PF00454	0.572
MOD_PIKK_1	76	82	PF00454	0.670
MOD_PKA_2	140	146	PF00069	0.720
MOD_PKA_2	161	167	PF00069	0.601
MOD_PKA_2	193	199	PF00069	0.632
MOD_PKA_2	236	242	PF00069	0.747
MOD_PKA_2	268	274	PF00069	0.572
MOD_PKA_2	440	446	PF00069	0.574
MOD_PKA_2	510	516	PF00069	0.691
MOD_Plk_1	48	54	PF00069	0.628
MOD_Plk_2-3	161	167	PF00069	0.601
MOD_Plk_4	148	154	PF00069	0.701
MOD_Plk_4	203	209	PF00069	0.575
MOD_Plk_4	22	28	PF00069	0.465
MOD_Plk_4	256	262	PF00069	0.484
MOD_Plk_4	286	292	PF00069	0.609
MOD_Plk_4	334	340	PF00069	0.580
MOD_Plk_4	341	347	PF00069	0.457
MOD_Plk_4	379	385	PF00069	0.649
MOD_Plk_4	476	482	PF00069	0.706
MOD_Plk_4	5	11	PF00069	0.649
MOD_Plk_4	503	509	PF00069	0.653
MOD_ProDKin_1	14	20	PF00069	0.634
MOD_ProDKin_1	141	147	PF00069	0.769
MOD_ProDKin_1	213	219	PF00069	0.762
MOD_ProDKin_1	413	419	PF00069	0.705
MOD_ProDKin_1	431	437	PF00069	0.558
MOD_ProDKin_1	501	507	PF00069	0.742
MOD_SUMO_for_1	520	523	PF00179	0.684
TRG_DiLeu_LyEn_5	296	301	PF01217	0.553
TRG_ENDOCYTIC_2	466	469	PF00928	0.715
TRG_ENDOCYTIC_2	481	484	PF00928	0.506
TRG_ENDOCYTIC_2	58	61	PF00928	0.632
TRG_ER_diArg_1	183	185	PF00400	0.698
TRG_ER_diArg_1	229	231	PF00400	0.687
TRG_ER_diArg_1	420	422	PF00400	0.737
TRG_ER_diArg_1	439	442	PF00400	0.506
TRG_ER_diArg_1	471	473	PF00400	0.725
TRG_ER_diArg_1	538	541	PF00400	0.726
TRG_Pf-PMV_PEXEL_1	244	249	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	399	404	PF00026	0.701
TRG_Pf-PMV_PEXEL_1	421	426	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IE86	Leishmania donovani	99%	100%
A4H9I6	Leishmania braziliensis	59%	96%
E9ARL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QDW7	Leishmania major	85%	99%