Origin recognition complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXU7_LEIIN

TriTrypDb:

LINF_180012400

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HXU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.652
CLV_NRD_NRD_1	180	182	PF00675	0.650
CLV_NRD_NRD_1	200	202	PF00675	0.651
CLV_NRD_NRD_1	438	440	PF00675	0.489
CLV_NRD_NRD_1	604	606	PF00675	0.441
CLV_NRD_NRD_1	663	665	PF00675	0.605
CLV_NRD_NRD_1	70	72	PF00675	0.421
CLV_PCSK_KEX2_1	180	182	PF00082	0.650
CLV_PCSK_KEX2_1	200	202	PF00082	0.699
CLV_PCSK_KEX2_1	333	335	PF00082	0.472
CLV_PCSK_KEX2_1	407	409	PF00082	0.502
CLV_PCSK_KEX2_1	438	440	PF00082	0.489
CLV_PCSK_KEX2_1	604	606	PF00082	0.440
CLV_PCSK_KEX2_1	663	665	PF00082	0.623
CLV_PCSK_KEX2_1	70	72	PF00082	0.421
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.472
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.502
CLV_PCSK_PC7_1	329	335	PF00082	0.473
CLV_PCSK_SKI1_1	354	358	PF00082	0.534
CLV_PCSK_SKI1_1	439	443	PF00082	0.474
CLV_PCSK_SKI1_1	604	608	PF00082	0.430
CLV_PCSK_SKI1_1	740	744	PF00082	0.425
CLV_PCSK_SKI1_1	783	787	PF00082	0.424
CLV_PCSK_SKI1_1	819	823	PF00082	0.389
CLV_PCSK_SKI1_1	83	87	PF00082	0.526
CLV_Separin_Metazoa	528	532	PF03568	0.455
CLV_Separin_Metazoa	843	847	PF03568	0.384
DEG_APCC_DBOX_1	437	445	PF00400	0.504
DEG_APCC_DBOX_1	604	612	PF00400	0.430
DEG_APCC_DBOX_1	739	747	PF00400	0.427
DEG_APCC_DBOX_1	794	802	PF00400	0.406
DEG_APCC_DBOX_1	818	826	PF00400	0.380
DEG_Nend_Nbox_1	1	3	PF02207	0.569
DEG_SPOP_SBC_1	244	248	PF00917	0.569
DEG_SPOP_SBC_1	493	497	PF00917	0.544
DOC_CKS1_1	163	168	PF01111	0.506
DOC_CYCLIN_RxL_1	435	446	PF00134	0.514
DOC_CYCLIN_RxL_1	54	68	PF00134	0.420
DOC_CYCLIN_yClb5_NLxxxL_5	718	727	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	479	485	PF00134	0.604
DOC_CYCLIN_yCln2_LP_2	718	721	PF00134	0.531
DOC_MAPK_DCC_7	475	485	PF00069	0.593
DOC_MAPK_DCC_7	708	718	PF00069	0.649
DOC_MAPK_gen_1	435	444	PF00069	0.464
DOC_MAPK_gen_1	817	825	PF00069	0.458
DOC_MAPK_MEF2A_6	475	483	PF00069	0.535
DOC_MAPK_MEF2A_6	740	747	PF00069	0.351
DOC_PP2B_LxvP_1	479	482	PF13499	0.544
DOC_PP2B_LxvP_1	718	721	PF13499	0.568
DOC_USP7_MATH_1	219	223	PF00917	0.716
DOC_USP7_MATH_1	3	7	PF00917	0.639
DOC_USP7_MATH_1	513	517	PF00917	0.616
DOC_USP7_MATH_1	53	57	PF00917	0.492
DOC_USP7_MATH_1	542	546	PF00917	0.624
DOC_USP7_MATH_1	551	555	PF00917	0.565
DOC_USP7_MATH_1	623	627	PF00917	0.629
DOC_USP7_MATH_1	631	635	PF00917	0.579
DOC_USP7_MATH_1	652	656	PF00917	0.461
DOC_WW_Pin1_4	102	107	PF00397	0.399
DOC_WW_Pin1_4	13	18	PF00397	0.521
DOC_WW_Pin1_4	162	167	PF00397	0.507
DOC_WW_Pin1_4	460	465	PF00397	0.629
DOC_WW_Pin1_4	69	74	PF00397	0.515
LIG_14-3-3_CanoR_1	183	188	PF00244	0.695
LIG_14-3-3_CanoR_1	338	346	PF00244	0.440
LIG_14-3-3_CanoR_1	396	405	PF00244	0.546
LIG_14-3-3_CanoR_1	423	431	PF00244	0.453
LIG_14-3-3_CanoR_1	439	445	PF00244	0.579
LIG_14-3-3_CanoR_1	475	483	PF00244	0.647
LIG_14-3-3_CanoR_1	504	509	PF00244	0.476
LIG_14-3-3_CanoR_1	605	611	PF00244	0.549
LIG_14-3-3_CanoR_1	71	77	PF00244	0.392
LIG_14-3-3_CanoR_1	846	851	PF00244	0.475
LIG_Actin_WH2_2	786	802	PF00022	0.467
LIG_Actin_WH2_2	96	114	PF00022	0.377
LIG_BRCT_BRCA1_1	496	500	PF00533	0.669
LIG_Clathr_ClatBox_1	128	132	PF01394	0.486
LIG_EH1_1	58	66	PF00400	0.408
LIG_eIF4E_1	295	301	PF01652	0.390
LIG_FHA_1	158	164	PF00498	0.571
LIG_FHA_1	246	252	PF00498	0.542
LIG_FHA_1	341	347	PF00498	0.411
LIG_FHA_1	445	451	PF00498	0.569
LIG_FHA_1	503	509	PF00498	0.568
LIG_FHA_1	516	522	PF00498	0.365
LIG_FHA_1	73	79	PF00498	0.345
LIG_FHA_1	752	758	PF00498	0.420
LIG_FHA_2	229	235	PF00498	0.623
LIG_FHA_2	428	434	PF00498	0.490
LIG_FHA_2	566	572	PF00498	0.546
LIG_FHA_2	759	765	PF00498	0.429
LIG_GBD_Chelix_1	562	570	PF00786	0.523
LIG_GBD_Chelix_1	95	103	PF00786	0.378
LIG_LIR_Apic_2	704	709	PF02991	0.657
LIG_LIR_Nem_3	122	128	PF02991	0.387
LIG_LIR_Nem_3	26	32	PF02991	0.455
LIG_LIR_Nem_3	342	348	PF02991	0.468
LIG_LIR_Nem_3	675	680	PF02991	0.586
LIG_MYND_1	711	715	PF01753	0.568
LIG_NRBOX	352	358	PF00104	0.454
LIG_NRBOX	440	446	PF00104	0.535
LIG_NRBOX	722	728	PF00104	0.546
LIG_PDZ_Class_1	846	851	PF00595	0.475
LIG_Pex14_2	125	129	PF04695	0.396
LIG_SH2_CRK	29	33	PF00017	0.405
LIG_SH2_CRK	706	710	PF00017	0.650
LIG_SH2_PTP2	345	348	PF00017	0.432
LIG_SH2_STAT5	116	119	PF00017	0.485
LIG_SH2_STAT5	250	253	PF00017	0.552
LIG_SH2_STAT5	295	298	PF00017	0.388
LIG_SH2_STAT5	345	348	PF00017	0.432
LIG_SH3_1	344	350	PF00018	0.437
LIG_SH3_1	616	622	PF00018	0.545
LIG_SH3_1	708	714	PF00018	0.605
LIG_SH3_3	184	190	PF00018	0.640
LIG_SH3_3	344	350	PF00018	0.437
LIG_SH3_3	616	622	PF00018	0.601
LIG_SH3_3	708	714	PF00018	0.605
LIG_SUMO_SIM_anti_2	574	585	PF11976	0.480
LIG_SUMO_SIM_anti_2	741	747	PF11976	0.348
LIG_SUMO_SIM_par_1	159	165	PF11976	0.565
LIG_SUMO_SIM_par_1	265	271	PF11976	0.373
LIG_SUMO_SIM_par_1	440	449	PF11976	0.550
LIG_SUMO_SIM_par_1	820	827	PF11976	0.399
LIG_TYR_ITIM	746	751	PF00017	0.354
LIG_UBA3_1	266	270	PF00899	0.365
LIG_UBA3_1	822	828	PF00899	0.458
LIG_ULM_U2AF65_1	200	205	PF00076	0.700
LIG_WRC_WIRS_1	99	104	PF05994	0.455
MOD_CK1_1	105	111	PF00069	0.408
MOD_CK1_1	176	182	PF00069	0.646
MOD_CK1_1	185	191	PF00069	0.601
MOD_CK1_1	246	252	PF00069	0.556
MOD_CK1_1	337	343	PF00069	0.464
MOD_CK1_1	390	396	PF00069	0.511
MOD_CK1_1	427	433	PF00069	0.537
MOD_CK1_1	460	466	PF00069	0.643
MOD_CK1_1	492	498	PF00069	0.598
MOD_CK1_1	499	505	PF00069	0.575
MOD_CK1_1	507	513	PF00069	0.494
MOD_CK1_1	515	521	PF00069	0.369
MOD_CK1_1	574	580	PF00069	0.480
MOD_CK1_1	626	632	PF00069	0.621
MOD_CK1_1	655	661	PF00069	0.550
MOD_CK1_1	772	778	PF00069	0.454
MOD_CK2_1	13	19	PF00069	0.554
MOD_CK2_1	228	234	PF00069	0.681
MOD_CK2_1	427	433	PF00069	0.527
MOD_CK2_1	565	571	PF00069	0.541
MOD_CK2_1	699	705	PF00069	0.698
MOD_Cter_Amidation	602	605	PF01082	0.427
MOD_GlcNHglycan	107	110	PF01048	0.480
MOD_GlcNHglycan	150	153	PF01048	0.583
MOD_GlcNHglycan	175	178	PF01048	0.670
MOD_GlcNHglycan	220	224	PF01048	0.662
MOD_GlcNHglycan	239	242	PF01048	0.581
MOD_GlcNHglycan	256	259	PF01048	0.433
MOD_GlcNHglycan	297	300	PF01048	0.390
MOD_GlcNHglycan	322	325	PF01048	0.411
MOD_GlcNHglycan	389	392	PF01048	0.458
MOD_GlcNHglycan	459	462	PF01048	0.744
MOD_GlcNHglycan	471	474	PF01048	0.541
MOD_GlcNHglycan	476	479	PF01048	0.624
MOD_GlcNHglycan	491	494	PF01048	0.584
MOD_GlcNHglycan	544	547	PF01048	0.579
MOD_GlcNHglycan	55	58	PF01048	0.422
MOD_GlcNHglycan	553	556	PF01048	0.635
MOD_GlcNHglycan	592	595	PF01048	0.496
MOD_GlcNHglycan	6	9	PF01048	0.661
MOD_GlcNHglycan	601	604	PF01048	0.566
MOD_GlcNHglycan	628	631	PF01048	0.622
MOD_GlcNHglycan	754	757	PF01048	0.514
MOD_GSK3_1	185	192	PF00069	0.719
MOD_GSK3_1	242	249	PF00069	0.556
MOD_GSK3_1	268	275	PF00069	0.385
MOD_GSK3_1	28	35	PF00069	0.406
MOD_GSK3_1	333	340	PF00069	0.481
MOD_GSK3_1	440	447	PF00069	0.537
MOD_GSK3_1	469	476	PF00069	0.640
MOD_GSK3_1	488	495	PF00069	0.595
MOD_GSK3_1	498	505	PF00069	0.576
MOD_GSK3_1	561	568	PF00069	0.612
MOD_GSK3_1	571	578	PF00069	0.536
MOD_GSK3_1	768	775	PF00069	0.436
MOD_GSK3_1	98	105	PF00069	0.455
MOD_N-GLC_1	572	577	PF02516	0.584
MOD_N-GLC_1	699	704	PF02516	0.642
MOD_NEK2_1	117	122	PF00069	0.457
MOD_NEK2_1	243	248	PF00069	0.553
MOD_NEK2_1	268	273	PF00069	0.378
MOD_NEK2_1	32	37	PF00069	0.472
MOD_NEK2_1	357	362	PF00069	0.502
MOD_NEK2_1	384	389	PF00069	0.401
MOD_NEK2_1	413	418	PF00069	0.464
MOD_NEK2_1	512	517	PF00069	0.503
MOD_NEK2_1	572	577	PF00069	0.521
MOD_NEK2_1	599	604	PF00069	0.488
MOD_NEK2_1	821	826	PF00069	0.370
MOD_NEK2_2	28	33	PF00069	0.404
MOD_OFUCOSY	40	47	PF10250	0.408
MOD_PIKK_1	803	809	PF00454	0.438
MOD_PK_1	504	510	PF00069	0.524
MOD_PKA_1	333	339	PF00069	0.480
MOD_PKA_2	182	188	PF00069	0.801
MOD_PKA_2	204	210	PF00069	0.646
MOD_PKA_2	32	38	PF00069	0.403
MOD_PKA_2	333	339	PF00069	0.490
MOD_PKA_2	395	401	PF00069	0.442
MOD_PKA_2	469	475	PF00069	0.601
MOD_PKA_2	53	59	PF00069	0.432
MOD_PKA_2	542	548	PF00069	0.518
MOD_PKA_2	682	688	PF00069	0.615
MOD_PKB_1	181	189	PF00069	0.699
MOD_Plk_1	427	433	PF00069	0.488
MOD_Plk_1	758	764	PF00069	0.512
MOD_Plk_2-3	228	234	PF00069	0.747
MOD_Plk_2-3	565	571	PF00069	0.527
MOD_Plk_4	157	163	PF00069	0.619
MOD_Plk_4	246	252	PF00069	0.563
MOD_Plk_4	272	278	PF00069	0.348
MOD_Plk_4	315	321	PF00069	0.378
MOD_Plk_4	440	446	PF00069	0.591
MOD_Plk_4	507	513	PF00069	0.521
MOD_Plk_4	576	582	PF00069	0.477
MOD_Plk_4	606	612	PF00069	0.466
MOD_Plk_4	652	658	PF00069	0.510
MOD_Plk_4	714	720	PF00069	0.547
MOD_Plk_4	72	78	PF00069	0.388
MOD_Plk_4	821	827	PF00069	0.378
MOD_Plk_4	98	104	PF00069	0.454
MOD_ProDKin_1	102	108	PF00069	0.394
MOD_ProDKin_1	13	19	PF00069	0.517
MOD_ProDKin_1	162	168	PF00069	0.507
MOD_ProDKin_1	460	466	PF00069	0.629
MOD_ProDKin_1	69	75	PF00069	0.509
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.431
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.422
TRG_DiLeu_BaLyEn_6	788	793	PF01217	0.380
TRG_DiLeu_BaLyEn_6	794	799	PF01217	0.403
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.277
TRG_ENDOCYTIC_2	29	32	PF00928	0.399
TRG_ENDOCYTIC_2	345	348	PF00928	0.475
TRG_ENDOCYTIC_2	748	751	PF00928	0.358
TRG_ER_diArg_1	180	183	PF00400	0.825
TRG_ER_diArg_1	200	203	PF00400	0.679
TRG_ER_diArg_1	604	606	PF00400	0.437
TRG_ER_diArg_1	611	614	PF00400	0.444
TRG_ER_diArg_1	69	71	PF00400	0.405
TRG_ER_FFAT_2	494	505	PF00635	0.650
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN4	Leptomonas seymouri	55%	76%
A0A3S5H733	Leishmania donovani	100%	100%
A4H9I3	Leishmania braziliensis	79%	100%
E9ARK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDX0	Leishmania major	91%	100%