Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXU3_LEIIN

TriTrypDb:

LINF_180012000

Length:

834

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXU3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.658
CLV_C14_Caspase3-7	487	491	PF00656	0.704
CLV_C14_Caspase3-7	582	586	PF00656	0.680
CLV_C14_Caspase3-7	801	805	PF00656	0.547
CLV_NRD_NRD_1	12	14	PF00675	0.679
CLV_NRD_NRD_1	2	4	PF00675	0.744
CLV_NRD_NRD_1	231	233	PF00675	0.646
CLV_NRD_NRD_1	536	538	PF00675	0.715
CLV_NRD_NRD_1	562	564	PF00675	0.779
CLV_NRD_NRD_1	58	60	PF00675	0.739
CLV_NRD_NRD_1	644	646	PF00675	0.709
CLV_NRD_NRD_1	814	816	PF00675	0.635
CLV_NRD_NRD_1	93	95	PF00675	0.760
CLV_PCSK_FUR_1	811	815	PF00082	0.535
CLV_PCSK_KEX2_1	12	14	PF00082	0.679
CLV_PCSK_KEX2_1	2	4	PF00082	0.744
CLV_PCSK_KEX2_1	536	538	PF00082	0.715
CLV_PCSK_KEX2_1	562	564	PF00082	0.759
CLV_PCSK_KEX2_1	579	581	PF00082	0.515
CLV_PCSK_KEX2_1	58	60	PF00082	0.739
CLV_PCSK_KEX2_1	644	646	PF00082	0.709
CLV_PCSK_KEX2_1	813	815	PF00082	0.565
CLV_PCSK_KEX2_1	93	95	PF00082	0.760
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.684
CLV_PCSK_PC7_1	640	646	PF00082	0.818
CLV_PCSK_PC7_1	8	14	PF00082	0.740
CLV_PCSK_SKI1_1	759	763	PF00082	0.497
CLV_PCSK_SKI1_1	88	92	PF00082	0.747
DEG_APCC_DBOX_1	12	20	PF00400	0.762
DEG_APCC_DBOX_1	235	243	PF00400	0.659
DEG_APCC_DBOX_1	639	647	PF00400	0.733
DEG_Nend_UBRbox_1	1	4	PF02207	0.713
DEG_SPOP_SBC_1	143	147	PF00917	0.633
DEG_SPOP_SBC_1	457	461	PF00917	0.622
DEG_SPOP_SBC_1	47	51	PF00917	0.713
DEG_SPOP_SBC_1	497	501	PF00917	0.630
DOC_CDC14_PxL_1	234	242	PF14671	0.570
DOC_CKS1_1	310	315	PF01111	0.726
DOC_CKS1_1	714	719	PF01111	0.495
DOC_CKS1_1	739	744	PF01111	0.535
DOC_CKS1_1	792	797	PF01111	0.598
DOC_MAPK_DCC_7	232	242	PF00069	0.582
DOC_MAPK_FxFP_2	442	445	PF00069	0.524
DOC_MAPK_gen_1	186	194	PF00069	0.618
DOC_MAPK_gen_1	232	242	PF00069	0.590
DOC_MAPK_HePTP_8	377	389	PF00069	0.563
DOC_MAPK_MEF2A_6	233	242	PF00069	0.576
DOC_MAPK_MEF2A_6	35	44	PF00069	0.698
DOC_MAPK_MEF2A_6	380	389	PF00069	0.658
DOC_PP2B_LxvP_1	150	153	PF13499	0.714
DOC_PP2B_LxvP_1	588	591	PF13499	0.706
DOC_PP2B_LxvP_1	748	751	PF13499	0.647
DOC_PP4_FxxP_1	343	346	PF00568	0.700
DOC_PP4_FxxP_1	44	47	PF00568	0.768
DOC_PP4_FxxP_1	442	445	PF00568	0.524
DOC_USP7_MATH_1	107	111	PF00917	0.717
DOC_USP7_MATH_1	23	27	PF00917	0.807
DOC_USP7_MATH_1	278	282	PF00917	0.657
DOC_USP7_MATH_1	289	293	PF00917	0.713
DOC_USP7_MATH_1	321	325	PF00917	0.571
DOC_USP7_MATH_1	410	414	PF00917	0.746
DOC_USP7_MATH_1	48	52	PF00917	0.749
DOC_USP7_MATH_1	484	488	PF00917	0.696
DOC_USP7_MATH_1	497	501	PF00917	0.674
DOC_USP7_MATH_1	635	639	PF00917	0.738
DOC_USP7_MATH_1	661	665	PF00917	0.551
DOC_USP7_MATH_1	733	737	PF00917	0.503
DOC_USP7_MATH_1	751	755	PF00917	0.604
DOC_WW_Pin1_4	145	150	PF00397	0.707
DOC_WW_Pin1_4	161	166	PF00397	0.649
DOC_WW_Pin1_4	172	177	PF00397	0.702
DOC_WW_Pin1_4	291	296	PF00397	0.674
DOC_WW_Pin1_4	309	314	PF00397	0.591
DOC_WW_Pin1_4	354	359	PF00397	0.618
DOC_WW_Pin1_4	417	422	PF00397	0.733
DOC_WW_Pin1_4	500	505	PF00397	0.783
DOC_WW_Pin1_4	522	527	PF00397	0.792
DOC_WW_Pin1_4	561	566	PF00397	0.660
DOC_WW_Pin1_4	620	625	PF00397	0.715
DOC_WW_Pin1_4	713	718	PF00397	0.514
DOC_WW_Pin1_4	738	743	PF00397	0.528
DOC_WW_Pin1_4	791	796	PF00397	0.610
LIG_14-3-3_CanoR_1	108	114	PF00244	0.699
LIG_14-3-3_CanoR_1	142	152	PF00244	0.632
LIG_14-3-3_CanoR_1	186	195	PF00244	0.607
LIG_14-3-3_CanoR_1	322	328	PF00244	0.622
LIG_14-3-3_CanoR_1	376	380	PF00244	0.687
LIG_14-3-3_CanoR_1	46	54	PF00244	0.781
LIG_14-3-3_CanoR_1	483	489	PF00244	0.751
LIG_14-3-3_CanoR_1	498	504	PF00244	0.634
LIG_14-3-3_CanoR_1	58	66	PF00244	0.695
LIG_14-3-3_CanoR_1	580	584	PF00244	0.770
LIG_14-3-3_CanoR_1	604	608	PF00244	0.720
LIG_14-3-3_CanoR_1	617	627	PF00244	0.579
LIG_14-3-3_CanoR_1	640	644	PF00244	0.738
LIG_Actin_WH2_2	365	382	PF00022	0.704
LIG_BRCT_BRCA1_1	108	112	PF00533	0.714
LIG_BRCT_BRCA1_1	275	279	PF00533	0.547
LIG_EVH1_1	16	20	PF00568	0.714
LIG_EVH1_2	95	99	PF00568	0.602
LIG_FHA_1	248	254	PF00498	0.669
LIG_FHA_1	483	489	PF00498	0.751
LIG_FHA_1	527	533	PF00498	0.636
LIG_FHA_1	565	571	PF00498	0.641
LIG_FHA_1	792	798	PF00498	0.526
LIG_FHA_2	407	413	PF00498	0.796
LIG_FHA_2	567	573	PF00498	0.789
LIG_FHA_2	580	586	PF00498	0.608
LIG_FHA_2	760	766	PF00498	0.481
LIG_FHA_2	799	805	PF00498	0.550
LIG_LIR_Apic_2	151	157	PF02991	0.620
LIG_LIR_Apic_2	340	346	PF02991	0.612
LIG_LIR_Apic_2	378	384	PF02991	0.693
LIG_LIR_Apic_2	441	445	PF02991	0.529
LIG_LIR_Gen_1	366	377	PF02991	0.635
LIG_LIR_Gen_1	438	445	PF02991	0.588
LIG_LIR_Gen_1	765	775	PF02991	0.502
LIG_LIR_LC3C_4	747	750	PF02991	0.532
LIG_LIR_Nem_3	214	219	PF02991	0.628
LIG_LIR_Nem_3	270	275	PF02991	0.547
LIG_LIR_Nem_3	366	372	PF02991	0.647
LIG_LIR_Nem_3	430	435	PF02991	0.562
LIG_LIR_Nem_3	438	442	PF02991	0.517
LIG_LIR_Nem_3	670	674	PF02991	0.652
LIG_LIR_Nem_3	765	771	PF02991	0.483
LIG_Pex14_2	549	553	PF04695	0.609
LIG_SH2_CRK	154	158	PF00017	0.612
LIG_SH2_CRK	425	429	PF00017	0.567
LIG_SH2_CRK	768	772	PF00017	0.502
LIG_SH2_NCK_1	154	158	PF00017	0.612
LIG_SH2_NCK_1	275	279	PF00017	0.506
LIG_SH2_SRC	435	438	PF00017	0.548
LIG_SH2_SRC	790	793	PF00017	0.586
LIG_SH2_STAP1	275	279	PF00017	0.506
LIG_SH2_STAT5	265	268	PF00017	0.605
LIG_SH2_STAT5	435	438	PF00017	0.548
LIG_SH2_STAT5	619	622	PF00017	0.704
LIG_SH2_STAT5	709	712	PF00017	0.661
LIG_SH3_3	14	20	PF00018	0.757
LIG_SH3_3	166	172	PF00018	0.817
LIG_SH3_3	235	241	PF00018	0.657
LIG_SH3_3	292	298	PF00018	0.720
LIG_SH3_3	463	469	PF00018	0.723
LIG_SH3_3	514	520	PF00018	0.674
LIG_SH3_3	555	561	PF00018	0.697
LIG_SH3_3	610	616	PF00018	0.735
LIG_SH3_3	621	627	PF00018	0.724
LIG_SH3_3	714	720	PF00018	0.614
LIG_SH3_3	736	742	PF00018	0.514
LIG_SH3_3	789	795	PF00018	0.583
LIG_SH3_3	92	98	PF00018	0.710
LIG_SH3_4	472	479	PF00018	0.584
LIG_SUMO_SIM_anti_2	250	255	PF11976	0.559
LIG_SUMO_SIM_anti_2	383	389	PF11976	0.536
LIG_SUMO_SIM_anti_2	735	741	PF11976	0.513
LIG_SUMO_SIM_par_1	240	247	PF11976	0.529
LIG_SUMO_SIM_par_1	249	255	PF11976	0.562
LIG_SUMO_SIM_par_1	484	490	PF11976	0.749
LIG_SUMO_SIM_par_1	759	765	PF11976	0.493
LIG_TRAF2_1	178	181	PF00917	0.600
LIG_TYR_ITIM	423	428	PF00017	0.581
LIG_TYR_ITIM	766	771	PF00017	0.483
LIG_WRC_WIRS_1	436	441	PF05994	0.650
LIG_WRC_WIRS_1	550	555	PF05994	0.730
LIG_WW_2	17	20	PF00397	0.711
LIG_WW_3	559	563	PF00397	0.748
MOD_CDK_SPxxK_3	500	507	PF00069	0.769
MOD_CK1_1	144	150	PF00069	0.657
MOD_CK1_1	174	180	PF00069	0.766
MOD_CK1_1	281	287	PF00069	0.761
MOD_CK1_1	482	488	PF00069	0.737
MOD_CK1_1	500	506	PF00069	0.594
MOD_CK1_1	525	531	PF00069	0.811
MOD_CK1_1	564	570	PF00069	0.695
MOD_CK1_1	606	612	PF00069	0.692
MOD_CK1_1	61	67	PF00069	0.689
MOD_CK1_1	628	634	PF00069	0.729
MOD_CK2_1	174	180	PF00069	0.749
MOD_CK2_1	4	10	PF00069	0.749
MOD_CK2_1	406	412	PF00069	0.801
MOD_CK2_1	435	441	PF00069	0.545
MOD_CK2_1	503	509	PF00069	0.764
MOD_CK2_1	645	651	PF00069	0.749
MOD_GlcNHglycan	209	212	PF01048	0.663
MOD_GlcNHglycan	225	228	PF01048	0.546
MOD_GlcNHglycan	275	278	PF01048	0.646
MOD_GlcNHglycan	280	283	PF01048	0.618
MOD_GlcNHglycan	287	290	PF01048	0.587
MOD_GlcNHglycan	331	334	PF01048	0.710
MOD_GlcNHglycan	390	393	PF01048	0.528
MOD_GlcNHglycan	460	463	PF01048	0.673
MOD_GlcNHglycan	50	53	PF01048	0.725
MOD_GlcNHglycan	54	57	PF01048	0.705
MOD_GlcNHglycan	608	611	PF01048	0.743
MOD_GlcNHglycan	662	666	PF01048	0.595
MOD_GlcNHglycan	710	713	PF01048	0.573
MOD_GlcNHglycan	772	775	PF01048	0.490
MOD_GSK3_1	141	148	PF00069	0.698
MOD_GSK3_1	203	210	PF00069	0.658
MOD_GSK3_1	217	224	PF00069	0.655
MOD_GSK3_1	243	250	PF00069	0.652
MOD_GSK3_1	273	280	PF00069	0.719
MOD_GSK3_1	281	288	PF00069	0.652
MOD_GSK3_1	317	324	PF00069	0.652
MOD_GSK3_1	329	336	PF00069	0.600
MOD_GSK3_1	406	413	PF00069	0.697
MOD_GSK3_1	42	49	PF00069	0.768
MOD_GSK3_1	496	503	PF00069	0.755
MOD_GSK3_1	522	529	PF00069	0.714
MOD_GSK3_1	545	552	PF00069	0.716
MOD_GSK3_1	574	581	PF00069	0.772
MOD_GSK3_1	602	609	PF00069	0.642
MOD_GSK3_1	625	632	PF00069	0.707
MOD_GSK3_1	635	642	PF00069	0.680
MOD_GSK3_1	766	773	PF00069	0.477
MOD_N-GLC_1	100	105	PF02516	0.749
MOD_N-GLC_1	256	261	PF02516	0.595
MOD_N-GLC_1	333	338	PF02516	0.579
MOD_N-GLC_1	410	415	PF02516	0.615
MOD_NEK2_1	204	209	PF00069	0.714
MOD_NEK2_1	42	47	PF00069	0.819
MOD_NEK2_1	512	517	PF00069	0.744
MOD_NEK2_1	639	644	PF00069	0.699
MOD_NEK2_1	690	695	PF00069	0.639
MOD_NEK2_1	770	775	PF00069	0.562
MOD_NEK2_1	82	87	PF00069	0.800
MOD_NEK2_1	99	104	PF00069	0.572
MOD_NEK2_2	375	380	PF00069	0.492
MOD_NEK2_2	484	489	PF00069	0.607
MOD_NEK2_2	574	579	PF00069	0.728
MOD_PIKK_1	341	347	PF00454	0.757
MOD_PIKK_1	472	478	PF00454	0.727
MOD_PIKK_1	61	67	PF00454	0.627
MOD_PIKK_1	625	631	PF00454	0.766
MOD_PIKK_1	690	696	PF00454	0.617
MOD_PIKK_1	715	721	PF00454	0.712
MOD_PKA_1	579	585	PF00069	0.757
MOD_PKA_1	58	64	PF00069	0.732
MOD_PKA_1	814	820	PF00069	0.623
MOD_PKA_2	107	113	PF00069	0.718
MOD_PKA_2	141	147	PF00069	0.594
MOD_PKA_2	187	193	PF00069	0.600
MOD_PKA_2	202	208	PF00069	0.607
MOD_PKA_2	321	327	PF00069	0.585
MOD_PKA_2	353	359	PF00069	0.720
MOD_PKA_2	375	381	PF00069	0.716
MOD_PKA_2	482	488	PF00069	0.762
MOD_PKA_2	497	503	PF00069	0.685
MOD_PKA_2	553	559	PF00069	0.709
MOD_PKA_2	579	585	PF00069	0.679
MOD_PKA_2	58	64	PF00069	0.692
MOD_PKA_2	603	609	PF00069	0.618
MOD_PKA_2	639	645	PF00069	0.737
MOD_PKA_2	814	820	PF00069	0.623
MOD_PKA_2	82	88	PF00069	0.800
MOD_Plk_1	211	217	PF00069	0.619
MOD_Plk_1	333	339	PF00069	0.648
MOD_Plk_1	545	551	PF00069	0.721
MOD_Plk_1	61	67	PF00069	0.689
MOD_Plk_2-3	647	653	PF00069	0.675
MOD_Plk_4	212	218	PF00069	0.703
MOD_Plk_4	247	253	PF00069	0.670
MOD_Plk_4	435	441	PF00069	0.545
MOD_Plk_4	545	551	PF00069	0.720
MOD_Plk_4	566	572	PF00069	0.686
MOD_Plk_4	733	739	PF00069	0.518
MOD_Plk_4	766	772	PF00069	0.524
MOD_Plk_4	798	804	PF00069	0.538
MOD_ProDKin_1	145	151	PF00069	0.707
MOD_ProDKin_1	161	167	PF00069	0.654
MOD_ProDKin_1	172	178	PF00069	0.703
MOD_ProDKin_1	291	297	PF00069	0.665
MOD_ProDKin_1	309	315	PF00069	0.594
MOD_ProDKin_1	354	360	PF00069	0.616
MOD_ProDKin_1	417	423	PF00069	0.726
MOD_ProDKin_1	500	506	PF00069	0.782
MOD_ProDKin_1	522	528	PF00069	0.795
MOD_ProDKin_1	561	567	PF00069	0.659
MOD_ProDKin_1	620	626	PF00069	0.713
MOD_ProDKin_1	713	719	PF00069	0.523
MOD_ProDKin_1	738	744	PF00069	0.531
MOD_ProDKin_1	791	797	PF00069	0.598
TRG_DiLeu_BaEn_1	383	388	PF01217	0.536
TRG_DiLeu_BaEn_1	509	514	PF01217	0.641
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.574
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.546
TRG_DiLeu_BaLyEn_6	517	522	PF01217	0.759
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.794
TRG_ENDOCYTIC_2	425	428	PF00928	0.567
TRG_ENDOCYTIC_2	768	771	PF00928	0.487
TRG_ER_diArg_1	1	3	PF00400	0.770
TRG_ER_diArg_1	11	13	PF00400	0.703
TRG_ER_diArg_1	561	563	PF00400	0.756
TRG_ER_diArg_1	643	645	PF00400	0.712
TRG_ER_diArg_1	810	813	PF00400	0.505
TRG_ER_diArg_1	93	95	PF00400	0.760
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.732
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G3	Leptomonas seymouri	31%	100%
A0A3S7WUV1	Leishmania donovani	100%	100%
A4H9H7	Leishmania braziliensis	63%	100%
E9ARK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QDX4	Leishmania major	83%	97%