Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXT9_LEIIN

TriTrypDb:

LINF_180011600

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.728
CLV_NRD_NRD_1	10	12	PF00675	0.740
CLV_NRD_NRD_1	133	135	PF00675	0.695
CLV_NRD_NRD_1	173	175	PF00675	0.849
CLV_NRD_NRD_1	187	189	PF00675	0.630
CLV_NRD_NRD_1	330	332	PF00675	0.716
CLV_NRD_NRD_1	352	354	PF00675	0.735
CLV_NRD_NRD_1	37	39	PF00675	0.735
CLV_NRD_NRD_1	382	384	PF00675	0.655
CLV_NRD_NRD_1	450	452	PF00675	0.736
CLV_NRD_NRD_1	495	497	PF00675	0.645
CLV_NRD_NRD_1	535	537	PF00675	0.721
CLV_PCSK_KEX2_1	133	135	PF00082	0.695
CLV_PCSK_KEX2_1	173	175	PF00082	0.849
CLV_PCSK_KEX2_1	330	332	PF00082	0.716
CLV_PCSK_KEX2_1	352	354	PF00082	0.735
CLV_PCSK_KEX2_1	36	38	PF00082	0.724
CLV_PCSK_KEX2_1	382	384	PF00082	0.812
CLV_PCSK_KEX2_1	450	452	PF00082	0.736
CLV_PCSK_KEX2_1	495	497	PF00082	0.645
CLV_PCSK_KEX2_1	53	55	PF00082	0.572
CLV_PCSK_KEX2_1	535	537	PF00082	0.721
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.724
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.572
CLV_PCSK_PC7_1	326	332	PF00082	0.727
CLV_PCSK_SKI1_1	24	28	PF00082	0.719
CLV_PCSK_SKI1_1	495	499	PF00082	0.585
CLV_PCSK_SKI1_1	535	539	PF00082	0.714
CLV_Separin_Metazoa	265	269	PF03568	0.765
CLV_Separin_Metazoa	308	312	PF03568	0.697
DEG_APCC_DBOX_1	359	367	PF00400	0.790
DEG_Nend_UBRbox_1	1	4	PF02207	0.627
DEG_SCF_FBW7_1	94	101	PF00400	0.831
DEG_SPOP_SBC_1	248	252	PF00917	0.769
DEG_SPOP_SBC_1	459	463	PF00917	0.680
DOC_MAPK_gen_1	21	30	PF00069	0.725
DOC_PP4_MxPP_1	264	267	PF00568	0.765
DOC_USP7_MATH_1	211	215	PF00917	0.545
DOC_USP7_MATH_1	22	26	PF00917	0.649
DOC_USP7_MATH_1	248	252	PF00917	0.776
DOC_USP7_MATH_1	270	274	PF00917	0.806
DOC_USP7_MATH_1	275	279	PF00917	0.762
DOC_USP7_MATH_1	284	288	PF00917	0.657
DOC_USP7_MATH_1	358	362	PF00917	0.593
DOC_USP7_MATH_1	408	412	PF00917	0.814
DOC_USP7_MATH_1	45	49	PF00917	0.743
DOC_USP7_MATH_1	459	463	PF00917	0.794
DOC_USP7_MATH_1	471	475	PF00917	0.612
DOC_USP7_MATH_1	70	74	PF00917	0.643
DOC_USP7_MATH_1	98	102	PF00917	0.789
DOC_USP7_UBL2_3	12	16	PF12436	0.700
DOC_USP7_UBL2_3	65	69	PF12436	0.841
DOC_WW_Pin1_4	105	110	PF00397	0.637
DOC_WW_Pin1_4	117	122	PF00397	0.656
DOC_WW_Pin1_4	160	165	PF00397	0.662
DOC_WW_Pin1_4	204	209	PF00397	0.810
DOC_WW_Pin1_4	214	219	PF00397	0.629
DOC_WW_Pin1_4	234	239	PF00397	0.582
DOC_WW_Pin1_4	252	257	PF00397	0.530
DOC_WW_Pin1_4	280	285	PF00397	0.763
DOC_WW_Pin1_4	296	301	PF00397	0.630
DOC_WW_Pin1_4	353	358	PF00397	0.781
DOC_WW_Pin1_4	455	460	PF00397	0.748
DOC_WW_Pin1_4	461	466	PF00397	0.786
DOC_WW_Pin1_4	512	517	PF00397	0.672
DOC_WW_Pin1_4	82	87	PF00397	0.730
DOC_WW_Pin1_4	94	99	PF00397	0.649
LIG_14-3-3_CanoR_1	21	30	PF00244	0.647
LIG_14-3-3_CanoR_1	210	219	PF00244	0.798
LIG_14-3-3_CanoR_1	246	256	PF00244	0.741
LIG_14-3-3_CanoR_1	271	279	PF00244	0.841
LIG_14-3-3_CanoR_1	315	319	PF00244	0.618
LIG_14-3-3_CanoR_1	360	364	PF00244	0.581
LIG_BRCT_BRCA1_1	363	367	PF00533	0.763
LIG_BRCT_BRCA1_1	368	372	PF00533	0.712
LIG_CSL_BTD_1	109	112	PF09270	0.823
LIG_CSL_BTD_1	215	218	PF09270	0.680
LIG_deltaCOP1_diTrp_1	107	114	PF00928	0.744
LIG_FHA_1	485	491	PF00498	0.629
LIG_FHA_2	143	149	PF00498	0.626
LIG_FHA_2	177	183	PF00498	0.672
LIG_FHA_2	340	346	PF00498	0.715
LIG_LIR_Apic_2	217	222	PF02991	0.669
LIG_LIR_Apic_2	250	256	PF02991	0.569
LIG_LIR_Nem_3	107	113	PF02991	0.817
LIG_LIR_Nem_3	147	153	PF02991	0.816
LIG_MLH1_MIPbox_1	368	372	PF16413	0.779
LIG_NRP_CendR_1	560	562	PF00754	0.595
LIG_Pex14_1	110	114	PF04695	0.826
LIG_Pex14_2	239	243	PF04695	0.681
LIG_Pex14_2	367	371	PF04695	0.776
LIG_REV1ctd_RIR_1	369	375	PF16727	0.783
LIG_SH2_CRK	253	257	PF00017	0.579
LIG_SH2_NCK_1	253	257	PF00017	0.579
LIG_SH2_NCK_1	387	391	PF00017	0.743
LIG_SH2_SRC	4	7	PF00017	0.687
LIG_SH2_STAP1	176	180	PF00017	0.670
LIG_SH2_STAP1	334	338	PF00017	0.746
LIG_SH2_STAP1	387	391	PF00017	0.743
LIG_SH2_STAT5	253	256	PF00017	0.580
LIG_SH2_STAT5	4	7	PF00017	0.687
LIG_SH2_STAT5	547	550	PF00017	0.743
LIG_SH3_1	294	300	PF00018	0.645
LIG_SH3_2	297	302	PF14604	0.721
LIG_SH3_3	106	112	PF00018	0.820
LIG_SH3_3	215	221	PF00018	0.751
LIG_SH3_3	264	270	PF00018	0.769
LIG_SH3_3	294	300	PF00018	0.820
LIG_SH3_3	313	319	PF00018	0.513
LIG_SH3_3	351	357	PF00018	0.820
LIG_SH3_3	71	77	PF00018	0.790
LIG_SH3_4	12	19	PF00018	0.707
LIG_SH3_5	423	427	PF00018	0.734
LIG_SH3_CIN85_PxpxPR_1	55	60	PF14604	0.683
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.631
LIG_SUMO_SIM_par_1	25	31	PF11976	0.631
LIG_TRAF2_1	135	138	PF00917	0.789
LIG_TRAF2_1	145	148	PF00917	0.611
LIG_TRAF2_1	31	34	PF00917	0.528
LIG_WW_3	265	269	PF00397	0.765
LIG_WW_3	308	312	PF00397	0.739
LIG_WW_3	76	80	PF00397	0.821
MOD_CDC14_SPxK_1	207	210	PF00782	0.805
MOD_CDC14_SPxK_1	299	302	PF00782	0.684
MOD_CDK_SPK_2	121	126	PF00069	0.784
MOD_CDK_SPxK_1	204	210	PF00069	0.810
MOD_CDK_SPxK_1	296	302	PF00069	0.682
MOD_CDK_SPxK_1	512	518	PF00069	0.678
MOD_CDK_SPxxK_3	353	360	PF00069	0.781
MOD_CK1_1	120	126	PF00069	0.763
MOD_CK1_1	214	220	PF00069	0.591
MOD_CK1_1	249	255	PF00069	0.757
MOD_CK1_1	278	284	PF00069	0.846
MOD_CK1_1	333	339	PF00069	0.745
MOD_CK1_1	361	367	PF00069	0.748
MOD_CK1_1	407	413	PF00069	0.828
MOD_CK1_1	458	464	PF00069	0.821
MOD_CK1_1	474	480	PF00069	0.544
MOD_CK2_1	133	139	PF00069	0.789
MOD_CK2_1	142	148	PF00069	0.626
MOD_CK2_1	193	199	PF00069	0.850
MOD_CK2_1	259	265	PF00069	0.854
MOD_CK2_1	28	34	PF00069	0.610
MOD_CK2_1	408	414	PF00069	0.640
MOD_CMANNOS	216	219	PF00535	0.798
MOD_DYRK1A_RPxSP_1	353	357	PF00069	0.782
MOD_DYRK1A_RPxSP_1	84	88	PF00069	0.829
MOD_GlcNHglycan	115	118	PF01048	0.768
MOD_GlcNHglycan	195	198	PF01048	0.847
MOD_GlcNHglycan	213	216	PF01048	0.502
MOD_GlcNHglycan	24	27	PF01048	0.642
MOD_GlcNHglycan	272	275	PF01048	0.808
MOD_GlcNHglycan	280	283	PF01048	0.737
MOD_GlcNHglycan	316	319	PF01048	0.750
MOD_GlcNHglycan	336	339	PF01048	0.743
MOD_GlcNHglycan	368	371	PF01048	0.775
MOD_GlcNHglycan	406	409	PF01048	0.827
MOD_GlcNHglycan	476	479	PF01048	0.611
MOD_GlcNHglycan	49	52	PF01048	0.703
MOD_GlcNHglycan	505	508	PF01048	0.733
MOD_GSK3_1	113	120	PF00069	0.530
MOD_GSK3_1	133	140	PF00069	0.632
MOD_GSK3_1	230	237	PF00069	0.799
MOD_GSK3_1	247	254	PF00069	0.533
MOD_GSK3_1	278	285	PF00069	0.811
MOD_GSK3_1	330	337	PF00069	0.749
MOD_GSK3_1	358	365	PF00069	0.761
MOD_GSK3_1	366	373	PF00069	0.683
MOD_GSK3_1	404	411	PF00069	0.825
MOD_GSK3_1	412	419	PF00069	0.712
MOD_GSK3_1	454	461	PF00069	0.785
MOD_GSK3_1	94	101	PF00069	0.831
MOD_LATS_1	328	334	PF00433	0.758
MOD_N-GLC_1	433	438	PF02516	0.691
MOD_N-GLC_2	433	435	PF02516	0.660
MOD_NEK2_1	113	118	PF00069	0.762
MOD_NEK2_1	28	33	PF00069	0.709
MOD_NEK2_1	366	371	PF00069	0.776
MOD_NEK2_1	40	45	PF00069	0.581
MOD_NEK2_1	412	417	PF00069	0.730
MOD_NEK2_1	503	508	PF00069	0.630
MOD_PIKK_1	115	121	PF00454	0.771
MOD_PIKK_1	347	353	PF00454	0.768
MOD_PIKK_1	40	46	PF00454	0.706
MOD_PIKK_1	412	418	PF00454	0.773
MOD_PKA_1	133	139	PF00069	0.693
MOD_PKA_1	330	336	PF00069	0.713
MOD_PKA_2	133	139	PF00069	0.859
MOD_PKA_2	20	26	PF00069	0.740
MOD_PKA_2	270	276	PF00069	0.843
MOD_PKA_2	314	320	PF00069	0.618
MOD_PKA_2	330	336	PF00069	0.596
MOD_PKA_2	359	365	PF00069	0.794
MOD_PKA_2	385	391	PF00069	0.822
MOD_PKA_2	491	497	PF00069	0.605
MOD_PKB_1	244	252	PF00069	0.732
MOD_Plk_1	433	439	PF00069	0.686
MOD_Plk_1	484	490	PF00069	0.653
MOD_Plk_4	362	368	PF00069	0.780
MOD_ProDKin_1	105	111	PF00069	0.638
MOD_ProDKin_1	117	123	PF00069	0.658
MOD_ProDKin_1	160	166	PF00069	0.663
MOD_ProDKin_1	204	210	PF00069	0.810
MOD_ProDKin_1	214	220	PF00069	0.628
MOD_ProDKin_1	234	240	PF00069	0.582
MOD_ProDKin_1	252	258	PF00069	0.533
MOD_ProDKin_1	280	286	PF00069	0.764
MOD_ProDKin_1	296	302	PF00069	0.632
MOD_ProDKin_1	353	359	PF00069	0.780
MOD_ProDKin_1	455	461	PF00069	0.753
MOD_ProDKin_1	512	518	PF00069	0.678
MOD_ProDKin_1	82	88	PF00069	0.728
MOD_ProDKin_1	94	100	PF00069	0.646
MOD_SUMO_rev_2	461	471	PF00179	0.787
TRG_DiLeu_BaEn_3	147	153	PF01217	0.602
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.718
TRG_ENDOCYTIC_2	149	152	PF00928	0.604
TRG_ER_diArg_1	173	175	PF00400	0.849
TRG_ER_diArg_1	243	246	PF00400	0.733
TRG_ER_diArg_1	352	354	PF00400	0.735
TRG_ER_diArg_1	427	430	PF00400	0.619
TRG_ER_diArg_1	450	452	PF00400	0.736
TRG_ER_diArg_1	534	536	PF00400	0.726
TRG_Pf-PMV_PEXEL_1	155	160	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.708
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	496	500	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WV31	Leishmania donovani	99%	100%
A4H9H3	Leishmania braziliensis	62%	100%
E9ARK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QDX8	Leishmania major	88%	100%