LeishMANIAdb
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RanBP2-type domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RanBP2-type domain-containing protein
Gene product:
Zn-finger in Ran binding protein and others/FYVE zinc finger containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HXT6_LEIIN
TriTrypDb:
LINF_180011100
Length:
635

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HXT6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXT6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 8
GO:0043167 ion binding 2 8
GO:0043169 cation binding 3 8
GO:0046872 metal ion binding 4 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 243 245 PF00675 0.442
CLV_NRD_NRD_1 254 256 PF00675 0.428
CLV_NRD_NRD_1 518 520 PF00675 0.320
CLV_NRD_NRD_1 580 582 PF00675 0.260
CLV_NRD_NRD_1 630 632 PF00675 0.509
CLV_PCSK_FUR_1 241 245 PF00082 0.447
CLV_PCSK_KEX2_1 243 245 PF00082 0.442
CLV_PCSK_KEX2_1 469 471 PF00082 0.586
CLV_PCSK_KEX2_1 528 530 PF00082 0.362
CLV_PCSK_KEX2_1 580 582 PF00082 0.264
CLV_PCSK_KEX2_1 630 632 PF00082 0.525
CLV_PCSK_PC1ET2_1 469 471 PF00082 0.586
CLV_PCSK_PC1ET2_1 528 530 PF00082 0.362
DEG_APCC_DBOX_1 232 240 PF00400 0.417
DEG_APCC_DBOX_1 270 278 PF00400 0.320
DEG_COP1_1 348 356 PF00400 0.429
DEG_MDM2_SWIB_1 376 384 PF02201 0.431
DEG_Nend_UBRbox_3 1 3 PF02207 0.615
DEG_SPOP_SBC_1 121 125 PF00917 0.693
DEG_SPOP_SBC_1 196 200 PF00917 0.546
DOC_CKS1_1 127 132 PF01111 0.618
DOC_CYCLIN_RxL_1 238 251 PF00134 0.452
DOC_MAPK_gen_1 238 248 PF00069 0.450
DOC_PP4_FxxP_1 27 30 PF00568 0.609
DOC_PP4_FxxP_1 513 516 PF00568 0.320
DOC_USP7_MATH_1 121 125 PF00917 0.707
DOC_USP7_MATH_1 222 226 PF00917 0.594
DOC_USP7_MATH_1 312 316 PF00917 0.676
DOC_USP7_MATH_1 345 349 PF00917 0.417
DOC_USP7_MATH_1 414 418 PF00917 0.590
DOC_USP7_MATH_1 426 430 PF00917 0.630
DOC_USP7_MATH_1 456 460 PF00917 0.387
DOC_USP7_MATH_1 593 597 PF00917 0.320
DOC_USP7_MATH_1 68 72 PF00917 0.577
DOC_USP7_UBL2_3 393 397 PF12436 0.446
DOC_USP7_UBL2_3 624 628 PF12436 0.474
DOC_WW_Pin1_4 108 113 PF00397 0.636
DOC_WW_Pin1_4 114 119 PF00397 0.577
DOC_WW_Pin1_4 123 128 PF00397 0.523
DOC_WW_Pin1_4 199 204 PF00397 0.631
DOC_WW_Pin1_4 310 315 PF00397 0.764
DOC_WW_Pin1_4 354 359 PF00397 0.531
DOC_WW_Pin1_4 371 376 PF00397 0.414
LIG_14-3-3_CanoR_1 286 292 PF00244 0.491
LIG_BIR_III_2 411 415 PF00653 0.547
LIG_EVH1_2 118 122 PF00568 0.557
LIG_FHA_1 408 414 PF00498 0.560
LIG_FHA_1 574 580 PF00498 0.351
LIG_IBAR_NPY_1 2 4 PF08397 0.603
LIG_LIR_Apic_2 111 116 PF02991 0.487
LIG_LIR_Apic_2 24 30 PF02991 0.582
LIG_LIR_Apic_2 262 266 PF02991 0.301
LIG_LIR_Apic_2 510 516 PF02991 0.320
LIG_LIR_Apic_2 596 601 PF02991 0.320
LIG_LIR_Gen_1 50 58 PF02991 0.658
LIG_LIR_Gen_1 573 579 PF02991 0.351
LIG_LIR_Nem_3 50 54 PF02991 0.624
LIG_LIR_Nem_3 573 578 PF02991 0.320
LIG_LYPXL_yS_3 155 158 PF13949 0.586
LIG_MYND_1 134 138 PF01753 0.574
LIG_Pex14_2 376 380 PF04695 0.443
LIG_SH2_CRK 100 104 PF00017 0.615
LIG_SH2_CRK 113 117 PF00017 0.488
LIG_SH2_CRK 177 181 PF00017 0.525
LIG_SH2_CRK 289 293 PF00017 0.550
LIG_SH2_CRK 51 55 PF00017 0.630
LIG_SH2_CRK 598 602 PF00017 0.351
LIG_SH2_NCK_1 289 293 PF00017 0.554
LIG_SH2_NCK_1 58 62 PF00017 0.649
LIG_SH2_PTP2 5 8 PF00017 0.536
LIG_SH2_STAP1 533 537 PF00017 0.481
LIG_SH2_STAT3 422 425 PF00017 0.499
LIG_SH2_STAT5 289 292 PF00017 0.536
LIG_SH2_STAT5 5 8 PF00017 0.513
LIG_SH2_STAT5 589 592 PF00017 0.260
LIG_SH3_1 113 119 PF00018 0.686
LIG_SH3_1 5 11 PF00018 0.559
LIG_SH3_3 113 119 PF00018 0.607
LIG_SH3_3 124 130 PF00018 0.573
LIG_SH3_3 132 138 PF00018 0.503
LIG_SH3_3 153 159 PF00018 0.632
LIG_SH3_3 162 168 PF00018 0.680
LIG_SH3_3 206 212 PF00018 0.638
LIG_SH3_3 295 301 PF00018 0.551
LIG_SH3_3 3 9 PF00018 0.580
LIG_SH3_3 385 391 PF00018 0.354
LIG_SH3_3 40 46 PF00018 0.593
LIG_SH3_3 410 416 PF00018 0.729
LIG_SH3_3 429 435 PF00018 0.373
LIG_SxIP_EBH_1 347 357 PF03271 0.463
LIG_TRAF2_1 227 230 PF00917 0.501
LIG_TRAF2_1 546 549 PF00917 0.546
LIG_WRC_WIRS_1 267 272 PF05994 0.309
LIG_WRC_WIRS_1 442 447 PF05994 0.410
LIG_WW_1 48 51 PF00397 0.605
LIG_WW_2 432 435 PF00397 0.520
MOD_CK1_1 123 129 PF00069 0.646
MOD_CK1_1 17 23 PF00069 0.661
MOD_CK1_1 199 205 PF00069 0.605
MOD_CK1_1 417 423 PF00069 0.596
MOD_CK1_1 441 447 PF00069 0.354
MOD_CK1_1 475 481 PF00069 0.621
MOD_CK1_1 483 489 PF00069 0.590
MOD_CK1_1 501 507 PF00069 0.308
MOD_CK1_1 596 602 PF00069 0.351
MOD_CK2_1 224 230 PF00069 0.555
MOD_CK2_1 561 567 PF00069 0.320
MOD_Cter_Amidation 517 520 PF01082 0.320
MOD_GlcNHglycan 108 111 PF01048 0.663
MOD_GlcNHglycan 203 206 PF01048 0.720
MOD_GlcNHglycan 219 222 PF01048 0.484
MOD_GlcNHglycan 226 229 PF01048 0.518
MOD_GlcNHglycan 293 296 PF01048 0.558
MOD_GlcNHglycan 348 351 PF01048 0.524
MOD_GlcNHglycan 358 361 PF01048 0.618
MOD_GlcNHglycan 399 402 PF01048 0.472
MOD_GlcNHglycan 419 422 PF01048 0.407
MOD_GlcNHglycan 428 431 PF01048 0.607
MOD_GlcNHglycan 449 452 PF01048 0.370
MOD_GlcNHglycan 458 461 PF01048 0.443
MOD_GlcNHglycan 485 488 PF01048 0.581
MOD_GlcNHglycan 490 494 PF01048 0.528
MOD_GlcNHglycan 59 62 PF01048 0.615
MOD_GlcNHglycan 81 84 PF01048 0.618
MOD_GSK3_1 122 129 PF00069 0.633
MOD_GSK3_1 191 198 PF00069 0.606
MOD_GSK3_1 287 294 PF00069 0.523
MOD_GSK3_1 352 359 PF00069 0.487
MOD_GSK3_1 371 378 PF00069 0.404
MOD_GSK3_1 441 448 PF00069 0.403
MOD_GSK3_1 497 504 PF00069 0.582
MOD_GSK3_1 596 603 PF00069 0.329
MOD_GSK3_1 79 86 PF00069 0.606
MOD_N-GLC_1 404 409 PF02516 0.385
MOD_N-GLC_1 596 601 PF02516 0.283
MOD_N-GLC_1 79 84 PF02516 0.648
MOD_N-GLC_2 569 571 PF02516 0.260
MOD_NEK2_1 122 127 PF00069 0.603
MOD_NEK2_1 195 200 PF00069 0.506
MOD_NEK2_1 281 286 PF00069 0.320
MOD_NEK2_1 436 441 PF00069 0.390
MOD_NEK2_1 445 450 PF00069 0.394
MOD_NEK2_2 266 271 PF00069 0.297
MOD_NEK2_2 83 88 PF00069 0.640
MOD_PIKK_1 312 318 PF00454 0.600
MOD_PIKK_1 501 507 PF00454 0.428
MOD_PKA_1 497 503 PF00069 0.524
MOD_PKA_2 17 23 PF00069 0.661
MOD_PKA_2 346 352 PF00069 0.439
MOD_PKA_2 483 489 PF00069 0.649
MOD_Plk_1 445 451 PF00069 0.460
MOD_Plk_1 561 567 PF00069 0.320
MOD_Plk_1 596 602 PF00069 0.327
MOD_Plk_1 83 89 PF00069 0.662
MOD_Plk_2-3 561 567 PF00069 0.320
MOD_Plk_4 191 197 PF00069 0.527
MOD_Plk_4 509 515 PF00069 0.320
MOD_Plk_4 83 89 PF00069 0.662
MOD_ProDKin_1 108 114 PF00069 0.639
MOD_ProDKin_1 123 129 PF00069 0.523
MOD_ProDKin_1 199 205 PF00069 0.631
MOD_ProDKin_1 310 316 PF00069 0.761
MOD_ProDKin_1 354 360 PF00069 0.538
MOD_ProDKin_1 371 377 PF00069 0.454
MOD_SUMO_for_1 277 280 PF00179 0.320
MOD_SUMO_for_1 546 549 PF00179 0.524
MOD_SUMO_rev_2 490 500 PF00179 0.723
MOD_SUMO_rev_2 621 626 PF00179 0.442
TRG_DiLeu_BaEn_4 229 235 PF01217 0.521
TRG_ENDOCYTIC_2 155 158 PF00928 0.586
TRG_ENDOCYTIC_2 51 54 PF00928 0.626
TRG_ER_diArg_1 240 243 PF00400 0.449
TRG_ER_diArg_1 579 581 PF00400 0.320
TRG_ER_diArg_1 630 632 PF00400 0.525
TRG_NES_CRM1_1 237 251 PF08389 0.451
TRG_NLS_MonoExtC_3 626 631 PF00514 0.508
TRG_NLS_MonoExtN_4 624 631 PF00514 0.503
TRG_Pf-PMV_PEXEL_1 244 249 PF00026 0.472

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2D5 Leptomonas seymouri 56% 100%
A0A3Q8I9Y5 Leishmania donovani 100% 100%
A4H9G8 Leishmania braziliensis 80% 100%
C9ZZX5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9ARJ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 99%
Q4QDY1 Leishmania major 92% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS