LeishMANIAdb
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Putative RNA binding protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative RNA binding protein
Gene product:
RNA binding protein - putative
Species:
Leishmania infantum
UniProt:
A4HXT4_LEIIN
TriTrypDb:
LINF_180010900
Length:
421

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
GO:1990904 ribonucleoprotein complex 2 1

Phosphorylation

Promastigote/Amastigote: 330

Expansion

Sequence features

A4HXT4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXT4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 7
GO:0003723 RNA binding 4 7
GO:0005488 binding 1 7
GO:0097159 organic cyclic compound binding 2 7
GO:1901363 heterocyclic compound binding 2 7
GO:0003729 mRNA binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 363 367 PF00656 0.599
CLV_PCSK_SKI1_1 201 205 PF00082 0.269
CLV_PCSK_SKI1_1 239 243 PF00082 0.304
CLV_PCSK_SKI1_1 3 7 PF00082 0.601
DEG_Nend_UBRbox_2 1 3 PF02207 0.661
DEG_SPOP_SBC_1 15 19 PF00917 0.514
DEG_SPOP_SBC_1 53 57 PF00917 0.564
DOC_CKS1_1 113 118 PF01111 0.635
DOC_CKS1_1 150 155 PF01111 0.640
DOC_CKS1_1 156 161 PF01111 0.591
DOC_CKS1_1 300 305 PF01111 0.618
DOC_CKS1_1 397 402 PF01111 0.620
DOC_PP1_RVXF_1 256 262 PF00149 0.433
DOC_PP4_FxxP_1 261 264 PF00568 0.471
DOC_USP7_MATH_1 104 108 PF00917 0.635
DOC_USP7_MATH_1 129 133 PF00917 0.602
DOC_USP7_MATH_1 15 19 PF00917 0.520
DOC_USP7_MATH_1 262 266 PF00917 0.559
DOC_USP7_MATH_1 275 279 PF00917 0.446
DOC_USP7_MATH_1 290 294 PF00917 0.528
DOC_USP7_MATH_1 336 340 PF00917 0.593
DOC_USP7_MATH_1 5 9 PF00917 0.608
DOC_USP7_MATH_1 69 73 PF00917 0.780
DOC_USP7_MATH_1 79 83 PF00917 0.646
DOC_WW_Pin1_4 112 117 PF00397 0.644
DOC_WW_Pin1_4 144 149 PF00397 0.601
DOC_WW_Pin1_4 155 160 PF00397 0.609
DOC_WW_Pin1_4 299 304 PF00397 0.752
DOC_WW_Pin1_4 318 323 PF00397 0.541
DOC_WW_Pin1_4 327 332 PF00397 0.685
DOC_WW_Pin1_4 34 39 PF00397 0.674
DOC_WW_Pin1_4 358 363 PF00397 0.598
DOC_WW_Pin1_4 375 380 PF00397 0.607
DOC_WW_Pin1_4 396 401 PF00397 0.622
DOC_WW_Pin1_4 62 67 PF00397 0.672
LIG_14-3-3_CanoR_1 140 148 PF00244 0.679
LIG_14-3-3_CanoR_1 3 12 PF00244 0.610
LIG_BRCT_BRCA1_1 108 112 PF00533 0.626
LIG_BRCT_BRCA1_1 183 187 PF00533 0.454
LIG_BRCT_BRCA1_1 92 96 PF00533 0.651
LIG_FHA_1 152 158 PF00498 0.611
LIG_FHA_1 252 258 PF00498 0.458
LIG_FHA_1 264 270 PF00498 0.525
LIG_FHA_2 207 213 PF00498 0.484
LIG_FHA_2 361 367 PF00498 0.604
LIG_Integrin_isoDGR_2 220 222 PF01839 0.269
LIG_LIR_Apic_2 299 303 PF02991 0.615
LIG_LIR_Apic_2 61 66 PF02991 0.610
LIG_LIR_Nem_3 226 231 PF02991 0.469
LIG_LIR_Nem_3 93 99 PF02991 0.584
LIG_MLH1_MIPbox_1 108 112 PF16413 0.627
LIG_SH2_CRK 113 117 PF00017 0.573
LIG_SH2_CRK 300 304 PF00017 0.621
LIG_SH2_CRK 63 67 PF00017 0.607
LIG_SH2_GRB2like 12 15 PF00017 0.615
LIG_SH2_NCK_1 113 117 PF00017 0.638
LIG_SH2_NCK_1 12 16 PF00017 0.655
LIG_SH2_NCK_1 294 298 PF00017 0.592
LIG_SH2_NCK_1 300 304 PF00017 0.533
LIG_SH2_NCK_1 357 361 PF00017 0.590
LIG_SH2_NCK_1 63 67 PF00017 0.566
LIG_SH2_STAP1 127 131 PF00017 0.553
LIG_SH2_STAP1 294 298 PF00017 0.568
LIG_SH2_STAT5 32 35 PF00017 0.640
LIG_SH2_STAT5 346 349 PF00017 0.581
LIG_SH2_STAT5 386 389 PF00017 0.574
LIG_SH2_STAT5 398 401 PF00017 0.558
LIG_SH3_3 145 151 PF00018 0.612
LIG_SH3_3 246 252 PF00018 0.591
LIG_SH3_3 282 288 PF00018 0.623
LIG_SH3_3 410 416 PF00018 0.666
LIG_UBA3_1 210 214 PF00899 0.469
MOD_CK1_1 10 16 PF00069 0.633
MOD_CK1_1 114 120 PF00069 0.619
MOD_CK1_1 223 229 PF00069 0.469
MOD_CK1_1 293 299 PF00069 0.593
MOD_CK1_1 31 37 PF00069 0.630
MOD_CK1_1 358 364 PF00069 0.557
MOD_CK1_1 55 61 PF00069 0.595
MOD_CK1_1 90 96 PF00069 0.654
MOD_CK2_1 206 212 PF00069 0.516
MOD_GlcNHglycan 104 107 PF01048 0.591
MOD_GlcNHglycan 108 111 PF01048 0.641
MOD_GlcNHglycan 116 119 PF01048 0.553
MOD_GlcNHglycan 127 130 PF01048 0.692
MOD_GlcNHglycan 131 134 PF01048 0.556
MOD_GlcNHglycan 174 177 PF01048 0.509
MOD_GlcNHglycan 225 228 PF01048 0.269
MOD_GlcNHglycan 234 238 PF01048 0.269
MOD_GlcNHglycan 273 276 PF01048 0.566
MOD_GlcNHglycan 282 285 PF01048 0.496
MOD_GlcNHglycan 338 341 PF01048 0.573
MOD_GlcNHglycan 81 84 PF01048 0.678
MOD_GSK3_1 102 109 PF00069 0.462
MOD_GSK3_1 125 132 PF00069 0.636
MOD_GSK3_1 140 147 PF00069 0.500
MOD_GSK3_1 151 158 PF00069 0.626
MOD_GSK3_1 17 24 PF00069 0.540
MOD_GSK3_1 27 34 PF00069 0.664
MOD_GSK3_1 271 278 PF00069 0.527
MOD_GSK3_1 3 10 PF00069 0.623
MOD_GSK3_1 356 363 PF00069 0.556
MOD_GSK3_1 54 61 PF00069 0.583
MOD_GSK3_1 85 92 PF00069 0.657
MOD_N-GLC_1 129 134 PF02516 0.550
MOD_N-GLC_1 15 20 PF02516 0.698
MOD_N-GLC_1 34 39 PF02516 0.471
MOD_N-GLC_1 46 51 PF02516 0.536
MOD_N-GLC_1 85 90 PF02516 0.657
MOD_NEK2_1 111 116 PF00069 0.661
MOD_NEK2_1 233 238 PF00069 0.484
MOD_NEK2_1 355 360 PF00069 0.571
MOD_NEK2_1 403 408 PF00069 0.757
MOD_NEK2_1 87 92 PF00069 0.662
MOD_PIKK_1 151 157 PF00454 0.619
MOD_PIKK_1 3 9 PF00454 0.592
MOD_PIKK_1 64 70 PF00454 0.607
MOD_PIKK_1 85 91 PF00454 0.614
MOD_Plk_4 206 212 PF00069 0.516
MOD_Plk_4 275 281 PF00069 0.611
MOD_Plk_4 28 34 PF00069 0.654
MOD_Plk_4 58 64 PF00069 0.592
MOD_Plk_4 7 13 PF00069 0.739
MOD_ProDKin_1 112 118 PF00069 0.641
MOD_ProDKin_1 144 150 PF00069 0.604
MOD_ProDKin_1 155 161 PF00069 0.607
MOD_ProDKin_1 299 305 PF00069 0.749
MOD_ProDKin_1 318 324 PF00069 0.541
MOD_ProDKin_1 327 333 PF00069 0.682
MOD_ProDKin_1 34 40 PF00069 0.672
MOD_ProDKin_1 358 364 PF00069 0.595
MOD_ProDKin_1 375 381 PF00069 0.608
MOD_ProDKin_1 396 402 PF00069 0.619
MOD_ProDKin_1 62 68 PF00069 0.674
TRG_Pf-PMV_PEXEL_1 201 206 PF00026 0.269

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4Z4 Leptomonas seymouri 46% 86%
A0A3S7WUU6 Leishmania donovani 100% 100%
A4H9G7 Leishmania braziliensis 80% 99%
E9ARJ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 99%
Q4QDY3 Leishmania major 95% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS