LeishMANIAdb
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V-type proton ATPase subunit C

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
V-type proton ATPase subunit C
Gene product:
vacuolar ATP synthase subunit c - putative
Species:
Leishmania infantum
UniProt:
A4HXT1_LEIIN
TriTrypDb:
LINF_180010600 *
Length:
412

Annotations

Annotations by Jardim et al.

Acidocalcisome, vacuolar ATP synthase subunit c

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 12
GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain 3 12
GO:0033180 proton-transporting V-type ATPase, V1 domain 4 12
GO:0098796 membrane protein complex 2 12
GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain 5 1
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HXT1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXT1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0005215 transporter activity 1 12
GO:0008324 monoatomic cation transmembrane transporter activity 4 12
GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity 5 12
GO:0015075 monoatomic ion transmembrane transporter activity 3 12
GO:0015078 proton transmembrane transporter activity 5 12
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 12
GO:0015399 primary active transmembrane transporter activity 4 12
GO:0016787 hydrolase activity 2 8
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3 12
GO:0022804 active transmembrane transporter activity 3 12
GO:0022853 active monoatomic ion transmembrane transporter activity 4 12
GO:0022857 transmembrane transporter activity 2 12
GO:0022890 inorganic cation transmembrane transporter activity 4 12
GO:0042625 ATPase-coupled ion transmembrane transporter activity 3 12
GO:0042626 ATPase-coupled transmembrane transporter activity 2 12
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4 12
GO:0046961 proton-transporting ATPase activity, rotational mechanism 4 12
GO:0140657 ATP-dependent activity 1 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 19 21 PF00675 0.417
CLV_NRD_NRD_1 192 194 PF00675 0.288
CLV_NRD_NRD_1 272 274 PF00675 0.282
CLV_NRD_NRD_1 283 285 PF00675 0.255
CLV_NRD_NRD_1 370 372 PF00675 0.290
CLV_PCSK_FUR_1 284 288 PF00082 0.288
CLV_PCSK_KEX2_1 286 288 PF00082 0.285
CLV_PCSK_KEX2_1 372 374 PF00082 0.373
CLV_PCSK_PC1ET2_1 286 288 PF00082 0.274
CLV_PCSK_PC1ET2_1 372 374 PF00082 0.373
CLV_PCSK_SKI1_1 141 145 PF00082 0.307
CLV_PCSK_SKI1_1 175 179 PF00082 0.273
CLV_PCSK_SKI1_1 31 35 PF00082 0.594
CLV_PCSK_SKI1_1 315 319 PF00082 0.292
CLV_PCSK_SKI1_1 72 76 PF00082 0.391
DEG_Nend_Nbox_1 1 3 PF02207 0.470
DOC_CDC14_PxL_1 39 47 PF14671 0.307
DOC_CKS1_1 381 386 PF01111 0.358
DOC_MAPK_DCC_7 72 81 PF00069 0.288
DOC_MAPK_gen_1 193 201 PF00069 0.273
DOC_MAPK_gen_1 202 210 PF00069 0.273
DOC_MAPK_MEF2A_6 354 362 PF00069 0.286
DOC_MAPK_MEF2A_6 72 81 PF00069 0.288
DOC_PP1_RVXF_1 10 16 PF00149 0.499
DOC_PP2B_LxvP_1 360 363 PF13499 0.393
DOC_PP2B_LxvP_1 40 43 PF13499 0.307
DOC_PP4_FxxP_1 349 352 PF00568 0.358
DOC_PP4_FxxP_1 74 77 PF00568 0.273
DOC_USP7_MATH_1 401 405 PF00917 0.324
DOC_WW_Pin1_4 380 385 PF00397 0.291
LIG_14-3-3_CanoR_1 120 128 PF00244 0.283
LIG_14-3-3_CanoR_1 165 174 PF00244 0.420
LIG_14-3-3_CanoR_1 26 31 PF00244 0.402
LIG_Actin_WH2_2 332 350 PF00022 0.273
LIG_APCC_ABBA_1 339 344 PF00400 0.273
LIG_deltaCOP1_diTrp_1 238 244 PF00928 0.273
LIG_FHA_1 123 129 PF00498 0.393
LIG_FHA_1 219 225 PF00498 0.266
LIG_FHA_1 22 28 PF00498 0.626
LIG_FHA_1 294 300 PF00498 0.393
LIG_FHA_1 326 332 PF00498 0.378
LIG_FHA_1 380 386 PF00498 0.310
LIG_FHA_1 391 397 PF00498 0.446
LIG_FHA_2 167 173 PF00498 0.309
LIG_HP1_1 401 405 PF01393 0.340
LIG_LIR_Apic_2 248 252 PF02991 0.272
LIG_LIR_Gen_1 161 170 PF02991 0.363
LIG_LIR_Gen_1 214 223 PF02991 0.342
LIG_LIR_Gen_1 226 235 PF02991 0.273
LIG_LIR_Gen_1 34 45 PF02991 0.289
LIG_LIR_Gen_1 399 410 PF02991 0.324
LIG_LIR_Gen_1 54 64 PF02991 0.089
LIG_LIR_Nem_3 161 166 PF02991 0.323
LIG_LIR_Nem_3 214 218 PF02991 0.342
LIG_LIR_Nem_3 226 231 PF02991 0.273
LIG_LIR_Nem_3 320 326 PF02991 0.281
LIG_LIR_Nem_3 34 40 PF02991 0.345
LIG_LIR_Nem_3 399 405 PF02991 0.332
LIG_LIR_Nem_3 54 60 PF02991 0.089
LIG_LIR_Nem_3 70 74 PF02991 0.235
LIG_LYPXL_S_1 377 381 PF13949 0.288
LIG_LYPXL_yS_3 378 381 PF13949 0.288
LIG_LYPXL_yS_3 400 403 PF13949 0.372
LIG_NRBOX 317 323 PF00104 0.358
LIG_Pex14_1 239 243 PF04695 0.273
LIG_Pex14_2 71 75 PF04695 0.342
LIG_PTB_Apo_2 209 216 PF02174 0.245
LIG_PTB_Phospho_1 209 215 PF10480 0.245
LIG_SH2_PTP2 249 252 PF00017 0.393
LIG_SH2_PTP2 402 405 PF00017 0.301
LIG_SH2_STAP1 319 323 PF00017 0.271
LIG_SH2_STAP1 57 61 PF00017 0.393
LIG_SH2_STAT3 44 47 PF00017 0.373
LIG_SH2_STAT5 139 142 PF00017 0.288
LIG_SH2_STAT5 23 26 PF00017 0.453
LIG_SH2_STAT5 249 252 PF00017 0.352
LIG_SH2_STAT5 264 267 PF00017 0.275
LIG_SH2_STAT5 288 291 PF00017 0.350
LIG_SH2_STAT5 319 322 PF00017 0.279
LIG_SH2_STAT5 326 329 PF00017 0.272
LIG_SH2_STAT5 330 333 PF00017 0.262
LIG_SH2_STAT5 402 405 PF00017 0.301
LIG_SH2_STAT5 44 47 PF00017 0.383
LIG_SH3_3 226 232 PF00018 0.307
LIG_SUMO_SIM_par_1 26 32 PF11976 0.397
LIG_TRFH_1 349 353 PF08558 0.273
LIG_WRC_WIRS_1 123 128 PF05994 0.393
LIG_WW_3 351 355 PF00397 0.273
MOD_CK1_1 121 127 PF00069 0.307
MOD_CK1_1 48 54 PF00069 0.355
MOD_CK1_1 6 12 PF00069 0.444
MOD_CK2_1 166 172 PF00069 0.289
MOD_CK2_1 26 32 PF00069 0.397
MOD_CK2_1 297 303 PF00069 0.277
MOD_CK2_1 83 89 PF00069 0.273
MOD_GlcNHglycan 113 118 PF01048 0.374
MOD_GlcNHglycan 135 138 PF01048 0.356
MOD_GlcNHglycan 300 303 PF01048 0.402
MOD_GlcNHglycan 53 56 PF01048 0.358
MOD_GSK3_1 118 125 PF00069 0.318
MOD_GSK3_1 128 135 PF00069 0.220
MOD_GSK3_1 293 300 PF00069 0.358
MOD_GSK3_1 3 10 PF00069 0.621
MOD_GSK3_1 401 408 PF00069 0.346
MOD_LATS_1 19 25 PF00433 0.415
MOD_N-GLC_1 128 133 PF02516 0.287
MOD_N-GLC_1 166 171 PF02516 0.376
MOD_N-GLC_1 181 186 PF02516 0.113
MOD_N-GLC_1 197 202 PF02516 0.287
MOD_NEK2_1 101 106 PF00069 0.357
MOD_NEK2_1 112 117 PF00069 0.283
MOD_NEK2_1 143 148 PF00069 0.287
MOD_NEK2_1 223 228 PF00069 0.273
MOD_NEK2_1 3 8 PF00069 0.546
MOD_NEK2_1 33 38 PF00069 0.475
MOD_NEK2_1 405 410 PF00069 0.379
MOD_NEK2_1 67 72 PF00069 0.420
MOD_NEK2_2 197 202 PF00069 0.307
MOD_NEK2_2 401 406 PF00069 0.333
MOD_PIKK_1 128 134 PF00454 0.330
MOD_PIKK_1 45 51 PF00454 0.331
MOD_PK_1 118 124 PF00069 0.291
MOD_Plk_1 101 107 PF00069 0.303
MOD_Plk_1 197 203 PF00069 0.288
MOD_Plk_1 387 393 PF00069 0.583
MOD_Plk_4 223 229 PF00069 0.323
MOD_Plk_4 239 245 PF00069 0.190
MOD_Plk_4 265 271 PF00069 0.282
MOD_Plk_4 3 9 PF00069 0.414
MOD_Plk_4 317 323 PF00069 0.288
MOD_Plk_4 33 39 PF00069 0.455
MOD_Plk_4 83 89 PF00069 0.273
MOD_ProDKin_1 380 386 PF00069 0.291
MOD_SUMO_rev_2 146 155 PF00179 0.393
MOD_SUMO_rev_2 277 282 PF00179 0.288
MOD_SUMO_rev_2 312 318 PF00179 0.345
TRG_ENDOCYTIC_2 215 218 PF00928 0.342
TRG_ENDOCYTIC_2 243 246 PF00928 0.273
TRG_ENDOCYTIC_2 319 322 PF00928 0.307
TRG_ENDOCYTIC_2 378 381 PF00928 0.288
TRG_ENDOCYTIC_2 400 403 PF00928 0.328
TRG_ENDOCYTIC_2 57 60 PF00928 0.358
TRG_ER_diArg_1 173 176 PF00400 0.284
TRG_ER_diArg_1 370 373 PF00400 0.393
TRG_NES_CRM1_1 222 236 PF08389 0.265
TRG_NES_CRM1_1 32 46 PF08389 0.303
TRG_NES_CRM1_1 380 392 PF08389 0.381
TRG_NLS_Bipartite_1 273 289 PF00514 0.273
TRG_NLS_MonoCore_2 283 288 PF00514 0.288
TRG_NLS_MonoExtN_4 284 289 PF00514 0.273
TRG_Pf-PMV_PEXEL_1 202 206 PF00026 0.393
TRG_Pf-PMV_PEXEL_1 305 309 PF00026 0.345

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2N6 Leptomonas seymouri 87% 100%
A0A0S4IV71 Bodo saltans 54% 98%
A0A1X0P723 Trypanosomatidae 70% 100%
A0A3S5IRA4 Trypanosoma rangeli 64% 100%
A0A3S7WV19 Leishmania donovani 100% 100%
A4H9G4 Leishmania braziliensis 88% 100%
D0A063 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9ARJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
P21282 Bos taurus 30% 100%
P21283 Homo sapiens 30% 100%
P31412 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
P54648 Dictyostelium discoideum 28% 100%
Q4QDY6 Leishmania major 95% 100%
Q4R5H9 Macaca fascicularis 30% 100%
Q5FVI6 Rattus norvegicus 30% 100%
Q5RDQ7 Pongo abelii 30% 100%
Q5XH14 Xenopus laevis 31% 100%
Q5XIY6 Danio rerio 31% 100%
Q612A4 Caenorhabditis briggsae 27% 100%
Q6AYE4 Rattus norvegicus 26% 97%
Q6P4Y9 Xenopus tropicalis 31% 100%
Q7T385 Danio rerio 29% 100%
Q8NEY4 Homo sapiens 26% 96%
Q99L60 Mus musculus 26% 96%
Q9HDW6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 100%
Q9NDR5 Ascidia sydneiensis samea 31% 100%
Q9SCB9 Hordeum vulgare 27% 100%
Q9SDS7 Arabidopsis thaliana 29% 100%
Q9U5N1 Manduca sexta 28% 100%
Q9XXU9 Caenorhabditis elegans 27% 100%
Q9Z1G3 Mus musculus 30% 100%
V5B6H3 Trypanosoma cruzi 68% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS