C-CAP/cofactor C-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin cofactor C domain-containing protein RP2 - putative

Species:

Leishmania infantum

UniProt:

A4HXS8_LEIIN

TriTrypDb:

LINF_180010300

Length:

525

Annotations

Annotations by Jardim et al.

Structural Proteins, tubulin cofactor C domain-containing RP2 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HXS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXS8

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0034453	microtubule anchoring	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	11
GO:0008047	enzyme activator activity	3	11
GO:0030234	enzyme regulator activity	2	11
GO:0030695	GTPase regulator activity	4	11
GO:0060589	nucleoside-triphosphatase regulator activity	3	11
GO:0098772	molecular function regulator activity	1	11
GO:0140677	molecular function activator activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.404
CLV_C14_Caspase3-7	39	43	PF00656	0.601
CLV_PCSK_KEX2_1	186	188	PF00082	0.523
CLV_PCSK_KEX2_1	457	459	PF00082	0.746
CLV_PCSK_KEX2_1	64	66	PF00082	0.474
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.523
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.623
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.474
CLV_PCSK_SKI1_1	244	248	PF00082	0.304
DEG_SCF_FBW7_2	322	328	PF00400	0.429
DEG_SPOP_SBC_1	436	440	PF00917	0.789
DEG_SPOP_SBC_1	441	445	PF00917	0.805
DOC_CDC14_PxL_1	471	479	PF14671	0.600
DOC_CKS1_1	322	327	PF01111	0.426
DOC_CYCLIN_RxL_1	47	57	PF00134	0.542
DOC_CYCLIN_RxL_1	85	93	PF00134	0.586
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.529
DOC_MAPK_gen_1	241	250	PF00069	0.300
DOC_MAPK_gen_1	256	265	PF00069	0.259
DOC_MAPK_HePTP_8	238	250	PF00069	0.302
DOC_MAPK_HePTP_8	255	267	PF00069	0.242
DOC_MAPK_MEF2A_6	241	250	PF00069	0.302
DOC_MAPK_MEF2A_6	258	267	PF00069	0.242
DOC_PP1_RVXF_1	48	55	PF00149	0.548
DOC_PP2B_LxvP_1	288	291	PF13499	0.323
DOC_USP7_MATH_1	162	166	PF00917	0.756
DOC_USP7_MATH_1	364	368	PF00917	0.423
DOC_USP7_MATH_1	40	44	PF00917	0.594
DOC_USP7_MATH_1	414	418	PF00917	0.755
DOC_USP7_MATH_1	431	435	PF00917	0.714
DOC_USP7_MATH_1	436	440	PF00917	0.690
DOC_USP7_MATH_1	460	464	PF00917	0.587
DOC_WW_Pin1_4	313	318	PF00397	0.447
DOC_WW_Pin1_4	321	326	PF00397	0.423
DOC_WW_Pin1_4	477	482	PF00397	0.780
LIG_14-3-3_CanoR_1	341	346	PF00244	0.548
LIG_14-3-3_CanoR_1	65	74	PF00244	0.548
LIG_Actin_WH2_2	22	38	PF00022	0.518
LIG_Actin_WH2_2	89	104	PF00022	0.601
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BIR_III_4	146	150	PF00653	0.601
LIG_CAP-Gly_1	517	525	PF01302	0.610
LIG_FHA_1	176	182	PF00498	0.403
LIG_FHA_1	208	214	PF00498	0.337
LIG_FHA_1	245	251	PF00498	0.323
LIG_FHA_1	269	275	PF00498	0.294
LIG_FHA_1	478	484	PF00498	0.743
LIG_FHA_1	55	61	PF00498	0.593
LIG_FHA_1	7	13	PF00498	0.456
LIG_FHA_1	84	90	PF00498	0.418
LIG_FHA_2	101	107	PF00498	0.496
LIG_FHA_2	151	157	PF00498	0.776
LIG_FHA_2	218	224	PF00498	0.289
LIG_FHA_2	3	9	PF00498	0.558
LIG_FHA_2	314	320	PF00498	0.403
LIG_LIR_Apic_2	344	348	PF02991	0.536
LIG_LIR_Gen_1	498	507	PF02991	0.650
LIG_LIR_Nem_3	282	286	PF02991	0.415
LIG_LIR_Nem_3	339	345	PF02991	0.474
LIG_LIR_Nem_3	498	503	PF02991	0.633
LIG_LIR_Nem_3	76	80	PF02991	0.438
LIG_MYND_1	475	479	PF01753	0.606
LIG_PDZ_Class_3	520	525	PF00595	0.610
LIG_Pex14_2	180	184	PF04695	0.370
LIG_Pex14_2	327	331	PF04695	0.471
LIG_PTB_Apo_2	494	501	PF02174	0.744
LIG_PTB_Phospho_1	494	500	PF10480	0.744
LIG_SH2_STAP1	85	89	PF00017	0.411
LIG_SH2_STAT5	179	182	PF00017	0.371
LIG_SH2_STAT5	204	207	PF00017	0.368
LIG_SH2_STAT5	77	80	PF00017	0.388
LIG_SH2_STAT5	85	88	PF00017	0.442
LIG_SH3_1	345	351	PF00018	0.392
LIG_SH3_3	314	320	PF00018	0.434
LIG_SH3_3	326	332	PF00018	0.359
LIG_SH3_3	345	351	PF00018	0.361
LIG_SH3_3	473	479	PF00018	0.718
LIG_SH3_3	50	56	PF00018	0.575
LIG_Sin3_3	398	405	PF02671	0.463
LIG_SUMO_SIM_anti_2	69	76	PF11976	0.476
LIG_SUMO_SIM_par_1	209	215	PF11976	0.413
LIG_SUMO_SIM_par_1	56	62	PF11976	0.558
LIG_TRAF2_1	148	151	PF00917	0.669
LIG_TRAF2_1	417	420	PF00917	0.603
LIG_TYR_ITIM	78	83	PF00017	0.485
LIG_WRC_WIRS_1	500	505	PF05994	0.647
MOD_CK1_1	164	170	PF00069	0.623
MOD_CK1_1	367	373	PF00069	0.485
MOD_CK1_1	43	49	PF00069	0.565
MOD_CK1_1	439	445	PF00069	0.718
MOD_CK1_1	446	452	PF00069	0.740
MOD_CK2_1	100	106	PF00069	0.522
MOD_CK2_1	150	156	PF00069	0.764
MOD_CK2_1	2	8	PF00069	0.622
MOD_CK2_1	313	319	PF00069	0.538
MOD_CK2_1	413	419	PF00069	0.715
MOD_CK2_1	444	450	PF00069	0.803
MOD_GlcNHglycan	103	106	PF01048	0.527
MOD_GlcNHglycan	123	126	PF01048	0.537
MOD_GlcNHglycan	164	167	PF01048	0.730
MOD_GlcNHglycan	18	22	PF01048	0.436
MOD_GlcNHglycan	195	198	PF01048	0.424
MOD_GlcNHglycan	2	5	PF01048	0.613
MOD_GlcNHglycan	369	372	PF01048	0.519
MOD_GlcNHglycan	38	41	PF01048	0.404
MOD_GlcNHglycan	408	411	PF01048	0.623
MOD_GlcNHglycan	433	436	PF01048	0.723
MOD_GlcNHglycan	439	442	PF01048	0.722
MOD_GlcNHglycan	44	48	PF01048	0.688
MOD_GlcNHglycan	462	465	PF01048	0.657
MOD_GSK3_1	175	182	PF00069	0.421
MOD_GSK3_1	2	9	PF00069	0.548
MOD_GSK3_1	203	210	PF00069	0.449
MOD_GSK3_1	275	282	PF00069	0.408
MOD_GSK3_1	34	41	PF00069	0.554
MOD_GSK3_1	431	438	PF00069	0.713
MOD_GSK3_1	439	446	PF00069	0.659
MOD_N-GLC_1	175	180	PF02516	0.457
MOD_N-GLC_1	244	249	PF02516	0.349
MOD_N-GLC_1	372	377	PF02516	0.513
MOD_NEK2_1	17	22	PF00069	0.528
MOD_NEK2_1	83	88	PF00069	0.431
MOD_NEK2_2	234	239	PF00069	0.289
MOD_PKA_2	101	107	PF00069	0.503
MOD_Plk_1	174	180	PF00069	0.418
MOD_Plk_1	244	250	PF00069	0.349
MOD_Plk_1	372	378	PF00069	0.529
MOD_Plk_1	498	504	PF00069	0.737
MOD_Plk_1	69	75	PF00069	0.495
MOD_Plk_2-3	217	223	PF00069	0.289
MOD_Plk_2-3	423	429	PF00069	0.749
MOD_Plk_2-3	499	505	PF00069	0.751
MOD_Plk_4	175	181	PF00069	0.388
MOD_Plk_4	2	8	PF00069	0.668
MOD_Plk_4	207	213	PF00069	0.282
MOD_Plk_4	234	240	PF00069	0.289
MOD_Plk_4	69	75	PF00069	0.442
MOD_ProDKin_1	313	319	PF00069	0.445
MOD_ProDKin_1	321	327	PF00069	0.420
MOD_ProDKin_1	477	483	PF00069	0.784
MOD_SUMO_rev_2	299	306	PF00179	0.349
TRG_DiLeu_BaEn_1	225	230	PF01217	0.304
TRG_DiLeu_BaEn_1	353	358	PF01217	0.373
TRG_DiLeu_BaEn_2	234	240	PF01217	0.304
TRG_ENDOCYTIC_2	23	26	PF00928	0.584
TRG_ENDOCYTIC_2	500	503	PF00928	0.651
TRG_ENDOCYTIC_2	80	83	PF00928	0.462
TRG_ER_diArg_1	255	258	PF00400	0.289
TRG_NLS_MonoExtN_4	183	189	PF00514	0.440
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z4	Leptomonas seymouri	60%	100%
A0A0S4J201	Bodo saltans	49%	100%
A0A1X0P6T6	Trypanosomatidae	53%	100%
A0A3R7NEX5	Trypanosoma rangeli	52%	100%
A0A3S5H730	Leishmania donovani	98%	99%
A4H9G1	Leishmania braziliensis	79%	99%
D0A060	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ARJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
V5BRP2	Trypanosoma cruzi	52%	100%