LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HXS5_LEIIN
TriTrypDb:
LINF_180010000
Length:
420

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXS5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXS5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 107 109 PF00675 0.586
CLV_NRD_NRD_1 239 241 PF00675 0.542
CLV_NRD_NRD_1 418 420 PF00675 0.468
CLV_PCSK_KEX2_1 107 109 PF00082 0.553
CLV_PCSK_KEX2_1 239 241 PF00082 0.542
CLV_PCSK_KEX2_1 30 32 PF00082 0.618
CLV_PCSK_KEX2_1 417 419 PF00082 0.445
CLV_PCSK_PC1ET2_1 30 32 PF00082 0.671
CLV_PCSK_SKI1_1 253 257 PF00082 0.470
CLV_Separin_Metazoa 293 297 PF03568 0.497
DEG_SCF_TRCP1_1 55 61 PF00400 0.502
DEG_SPOP_SBC_1 174 178 PF00917 0.512
DOC_CKS1_1 355 360 PF01111 0.524
DOC_CYCLIN_yCln2_LP_2 325 331 PF00134 0.511
DOC_MAPK_gen_1 107 114 PF00069 0.581
DOC_PP1_RVXF_1 91 97 PF00149 0.602
DOC_PP4_FxxP_1 221 224 PF00568 0.481
DOC_USP7_MATH_1 174 178 PF00917 0.731
DOC_USP7_MATH_1 185 189 PF00917 0.576
DOC_USP7_MATH_1 242 246 PF00917 0.486
DOC_USP7_MATH_1 321 325 PF00917 0.616
DOC_USP7_MATH_1 345 349 PF00917 0.682
DOC_USP7_MATH_1 351 355 PF00917 0.666
DOC_USP7_MATH_1 48 52 PF00917 0.698
DOC_USP7_MATH_1 53 57 PF00917 0.698
DOC_USP7_MATH_1 59 63 PF00917 0.651
DOC_USP7_MATH_1 79 83 PF00917 0.713
DOC_WW_Pin1_4 340 345 PF00397 0.634
DOC_WW_Pin1_4 347 352 PF00397 0.588
DOC_WW_Pin1_4 354 359 PF00397 0.444
DOC_WW_Pin1_4 37 42 PF00397 0.671
DOC_WW_Pin1_4 49 54 PF00397 0.518
LIG_14-3-3_CanoR_1 122 130 PF00244 0.427
LIG_14-3-3_CanoR_1 353 358 PF00244 0.506
LIG_deltaCOP1_diTrp_1 139 147 PF00928 0.495
LIG_deltaCOP1_diTrp_1 249 256 PF00928 0.426
LIG_EVH1_1 183 187 PF00568 0.517
LIG_FHA_1 126 132 PF00498 0.502
LIG_FHA_1 198 204 PF00498 0.369
LIG_FHA_2 328 334 PF00498 0.588
LIG_LIR_Gen_1 210 220 PF02991 0.473
LIG_LIR_Gen_1 254 264 PF02991 0.536
LIG_LIR_Gen_1 365 373 PF02991 0.339
LIG_LIR_Gen_1 398 407 PF02991 0.407
LIG_LIR_Nem_3 210 215 PF02991 0.494
LIG_LIR_Nem_3 254 259 PF02991 0.509
LIG_LIR_Nem_3 365 369 PF02991 0.343
LIG_LIR_Nem_3 398 404 PF02991 0.402
LIG_Pex14_1 252 256 PF04695 0.483
LIG_SH2_CRK 366 370 PF00017 0.360
LIG_SH2_CRK 401 405 PF00017 0.404
LIG_SH2_STAP1 366 370 PF00017 0.360
LIG_SH2_STAP1 401 405 PF00017 0.404
LIG_SH2_STAT5 130 133 PF00017 0.397
LIG_SH2_STAT5 258 261 PF00017 0.497
LIG_SH3_2 184 189 PF14604 0.446
LIG_SH3_3 181 187 PF00018 0.601
LIG_SH3_3 221 227 PF00018 0.490
LIG_SH3_3 355 361 PF00018 0.472
LIG_SUMO_SIM_par_1 2 7 PF11976 0.440
LIG_SUMO_SIM_par_1 403 409 PF11976 0.512
LIG_TRAF2_1 309 312 PF00917 0.486
LIG_TYR_ITIM 364 369 PF00017 0.365
LIG_UBA3_1 369 378 PF00899 0.372
MOD_CDC14_SPxK_1 350 353 PF00782 0.540
MOD_CDK_SPxK_1 347 353 PF00069 0.538
MOD_CK1_1 110 116 PF00069 0.690
MOD_CK1_1 163 169 PF00069 0.602
MOD_CK1_1 177 183 PF00069 0.467
MOD_CK1_1 243 249 PF00069 0.661
MOD_CK1_1 332 338 PF00069 0.664
MOD_CK1_1 343 349 PF00069 0.682
MOD_CK1_1 354 360 PF00069 0.541
MOD_CK1_1 365 371 PF00069 0.484
MOD_CK1_1 380 386 PF00069 0.231
MOD_CK1_1 46 52 PF00069 0.626
MOD_CK1_1 82 88 PF00069 0.702
MOD_CK2_1 243 249 PF00069 0.569
MOD_GlcNHglycan 116 119 PF01048 0.664
MOD_GlcNHglycan 123 126 PF01048 0.584
MOD_GlcNHglycan 168 171 PF01048 0.628
MOD_GlcNHglycan 189 192 PF01048 0.519
MOD_GlcNHglycan 244 248 PF01048 0.593
MOD_GlcNHglycan 253 256 PF01048 0.409
MOD_GlcNHglycan 33 36 PF01048 0.561
MOD_GlcNHglycan 347 350 PF01048 0.652
MOD_GlcNHglycan 382 385 PF01048 0.468
MOD_GlcNHglycan 55 58 PF01048 0.702
MOD_GlcNHglycan 81 84 PF01048 0.641
MOD_GSK3_1 110 117 PF00069 0.573
MOD_GSK3_1 121 128 PF00069 0.429
MOD_GSK3_1 130 137 PF00069 0.379
MOD_GSK3_1 165 172 PF00069 0.612
MOD_GSK3_1 173 180 PF00069 0.670
MOD_GSK3_1 332 339 PF00069 0.650
MOD_GSK3_1 343 350 PF00069 0.650
MOD_GSK3_1 353 360 PF00069 0.551
MOD_GSK3_1 365 372 PF00069 0.502
MOD_GSK3_1 44 51 PF00069 0.683
MOD_N-GLC_2 276 278 PF02516 0.309
MOD_NEK2_1 10 15 PF00069 0.466
MOD_NEK2_1 406 411 PF00069 0.547
MOD_NEK2_1 67 72 PF00069 0.624
MOD_PIKK_1 18 24 PF00454 0.516
MOD_PKA_1 107 113 PF00069 0.708
MOD_PKA_2 107 113 PF00069 0.563
MOD_PKA_2 121 127 PF00069 0.425
MOD_PKA_2 59 65 PF00069 0.757
MOD_Plk_1 125 131 PF00069 0.512
MOD_Plk_1 148 154 PF00069 0.504
MOD_Plk_1 268 274 PF00069 0.551
MOD_Plk_4 126 132 PF00069 0.427
MOD_Plk_4 365 371 PF00069 0.363
MOD_ProDKin_1 340 346 PF00069 0.633
MOD_ProDKin_1 347 353 PF00069 0.589
MOD_ProDKin_1 354 360 PF00069 0.436
MOD_ProDKin_1 37 43 PF00069 0.674
MOD_ProDKin_1 49 55 PF00069 0.518
TRG_DiLeu_BaEn_1 210 215 PF01217 0.407
TRG_ENDOCYTIC_2 366 369 PF00928 0.361
TRG_ENDOCYTIC_2 401 404 PF00928 0.399
TRG_ER_diArg_1 17 20 PF00400 0.576
TRG_ER_diArg_1 239 241 PF00400 0.395
TRG_ER_diArg_1 417 419 PF00400 0.478

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5D0 Leptomonas seymouri 53% 98%
A0A0S4JE52 Bodo saltans 24% 100%
A0A1X0P6Z6 Trypanosomatidae 38% 100%
A0A3Q8IB26 Leishmania donovani 100% 100%
A0A422NJ49 Trypanosoma rangeli 38% 100%
A4H9F8 Leishmania braziliensis 78% 100%
D0A057 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9ARI7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QDZ2 Leishmania major 94% 100%
V5BRN6 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS