LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
BTB/POZ domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HXS4_LEIIN
TriTrypDb:
LINF_180009900
Length:
288

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXS4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXS4

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 7
GO:0016043 cellular component organization 3 7
GO:0022607 cellular component assembly 4 7
GO:0043933 protein-containing complex organization 4 7
GO:0051259 protein complex oligomerization 6 7
GO:0051260 protein homooligomerization 7 7
GO:0065003 protein-containing complex assembly 5 7
GO:0071840 cellular component organization or biogenesis 2 7
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 87 91 PF00656 0.416
CLV_NRD_NRD_1 126 128 PF00675 0.629
CLV_NRD_NRD_1 242 244 PF00675 0.587
CLV_NRD_NRD_1 36 38 PF00675 0.411
CLV_PCSK_KEX2_1 126 128 PF00082 0.527
CLV_PCSK_KEX2_1 242 244 PF00082 0.587
CLV_PCSK_KEX2_1 36 38 PF00082 0.411
CLV_PCSK_SKI1_1 184 188 PF00082 0.722
CLV_PCSK_SKI1_1 243 247 PF00082 0.571
CLV_PCSK_SKI1_1 279 283 PF00082 0.477
CLV_PCSK_SKI1_1 41 45 PF00082 0.513
DEG_APCC_DBOX_1 36 44 PF00400 0.411
DEG_SCF_FBW7_1 162 167 PF00400 0.549
DOC_CDC14_PxL_1 225 233 PF14671 0.424
DOC_CYCLIN_RxL_1 276 283 PF00134 0.490
DOC_MAPK_DCC_7 226 236 PF00069 0.516
DOC_MAPK_gen_1 277 284 PF00069 0.524
DOC_MAPK_MEF2A_6 277 284 PF00069 0.584
DOC_PP1_RVXF_1 240 247 PF00149 0.620
DOC_PP2B_LxvP_1 282 285 PF13499 0.491
DOC_PP2B_LxvP_1 86 89 PF13499 0.411
DOC_USP7_MATH_1 139 143 PF00917 0.570
DOC_USP7_MATH_1 206 210 PF00917 0.694
DOC_WW_Pin1_4 160 165 PF00397 0.687
LIG_14-3-3_CanoR_1 208 215 PF00244 0.703
LIG_14-3-3_CanoR_1 279 285 PF00244 0.488
LIG_14-3-3_CanoR_1 36 41 PF00244 0.513
LIG_14-3-3_CanoR_1 85 89 PF00244 0.436
LIG_APCC_ABBAyCdc20_2 242 248 PF00400 0.627
LIG_BIR_II_1 1 5 PF00653 0.494
LIG_CSL_BTD_1 135 138 PF09270 0.473
LIG_FHA_1 189 195 PF00498 0.816
LIG_FHA_1 247 253 PF00498 0.504
LIG_FHA_1 258 264 PF00498 0.362
LIG_FHA_2 37 43 PF00498 0.513
LIG_LIR_Gen_1 94 102 PF02991 0.513
LIG_LIR_Nem_3 101 107 PF02991 0.418
LIG_LIR_Nem_3 72 77 PF02991 0.357
LIG_LIR_Nem_3 94 98 PF02991 0.416
LIG_SH2_NCK_1 105 109 PF00017 0.513
LIG_SH2_SRC 76 79 PF00017 0.494
LIG_SH2_STAT5 134 137 PF00017 0.475
LIG_SH2_STAT5 33 36 PF00017 0.411
LIG_SH2_STAT5 38 41 PF00017 0.411
LIG_SH2_STAT5 76 79 PF00017 0.411
LIG_SH2_STAT5 80 83 PF00017 0.411
LIG_SH3_1 226 232 PF00018 0.516
LIG_SH3_3 132 138 PF00018 0.474
LIG_SH3_3 159 165 PF00018 0.750
LIG_SH3_3 226 232 PF00018 0.620
LIG_SUMO_SIM_par_1 259 264 PF11976 0.573
LIG_TYR_ITIM 102 107 PF00017 0.513
LIG_WW_2 229 232 PF00397 0.517
MOD_CK1_1 160 166 PF00069 0.586
MOD_CK1_1 216 222 PF00069 0.641
MOD_CK2_1 139 145 PF00069 0.587
MOD_CK2_1 36 42 PF00069 0.513
MOD_Cter_Amidation 240 243 PF01082 0.601
MOD_GlcNHglycan 1 4 PF01048 0.560
MOD_GlcNHglycan 159 162 PF01048 0.632
MOD_GlcNHglycan 209 212 PF01048 0.797
MOD_GlcNHglycan 219 222 PF01048 0.548
MOD_GlcNHglycan 239 242 PF01048 0.653
MOD_GSK3_1 160 167 PF00069 0.620
MOD_GSK3_1 171 178 PF00069 0.678
MOD_GSK3_1 184 191 PF00069 0.590
MOD_GSK3_1 213 220 PF00069 0.716
MOD_GSK3_1 257 264 PF00069 0.556
MOD_GSK3_1 28 35 PF00069 0.513
MOD_NEK2_1 110 115 PF00069 0.573
MOD_NEK2_1 120 125 PF00069 0.564
MOD_NEK2_1 169 174 PF00069 0.592
MOD_NEK2_1 246 251 PF00069 0.488
MOD_NEK2_1 32 37 PF00069 0.411
MOD_NEK2_1 8 13 PF00069 0.509
MOD_PIKK_1 246 252 PF00454 0.523
MOD_PKA_1 36 42 PF00069 0.513
MOD_PKA_2 175 181 PF00069 0.562
MOD_PKA_2 207 213 PF00069 0.709
MOD_PKA_2 246 252 PF00069 0.523
MOD_PKA_2 36 42 PF00069 0.513
MOD_PKA_2 84 90 PF00069 0.436
MOD_Plk_1 110 116 PF00069 0.580
MOD_Plk_4 110 116 PF00069 0.586
MOD_Plk_4 120 126 PF00069 0.443
MOD_Plk_4 164 170 PF00069 0.654
MOD_Plk_4 257 263 PF00069 0.461
MOD_Plk_4 28 34 PF00069 0.513
MOD_Plk_4 3 9 PF00069 0.540
MOD_Plk_4 61 67 PF00069 0.355
MOD_Plk_4 69 75 PF00069 0.349
MOD_ProDKin_1 160 166 PF00069 0.689
TRG_DiLeu_BaEn_1 94 99 PF01217 0.411
TRG_DiLeu_BaEn_2 60 66 PF01217 0.411
TRG_ENDOCYTIC_2 104 107 PF00928 0.513
TRG_ER_diArg_1 125 127 PF00400 0.616
TRG_ER_diArg_1 242 244 PF00400 0.587
TRG_ER_diArg_1 277 280 PF00400 0.585
TRG_ER_diArg_1 36 38 PF00400 0.513
TRG_Pf-PMV_PEXEL_1 192 197 PF00026 0.677
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.436

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4Z1 Leptomonas seymouri 56% 100%
A0A3S5H729 Leishmania donovani 99% 100%
A4H9F7 Leishmania braziliensis 78% 100%
E9ARI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QDZ3 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS