LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
paralyzed flagella protein 20
Species:
Leishmania infantum
UniProt:
A4HXS2_LEIIN
TriTrypDb:
LINF_180009700
Length:
620

Annotations

Annotations by Jardim et al.

Flagella, paralyzed flagella 20 Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 11
GO:0032991 protein-containing complex 1 11
GO:0043226 organelle 2 11
GO:0043228 non-membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043232 intracellular non-membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 11
GO:1990904 ribonucleoprotein complex 2 11
GO:0005737 cytoplasm 2 1
GO:0005930 axoneme 2 1
GO:0005929 cilium 4 1
GO:0031514 motile cilium 5 1
GO:0042995 cell projection 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

A4HXS2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXS2

Function

Biological processes
Term Name Level Count
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0003341 cilium movement 4 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
GO:0048870 cell motility 2 1
GO:0060285 cilium-dependent cell motility 4 1
GO:0060294 cilium movement involved in cell motility 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 213 215 PF00675 0.534
CLV_NRD_NRD_1 41 43 PF00675 0.570
CLV_NRD_NRD_1 538 540 PF00675 0.374
CLV_PCSK_KEX2_1 213 215 PF00082 0.549
CLV_PCSK_KEX2_1 41 43 PF00082 0.473
CLV_PCSK_KEX2_1 538 540 PF00082 0.374
CLV_PCSK_PC7_1 209 215 PF00082 0.504
CLV_PCSK_SKI1_1 172 176 PF00082 0.434
CLV_PCSK_SKI1_1 202 206 PF00082 0.382
CLV_PCSK_SKI1_1 403 407 PF00082 0.214
CLV_PCSK_SKI1_1 72 76 PF00082 0.449
DOC_ANK_TNKS_1 295 302 PF00023 0.526
DOC_CYCLIN_RxL_1 199 208 PF00134 0.445
DOC_MAPK_gen_1 200 207 PF00069 0.420
DOC_MAPK_gen_1 538 546 PF00069 0.345
DOC_PP2B_LxvP_1 50 53 PF13499 0.630
DOC_PP2B_LxvP_1 61 64 PF13499 0.541
DOC_PP4_FxxP_1 18 21 PF00568 0.559
DOC_PP4_FxxP_1 289 292 PF00568 0.554
DOC_USP7_MATH_1 252 256 PF00917 0.565
DOC_USP7_MATH_1 304 308 PF00917 0.642
DOC_USP7_MATH_1 341 345 PF00917 0.467
DOC_USP7_MATH_1 355 359 PF00917 0.379
DOC_USP7_MATH_1 373 377 PF00917 0.302
DOC_USP7_MATH_1 397 401 PF00917 0.414
DOC_USP7_MATH_1 517 521 PF00917 0.379
DOC_USP7_MATH_1 566 570 PF00917 0.359
DOC_USP7_MATH_1 593 597 PF00917 0.535
DOC_USP7_MATH_1 86 90 PF00917 0.428
DOC_WW_Pin1_4 17 22 PF00397 0.626
DOC_WW_Pin1_4 270 275 PF00397 0.631
DOC_WW_Pin1_4 321 326 PF00397 0.698
LIG_14-3-3_CanoR_1 157 164 PF00244 0.549
LIG_14-3-3_CanoR_1 16 21 PF00244 0.503
LIG_14-3-3_CanoR_1 268 274 PF00244 0.639
LIG_14-3-3_CanoR_1 3 10 PF00244 0.543
LIG_14-3-3_CanoR_1 364 369 PF00244 0.541
LIG_14-3-3_CanoR_1 41 45 PF00244 0.526
LIG_14-3-3_CanoR_1 414 420 PF00244 0.449
LIG_14-3-3_CanoR_1 458 462 PF00244 0.445
LIG_BIR_II_1 1 5 PF00653 0.588
LIG_BRCT_BRCA1_1 5 9 PF00533 0.543
LIG_BRCT_BRCA1_1 519 523 PF00533 0.437
LIG_BRCT_BRCA1_1 595 599 PF00533 0.496
LIG_BRCT_BRCA1_1 602 606 PF00533 0.444
LIG_Clathr_ClatBox_1 204 208 PF01394 0.408
LIG_Clathr_ClatBox_1 543 547 PF01394 0.471
LIG_CSL_BTD_1 290 293 PF09270 0.482
LIG_deltaCOP1_diTrp_1 328 335 PF00928 0.517
LIG_deltaCOP1_diTrp_1 424 431 PF00928 0.400
LIG_FHA_1 116 122 PF00498 0.432
LIG_FHA_1 277 283 PF00498 0.628
LIG_FHA_1 325 331 PF00498 0.487
LIG_FHA_1 337 343 PF00498 0.444
LIG_FHA_1 402 408 PF00498 0.414
LIG_FHA_1 421 427 PF00498 0.414
LIG_FHA_1 432 438 PF00498 0.386
LIG_FHA_1 444 450 PF00498 0.414
LIG_FHA_1 475 481 PF00498 0.414
LIG_FHA_1 5 11 PF00498 0.693
LIG_FHA_1 55 61 PF00498 0.639
LIG_FHA_1 571 577 PF00498 0.318
LIG_FHA_1 596 602 PF00498 0.500
LIG_FHA_1 79 85 PF00498 0.467
LIG_FHA_1 97 103 PF00498 0.512
LIG_FHA_2 185 191 PF00498 0.403
LIG_FHA_2 3 9 PF00498 0.659
LIG_FHA_2 531 537 PF00498 0.388
LIG_LIR_Apic_2 287 292 PF02991 0.571
LIG_NRBOX 169 175 PF00104 0.488
LIG_PCNA_yPIPBox_3 162 174 PF02747 0.543
LIG_PDZ_Class_2 615 620 PF00595 0.445
LIG_PDZ_Wminus1_1 618 620 PF00595 0.445
LIG_Pex14_1 427 431 PF04695 0.414
LIG_Pex14_2 70 74 PF04695 0.406
LIG_Pex14_2 87 91 PF04695 0.415
LIG_RPA_C_Fungi 533 545 PF08784 0.454
LIG_SH3_3 103 109 PF00018 0.579
LIG_SH3_3 238 244 PF00018 0.739
LIG_SH3_3 287 293 PF00018 0.523
LIG_SH3_3 294 300 PF00018 0.536
LIG_SH3_3 346 352 PF00018 0.335
LIG_SH3_3 49 55 PF00018 0.535
LIG_SUMO_SIM_par_1 203 208 PF11976 0.405
LIG_SUMO_SIM_par_1 575 581 PF11976 0.341
LIG_UBA3_1 204 211 PF00899 0.391
LIG_WRC_WIRS_1 500 505 PF05994 0.334
MOD_CK1_1 2 8 PF00069 0.732
MOD_CK1_1 203 209 PF00069 0.511
MOD_CK1_1 256 262 PF00069 0.680
MOD_CK1_1 272 278 PF00069 0.528
MOD_CK1_1 318 324 PF00069 0.584
MOD_CK1_1 420 426 PF00069 0.405
MOD_CK1_1 525 531 PF00069 0.398
MOD_CK1_1 609 615 PF00069 0.268
MOD_CK2_1 184 190 PF00069 0.412
MOD_CK2_1 21 27 PF00069 0.627
MOD_GlcNHglycan 258 261 PF01048 0.653
MOD_GlcNHglycan 308 311 PF01048 0.653
MOD_GlcNHglycan 355 358 PF01048 0.327
MOD_GlcNHglycan 375 378 PF01048 0.234
MOD_GlcNHglycan 399 402 PF01048 0.249
MOD_GlcNHglycan 419 422 PF01048 0.128
MOD_GlcNHglycan 439 442 PF01048 0.128
MOD_GlcNHglycan 483 486 PF01048 0.249
MOD_GlcNHglycan 608 611 PF01048 0.292
MOD_GSK3_1 140 147 PF00069 0.423
MOD_GSK3_1 17 24 PF00069 0.633
MOD_GSK3_1 184 191 PF00069 0.538
MOD_GSK3_1 252 259 PF00069 0.652
MOD_GSK3_1 272 279 PF00069 0.643
MOD_GSK3_1 300 307 PF00069 0.632
MOD_GSK3_1 315 322 PF00069 0.685
MOD_GSK3_1 336 343 PF00069 0.339
MOD_GSK3_1 355 362 PF00069 0.249
MOD_GSK3_1 36 43 PF00069 0.513
MOD_GSK3_1 363 370 PF00069 0.346
MOD_GSK3_1 378 385 PF00069 0.233
MOD_GSK3_1 391 398 PF00069 0.207
MOD_GSK3_1 4 11 PF00069 0.640
MOD_GSK3_1 495 502 PF00069 0.454
MOD_GSK3_1 518 525 PF00069 0.440
MOD_GSK3_1 566 573 PF00069 0.311
MOD_GSK3_1 608 615 PF00069 0.405
MOD_NEK2_1 1 6 PF00069 0.632
MOD_NEK2_1 188 193 PF00069 0.530
MOD_NEK2_1 340 345 PF00069 0.327
MOD_NEK2_1 395 400 PF00069 0.249
MOD_NEK2_1 40 45 PF00069 0.505
MOD_NEK2_1 410 415 PF00069 0.358
MOD_NEK2_1 431 436 PF00069 0.254
MOD_NEK2_1 437 442 PF00069 0.243
MOD_NEK2_1 443 448 PF00069 0.238
MOD_NEK2_1 479 484 PF00069 0.297
MOD_NEK2_1 606 611 PF00069 0.254
MOD_NEK2_1 80 85 PF00069 0.563
MOD_NEK2_2 401 406 PF00069 0.249
MOD_NEK2_2 457 462 PF00069 0.268
MOD_PIKK_1 140 146 PF00454 0.539
MOD_PIKK_1 244 250 PF00454 0.790
MOD_PIKK_1 525 531 PF00454 0.430
MOD_PKA_2 115 121 PF00069 0.545
MOD_PKA_2 140 146 PF00069 0.526
MOD_PKA_2 156 162 PF00069 0.425
MOD_PKA_2 168 174 PF00069 0.393
MOD_PKA_2 2 8 PF00069 0.542
MOD_PKA_2 363 369 PF00069 0.362
MOD_PKA_2 391 397 PF00069 0.382
MOD_PKA_2 40 46 PF00069 0.530
MOD_PKA_2 457 463 PF00069 0.292
MOD_Plk_1 330 336 PF00069 0.314
MOD_Plk_1 401 407 PF00069 0.249
MOD_Plk_1 612 618 PF00069 0.327
MOD_Plk_4 115 121 PF00069 0.373
MOD_Plk_4 200 206 PF00069 0.422
MOD_Plk_4 330 336 PF00069 0.285
MOD_Plk_4 391 397 PF00069 0.272
MOD_Plk_4 469 475 PF00069 0.432
MOD_Plk_4 518 524 PF00069 0.485
MOD_Plk_4 530 536 PF00069 0.321
MOD_ProDKin_1 17 23 PF00069 0.622
MOD_ProDKin_1 270 276 PF00069 0.628
MOD_ProDKin_1 321 327 PF00069 0.685
TRG_DiLeu_BaEn_2 284 290 PF01217 0.605
TRG_DiLeu_BaLyEn_6 169 174 PF01217 0.541
TRG_ER_diArg_1 212 214 PF00400 0.513
TRG_ER_diArg_1 40 42 PF00400 0.484
TRG_ER_diArg_1 538 540 PF00400 0.374
TRG_NES_CRM1_1 36 49 PF08389 0.541
TRG_Pf-PMV_PEXEL_1 130 134 PF00026 0.476
TRG_Pf-PMV_PEXEL_1 172 176 PF00026 0.543

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCN2 Leptomonas seymouri 70% 97%
A0A0S4JA64 Bodo saltans 46% 100%
A0A1X0P716 Trypanosomatidae 52% 100%
A0A3R7NP23 Trypanosoma rangeli 51% 100%
A0A3S7WR72 Leishmania donovani 31% 100%
A0A3S7WUV4 Leishmania donovani 100% 100%
A1DDL6 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 23% 94%
A2R3Z3 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 23% 94%
A4H666 Leishmania braziliensis 31% 100%
A4H9F5 Leishmania braziliensis 84% 100%
A4HUJ0 Leishmania infantum 31% 100%
A6ZQL5 Saccharomyces cerevisiae (strain YJM789) 23% 87%
D0A054 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9AN88 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9ARI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
P47025 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 87%
P93107 Chlamydomonas reinhardtii 36% 100%
Q4QDZ5 Leishmania major 95% 100%
Q4QHD6 Leishmania major 31% 100%
Q4WVS4 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 23% 94%
Q5I0B9 Xenopus tropicalis 22% 100%
Q8K450 Mus musculus 32% 97%
Q8N0X2 Homo sapiens 33% 98%
Q9P7I3 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS