Putative phosphatidic acid phosphatase

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidic acid phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4HXR9_LEIIN

TriTrypDb:

LINF_180009400

Length:

416

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, phosphatidic acid phosphatase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Phosphorylation

Amastigote: 218

Expansion

Sequence features

A4HXR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXR9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0006644	phospholipid metabolic process	4	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0019637	organophosphate metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044255	cellular lipid metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008195	phosphatidate phosphatase activity	6	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.649
CLV_NRD_NRD_1	225	227	PF00675	0.552
CLV_NRD_NRD_1	333	335	PF00675	0.275
CLV_NRD_NRD_1	91	93	PF00675	0.385
CLV_PCSK_KEX2_1	333	335	PF00082	0.275
CLV_PCSK_KEX2_1	90	92	PF00082	0.393
CLV_PCSK_SKI1_1	105	109	PF00082	0.384
CLV_PCSK_SKI1_1	241	245	PF00082	0.376
DEG_SPOP_SBC_1	175	179	PF00917	0.654
DOC_CKS1_1	192	197	PF01111	0.690
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.383
DOC_MAPK_DCC_7	341	351	PF00069	0.383
DOC_MAPK_gen_1	333	339	PF00069	0.466
DOC_MAPK_MEF2A_6	151	159	PF00069	0.651
DOC_PP1_RVXF_1	301	307	PF00149	0.275
DOC_PP1_RVXF_1	9	16	PF00149	0.525
DOC_PP2B_LxvP_1	349	352	PF13499	0.383
DOC_PP2B_PxIxI_1	66	72	PF00149	0.279
DOC_SPAK_OSR1_1	11	15	PF12202	0.549
DOC_USP7_MATH_1	139	143	PF00917	0.693
DOC_USP7_MATH_1	215	219	PF00917	0.738
DOC_USP7_MATH_1	220	224	PF00917	0.689
DOC_USP7_MATH_1	406	410	PF00917	0.569
DOC_WW_Pin1_4	131	136	PF00397	0.672
DOC_WW_Pin1_4	191	196	PF00397	0.782
DOC_WW_Pin1_4	213	218	PF00397	0.648
DOC_WW_Pin1_4	284	289	PF00397	0.293
LIG_14-3-3_CanoR_1	219	225	PF00244	0.684
LIG_14-3-3_CanoR_1	303	307	PF00244	0.275
LIG_14-3-3_CanoR_1	334	340	PF00244	0.527
LIG_14-3-3_CanoR_1	405	412	PF00244	0.575
LIG_14-3-3_CanoR_1	42	47	PF00244	0.327
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_BIR_III_2	214	218	PF00653	0.688
LIG_BRCT_BRCA1_1	255	259	PF00533	0.337
LIG_BRCT_BRCA1_1	311	315	PF00533	0.327
LIG_BRCT_BRCA1_1	49	53	PF00533	0.429
LIG_FHA_1	179	185	PF00498	0.665
LIG_FHA_1	230	236	PF00498	0.634
LIG_FHA_1	348	354	PF00498	0.317
LIG_FHA_1	393	399	PF00498	0.513
LIG_FHA_1	63	69	PF00498	0.334
LIG_FHA_2	197	203	PF00498	0.690
LIG_FHA_2	289	295	PF00498	0.293
LIG_LIR_Apic_2	45	49	PF02991	0.361
LIG_LIR_Apic_2	63	67	PF02991	0.200
LIG_LIR_Gen_1	256	266	PF02991	0.293
LIG_LIR_Gen_1	312	323	PF02991	0.258
LIG_LIR_Nem_3	256	262	PF02991	0.305
LIG_LIR_Nem_3	312	318	PF02991	0.431
LIG_LIR_Nem_3	338	343	PF02991	0.527
LIG_LRP6_Inhibitor_1	261	267	PF00058	0.253
LIG_Pex14_2	12	16	PF04695	0.527
LIG_Pex14_2	255	259	PF04695	0.291
LIG_PTB_Apo_2	280	287	PF02174	0.310
LIG_PTB_Phospho_1	280	286	PF10480	0.277
LIG_REV1ctd_RIR_1	13	21	PF16727	0.468
LIG_SH2_STAT3	286	289	PF00017	0.277
LIG_SH2_STAT5	21	24	PF00017	0.312
LIG_SH2_STAT5	324	327	PF00017	0.312
LIG_SH2_STAT5	366	369	PF00017	0.293
LIG_SH2_STAT5	77	80	PF00017	0.335
LIG_SH3_3	301	307	PF00018	0.261
LIG_Sin3_3	258	265	PF02671	0.253
LIG_SUMO_SIM_anti_2	154	159	PF11976	0.651
LIG_SUMO_SIM_par_1	353	358	PF11976	0.285
LIG_SUMO_SIM_par_1	380	386	PF11976	0.278
MOD_CDC14_SPxK_1	216	219	PF00782	0.657
MOD_CDK_SPxK_1	213	219	PF00069	0.657
MOD_CK1_1	134	140	PF00069	0.789
MOD_CK1_1	142	148	PF00069	0.703
MOD_CK1_1	178	184	PF00069	0.636
MOD_CK1_1	191	197	PF00069	0.732
MOD_CK1_1	218	224	PF00069	0.761
MOD_CK1_1	287	293	PF00069	0.255
MOD_CK1_1	305	311	PF00069	0.361
MOD_CK1_1	335	341	PF00069	0.527
MOD_CK2_1	196	202	PF00069	0.691
MOD_Cter_Amidation	88	91	PF01082	0.370
MOD_GlcNHglycan	131	134	PF01048	0.421
MOD_GlcNHglycan	144	147	PF01048	0.573
MOD_GlcNHglycan	160	163	PF01048	0.453
MOD_GlcNHglycan	164	167	PF01048	0.464
MOD_GlcNHglycan	222	225	PF01048	0.452
MOD_GlcNHglycan	307	310	PF01048	0.475
MOD_GlcNHglycan	315	318	PF01048	0.312
MOD_GlcNHglycan	334	337	PF01048	0.192
MOD_GlcNHglycan	373	376	PF01048	0.319
MOD_GlcNHglycan	379	382	PF01048	0.266
MOD_GlcNHglycan	385	388	PF01048	0.255
MOD_GlcNHglycan	408	411	PF01048	0.426
MOD_GSK3_1	125	132	PF00069	0.702
MOD_GSK3_1	158	165	PF00069	0.736
MOD_GSK3_1	174	181	PF00069	0.614
MOD_GSK3_1	249	256	PF00069	0.374
MOD_GSK3_1	284	291	PF00069	0.293
MOD_GSK3_1	305	312	PF00069	0.327
MOD_LATS_1	40	46	PF00433	0.312
MOD_NEK2_1	158	163	PF00069	0.634
MOD_NEK2_1	32	37	PF00069	0.380
MOD_NEK2_1	332	337	PF00069	0.475
MOD_NEK2_1	371	376	PF00069	0.273
MOD_PIKK_1	137	143	PF00454	0.635
MOD_PIKK_1	249	255	PF00454	0.291
MOD_PKA_2	206	212	PF00069	0.706
MOD_PKA_2	218	224	PF00069	0.731
MOD_PKA_2	302	308	PF00069	0.275
MOD_PKA_2	332	338	PF00069	0.475
MOD_Plk_1	207	213	PF00069	0.653
MOD_Plk_2-3	208	214	PF00069	0.652
MOD_Plk_4	2	8	PF00069	0.561
MOD_Plk_4	335	341	PF00069	0.527
MOD_ProDKin_1	131	137	PF00069	0.673
MOD_ProDKin_1	191	197	PF00069	0.781
MOD_ProDKin_1	213	219	PF00069	0.649
MOD_ProDKin_1	284	290	PF00069	0.293
TRG_DiLeu_BaEn_1	154	159	PF01217	0.657
TRG_ER_diArg_1	272	275	PF00400	0.291
TRG_ER_diArg_1	332	334	PF00400	0.475
TRG_ER_diArg_1	90	92	PF00400	0.580
TRG_NLS_MonoExtN_4	225	230	PF00514	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I046	Leptomonas seymouri	45%	90%
A0A3S7WUU8	Leishmania donovani	99%	100%
A4H9E7	Leishmania braziliensis	54%	96%
A4H9F0	Leishmania braziliensis	54%	96%
E9ARI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	96%
Q4QDZ8	Leishmania major	79%	100%