LeishMANIAdb
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Putative phosphatidic acid phosphatase

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative phosphatidic acid phosphatase
Gene product:
phosphatidic acid phosphatase - putative
Species:
Leishmania infantum
UniProt:
A4HXR9_LEIIN
TriTrypDb:
LINF_180009400
Length:
416

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, phosphatidic acid phosphatase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8
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Phosphorylation

Amastigote: 218

Expansion

Sequence features

A4HXR9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXR9

Function

Biological processes
TermNameLevelCount
GO:0006629 lipid metabolic process 3 8
GO:0006644 phospholipid metabolic process 4 8
GO:0006793 phosphorus metabolic process 3 8
GO:0006796 phosphate-containing compound metabolic process 4 8
GO:0008152 metabolic process 1 8
GO:0009987 cellular process 1 8
GO:0019637 organophosphate metabolic process 3 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0044255 cellular lipid metabolic process 3 8
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 7
GO:0008195 phosphatidate phosphatase activity 6 7
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 7
GO:0016791 phosphatase activity 5 7
GO:0042578 phosphoric ester hydrolase activity 4 7
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 211 215 PF00656 0.649
CLV_NRD_NRD_1 225 227 PF00675 0.552
CLV_NRD_NRD_1 333 335 PF00675 0.275
CLV_NRD_NRD_1 91 93 PF00675 0.385
CLV_PCSK_KEX2_1 333 335 PF00082 0.275
CLV_PCSK_KEX2_1 90 92 PF00082 0.393
CLV_PCSK_SKI1_1 105 109 PF00082 0.384
CLV_PCSK_SKI1_1 241 245 PF00082 0.376
DEG_SPOP_SBC_1 175 179 PF00917 0.654
DOC_CKS1_1 192 197 PF01111 0.690
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I046 Leptomonas seymouri 45% 90%
A0A3S7WUU8 Leishmania donovani 99% 100%
A4H9E7 Leishmania braziliensis 54% 96%
A4H9F0 Leishmania braziliensis 54% 96%
E9ARI1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 69% 96%
Q4QDZ8 Leishmania major 79% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS