acidPPc domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidic acid phosphatase protein-like protein

Species:

Leishmania infantum

UniProt:

A4HXR8_LEIIN

TriTrypDb:

LINF_190019800

Length:

369

Annotations

LeishMANIAdb annotations

Distinctively related to eukaryotic PLPP enzymes.. This family of protens expanded considerably in Kinetoplastids (might be due to metabolic dependence on host lipids)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

A4HXR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXR8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	19
GO:0006644	phospholipid metabolic process	4	19
GO:0006793	phosphorus metabolic process	3	19
GO:0006796	phosphate-containing compound metabolic process	4	19
GO:0008152	metabolic process	1	19
GO:0009987	cellular process	1	19
GO:0019637	organophosphate metabolic process	3	19
GO:0044237	cellular metabolic process	2	19
GO:0044238	primary metabolic process	2	19
GO:0044255	cellular lipid metabolic process	3	19
GO:0071704	organic substance metabolic process	2	19

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	317	319	PF00675	0.692
CLV_PCSK_KEX2_1	17	19	PF00082	0.464
CLV_PCSK_KEX2_1	317	319	PF00082	0.660
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.458
CLV_PCSK_SKI1_1	281	285	PF00082	0.537
CLV_PCSK_SKI1_1	318	322	PF00082	0.571
CLV_PCSK_SKI1_1	69	73	PF00082	0.604
DEG_APCC_DBOX_1	203	211	PF00400	0.268
DEG_APCC_DBOX_1	316	324	PF00400	0.372
DEG_SPOP_SBC_1	6	10	PF00917	0.521
DOC_CYCLIN_yCln2_LP_2	211	217	PF00134	0.337
DOC_MAPK_gen_1	165	174	PF00069	0.485
DOC_MAPK_gen_1	198	207	PF00069	0.321
DOC_MAPK_MEF2A_6	102	109	PF00069	0.497
DOC_MAPK_MEF2A_6	204	212	PF00069	0.258
DOC_MAPK_MEF2A_6	27	36	PF00069	0.521
DOC_MAPK_NFAT4_5	102	110	PF00069	0.496
DOC_PP1_RVXF_1	169	175	PF00149	0.451
DOC_PP1_RVXF_1	51	58	PF00149	0.387
DOC_PP2B_LxvP_1	211	214	PF13499	0.337
DOC_PP2B_LxvP_1	215	218	PF13499	0.315
DOC_USP7_MATH_1	125	129	PF00917	0.499
DOC_USP7_MATH_1	309	313	PF00917	0.415
DOC_USP7_MATH_1	363	367	PF00917	0.365
DOC_WW_Pin1_4	2	7	PF00397	0.528
DOC_WW_Pin1_4	299	304	PF00397	0.551
DOC_WW_Pin1_4	324	329	PF00397	0.536
LIG_14-3-3_CanoR_1	171	175	PF00244	0.442
LIG_14-3-3_CanoR_1	225	233	PF00244	0.418
LIG_14-3-3_CanoR_1	281	290	PF00244	0.505
LIG_14-3-3_CanoR_1	308	314	PF00244	0.475
LIG_Actin_WH2_2	187	203	PF00022	0.406
LIG_BRCT_BRCA1_1	179	183	PF00533	0.322
LIG_eIF4E_1	87	93	PF01652	0.393
LIG_EVH1_2	19	23	PF00568	0.443
LIG_FHA_1	10	16	PF00498	0.682
LIG_FHA_1	115	121	PF00498	0.521
LIG_FHA_1	207	213	PF00498	0.403
LIG_FHA_1	218	224	PF00498	0.405
LIG_FHA_1	273	279	PF00498	0.465
LIG_FHA_1	66	72	PF00498	0.284
LIG_FHA_2	262	268	PF00498	0.409
LIG_FHA_2	6	12	PF00498	0.704
LIG_LIR_Apic_2	184	189	PF02991	0.234
LIG_LIR_Apic_2	264	269	PF02991	0.261
LIG_LIR_Apic_2	54	60	PF02991	0.291
LIG_LIR_Apic_2	94	99	PF02991	0.591
LIG_LIR_Gen_1	121	132	PF02991	0.412
LIG_LIR_Gen_1	152	161	PF02991	0.506
LIG_LIR_Gen_1	30	39	PF02991	0.360
LIG_LIR_Gen_1	74	83	PF02991	0.218
LIG_LIR_Nem_3	121	127	PF02991	0.399
LIG_LIR_Nem_3	180	186	PF02991	0.295
LIG_LIR_Nem_3	262	266	PF02991	0.311
LIG_LIR_Nem_3	30	34	PF02991	0.363
LIG_LIR_Nem_3	70	75	PF02991	0.317
LIG_NRBOX	206	212	PF00104	0.214
LIG_SH2_CRK	300	304	PF00017	0.358
LIG_SH2_CRK	75	79	PF00017	0.340
LIG_SH2_NCK_1	266	270	PF00017	0.437
LIG_SH2_NCK_1	300	304	PF00017	0.358
LIG_SH2_PTP2	186	189	PF00017	0.453
LIG_SH2_SRC	186	189	PF00017	0.258
LIG_SH2_SRC	266	269	PF00017	0.280
LIG_SH2_STAP1	75	79	PF00017	0.379
LIG_SH2_STAT5	186	189	PF00017	0.393
LIG_SH2_STAT5	192	195	PF00017	0.150
LIG_SH2_STAT5	24	27	PF00017	0.476
LIG_SH2_STAT5	31	34	PF00017	0.259
LIG_SH2_STAT5	87	90	PF00017	0.304
LIG_SH3_1	300	306	PF00018	0.353
LIG_SH3_2	303	308	PF14604	0.353
LIG_SH3_3	300	306	PF00018	0.503
LIG_SH3_3	356	362	PF00018	0.436
LIG_SUMO_SIM_anti_2	209	214	PF11976	0.356
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.334
LIG_SUMO_SIM_par_1	125	130	PF11976	0.480
LIG_SUMO_SIM_par_1	219	224	PF11976	0.352
LIG_UBA3_1	13	17	PF00899	0.519
LIG_WRC_WIRS_1	252	257	PF05994	0.369
LIG_WRC_WIRS_1	79	84	PF05994	0.176
MOD_CDK_SPK_2	324	329	PF00069	0.361
MOD_CDK_SPxxK_3	301	308	PF00069	0.352
MOD_CDK_SPxxK_3	324	331	PF00069	0.540
MOD_CK1_1	154	160	PF00069	0.511
MOD_CK1_1	173	179	PF00069	0.444
MOD_CK1_1	224	230	PF00069	0.557
MOD_CK1_1	334	340	PF00069	0.417
MOD_CK1_1	346	352	PF00069	0.359
MOD_CK2_1	337	343	PF00069	0.377
MOD_CK2_1	5	11	PF00069	0.715
MOD_GlcNHglycan	175	178	PF01048	0.244
MOD_GlcNHglycan	183	186	PF01048	0.295
MOD_GlcNHglycan	243	246	PF01048	0.351
MOD_GlcNHglycan	333	336	PF01048	0.754
MOD_GlcNHglycan	351	354	PF01048	0.526
MOD_GlcNHglycan	365	368	PF01048	0.552
MOD_GSK3_1	112	119	PF00069	0.428
MOD_GSK3_1	140	147	PF00069	0.503
MOD_GSK3_1	150	157	PF00069	0.472
MOD_GSK3_1	173	180	PF00069	0.455
MOD_GSK3_1	2	9	PF00069	0.659
MOD_GSK3_1	217	224	PF00069	0.407
MOD_GSK3_1	237	244	PF00069	0.381
MOD_GSK3_1	247	254	PF00069	0.362
MOD_GSK3_1	362	369	PF00069	0.384
MOD_N-GLC_1	290	295	PF02516	0.696
MOD_NEK2_1	114	119	PF00069	0.433
MOD_NEK2_1	196	201	PF00069	0.314
MOD_NEK2_1	237	242	PF00069	0.306
MOD_NEK2_2	261	266	PF00069	0.376
MOD_PIKK_1	112	118	PF00454	0.506
MOD_PIKK_1	159	165	PF00454	0.482
MOD_PIKK_1	272	278	PF00454	0.311
MOD_PKA_2	170	176	PF00069	0.444
MOD_PKA_2	224	230	PF00069	0.418
MOD_PKA_2	255	261	PF00069	0.340
MOD_PKA_2	94	100	PF00069	0.601
MOD_Plk_1	151	157	PF00069	0.480
MOD_Plk_1	261	267	PF00069	0.398
MOD_Plk_4	206	212	PF00069	0.345
MOD_Plk_4	247	253	PF00069	0.307
MOD_Plk_4	73	79	PF00069	0.285
MOD_Plk_4	9	15	PF00069	0.653
MOD_ProDKin_1	2	8	PF00069	0.525
MOD_ProDKin_1	299	305	PF00069	0.549
MOD_ProDKin_1	324	330	PF00069	0.536
TRG_DiLeu_BaEn_1	274	279	PF01217	0.444
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.342
TRG_ENDOCYTIC_2	31	34	PF00928	0.355
TRG_ENDOCYTIC_2	75	78	PF00928	0.313
TRG_ER_diArg_1	136	139	PF00400	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P344	Leptomonas seymouri	30%	94%
A0A0N1I1J3	Leptomonas seymouri	65%	100%
A0A0S4IVL2	Bodo saltans	32%	100%
A0A0S4JH63	Bodo saltans	39%	100%
A0A1X0P677	Trypanosomatidae	34%	100%
A0A1X0P729	Trypanosomatidae	48%	100%
A0A3Q8ID01	Leishmania donovani	100%	100%
A0A3Q8IK66	Leishmania donovani	29%	92%
A4H9I2	Leishmania braziliensis	73%	100%
A4HA84	Leishmania braziliensis	29%	100%
A4HYG7	Leishmania infantum	28%	92%
C9ZUG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZZW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ARI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9AS87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AS88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O08564	Rattus norvegicus	27%	100%
O14494	Homo sapiens	27%	100%
O88956	Cavia porcellus	29%	100%
P60588	Sus scrofa	26%	100%
Q4QD76	Leishmania major	28%	100%
Q61469	Mus musculus	28%	100%
Q9UUA6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
V5BM01	Trypanosoma cruzi	39%	100%
V5BWA7	Trypanosoma cruzi	45%	100%