LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HXR7_LEIIN
TriTrypDb:
LINF_180009200
Length:
137

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXR7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXR7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 109 111 PF00675 0.572
CLV_NRD_NRD_1 135 137 PF00675 0.646
CLV_NRD_NRD_1 56 58 PF00675 0.668
CLV_PCSK_KEX2_1 108 110 PF00082 0.570
CLV_PCSK_KEX2_1 56 58 PF00082 0.678
CLV_PCSK_PC1ET2_1 56 58 PF00082 0.678
DEG_Nend_UBRbox_3 1 3 PF02207 0.685
DOC_USP7_MATH_1 27 31 PF00917 0.706
DOC_USP7_MATH_1 96 100 PF00917 0.583
DOC_USP7_UBL2_3 51 55 PF12436 0.657
DOC_WW_Pin1_4 22 27 PF00397 0.679
DOC_WW_Pin1_4 60 65 PF00397 0.680
LIG_14-3-3_CanoR_1 10 19 PF00244 0.650
LIG_APCC_ABBA_1 62 67 PF00400 0.654
LIG_BRCT_BRCA1_1 31 35 PF00533 0.596
LIG_FHA_1 12 18 PF00498 0.730
LIG_LIR_Gen_1 6 15 PF02991 0.524
LIG_PCNA_PIPBox_1 77 86 PF02747 0.590
LIG_PCNA_yPIPBox_3 72 84 PF02747 0.588
LIG_SH2_SRC 112 115 PF00017 0.652
LIG_SH2_SRC 60 63 PF00017 0.710
LIG_SH2_STAT5 112 115 PF00017 0.647
LIG_SH2_STAT5 60 63 PF00017 0.656
LIG_SH2_STAT5 83 86 PF00017 0.586
LIG_SH3_2 46 51 PF14604 0.655
LIG_SH3_3 43 49 PF00018 0.592
LIG_SH3_3 86 92 PF00018 0.514
MOD_CK1_1 22 28 PF00069 0.703
MOD_CK1_1 63 69 PF00069 0.666
MOD_GlcNHglycan 19 22 PF01048 0.732
MOD_GlcNHglycan 29 32 PF01048 0.574
MOD_GSK3_1 13 20 PF00069 0.673
MOD_N-GLC_1 17 22 PF02516 0.653
MOD_NEK2_1 11 16 PF00069 0.605
MOD_NEK2_1 3 8 PF00069 0.613
MOD_NEK2_1 34 39 PF00069 0.615
MOD_Plk_1 96 102 PF00069 0.629
MOD_Plk_4 96 102 PF00069 0.636
MOD_ProDKin_1 22 28 PF00069 0.679
MOD_ProDKin_1 60 66 PF00069 0.670
TRG_ENDOCYTIC_2 8 11 PF00928 0.566
TRG_ER_diArg_1 107 110 PF00400 0.575
TRG_ER_diArg_1 57 60 PF00400 0.749
TRG_NLS_MonoCore_2 55 60 PF00514 0.692
TRG_NLS_MonoExtN_4 55 61 PF00514 0.622
TRG_Pf-PMV_PEXEL_1 78 82 PF00026 0.575

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I151 Leptomonas seymouri 60% 99%
A0A1X0P882 Trypanosomatidae 44% 100%
A0A3S7WUT1 Leishmania donovani 99% 100%
A4H9E6 Leishmania braziliensis 81% 100%
D0A049 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9ARH9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QE00 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS