Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXR6_LEIIN

TriTrypDb:

LINF_180009100

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HXR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.539
CLV_NRD_NRD_1	3	5	PF00675	0.589
CLV_PCSK_KEX2_1	140	142	PF00082	0.609
CLV_PCSK_KEX2_1	145	147	PF00082	0.615
CLV_PCSK_KEX2_1	3	5	PF00082	0.589
CLV_PCSK_KEX2_1	86	88	PF00082	0.583
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.609
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.615
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.607
CLV_PCSK_PC7_1	141	147	PF00082	0.533
CLV_PCSK_SKI1_1	101	105	PF00082	0.489
CLV_PCSK_SKI1_1	4	8	PF00082	0.643
DEG_Nend_Nbox_1	1	3	PF02207	0.594
DEG_SCF_FBW7_1	187	194	PF00400	0.563
DOC_CKS1_1	188	193	PF01111	0.563
DOC_CKS1_1	48	53	PF01111	0.480
DOC_CYCLIN_RxL_1	1	10	PF00134	0.551
DOC_PP4_FxxP_1	48	51	PF00568	0.510
DOC_WW_Pin1_4	111	116	PF00397	0.633
DOC_WW_Pin1_4	187	192	PF00397	0.594
DOC_WW_Pin1_4	23	28	PF00397	0.521
DOC_WW_Pin1_4	47	52	PF00397	0.520
LIG_BRCT_BRCA1_1	157	161	PF00533	0.532
LIG_FHA_1	62	68	PF00498	0.572
LIG_FHA_2	47	53	PF00498	0.583
LIG_LIR_Apic_2	47	51	PF02991	0.518
LIG_LIR_Gen_1	55	62	PF02991	0.526
LIG_LIR_Nem_3	55	60	PF02991	0.531
LIG_SH2_STAT5	150	153	PF00017	0.545
LIG_SH2_STAT5	162	165	PF00017	0.519
LIG_SH2_STAT5	181	184	PF00017	0.578
LIG_SH3_1	33	39	PF00018	0.468
LIG_SH3_2	195	200	PF14604	0.580
LIG_SH3_2	36	41	PF14604	0.491
LIG_SH3_3	151	157	PF00018	0.634
LIG_SH3_3	192	198	PF00018	0.559
LIG_SH3_3	33	39	PF00018	0.448
LIG_SH3_5	152	156	PF00018	0.485
MOD_CDK_SPxxK_3	111	118	PF00069	0.603
MOD_CK1_1	89	95	PF00069	0.661
MOD_CK2_1	46	52	PF00069	0.576
MOD_CK2_1	73	79	PF00069	0.671
MOD_GlcNHglycan	101	104	PF01048	0.492
MOD_GlcNHglycan	76	79	PF01048	0.589
MOD_GlcNHglycan	88	91	PF01048	0.648
MOD_GlcNHglycan	9	12	PF01048	0.625
MOD_GSK3_1	187	194	PF00069	0.576
MOD_GSK3_1	69	76	PF00069	0.563
MOD_GSK3_1	82	89	PF00069	0.477
MOD_GSK3_1	99	106	PF00069	0.484
MOD_N-GLC_1	111	116	PF02516	0.594
MOD_NEK2_1	7	12	PF00069	0.614
MOD_PIKK_1	156	162	PF00454	0.535
MOD_PKA_1	86	92	PF00069	0.541
MOD_PKA_2	86	92	PF00069	0.489
MOD_ProDKin_1	111	117	PF00069	0.623
MOD_ProDKin_1	187	193	PF00069	0.602
MOD_ProDKin_1	23	29	PF00069	0.523
MOD_ProDKin_1	47	53	PF00069	0.524
MOD_SUMO_rev_2	63	70	PF00179	0.490
TRG_ENDOCYTIC_2	45	48	PF00928	0.463
TRG_ER_diArg_1	2	4	PF00400	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC40	Leptomonas seymouri	65%	100%
A0A0S4JE60	Bodo saltans	30%	100%
A0A1X0P7T6	Trypanosomatidae	38%	100%
A0A3Q8I9X5	Leishmania donovani	100%	100%
A4H9E5	Leishmania braziliensis	82%	100%
D0A048	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	70%
E9ARH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QE01	Leishmania major	93%	100%