RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4475) - putative

Species:

Leishmania infantum

UniProt:

A4HXQ9_LEIIN

TriTrypDb:

LINF_180008400

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.416
CLV_NRD_NRD_1	45	47	PF00675	0.608
CLV_PCSK_KEX2_1	183	185	PF00082	0.415
CLV_PCSK_KEX2_1	367	369	PF00082	0.604
CLV_PCSK_KEX2_1	45	47	PF00082	0.608
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.461
CLV_PCSK_SKI1_1	45	49	PF00082	0.437
DEG_APCC_KENBOX_2	49	53	PF00400	0.451
DOC_CKS1_1	170	175	PF01111	0.470
DOC_PP1_RVXF_1	54	60	PF00149	0.477
DOC_PP1_RVXF_1	87	94	PF00149	0.432
DOC_USP7_MATH_1	107	111	PF00917	0.559
DOC_USP7_MATH_1	114	118	PF00917	0.587
DOC_USP7_MATH_1	309	313	PF00917	0.513
DOC_WW_Pin1_4	100	105	PF00397	0.493
DOC_WW_Pin1_4	169	174	PF00397	0.461
DOC_WW_Pin1_4	344	349	PF00397	0.556
LIG_14-3-3_CanoR_1	360	366	PF00244	0.522
LIG_deltaCOP1_diTrp_1	178	187	PF00928	0.385
LIG_deltaCOP1_diTrp_1	231	241	PF00928	0.411
LIG_FHA_2	170	176	PF00498	0.471
LIG_FHA_2	237	243	PF00498	0.257
LIG_FHA_2	24	30	PF00498	0.584
LIG_LIR_Apic_2	364	369	PF02991	0.498
LIG_LIR_Gen_1	222	233	PF02991	0.325
LIG_LIR_Gen_1	355	366	PF02991	0.554
LIG_LIR_Nem_3	222	228	PF02991	0.300
LIG_LIR_Nem_3	256	261	PF02991	0.266
LIG_LIR_Nem_3	285	291	PF02991	0.594
LIG_LIR_Nem_3	355	361	PF02991	0.569
LIG_Pex14_2	221	225	PF04695	0.281
LIG_SH2_CRK	166	170	PF00017	0.351
LIG_SH2_CRK	258	262	PF00017	0.411
LIG_SH2_STAT5	168	171	PF00017	0.311
LIG_SH2_STAT5	288	291	PF00017	0.570
LIG_SH2_STAT5	358	361	PF00017	0.440
LIG_SH2_STAT5	64	67	PF00017	0.325
LIG_SH3_1	167	173	PF00018	0.368
LIG_SH3_3	167	173	PF00018	0.305
LIG_SH3_3	201	207	PF00018	0.265
LIG_SH3_3	379	385	PF00018	0.549
LIG_SUMO_SIM_par_1	172	178	PF11976	0.493
LIG_TYR_ITIM	86	91	PF00017	0.449
MOD_CDK_SPxK_1	100	106	PF00069	0.427
MOD_CK1_1	136	142	PF00069	0.534
MOD_CK1_1	190	196	PF00069	0.325
MOD_CK1_1	219	225	PF00069	0.360
MOD_CK1_1	295	301	PF00069	0.620
MOD_CK1_1	41	47	PF00069	0.408
MOD_CK2_1	169	175	PF00069	0.464
MOD_CK2_1	23	29	PF00069	0.599
MOD_CK2_1	236	242	PF00069	0.257
MOD_GlcNHglycan	110	113	PF01048	0.630
MOD_GlcNHglycan	191	195	PF01048	0.341
MOD_GlcNHglycan	218	221	PF01048	0.360
MOD_GlcNHglycan	222	225	PF01048	0.360
MOD_GlcNHglycan	283	287	PF01048	0.619
MOD_GlcNHglycan	295	298	PF01048	0.545
MOD_GlcNHglycan	312	315	PF01048	0.586
MOD_GlcNHglycan	336	339	PF01048	0.648
MOD_GlcNHglycan	75	78	PF01048	0.405
MOD_GSK3_1	133	140	PF00069	0.570
MOD_GSK3_1	216	223	PF00069	0.348
MOD_GSK3_1	236	243	PF00069	0.145
MOD_GSK3_1	310	317	PF00069	0.656
MOD_GSK3_1	8	15	PF00069	0.519
MOD_N-GLC_1	108	113	PF02516	0.610
MOD_NEK2_1	301	306	PF00069	0.695
MOD_NEK2_1	361	366	PF00069	0.522
MOD_OFUCOSY	156	163	PF10250	0.354
MOD_PIKK_1	8	14	PF00454	0.463
MOD_PKA_2	293	299	PF00069	0.611
MOD_PKA_2	321	327	PF00069	0.579
MOD_PKA_2	73	79	PF00069	0.532
MOD_Plk_1	274	280	PF00069	0.485
MOD_Plk_1	302	308	PF00069	0.469
MOD_Plk_4	12	18	PF00069	0.570
MOD_Plk_4	236	242	PF00069	0.266
MOD_Plk_4	284	290	PF00069	0.586
MOD_Plk_4	361	367	PF00069	0.463
MOD_ProDKin_1	100	106	PF00069	0.507
MOD_ProDKin_1	169	175	PF00069	0.464
MOD_ProDKin_1	344	350	PF00069	0.552
TRG_ENDOCYTIC_2	166	169	PF00928	0.431
TRG_ENDOCYTIC_2	258	261	PF00928	0.300
TRG_ENDOCYTIC_2	288	291	PF00928	0.570
TRG_ENDOCYTIC_2	358	361	PF00928	0.446
TRG_ENDOCYTIC_2	88	91	PF00928	0.462
TRG_ER_diArg_1	45	47	PF00400	0.601
TRG_ER_diArg_1	67	70	PF00400	0.347
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P400	Leptomonas seymouri	61%	92%
A0A1X0P6R6	Trypanosomatidae	44%	100%
A0A3Q8IAW5	Leishmania donovani	100%	100%
A0A422NWL4	Trypanosoma rangeli	42%	100%
A4H9D8	Leishmania braziliensis	79%	100%
B6DTF3	Bodo saltans	31%	100%
D0A041	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ARH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QE08	Leishmania major	96%	100%
V5DN00	Trypanosoma cruzi	40%	100%