LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
DnaJ domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HXQ8_LEIIN
TriTrypDb:
LINF_180008300
Length:
244

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 15
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 14
GO:0031207 Sec62/Sec63 complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0098796 membrane protein complex 2 1
GO:0110165 cellular anatomical entity 1 14
GO:0140534 endoplasmic reticulum protein-containing complex 2 1

Expansion

Sequence features

A4HXQ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXQ8

Function

Biological processes
Term Name Level Count
GO:0006605 protein targeting 5 1
GO:0006612 protein targeting to membrane 5 1
GO:0006613 cotranslational protein targeting to membrane 6 1
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 7 1
GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane 6 1
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0045047 protein targeting to ER 6 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051668 localization within membrane 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0070972 protein localization to endoplasmic reticulum 6 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072599 establishment of protein localization to endoplasmic reticulum 5 1
GO:0072657 protein localization to membrane 4 1
GO:0090150 establishment of protein localization to membrane 4 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0008320 protein transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1
GO:0022884 macromolecule transmembrane transporter activity 3 1
GO:0140318 protein transporter activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 111 115 PF00656 0.525
CLV_NRD_NRD_1 104 106 PF00675 0.697
CLV_NRD_NRD_1 172 174 PF00675 0.602
CLV_NRD_NRD_1 216 218 PF00675 0.399
CLV_NRD_NRD_1 226 228 PF00675 0.401
CLV_NRD_NRD_1 73 75 PF00675 0.434
CLV_PCSK_KEX2_1 172 174 PF00082 0.602
CLV_PCSK_SKI1_1 12 16 PF00082 0.661
CLV_PCSK_SKI1_1 201 205 PF00082 0.312
DEG_APCC_DBOX_1 200 208 PF00400 0.353
DEG_APCC_DBOX_1 7 15 PF00400 0.501
DEG_MDM2_SWIB_1 189 196 PF02201 0.287
DEG_Nend_UBRbox_1 1 4 PF02207 0.414
DOC_CYCLIN_RxL_1 227 240 PF00134 0.550
DOC_MAPK_DCC_7 227 237 PF00069 0.576
DOC_MAPK_MEF2A_6 201 208 PF00069 0.279
DOC_MAPK_NFAT4_5 201 209 PF00069 0.280
DOC_PP1_RVXF_1 199 206 PF00149 0.344
DOC_PP4_MxPP_1 207 210 PF00568 0.379
DOC_SPAK_OSR1_1 188 192 PF12202 0.303
DOC_USP7_MATH_1 81 85 PF00917 0.248
DOC_USP7_UBL2_3 214 218 PF12436 0.652
DOC_USP7_UBL2_3 62 66 PF12436 0.263
LIG_14-3-3_CanoR_1 236 243 PF00244 0.568
LIG_14-3-3_CanoR_1 43 51 PF00244 0.367
LIG_Actin_WH2_1 188 203 PF00022 0.397
LIG_Actin_WH2_2 174 190 PF00022 0.367
LIG_AP2alpha_2 155 157 PF02296 0.451
LIG_BIR_III_4 79 83 PF00653 0.234
LIG_EH_1 173 177 PF12763 0.403
LIG_FHA_1 13 19 PF00498 0.422
LIG_FHA_1 147 153 PF00498 0.379
LIG_FHA_1 26 32 PF00498 0.468
LIG_FHA_1 33 39 PF00498 0.425
LIG_IBAR_NPY_1 49 51 PF08397 0.225
LIG_LIR_Gen_1 139 147 PF02991 0.367
LIG_LIR_Gen_1 93 102 PF02991 0.281
LIG_LIR_Nem_3 139 143 PF02991 0.376
LIG_LIR_Nem_3 85 91 PF02991 0.256
LIG_LIR_Nem_3 93 98 PF02991 0.273
LIG_MAD2 70 78 PF02301 0.234
LIG_PDZ_Class_2 239 244 PF00595 0.584
LIG_Pex14_1 193 197 PF04695 0.251
LIG_Pex14_2 189 193 PF04695 0.324
LIG_Pex14_2 208 212 PF04695 0.593
LIG_SH2_CRK 51 55 PF00017 0.263
LIG_SH2_CRK 69 73 PF00017 0.263
LIG_SH2_STAP1 140 144 PF00017 0.361
LIG_SH2_STAT5 128 131 PF00017 0.482
LIG_SH2_STAT5 51 54 PF00017 0.229
LIG_SH3_1 228 234 PF00018 0.600
LIG_SH3_1 75 81 PF00018 0.246
LIG_SH3_2 231 236 PF14604 0.613
LIG_SH3_3 226 232 PF00018 0.631
LIG_SH3_3 75 81 PF00018 0.246
LIG_SH3_4 214 221 PF00018 0.677
LIG_UBA3_1 204 211 PF00899 0.535
LIG_WW_3 219 223 PF00397 0.725
MOD_CK1_1 136 142 PF00069 0.388
MOD_Cter_Amidation 225 228 PF01082 0.421
MOD_GlcNHglycan 109 113 PF01048 0.683
MOD_GlcNHglycan 123 126 PF01048 0.692
MOD_GlcNHglycan 3 6 PF01048 0.575
MOD_GlcNHglycan 99 102 PF01048 0.598
MOD_GSK3_1 129 136 PF00069 0.499
MOD_NEK2_1 1 6 PF00069 0.419
MOD_NEK2_1 126 131 PF00069 0.423
MOD_NEK2_1 25 30 PF00069 0.469
MOD_PIKK_1 37 43 PF00454 0.490
MOD_PKA_2 1 7 PF00069 0.483
MOD_PKA_2 121 127 PF00069 0.379
MOD_PKA_2 235 241 PF00069 0.570
MOD_Plk_4 49 55 PF00069 0.224
MOD_SUMO_for_1 210 213 PF00179 0.583
MOD_SUMO_rev_2 61 68 PF00179 0.296
TRG_DiLeu_BaLyEn_6 34 39 PF01217 0.576
TRG_ENDOCYTIC_2 123 126 PF00928 0.402
TRG_ENDOCYTIC_2 140 143 PF00928 0.398
TRG_ENDOCYTIC_2 144 147 PF00928 0.345
TRG_ENDOCYTIC_2 51 54 PF00928 0.263
TRG_ENDOCYTIC_2 69 72 PF00928 0.263
TRG_ENDOCYTIC_2 95 98 PF00928 0.283
TRG_ER_diArg_1 171 173 PF00400 0.421
TRG_ER_diArg_1 224 227 PF00400 0.682

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA62 Leptomonas seymouri 74% 100%
A0A1X0NIB0 Trypanosomatidae 29% 100%
A0A1X0P719 Trypanosomatidae 65% 100%
A0A3Q8IAY4 Leishmania donovani 100% 100%
A0A3R7M6A3 Trypanosoma rangeli 60% 100%
A0A3S7X515 Leishmania donovani 28% 100%
A4H9D7 Leishmania braziliensis 85% 100%
A4HJV4 Leishmania braziliensis 28% 100%
A4I7B6 Leishmania infantum 28% 100%
B6DTF2 Bodo saltans 62% 100%
D0A039 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
E9ARH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9B2A9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q5U7 Leishmania major 29% 100%
Q4QE09 Leishmania major 97% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS