Uncharacterized protein

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXQ6_LEIIN

TriTrypDb:

LINF_180008000

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0005930	axoneme	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	4
GO:1990904	ribonucleoprotein complex	2	1
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	3
GO:0043229	intracellular organelle	3	3

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HXQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXQ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.601
CLV_NRD_NRD_1	313	315	PF00675	0.629
CLV_NRD_NRD_1	370	372	PF00675	0.720
CLV_NRD_NRD_1	379	381	PF00675	0.639
CLV_PCSK_KEX2_1	311	313	PF00082	0.615
CLV_PCSK_KEX2_1	370	372	PF00082	0.508
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.592
CLV_PCSK_SKI1_1	242	246	PF00082	0.702
CLV_PCSK_SKI1_1	382	386	PF00082	0.614
DEG_Nend_UBRbox_1	1	4	PF02207	0.450
DEG_SPOP_SBC_1	265	269	PF00917	0.549
DEG_SPOP_SBC_1	283	287	PF00917	0.334
DEG_SPOP_SBC_1	76	80	PF00917	0.482
DOC_CKS1_1	294	299	PF01111	0.483
DOC_CKS1_1	33	38	PF01111	0.427
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.538
DOC_USP7_MATH_1	159	163	PF00917	0.654
DOC_USP7_MATH_1	165	169	PF00917	0.588
DOC_USP7_MATH_1	250	254	PF00917	0.691
DOC_USP7_MATH_1	77	81	PF00917	0.504
DOC_USP7_UBL2_3	238	242	PF12436	0.730
DOC_USP7_UBL2_3	260	264	PF12436	0.730
DOC_USP7_UBL2_3	381	385	PF12436	0.695
DOC_USP7_UBL2_3	84	88	PF12436	0.509
DOC_WW_Pin1_4	132	137	PF00397	0.541
DOC_WW_Pin1_4	154	159	PF00397	0.560
DOC_WW_Pin1_4	248	253	PF00397	0.649
DOC_WW_Pin1_4	293	298	PF00397	0.515
DOC_WW_Pin1_4	32	37	PF00397	0.432
LIG_14-3-3_CanoR_1	2	8	PF00244	0.438
LIG_FHA_1	111	117	PF00498	0.505
LIG_FHA_1	12	18	PF00498	0.406
LIG_FHA_1	133	139	PF00498	0.628
LIG_FHA_1	19	25	PF00498	0.389
LIG_FHA_1	227	233	PF00498	0.653
LIG_FHA_1	27	33	PF00498	0.393
LIG_FHA_1	99	105	PF00498	0.389
LIG_FHA_2	284	290	PF00498	0.419
LIG_LIR_Gen_1	122	130	PF02991	0.584
LIG_LIR_Gen_1	322	333	PF02991	0.417
LIG_LIR_Nem_3	122	126	PF02991	0.482
LIG_LIR_Nem_3	271	277	PF02991	0.450
LIG_LIR_Nem_3	322	328	PF02991	0.412
LIG_NRBOX	52	58	PF00104	0.539
LIG_PDZ_Class_2	381	386	PF00595	0.615
LIG_SH2_CRK	123	127	PF00017	0.560
LIG_SH2_CRK	275	279	PF00017	0.361
LIG_SH2_NCK_1	123	127	PF00017	0.574
LIG_SH2_SRC	275	278	PF00017	0.408
LIG_SH2_STAP1	275	279	PF00017	0.361
LIG_SH2_STAT5	34	37	PF00017	0.393
LIG_SH2_STAT5	340	343	PF00017	0.453
LIG_SH3_3	21	27	PF00018	0.379
LIG_SH3_3	291	297	PF00018	0.481
LIG_SH3_4	260	267	PF00018	0.646
LIG_SUMO_SIM_anti_2	28	35	PF11976	0.215
LIG_TRAF2_1	286	289	PF00917	0.453
LIG_TYR_ITIM	121	126	PF00017	0.521
LIG_TYR_ITIM	272	277	PF00017	0.415
MOD_CDK_SPxxK_3	132	139	PF00069	0.644
MOD_CK1_1	253	259	PF00069	0.710
MOD_CK1_1	55	61	PF00069	0.556
MOD_CK2_1	104	110	PF00069	0.426
MOD_CK2_1	202	208	PF00069	0.524
MOD_CK2_1	282	288	PF00069	0.441
MOD_GlcNHglycan	123	126	PF01048	0.563
MOD_GlcNHglycan	161	164	PF01048	0.623
MOD_GlcNHglycan	167	170	PF01048	0.599
MOD_GlcNHglycan	252	255	PF01048	0.661
MOD_GlcNHglycan	36	39	PF01048	0.501
MOD_GlcNHglycan	365	368	PF01048	0.671
MOD_GlcNHglycan	79	82	PF01048	0.517
MOD_GlcNHglycan	92	95	PF01048	0.532
MOD_GSK3_1	115	122	PF00069	0.403
MOD_GSK3_1	264	271	PF00069	0.699
MOD_GSK3_1	317	324	PF00069	0.539
MOD_GSK3_1	51	58	PF00069	0.513
MOD_GSK3_1	90	97	PF00069	0.491
MOD_NEK2_1	121	126	PF00069	0.496
MOD_NEK2_1	221	226	PF00069	0.632
MOD_NEK2_1	56	61	PF00069	0.536
MOD_PIKK_1	94	100	PF00454	0.479
MOD_PKA_1	312	318	PF00069	0.555
MOD_PKA_2	1	7	PF00069	0.510
MOD_PKA_2	226	232	PF00069	0.627
MOD_PKA_2	312	318	PF00069	0.628
MOD_PKA_2	369	375	PF00069	0.643
MOD_Plk_1	51	57	PF00069	0.514
MOD_Plk_4	19	25	PF00069	0.356
MOD_Plk_4	268	274	PF00069	0.607
MOD_Plk_4	336	342	PF00069	0.462
MOD_Plk_4	52	58	PF00069	0.544
MOD_ProDKin_1	132	138	PF00069	0.541
MOD_ProDKin_1	154	160	PF00069	0.562
MOD_ProDKin_1	248	254	PF00069	0.649
MOD_ProDKin_1	293	299	PF00069	0.508
MOD_ProDKin_1	32	38	PF00069	0.427
MOD_SUMO_for_1	307	310	PF00179	0.558
MOD_SUMO_rev_2	285	291	PF00179	0.558
TRG_DiLeu_BaEn_1	52	57	PF01217	0.501
TRG_ENDOCYTIC_2	123	126	PF00928	0.546
TRG_ENDOCYTIC_2	274	277	PF00928	0.388
TRG_ER_diArg_1	312	314	PF00400	0.639
TRG_ER_diArg_1	370	373	PF00400	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAH4	Leptomonas seymouri	53%	97%
A0A1X0P6X4	Trypanosomatidae	31%	76%
A0A3S7WUR4	Leishmania donovani	98%	100%
A0A422NWQ6	Trypanosoma rangeli	28%	83%
A4H9D4	Leishmania braziliensis	63%	93%
B6DTE9	Bodo saltans	25%	85%
D0A036	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	90%
E9ARG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QE12	Leishmania major	84%	95%