LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative RNA-binding protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative RNA-binding protein
Gene product:
RNA-binding protein 29 - putative
Species:
Leishmania infantum
UniProt:
A4HXP8_LEIIN
TriTrypDb:
LINF_180007200
Length:
409

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA-binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005654 nucleoplasm 2 1
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex 4 1
GO:0005849 mRNA cleavage factor complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
GO:0140513 nuclear protein-containing complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HXP8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXP8

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006379 mRNA cleavage 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:0090305 nucleic acid phosphodiester bond hydrolysis 5 1
GO:0090501 RNA phosphodiester bond hydrolysis 6 1
GO:0098787 mRNA cleavage involved in mRNA processing 8 1
GO:0098789 pre-mRNA cleavage required for polyadenylation 9 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 7
GO:0003723 RNA binding 4 7
GO:0005488 binding 1 7
GO:0097159 organic cyclic compound binding 2 7
GO:1901363 heterocyclic compound binding 2 7
GO:0003729 mRNA binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 176 180 PF00656 0.628
CLV_NRD_NRD_1 358 360 PF00675 0.493
CLV_NRD_NRD_1 366 368 PF00675 0.539
CLV_NRD_NRD_1 75 77 PF00675 0.290
CLV_PCSK_KEX2_1 401 403 PF00082 0.714
CLV_PCSK_PC1ET2_1 401 403 PF00082 0.714
CLV_PCSK_SKI1_1 134 138 PF00082 0.464
CLV_PCSK_SKI1_1 19 23 PF00082 0.274
CLV_PCSK_SKI1_1 27 31 PF00082 0.274
CLV_PCSK_SKI1_1 398 402 PF00082 0.601
CLV_PCSK_SKI1_1 64 68 PF00082 0.235
CLV_PCSK_SKI1_1 76 80 PF00082 0.274
CLV_Separin_Metazoa 356 360 PF03568 0.502
DEG_APCC_DBOX_1 133 141 PF00400 0.487
DEG_SCF_FBW7_1 1 8 PF00400 0.652
DOC_MAPK_gen_1 76 82 PF00069 0.474
DOC_MAPK_MEF2A_6 297 304 PF00069 0.544
DOC_PP2B_LxvP_1 203 206 PF13499 0.727
DOC_PP4_FxxP_1 334 337 PF00568 0.724
DOC_PP4_MxPP_1 265 268 PF00568 0.720
DOC_PP4_MxPP_1 286 289 PF00568 0.713
DOC_USP7_MATH_1 198 202 PF00917 0.543
DOC_USP7_MATH_1 382 386 PF00917 0.656
DOC_USP7_MATH_1 400 404 PF00917 0.625
DOC_USP7_UBL2_3 345 349 PF12436 0.604
DOC_USP7_UBL2_3 360 364 PF12436 0.426
DOC_USP7_UBL2_3 368 372 PF12436 0.546
DOC_USP7_UBL2_3 397 401 PF12436 0.623
DOC_USP7_UBL2_3 405 409 PF12436 0.616
DOC_WW_Pin1_4 1 6 PF00397 0.672
DOC_WW_Pin1_4 123 128 PF00397 0.624
DOC_WW_Pin1_4 148 153 PF00397 0.489
DOC_WW_Pin1_4 179 184 PF00397 0.757
LIG_Actin_WH2_2 14 29 PF00022 0.474
LIG_BIR_II_1 1 5 PF00653 0.577
LIG_eIF4E_1 68 74 PF01652 0.474
LIG_FHA_1 341 347 PF00498 0.529
LIG_FHA_2 174 180 PF00498 0.631
LIG_FHA_2 33 39 PF00498 0.474
LIG_FHA_2 56 62 PF00498 0.474
LIG_Integrin_isoDGR_2 42 44 PF01839 0.274
LIG_LIR_Gen_1 352 362 PF02991 0.504
LIG_LIR_Nem_3 352 358 PF02991 0.506
LIG_LIR_Nem_3 8 13 PF02991 0.417
LIG_SH2_STAP1 365 369 PF00017 0.467
LIG_SH2_STAT5 13 16 PF00017 0.474
LIG_SH3_1 297 303 PF00018 0.641
LIG_SH3_3 265 271 PF00018 0.649
LIG_SH3_3 297 303 PF00018 0.581
LIG_SH3_3 84 90 PF00018 0.535
LIG_TRAF2_2 273 278 PF00917 0.675
LIG_UBA3_1 136 144 PF00899 0.445
LIG_WW_3 266 270 PF00397 0.647
MOD_CK1_1 175 181 PF00069 0.641
MOD_CK1_1 385 391 PF00069 0.627
MOD_CK2_1 400 406 PF00069 0.603
MOD_Cter_Amidation 74 77 PF01082 0.274
MOD_GlcNHglycan 1 4 PF01048 0.608
MOD_GlcNHglycan 166 169 PF01048 0.539
MOD_GlcNHglycan 184 187 PF01048 0.654
MOD_GlcNHglycan 196 199 PF01048 0.723
MOD_GlcNHglycan 210 213 PF01048 0.536
MOD_GlcNHglycan 259 262 PF01048 0.685
MOD_GlcNHglycan 321 324 PF01048 0.677
MOD_GlcNHglycan 383 387 PF01048 0.630
MOD_GlcNHglycan 388 391 PF01048 0.617
MOD_GSK3_1 1 8 PF00069 0.652
MOD_GSK3_1 171 178 PF00069 0.623
MOD_GSK3_1 194 201 PF00069 0.724
MOD_GSK3_1 204 211 PF00069 0.560
MOD_GSK3_1 382 389 PF00069 0.735
MOD_GSK3_1 400 407 PF00069 0.428
MOD_N-GLC_1 171 176 PF02516 0.658
MOD_NEK2_1 118 123 PF00069 0.537
MOD_NEK2_1 157 162 PF00069 0.492
MOD_NEK2_1 194 199 PF00069 0.711
MOD_NEK2_1 208 213 PF00069 0.546
MOD_NEK2_2 340 345 PF00069 0.582
MOD_Plk_1 17 23 PF00069 0.474
MOD_Plk_1 37 43 PF00069 0.311
MOD_Plk_2-3 55 61 PF00069 0.474
MOD_Plk_4 251 257 PF00069 0.705
MOD_Plk_4 32 38 PF00069 0.474
MOD_ProDKin_1 1 7 PF00069 0.663
MOD_ProDKin_1 123 129 PF00069 0.618
MOD_ProDKin_1 148 154 PF00069 0.482
MOD_ProDKin_1 179 185 PF00069 0.756
MOD_SUMO_rev_2 361 369 PF00179 0.513
MOD_SUMO_rev_2 389 399 PF00179 0.623
TRG_DiLeu_BaEn_1 132 137 PF01217 0.476
TRG_DiLeu_BaLyEn_6 131 136 PF01217 0.477
TRG_ENDOCYTIC_2 263 266 PF00928 0.650
TRG_ENDOCYTIC_2 68 71 PF00928 0.474
TRG_NLS_MonoExtC_3 400 405 PF00514 0.623
TRG_NLS_MonoExtN_4 398 405 PF00514 0.622
TRG_Pf-PMV_PEXEL_1 134 138 PF00026 0.489
TRG_Pf-PMV_PEXEL_1 367 371 PF00026 0.534

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P353 Leptomonas seymouri 54% 100%
A0A3Q8IE55 Leishmania donovani 100% 100%
E9AI57 Leishmania braziliensis 85% 100%
E9ARF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QE20 Leishmania major 95% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS