LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Activator of Hsp90 ATPase - N-terminal/Activator of Hsp90 ATPase homolog 1-like protein - putative
Species:
Leishmania infantum
UniProt:
A4HXP7_LEIIN
TriTrypDb:
LINF_180007100
Length:
351

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Activator of Hsp90 ATPase, N-terminal

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HXP7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXP7

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
GO:0032781 positive regulation of ATP-dependent activity 4 1
GO:0043462 regulation of ATP-dependent activity 3 1
GO:0044093 positive regulation of molecular function 3 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
Molecular functions
Term Name Level Count
GO:0001671 ATPase activator activity 3 12
GO:0005488 binding 1 12
GO:0005515 protein binding 2 12
GO:0031072 heat shock protein binding 3 12
GO:0051087 protein-folding chaperone binding 3 12
GO:0051879 Hsp90 protein binding 4 12
GO:0098772 molecular function regulator activity 1 12
GO:0140677 molecular function activator activity 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 129 133 PF00656 0.458
CLV_C14_Caspase3-7 15 19 PF00656 0.541
CLV_NRD_NRD_1 78 80 PF00675 0.261
CLV_PCSK_SKI1_1 171 175 PF00082 0.512
CLV_PCSK_SKI1_1 341 345 PF00082 0.261
CLV_PCSK_SKI1_1 41 45 PF00082 0.287
DOC_PP2B_LxvP_1 179 182 PF13499 0.551
DOC_USP7_MATH_1 188 192 PF00917 0.744
DOC_USP7_UBL2_3 90 94 PF12436 0.456
DOC_WW_Pin1_4 190 195 PF00397 0.674
DOC_WW_Pin1_4 247 252 PF00397 0.547
LIG_14-3-3_CanoR_1 149 153 PF00244 0.547
LIG_14-3-3_CanoR_1 249 255 PF00244 0.485
LIG_BIR_II_1 1 5 PF00653 0.543
LIG_BRCT_BRCA1_1 217 221 PF00533 0.519
LIG_CtBP_PxDLS_1 52 56 PF00389 0.477
LIG_deltaCOP1_diTrp_1 330 337 PF00928 0.461
LIG_EVH1_1 179 183 PF00568 0.599
LIG_FHA_1 100 106 PF00498 0.441
LIG_FHA_1 196 202 PF00498 0.695
LIG_FHA_1 251 257 PF00498 0.566
LIG_FHA_2 127 133 PF00498 0.476
LIG_FHA_2 156 162 PF00498 0.497
LIG_FHA_2 309 315 PF00498 0.491
LIG_LIR_Gen_1 158 167 PF02991 0.459
LIG_LIR_Gen_1 233 241 PF02991 0.455
LIG_LIR_Gen_1 270 281 PF02991 0.471
LIG_LIR_Gen_1 58 67 PF02991 0.550
LIG_LIR_LC3C_4 297 300 PF02991 0.483
LIG_LIR_Nem_3 158 163 PF02991 0.467
LIG_LIR_Nem_3 233 238 PF02991 0.445
LIG_LIR_Nem_3 270 276 PF02991 0.471
LIG_LIR_Nem_3 58 64 PF02991 0.550
LIG_Pex14_1 332 336 PF04695 0.461
LIG_Pex14_2 160 164 PF04695 0.461
LIG_SH2_CRK 235 239 PF00017 0.526
LIG_SH2_PTP2 273 276 PF00017 0.522
LIG_SH2_SRC 124 127 PF00017 0.522
LIG_SH2_SRC 167 170 PF00017 0.430
LIG_SH2_SRC 273 276 PF00017 0.522
LIG_SH2_STAP1 124 128 PF00017 0.473
LIG_SH2_STAP1 346 350 PF00017 0.381
LIG_SH2_STAT5 247 250 PF00017 0.461
LIG_SH2_STAT5 273 276 PF00017 0.500
LIG_SH2_STAT5 61 64 PF00017 0.538
LIG_SH2_STAT5 86 89 PF00017 0.461
LIG_SH3_3 177 183 PF00018 0.585
LIG_SUMO_SIM_anti_2 297 302 PF11976 0.533
LIG_TRAF2_1 327 330 PF00917 0.522
LIG_TYR_ITIM 59 64 PF00017 0.547
LIG_WRC_WIRS_1 156 161 PF05994 0.497
MOD_CK1_1 14 20 PF00069 0.655
MOD_CK1_1 186 192 PF00069 0.752
MOD_CK1_1 193 199 PF00069 0.700
MOD_CK1_1 209 215 PF00069 0.522
MOD_CK1_1 242 248 PF00069 0.482
MOD_CK1_1 250 256 PF00069 0.459
MOD_CK1_1 33 39 PF00069 0.547
MOD_CK1_1 68 74 PF00069 0.467
MOD_CK2_1 211 217 PF00069 0.705
MOD_CK2_1 308 314 PF00069 0.477
MOD_CK2_1 324 330 PF00069 0.473
MOD_Cter_Amidation 201 204 PF01082 0.618
MOD_GlcNHglycan 174 177 PF01048 0.673
MOD_GlcNHglycan 186 189 PF01048 0.677
MOD_GlcNHglycan 269 272 PF01048 0.310
MOD_GlcNHglycan 317 320 PF01048 0.335
MOD_GlcNHglycan 69 73 PF01048 0.261
MOD_GSK3_1 184 191 PF00069 0.711
MOD_GSK3_1 202 209 PF00069 0.654
MOD_GSK3_1 211 218 PF00069 0.567
MOD_GSK3_1 309 316 PF00069 0.563
MOD_GSK3_1 35 42 PF00069 0.548
MOD_GSK3_1 68 75 PF00069 0.465
MOD_LATS_1 37 43 PF00433 0.558
MOD_N-GLC_1 215 220 PF02516 0.576
MOD_NEK2_1 313 318 PF00069 0.550
MOD_NEK2_1 89 94 PF00069 0.475
MOD_NEK2_2 148 153 PF00069 0.547
MOD_PIKK_1 134 140 PF00454 0.470
MOD_PIKK_1 30 36 PF00454 0.547
MOD_PIKK_1 313 319 PF00454 0.566
MOD_PK_1 39 45 PF00069 0.566
MOD_PKA_1 203 209 PF00069 0.740
MOD_PKA_2 148 154 PF00069 0.545
MOD_Plk_1 216 222 PF00069 0.514
MOD_Plk_1 72 78 PF00069 0.453
MOD_Plk_2-3 155 161 PF00069 0.537
MOD_Plk_2-3 324 330 PF00069 0.539
MOD_Plk_4 139 145 PF00069 0.547
MOD_Plk_4 155 161 PF00069 0.547
MOD_Plk_4 242 248 PF00069 0.478
MOD_Plk_4 277 283 PF00069 0.514
MOD_Plk_4 294 300 PF00069 0.379
MOD_Plk_4 39 45 PF00069 0.556
MOD_ProDKin_1 190 196 PF00069 0.670
MOD_ProDKin_1 247 253 PF00069 0.547
MOD_SUMO_for_1 304 307 PF00179 0.488
MOD_SUMO_for_1 62 65 PF00179 0.547
MOD_SUMO_rev_2 250 258 PF00179 0.547
TRG_ENDOCYTIC_2 235 238 PF00928 0.537
TRG_ENDOCYTIC_2 273 276 PF00928 0.522
TRG_ENDOCYTIC_2 61 64 PF00928 0.547
TRG_ENDOCYTIC_2 86 89 PF00928 0.461
TRG_NES_CRM1_1 53 66 PF08389 0.520
TRG_Pf-PMV_PEXEL_1 30 34 PF00026 0.273

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2A4 Leptomonas seymouri 71% 99%
A0A0S4JAT2 Bodo saltans 48% 100%
A0A1X0P6W4 Trypanosomatidae 58% 100%
A0A3R7MY48 Trypanosoma rangeli 54% 100%
A0A3S7WUS5 Leishmania donovani 99% 100%
A4H9C6 Leishmania braziliensis 84% 100%
A6QQC0 Bos taurus 27% 100%
D0A023 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9ARF8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
O95433 Homo sapiens 31% 100%
Q12449 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
Q4QE21 Leishmania major 96% 100%
Q8BK64 Mus musculus 30% 100%
Q8N9S3 Mus musculus 28% 100%
Q9P782 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
V5B6E4 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS