RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM - RBD - or RNP domain)/RNA recognition motif (a.k.a. RRM - RBD - or RNP domain) - putative

Species:

Leishmania infantum

UniProt:

A4HXP5_LEIIN

TriTrypDb:

LINF_180006900

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

A4HXP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXP5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0008143	poly(A) binding	7	2
GO:0008187	poly-pyrimidine tract binding	6	2
GO:0008266	poly(U) RNA binding	7	2
GO:0070717	poly-purine tract binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.447
CLV_C14_Caspase3-7	290	294	PF00656	0.571
CLV_NRD_NRD_1	162	164	PF00675	0.260
CLV_NRD_NRD_1	338	340	PF00675	0.459
CLV_PCSK_KEX2_1	162	164	PF00082	0.288
CLV_PCSK_KEX2_1	338	340	PF00082	0.459
CLV_PCSK_KEX2_1	88	90	PF00082	0.251
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.251
CLV_PCSK_SKI1_1	118	122	PF00082	0.338
CLV_PCSK_SKI1_1	163	167	PF00082	0.246
CLV_PCSK_SKI1_1	41	45	PF00082	0.289
CLV_PCSK_SKI1_1	57	61	PF00082	0.289
DEG_SCF_FBW7_1	262	267	PF00400	0.594
DOC_MAPK_gen_1	113	121	PF00069	0.424
DOC_MAPK_gen_1	162	169	PF00069	0.488
DOC_MAPK_MEF2A_6	23	30	PF00069	0.320
DOC_MAPK_MEF2A_6	304	311	PF00069	0.584
DOC_PP1_RVXF_1	160	167	PF00149	0.489
DOC_PP1_RVXF_1	39	45	PF00149	0.464
DOC_PP2B_LxvP_1	314	317	PF13499	0.529
DOC_PP2B_LxvP_1	334	337	PF13499	0.536
DOC_PP4_FxxP_1	223	226	PF00568	0.547
DOC_PP4_FxxP_1	43	46	PF00568	0.476
DOC_USP7_MATH_1	19	23	PF00917	0.434
DOC_USP7_MATH_1	264	268	PF00917	0.616
DOC_USP7_MATH_1	275	279	PF00917	0.610
DOC_USP7_MATH_1	287	291	PF00917	0.653
DOC_WW_Pin1_4	104	109	PF00397	0.488
DOC_WW_Pin1_4	258	263	PF00397	0.561
DOC_WW_Pin1_4	278	283	PF00397	0.754
DOC_WW_Pin1_4	303	308	PF00397	0.643
LIG_14-3-3_CanoR_1	310	315	PF00244	0.697
LIG_14-3-3_CterR_2	338	342	PF00244	0.560
LIG_APCC_ABBA_1	166	171	PF00400	0.476
LIG_APCC_ABBA_1	40	45	PF00400	0.474
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BRCT_BRCA1_1	63	67	PF00533	0.443
LIG_FHA_1	311	317	PF00498	0.547
LIG_FHA_2	127	133	PF00498	0.470
LIG_FHA_2	140	146	PF00498	0.470
LIG_FHA_2	16	22	PF00498	0.464
LIG_IBAR_NPY_1	328	330	PF08397	0.698
LIG_LIR_Gen_1	245	256	PF02991	0.539
LIG_LIR_Nem_3	245	251	PF02991	0.560
LIG_LIR_Nem_3	37	43	PF02991	0.521
LIG_LIR_Nem_3	45	50	PF02991	0.601
LIG_LIR_Nem_3	64	70	PF02991	0.424
LIG_NRBOX	132	138	PF00104	0.451
LIG_Pex14_2	40	44	PF04695	0.452
LIG_SH2_CRK	140	144	PF00017	0.605
LIG_SH2_STAP1	330	334	PF00017	0.650
LIG_SH3_3	316	322	PF00018	0.531
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.462
LIG_TRAF2_1	109	112	PF00917	0.652
LIG_TRAF2_1	297	300	PF00917	0.567
LIG_UBA3_1	196	205	PF00899	0.404
LIG_WRC_WIRS_1	248	253	PF05994	0.569
MOD_CDK_SPxxK_3	303	310	PF00069	0.582
MOD_CK1_1	147	153	PF00069	0.507
MOD_CK1_1	15	21	PF00069	0.438
MOD_CK1_1	211	217	PF00069	0.690
MOD_CK1_1	224	230	PF00069	0.598
MOD_CK1_1	278	284	PF00069	0.742
MOD_CK2_1	126	132	PF00069	0.473
MOD_CK2_1	139	145	PF00069	0.402
MOD_CK2_1	270	276	PF00069	0.676
MOD_Cter_Amidation	86	89	PF01082	0.243
MOD_GlcNHglycan	210	213	PF01048	0.592
MOD_GlcNHglycan	223	226	PF01048	0.553
MOD_GlcNHglycan	272	275	PF01048	0.550
MOD_GlcNHglycan	282	285	PF01048	0.553
MOD_GlcNHglycan	74	77	PF01048	0.280
MOD_GSK3_1	15	22	PF00069	0.594
MOD_GSK3_1	208	215	PF00069	0.712
MOD_GSK3_1	260	267	PF00069	0.560
MOD_N-GLC_1	212	217	PF02516	0.691
MOD_N-GLC_1	221	226	PF02516	0.574
MOD_N-GLC_2	184	186	PF02516	0.289
MOD_NEK2_1	270	275	PF00069	0.583
MOD_NEK2_1	309	314	PF00069	0.572
MOD_NEK2_2	264	269	PF00069	0.586
MOD_NEK2_2	275	280	PF00069	0.492
MOD_OFUCOSY	186	191	PF10250	0.366
MOD_PIKK_1	287	293	PF00454	0.538
MOD_PIKK_1	35	41	PF00454	0.451
MOD_PKA_2	12	18	PF00069	0.590
MOD_PKA_2	309	315	PF00069	0.610
MOD_Plk_1	144	150	PF00069	0.443
MOD_Plk_1	275	281	PF00069	0.606
MOD_Plk_1	35	41	PF00069	0.471
MOD_Plk_4	275	281	PF00069	0.475
MOD_Plk_4	330	336	PF00069	0.713
MOD_Plk_4	50	56	PF00069	0.489
MOD_ProDKin_1	104	110	PF00069	0.487
MOD_ProDKin_1	258	264	PF00069	0.562
MOD_ProDKin_1	278	284	PF00069	0.754
MOD_ProDKin_1	303	309	PF00069	0.643
MOD_SUMO_rev_2	15	24	PF00179	0.420
MOD_SUMO_rev_2	201	206	PF00179	0.476
MOD_SUMO_rev_2	84	90	PF00179	0.476
TRG_DiLeu_BaEn_1	132	137	PF01217	0.476
TRG_ENDOCYTIC_2	140	143	PF00928	0.605
TRG_ER_diArg_1	11	14	PF00400	0.548
TRG_ER_diArg_1	162	164	PF00400	0.488
TRG_ER_diArg_1	337	339	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUA1	Leptomonas seymouri	51%	97%
A0A3Q8IAV4	Leishmania donovani	100%	100%
A0A3Q8IAX1	Leishmania donovani	48%	99%
A4H9C2	Leishmania braziliensis	47%	99%
A4H9C4	Leishmania braziliensis	82%	100%
A4HXP3	Leishmania infantum	48%	99%
E9ARF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9ARF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QE23	Leishmania major	97%	100%
Q4QE25	Leishmania major	48%	99%
Q8IUH3	Homo sapiens	24%	72%
Q9FPJ8	Arabidopsis thaliana	23%	88%