RNA recognition motif family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM - RBD - or RNP domain)/RNA recognition motif (a.k.a. RRM - RBD - or RNP domain) - putative

Species:

Leishmania infantum

UniProt:

A4HXP3_LEIIN

TriTrypDb:

LINF_180006700

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	3
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HXP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXP3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	15
GO:0003723	RNA binding	4	15
GO:0005488	binding	1	15
GO:0097159	organic cyclic compound binding	2	15
GO:1901363	heterocyclic compound binding	2	15
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	3
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0008143	poly(A) binding	7	2
GO:0008187	poly-pyrimidine tract binding	6	2
GO:0008266	poly(U) RNA binding	7	2
GO:0070717	poly-purine tract binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.519
CLV_NRD_NRD_1	145	147	PF00675	0.401
CLV_NRD_NRD_1	164	166	PF00675	0.300
CLV_NRD_NRD_1	255	257	PF00675	0.568
CLV_PCSK_KEX2_1	163	165	PF00082	0.327
CLV_PCSK_KEX2_1	210	212	PF00082	0.620
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.552
CLV_PCSK_SKI1_1	120	124	PF00082	0.403
CLV_PCSK_SKI1_1	146	150	PF00082	0.344
CLV_PCSK_SKI1_1	165	169	PF00082	0.300
CLV_PCSK_SKI1_1	43	47	PF00082	0.332
DEG_Nend_UBRbox_3	1	3	PF02207	0.542
DEG_SCF_FBW7_1	279	286	PF00400	0.541
DEG_SPOP_SBC_1	321	325	PF00917	0.536
DOC_CKS1_1	20	25	PF01111	0.520
DOC_MAPK_gen_1	10	20	PF00069	0.481
DOC_MAPK_gen_1	115	123	PF00069	0.470
DOC_MAPK_gen_1	163	171	PF00069	0.505
DOC_MAPK_gen_1	82	92	PF00069	0.494
DOC_MAPK_MEF2A_6	163	171	PF00069	0.519
DOC_PP1_RVXF_1	162	169	PF00149	0.527
DOC_PP4_FxxP_1	20	23	PF00568	0.549
DOC_USP7_MATH_1	141	145	PF00917	0.541
DOC_USP7_MATH_1	206	210	PF00917	0.569
DOC_USP7_MATH_1	216	220	PF00917	0.590
DOC_USP7_MATH_1	236	240	PF00917	0.676
DOC_USP7_MATH_1	283	287	PF00917	0.762
DOC_USP7_MATH_1	321	325	PF00917	0.572
DOC_USP7_MATH_1	8	12	PF00917	0.592
DOC_WW_Pin1_4	1	6	PF00397	0.605
DOC_WW_Pin1_4	106	111	PF00397	0.528
DOC_WW_Pin1_4	137	142	PF00397	0.472
DOC_WW_Pin1_4	19	24	PF00397	0.480
DOC_WW_Pin1_4	227	232	PF00397	0.664
DOC_WW_Pin1_4	261	266	PF00397	0.592
DOC_WW_Pin1_4	279	284	PF00397	0.684
DOC_WW_Pin1_4	300	305	PF00397	0.703
LIG_14-3-3_CanoR_1	146	151	PF00244	0.453
LIG_14-3-3_CanoR_1	256	261	PF00244	0.519
LIG_14-3-3_CanoR_1	322	329	PF00244	0.653
LIG_Actin_WH2_2	30	45	PF00022	0.539
LIG_APCC_ABBA_1	148	153	PF00400	0.497
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.539
LIG_BIR_III_4	86	90	PF00653	0.491
LIG_BRCT_BRCA1_1	329	333	PF00533	0.618
LIG_FHA_1	152	158	PF00498	0.528
LIG_FHA_1	67	73	PF00498	0.541
LIG_FHA_1	94	100	PF00498	0.536
LIG_FHA_2	168	174	PF00498	0.556
LIG_IBAR_NPY_1	336	338	PF08397	0.650
LIG_LIR_Gen_1	44	52	PF02991	0.472
LIG_LIR_Nem_3	140	145	PF02991	0.522
LIG_LIR_Nem_3	26	32	PF02991	0.412
LIG_LIR_Nem_3	44	49	PF02991	0.499
LIG_LIR_Nem_3	69	74	PF02991	0.518
LIG_PCNA_yPIPBox_3	285	298	PF02747	0.518
LIG_PDZ_Class_1	342	347	PF00595	0.501
LIG_SH2_CRK	142	146	PF00017	0.566
LIG_SH2_CRK	338	342	PF00017	0.517
LIG_SH2_SRC	74	77	PF00017	0.472
LIG_SH2_STAP1	329	333	PF00017	0.532
LIG_SH2_STAT3	62	65	PF00017	0.491
LIG_SH2_STAT5	21	24	PF00017	0.466
LIG_SH2_STAT5	32	35	PF00017	0.461
LIG_SH3_3	239	245	PF00018	0.747
LIG_SH3_3	304	310	PF00018	0.630
LIG_SH3_CIN85_PxpxPR_1	304	309	PF14604	0.513
LIG_SUMO_SIM_par_1	126	134	PF11976	0.537
LIG_SxIP_EBH_1	237	247	PF03271	0.466
LIG_TRAF2_1	111	114	PF00917	0.581
LIG_TRAF2_1	274	277	PF00917	0.518
LIG_WRC_WIRS_1	168	173	PF05994	0.539
LIG_WRC_WIRS_1	260	265	PF05994	0.570
MOD_CDK_SPxK_1	279	285	PF00069	0.542
MOD_CK1_1	221	227	PF00069	0.710
MOD_CK1_1	235	241	PF00069	0.659
MOD_CK1_1	259	265	PF00069	0.644
MOD_CK1_1	275	281	PF00069	0.674
MOD_CK1_1	300	306	PF00069	0.578
MOD_CK1_1	315	321	PF00069	0.545
MOD_CK1_1	325	331	PF00069	0.641
MOD_CK1_1	63	69	PF00069	0.536
MOD_CK2_1	167	173	PF00069	0.539
MOD_CK2_1	270	276	PF00069	0.544
MOD_GlcNHglycan	234	237	PF01048	0.559
MOD_GlcNHglycan	46	49	PF01048	0.408
MOD_GlcNHglycan	62	65	PF01048	0.292
MOD_GSK3_1	137	144	PF00069	0.509
MOD_GSK3_1	19	26	PF00069	0.523
MOD_GSK3_1	214	221	PF00069	0.688
MOD_GSK3_1	225	232	PF00069	0.620
MOD_GSK3_1	252	259	PF00069	0.659
MOD_GSK3_1	271	278	PF00069	0.704
MOD_GSK3_1	279	286	PF00069	0.645
MOD_GSK3_1	312	319	PF00069	0.594
MOD_GSK3_1	321	328	PF00069	0.602
MOD_GSK3_1	9	16	PF00069	0.642
MOD_N-GLC_1	151	156	PF02516	0.339
MOD_N-GLC_1	214	219	PF02516	0.758
MOD_N-GLC_1	232	237	PF02516	0.483
MOD_N-GLC_1	252	257	PF02516	0.491
MOD_N-GLC_2	186	188	PF02516	0.327
MOD_NEK2_1	214	219	PF00069	0.730
MOD_NEK2_1	252	257	PF00069	0.554
MOD_NEK2_1	9	14	PF00069	0.637
MOD_NEK2_1	93	98	PF00069	0.615
MOD_NEK2_2	141	146	PF00069	0.553
MOD_PIKK_1	13	19	PF00454	0.669
MOD_PIKK_1	263	269	PF00454	0.557
MOD_PK_1	218	224	PF00069	0.653
MOD_PK_1	95	101	PF00069	0.604
MOD_PKA_1	146	152	PF00069	0.539
MOD_PKA_1	256	262	PF00069	0.514
MOD_PKA_2	236	242	PF00069	0.543
MOD_PKA_2	321	327	PF00069	0.684
MOD_PKA_2	9	15	PF00069	0.696
MOD_Plk_1	275	281	PF00069	0.638
MOD_Plk_1	316	322	PF00069	0.723
MOD_Plk_1	325	331	PF00069	0.535
MOD_Plk_4	336	342	PF00069	0.659
MOD_Plk_4	52	58	PF00069	0.506
MOD_ProDKin_1	1	7	PF00069	0.604
MOD_ProDKin_1	106	112	PF00069	0.528
MOD_ProDKin_1	137	143	PF00069	0.472
MOD_ProDKin_1	19	25	PF00069	0.472
MOD_ProDKin_1	227	233	PF00069	0.665
MOD_ProDKin_1	261	267	PF00069	0.592
MOD_ProDKin_1	279	285	PF00069	0.686
MOD_ProDKin_1	300	306	PF00069	0.704
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.472
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.491
TRG_ENDOCYTIC_2	142	145	PF00928	0.573
TRG_ENDOCYTIC_2	338	341	PF00928	0.617
TRG_ER_diArg_1	163	165	PF00400	0.566
TRG_ER_diArg_1	211	214	PF00400	0.627
TRG_NLS_MonoExtN_4	208	214	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P516	Leptomonas seymouri	57%	93%
A0A0N1HUA1	Leptomonas seymouri	46%	99%
A0A3Q8IAV4	Leishmania donovani	48%	100%
A0A3Q8IAX1	Leishmania donovani	100%	100%
A0A3R7NAH9	Trypanosoma rangeli	27%	71%
A4H9C2	Leishmania braziliensis	79%	100%
A4HXP5	Leishmania infantum	48%	100%
E9ARF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9ARF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9ARF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
Q4Q774	Leishmania major	26%	70%
Q4QE24	Leishmania major	76%	100%
Q4QE25	Leishmania major	96%	100%