LeishMANIAdb
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Protein-serine/threonine phosphatase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein-serine/threonine phosphatase
Gene product:
serine/threonine protein phosphatase type 5 - putative
Species:
Leishmania infantum
UniProt:
A4HXP1_LEIIN
TriTrypDb:
LINF_180006500
Length:
469

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Annotations by Jardim et al.

Phosphatase, serine/threonine phosphatase type 5

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005634 nucleus 5 1
GO:0005829 cytosol 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HXP1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXP1

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016311 dephosphorylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004721 phosphoprotein phosphatase activity 3 12
GO:0004722 protein serine/threonine phosphatase activity 4 12
GO:0016787 hydrolase activity 2 12
GO:0016788 hydrolase activity, acting on ester bonds 3 12
GO:0016791 phosphatase activity 5 12
GO:0017018 myosin phosphatase activity 5 12
GO:0042578 phosphoric ester hydrolase activity 4 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 103 107 PF00656 0.494
CLV_C14_Caspase3-7 202 206 PF00656 0.491
CLV_NRD_NRD_1 178 180 PF00675 0.338
CLV_NRD_NRD_1 75 77 PF00675 0.300
CLV_PCSK_KEX2_1 119 121 PF00082 0.284
CLV_PCSK_KEX2_1 178 180 PF00082 0.301
CLV_PCSK_KEX2_1 371 373 PF00082 0.284
CLV_PCSK_KEX2_1 457 459 PF00082 0.441
CLV_PCSK_PC1ET2_1 119 121 PF00082 0.369
CLV_PCSK_PC1ET2_1 371 373 PF00082 0.284
CLV_PCSK_PC1ET2_1 457 459 PF00082 0.441
CLV_PCSK_PC7_1 367 373 PF00082 0.284
CLV_PCSK_SKI1_1 116 120 PF00082 0.388
CLV_PCSK_SKI1_1 190 194 PF00082 0.297
CLV_PCSK_SKI1_1 237 241 PF00082 0.284
CLV_PCSK_SKI1_1 414 418 PF00082 0.334
CLV_PCSK_SKI1_1 431 435 PF00082 0.278
DEG_Nend_UBRbox_2 1 3 PF02207 0.597
DEG_SPOP_SBC_1 134 138 PF00917 0.327
DOC_CYCLIN_RxL_1 231 243 PF00134 0.311
DOC_MAPK_gen_1 174 183 PF00069 0.332
DOC_MAPK_gen_1 76 84 PF00069 0.300
DOC_MAPK_HePTP_8 176 188 PF00069 0.325
DOC_MAPK_HePTP_8 40 52 PF00069 0.403
DOC_MAPK_MEF2A_6 179 188 PF00069 0.288
DOC_MAPK_MEF2A_6 389 397 PF00069 0.317
DOC_MAPK_MEF2A_6 43 52 PF00069 0.407
DOC_PP1_RVXF_1 117 124 PF00149 0.319
DOC_PP1_RVXF_1 177 184 PF00149 0.396
DOC_PP2B_LxvP_1 50 53 PF13499 0.472
DOC_PP4_FxxP_1 419 422 PF00568 0.315
DOC_USP7_MATH_1 126 130 PF00917 0.381
DOC_USP7_MATH_1 23 27 PF00917 0.405
DOC_USP7_UBL2_3 227 231 PF12436 0.368
DOC_USP7_UBL2_3 88 92 PF12436 0.282
DOC_WW_Pin1_4 230 235 PF00397 0.319
DOC_WW_Pin1_4 33 38 PF00397 0.361
DOC_WW_Pin1_4 365 370 PF00397 0.319
LIG_14-3-3_CanoR_1 247 253 PF00244 0.284
LIG_14-3-3_CanoR_1 292 302 PF00244 0.384
LIG_14-3-3_CanoR_1 76 84 PF00244 0.319
LIG_APCC_ABBA_1 300 305 PF00400 0.284
LIG_BRCT_BRCA1_1 303 307 PF00533 0.283
LIG_FHA_1 136 142 PF00498 0.284
LIG_FHA_1 155 161 PF00498 0.296
LIG_FHA_1 198 204 PF00498 0.449
LIG_FHA_1 310 316 PF00498 0.319
LIG_FHA_1 34 40 PF00498 0.368
LIG_FHA_2 101 107 PF00498 0.458
LIG_FHA_2 200 206 PF00498 0.427
LIG_FHA_2 332 338 PF00498 0.305
LIG_GBD_Chelix_1 181 189 PF00786 0.319
LIG_LIR_Apic_2 147 151 PF02991 0.289
LIG_LIR_Apic_2 355 361 PF02991 0.284
LIG_LIR_Apic_2 417 422 PF02991 0.314
LIG_LIR_Gen_1 180 191 PF02991 0.300
LIG_LIR_Gen_1 298 307 PF02991 0.288
LIG_LIR_Gen_1 447 455 PF02991 0.403
LIG_LIR_Gen_1 93 102 PF02991 0.405
LIG_LIR_Nem_3 180 186 PF02991 0.300
LIG_LIR_Nem_3 194 198 PF02991 0.101
LIG_LIR_Nem_3 298 303 PF02991 0.285
LIG_LIR_Nem_3 304 310 PF02991 0.285
LIG_LIR_Nem_3 447 452 PF02991 0.398
LIG_LIR_Nem_3 93 97 PF02991 0.314
LIG_Pex14_2 240 244 PF04695 0.284
LIG_Pex14_2 303 307 PF04695 0.284
LIG_PTB_Apo_2 238 245 PF02174 0.284
LIG_PTB_Apo_2 39 46 PF02174 0.369
LIG_RPA_C_Fungi 38 50 PF08784 0.376
LIG_SH2_CRK 148 152 PF00017 0.300
LIG_SH2_CRK 220 224 PF00017 0.270
LIG_SH2_CRK 261 265 PF00017 0.300
LIG_SH2_STAP1 27 31 PF00017 0.284
LIG_SH2_STAP1 295 299 PF00017 0.319
LIG_SH2_STAT3 424 427 PF00017 0.365
LIG_SH2_STAT5 14 17 PF00017 0.389
LIG_SH2_STAT5 238 241 PF00017 0.271
LIG_SH2_STAT5 424 427 PF00017 0.362
LIG_SH2_STAT5 446 449 PF00017 0.503
LIG_SH2_STAT5 47 50 PF00017 0.381
LIG_SH3_3 198 204 PF00018 0.422
LIG_SH3_3 371 377 PF00018 0.319
LIG_SH3_3 449 455 PF00018 0.409
LIG_SUMO_SIM_par_1 199 205 PF11976 0.437
LIG_TRAF2_1 165 168 PF00917 0.405
LIG_UBA3_1 185 193 PF00899 0.300
LIG_UBA3_1 222 227 PF00899 0.300
LIG_WRC_WIRS_1 446 451 PF05994 0.410
MOD_CDK_SPxK_1 365 371 PF00069 0.341
MOD_CDK_SPxxK_3 230 237 PF00069 0.319
MOD_CDK_SPxxK_3 365 372 PF00069 0.341
MOD_Cter_Amidation 455 458 PF01082 0.443
MOD_GlcNHglycan 295 298 PF01048 0.396
MOD_GlcNHglycan 419 422 PF01048 0.315
MOD_GlcNHglycan 78 81 PF01048 0.291
MOD_N-GLC_1 154 159 PF02516 0.342
MOD_N-GLC_2 423 425 PF02516 0.330
MOD_NEK2_1 191 196 PF00069 0.307
MOD_PIKK_1 25 31 PF00454 0.344
MOD_PKA_1 76 82 PF00069 0.300
MOD_PKA_2 246 252 PF00069 0.284
MOD_PKA_2 435 441 PF00069 0.374
MOD_Plk_1 154 160 PF00069 0.354
MOD_Plk_1 207 213 PF00069 0.300
MOD_Plk_1 331 337 PF00069 0.341
MOD_Plk_2-3 331 337 PF00069 0.319
MOD_Plk_4 254 260 PF00069 0.284
MOD_Plk_4 35 41 PF00069 0.416
MOD_Plk_4 353 359 PF00069 0.284
MOD_ProDKin_1 230 236 PF00069 0.319
MOD_ProDKin_1 33 39 PF00069 0.353
MOD_ProDKin_1 365 371 PF00069 0.319
MOD_SUMO_for_1 48 51 PF00179 0.344
MOD_SUMO_for_1 7 10 PF00179 0.466
MOD_SUMO_rev_2 112 121 PF00179 0.399
MOD_SUMO_rev_2 168 176 PF00179 0.405
TRG_DiLeu_BaEn_4 2 8 PF01217 0.423
TRG_ENDOCYTIC_2 195 198 PF00928 0.339
TRG_ENDOCYTIC_2 220 223 PF00928 0.293
TRG_ENDOCYTIC_2 261 264 PF00928 0.300
TRG_ENDOCYTIC_2 446 449 PF00928 0.503
TRG_ENDOCYTIC_2 47 50 PF00928 0.421
TRG_ER_diArg_1 120 123 PF00400 0.290
TRG_NLS_MonoExtC_3 118 124 PF00514 0.405
TRG_NLS_MonoExtN_4 116 123 PF00514 0.369
TRG_Pf-PMV_PEXEL_1 345 349 PF00026 0.300

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HSR2 Leptomonas seymouri 36% 100%
A0A0N1ILH2 Leptomonas seymouri 29% 100%
A0A0N1PBN9 Leptomonas seymouri 85% 100%
A0A0S4JDD1 Bodo saltans 34% 100%
A0A0S4JEU6 Bodo saltans 68% 99%
A0A0S4JKZ6 Bodo saltans 34% 95%
A0A1X0P6J3 Trypanosomatidae 33% 100%
A0A1X0P6Y9 Trypanosomatidae 79% 99%
A0A1X0P7H9 Trypanosomatidae 36% 100%
A0A1X0P7Q5 Trypanosomatidae 34% 100%
A0A1X0P9R6 Trypanosomatidae 30% 100%
A0A3R7MM48 Trypanosoma rangeli 31% 100%
A0A3S5H6T9 Leishmania donovani 35% 100%
A0A3S5H7Q6 Leishmania donovani 42% 100%
A0A3S7WUR2 Leishmania donovani 100% 100%
A0A3S7WZ39 Leishmania donovani 41% 100%
A0A3S7XAY3 Leishmania donovani 30% 100%
A0A422N1U7 Trypanosoma rangeli 28% 78%
A0A422N9D5 Trypanosoma rangeli 34% 100%
A0A422NWG6 Trypanosoma rangeli 77% 99%
A4H7D2 Leishmania braziliensis 34% 86%
A4H7Z3 Leishmania braziliensis 35% 100%
A4H9C0 Leishmania braziliensis 92% 100%
A4HJQ1 Leishmania braziliensis 42% 100%
A4HP65 Leishmania braziliensis 28% 100%
A4HWC1 Leishmania infantum 35% 100%
A4I1H6 Leishmania infantum 41% 100%
A4I768 Leishmania infantum 42% 100%
A4IDH0 Leishmania infantum 30% 100%
C9ZM48 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
D0A019 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 72% 99%
D0A358 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
D0A366 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 74%
E9AQ21 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9ARF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9ASX3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AXL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B262 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
G5EBX9 Caenorhabditis elegans 36% 66%
O14829 Homo sapiens 34% 72%
O35655 Mus musculus 35% 72%
O43049 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 49% 99%
O74789 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
P14747 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 78%
P20654 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 36% 100%
P23287 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 85%
P48456 Drosophila melanogaster 35% 75%
P53041 Homo sapiens 49% 94%
P53042 Rattus norvegicus 49% 94%
P53043 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 91%
P62136 Homo sapiens 36% 100%
P62137 Mus musculus 36% 100%
P62138 Rattus norvegicus 36% 100%
P62139 Oryctolagus cuniculus 36% 100%
Q05681 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 34% 84%
Q28IV3 Xenopus tropicalis 26% 71%
Q3SWT6 Rattus norvegicus 36% 73%
Q3T0E7 Bos taurus 36% 100%
Q4Q1M5 Leishmania major 29% 100%
Q4Q5Z8 Leishmania major 43% 100%
Q4Q9W1 Leishmania major 41% 100%
Q4QE27 Leishmania major 98% 100%
Q4QFG0 Leishmania major 35% 100%
Q60676 Mus musculus 49% 94%
Q84K11 Solanum lycopersicum 58% 84%
Q84XU2 Arabidopsis thaliana 46% 87%
Q8WMS6 Canis lupus familiaris 36% 100%
Q9NES8 Caenorhabditis elegans 53% 95%
V5B3V2 Trypanosoma cruzi 34% 100%
V5BBR3 Trypanosoma cruzi 33% 100%
V5BBS3 Trypanosoma cruzi 28% 78%
V5BGM0 Trypanosoma cruzi 33% 100%
V5D5S2 Trypanosoma cruzi 79% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS