LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Domain of unknown function DUF21 - putative
Species:
Leishmania infantum
UniProt:
A4HXP0_LEIIN
TriTrypDb:
LINF_180006400
Length:
745

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 27
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 13, no: 11
NetGPI no yes: 0, no: 24
Cellular components
Term Name Level Count
GO:0016020 membrane 2 25
GO:0110165 cellular anatomical entity 1 25
GO:0005886 plasma membrane 3 8
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3

Expansion

Sequence features

A4HXP0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXP0

Function

Biological processes
Term Name Level Count
GO:0010960 magnesium ion homeostasis 8 25
GO:0042592 homeostatic process 3 25
GO:0048878 chemical homeostasis 4 25
GO:0050801 monoatomic ion homeostasis 5 25
GO:0055065 obsolete metal ion homeostasis 7 25
GO:0055080 monoatomic cation homeostasis 6 25
GO:0065007 biological regulation 1 25
GO:0065008 regulation of biological quality 2 25
GO:0072507 obsolete divalent inorganic cation homeostasis 7 25
GO:0098771 inorganic ion homeostasis 6 25
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 717 721 PF00656 0.529
CLV_NRD_NRD_1 117 119 PF00675 0.246
CLV_NRD_NRD_1 244 246 PF00675 0.457
CLV_NRD_NRD_1 278 280 PF00675 0.535
CLV_NRD_NRD_1 54 56 PF00675 0.597
CLV_PCSK_KEX2_1 59 61 PF00082 0.607
CLV_PCSK_PC1ET2_1 59 61 PF00082 0.630
CLV_PCSK_PC7_1 55 61 PF00082 0.523
CLV_PCSK_SKI1_1 268 272 PF00082 0.611
CLV_PCSK_SKI1_1 373 377 PF00082 0.553
CLV_PCSK_SKI1_1 528 532 PF00082 0.507
CLV_PCSK_SKI1_1 614 618 PF00082 0.518
CLV_PCSK_SKI1_1 671 675 PF00082 0.593
DEG_COP1_1 648 656 PF00400 0.398
DEG_Nend_UBRbox_3 1 3 PF02207 0.617
DOC_CKS1_1 284 289 PF01111 0.334
DOC_CKS1_1 299 304 PF01111 0.316
DOC_CKS1_1 337 342 PF01111 0.313
DOC_CKS1_1 479 484 PF01111 0.358
DOC_CKS1_1 555 560 PF01111 0.525
DOC_CKS1_1 647 652 PF01111 0.294
DOC_CYCLIN_RxL_1 525 533 PF00134 0.273
DOC_CYCLIN_RxL_1 665 675 PF00134 0.385
DOC_CYCLIN_yCln2_LP_2 214 220 PF00134 0.300
DOC_CYCLIN_yCln2_LP_2 647 653 PF00134 0.410
DOC_MAPK_DCC_7 665 674 PF00069 0.233
DOC_MAPK_gen_1 12 20 PF00069 0.553
DOC_MAPK_gen_1 193 200 PF00069 0.428
DOC_MAPK_gen_1 241 249 PF00069 0.349
DOC_MAPK_gen_1 310 318 PF00069 0.363
DOC_MAPK_gen_1 454 463 PF00069 0.482
DOC_MAPK_gen_1 608 618 PF00069 0.359
DOC_MAPK_gen_1 685 693 PF00069 0.487
DOC_MAPK_MEF2A_6 12 20 PF00069 0.551
DOC_MAPK_MEF2A_6 264 271 PF00069 0.386
DOC_MAPK_MEF2A_6 379 386 PF00069 0.220
DOC_MAPK_MEF2A_6 611 619 PF00069 0.386
DOC_MAPK_MEF2A_6 665 674 PF00069 0.372
DOC_MAPK_NFAT4_5 264 272 PF00069 0.303
DOC_PP1_RVXF_1 482 488 PF00149 0.437
DOC_PP1_RVXF_1 669 675 PF00149 0.320
DOC_PP2B_LxvP_1 473 476 PF13499 0.429
DOC_PP4_FxxP_1 491 494 PF00568 0.488
DOC_PP4_FxxP_1 651 654 PF00568 0.389
DOC_USP7_MATH_1 10 14 PF00917 0.636
DOC_USP7_MATH_1 202 206 PF00917 0.328
DOC_USP7_MATH_1 3 7 PF00917 0.697
DOC_USP7_MATH_1 317 321 PF00917 0.403
DOC_USP7_MATH_1 364 368 PF00917 0.318
DOC_USP7_MATH_1 494 498 PF00917 0.378
DOC_USP7_UBL2_3 119 123 PF12436 0.530
DOC_USP7_UBL2_3 242 246 PF12436 0.359
DOC_USP7_UBL2_3 264 268 PF12436 0.423
DOC_WW_Pin1_4 102 107 PF00397 0.416
DOC_WW_Pin1_4 283 288 PF00397 0.352
DOC_WW_Pin1_4 298 303 PF00397 0.348
DOC_WW_Pin1_4 336 341 PF00397 0.425
DOC_WW_Pin1_4 478 483 PF00397 0.485
DOC_WW_Pin1_4 547 552 PF00397 0.519
DOC_WW_Pin1_4 554 559 PF00397 0.525
DOC_WW_Pin1_4 646 651 PF00397 0.411
DOC_WW_Pin1_4 692 697 PF00397 0.528
LIG_14-3-3_CanoR_1 193 199 PF00244 0.537
LIG_14-3-3_CanoR_1 468 474 PF00244 0.469
LIG_14-3-3_CanoR_1 60 65 PF00244 0.360
LIG_14-3-3_CanoR_1 608 618 PF00244 0.337
LIG_14-3-3_CanoR_1 685 694 PF00244 0.476
LIG_14-3-3_CanoR_1 7 14 PF00244 0.601
LIG_14-3-3_CanoR_1 703 711 PF00244 0.523
LIG_Actin_WH2_2 184 201 PF00022 0.300
LIG_AP2alpha_1 143 147 PF02296 0.344
LIG_APCC_ABBA_1 180 185 PF00400 0.309
LIG_APCC_ABBA_1 248 253 PF00400 0.265
LIG_BRCT_BRCA1_1 581 585 PF00533 0.538
LIG_BRCT_BRCA1_1 77 81 PF00533 0.272
LIG_BRCT_BRCA1_2 582 588 PF00533 0.391
LIG_FHA_1 125 131 PF00498 0.323
LIG_FHA_1 158 164 PF00498 0.309
LIG_FHA_1 175 181 PF00498 0.264
LIG_FHA_1 213 219 PF00498 0.430
LIG_FHA_1 233 239 PF00498 0.154
LIG_FHA_1 295 301 PF00498 0.334
LIG_FHA_1 470 476 PF00498 0.484
LIG_FHA_1 493 499 PF00498 0.427
LIG_FHA_1 56 62 PF00498 0.472
LIG_FHA_1 571 577 PF00498 0.557
LIG_FHA_1 83 89 PF00498 0.314
LIG_FHA_1 91 97 PF00498 0.455
LIG_FHA_2 284 290 PF00498 0.384
LIG_FHA_2 337 343 PF00498 0.452
LIG_FHA_2 400 406 PF00498 0.463
LIG_FHA_2 427 433 PF00498 0.312
LIG_FHA_2 555 561 PF00498 0.552
LIG_FHA_2 61 67 PF00498 0.360
LIG_IRF3_LxIS_1 125 131 PF10401 0.349
LIG_LIR_Apic_2 489 494 PF02991 0.454
LIG_LIR_Apic_2 521 525 PF02991 0.371
LIG_LIR_Apic_2 648 654 PF02991 0.362
LIG_LIR_Gen_1 142 150 PF02991 0.327
LIG_LIR_Gen_1 205 214 PF02991 0.427
LIG_LIR_Gen_1 301 308 PF02991 0.444
LIG_LIR_Gen_1 356 365 PF02991 0.308
LIG_LIR_Gen_1 455 464 PF02991 0.470
LIG_LIR_Gen_1 638 647 PF02991 0.321
LIG_LIR_LC3C_4 326 331 PF02991 0.395
LIG_LIR_Nem_3 142 146 PF02991 0.314
LIG_LIR_Nem_3 168 174 PF02991 0.257
LIG_LIR_Nem_3 205 210 PF02991 0.400
LIG_LIR_Nem_3 342 346 PF02991 0.427
LIG_LIR_Nem_3 356 362 PF02991 0.292
LIG_LIR_Nem_3 440 446 PF02991 0.367
LIG_LIR_Nem_3 447 452 PF02991 0.409
LIG_LIR_Nem_3 455 461 PF02991 0.399
LIG_LIR_Nem_3 638 642 PF02991 0.325
LIG_LIR_Nem_3 675 680 PF02991 0.357
LIG_LIR_Nem_3 78 84 PF02991 0.339
LIG_MLH1_MIPbox_1 582 586 PF16413 0.399
LIG_NRBOX 266 272 PF00104 0.371
LIG_Pex14_1 506 510 PF04695 0.319
LIG_Pex14_1 522 526 PF04695 0.323
LIG_Pex14_2 143 147 PF04695 0.349
LIG_Pex14_2 487 491 PF04695 0.341
LIG_REV1ctd_RIR_1 583 592 PF16727 0.355
LIG_RPA_C_Fungi 721 733 PF08784 0.504
LIG_SH2_CRK 667 671 PF00017 0.362
LIG_SH2_CRK 74 78 PF00017 0.342
LIG_SH2_GRB2like 511 514 PF00017 0.321
LIG_SH2_NCK_1 449 453 PF00017 0.627
LIG_SH2_NCK_1 458 462 PF00017 0.585
LIG_SH2_PTP2 526 529 PF00017 0.457
LIG_SH2_SRC 449 452 PF00017 0.658
LIG_SH2_STAP1 110 114 PF00017 0.362
LIG_SH2_STAP1 196 200 PF00017 0.262
LIG_SH2_STAP1 656 660 PF00017 0.375
LIG_SH2_STAT3 520 523 PF00017 0.505
LIG_SH2_STAT5 490 493 PF00017 0.376
LIG_SH2_STAT5 511 514 PF00017 0.373
LIG_SH2_STAT5 526 529 PF00017 0.351
LIG_SH2_STAT5 62 65 PF00017 0.400
LIG_SH2_STAT5 641 644 PF00017 0.483
LIG_SH3_2 479 484 PF14604 0.562
LIG_SH3_3 334 340 PF00018 0.338
LIG_SH3_3 458 464 PF00018 0.632
LIG_SH3_3 473 479 PF00018 0.512
LIG_SH3_3 693 699 PF00018 0.717
LIG_SUMO_SIM_anti_2 176 183 PF11976 0.343
LIG_SUMO_SIM_anti_2 326 333 PF11976 0.385
LIG_SUMO_SIM_anti_2 612 619 PF11976 0.536
LIG_SUMO_SIM_anti_2 95 102 PF11976 0.277
LIG_SUMO_SIM_par_1 126 131 PF11976 0.307
LIG_SUMO_SIM_par_1 136 142 PF11976 0.333
LIG_SUMO_SIM_par_1 326 333 PF11976 0.347
LIG_TRAF2_2 559 564 PF00917 0.553
LIG_UBA3_1 114 119 PF00899 0.425
LIG_UBA3_1 284 290 PF00899 0.468
LIG_WRC_WIRS_1 636 641 PF05994 0.482
LIG_WW_3 481 485 PF00397 0.592
MOD_CDK_SPxK_1 478 484 PF00069 0.641
MOD_CDK_SPxxK_3 102 109 PF00069 0.241
MOD_CDK_SPxxK_3 283 290 PF00069 0.517
MOD_CK1_1 102 108 PF00069 0.263
MOD_CK1_1 194 200 PF00069 0.314
MOD_CK1_1 232 238 PF00069 0.427
MOD_CK1_1 311 317 PF00069 0.406
MOD_CK1_1 344 350 PF00069 0.543
MOD_CK1_1 367 373 PF00069 0.379
MOD_CK1_1 43 49 PF00069 0.563
MOD_CK1_1 489 495 PF00069 0.547
MOD_CK1_1 565 571 PF00069 0.669
MOD_CK1_1 599 605 PF00069 0.517
MOD_CK1_1 6 12 PF00069 0.557
MOD_CK2_1 283 289 PF00069 0.526
MOD_CK2_1 336 342 PF00069 0.528
MOD_CK2_1 474 480 PF00069 0.636
MOD_GlcNHglycan 101 104 PF01048 0.305
MOD_GlcNHglycan 167 170 PF01048 0.323
MOD_GlcNHglycan 218 221 PF01048 0.399
MOD_GlcNHglycan 310 313 PF01048 0.425
MOD_GlcNHglycan 319 322 PF01048 0.405
MOD_GlcNHglycan 410 414 PF01048 0.574
MOD_GlcNHglycan 655 659 PF01048 0.471
MOD_GlcNHglycan 704 707 PF01048 0.617
MOD_GlcNHglycan 728 731 PF01048 0.640
MOD_GlcNHglycan 77 80 PF01048 0.315
MOD_GlcNHglycan 8 11 PF01048 0.573
MOD_GSK3_1 124 131 PF00069 0.331
MOD_GSK3_1 187 194 PF00069 0.372
MOD_GSK3_1 212 219 PF00069 0.427
MOD_GSK3_1 294 301 PF00069 0.454
MOD_GSK3_1 363 370 PF00069 0.415
MOD_GSK3_1 399 406 PF00069 0.622
MOD_GSK3_1 474 481 PF00069 0.623
MOD_GSK3_1 494 501 PF00069 0.546
MOD_GSK3_1 562 569 PF00069 0.643
MOD_GSK3_1 576 583 PF00069 0.544
MOD_GSK3_1 6 13 PF00069 0.646
MOD_GSK3_1 681 688 PF00069 0.493
MOD_GSK3_1 709 716 PF00069 0.634
MOD_N-GLC_1 512 517 PF02516 0.490
MOD_N-GLC_1 547 552 PF02516 0.520
MOD_N-GLC_1 565 570 PF02516 0.501
MOD_NEK2_1 128 133 PF00069 0.326
MOD_NEK2_1 173 178 PF00069 0.292
MOD_NEK2_1 212 217 PF00069 0.457
MOD_NEK2_1 218 223 PF00069 0.455
MOD_NEK2_1 27 32 PF00069 0.568
MOD_NEK2_1 308 313 PF00069 0.433
MOD_NEK2_1 409 414 PF00069 0.566
MOD_NEK2_1 417 422 PF00069 0.683
MOD_NEK2_1 500 505 PF00069 0.454
MOD_NEK2_1 512 517 PF00069 0.421
MOD_NEK2_1 542 547 PF00069 0.612
MOD_NEK2_1 553 558 PF00069 0.700
MOD_NEK2_1 562 567 PF00069 0.642
MOD_NEK2_1 580 585 PF00069 0.562
MOD_NEK2_1 65 70 PF00069 0.469
MOD_NEK2_1 702 707 PF00069 0.635
MOD_NEK2_2 10 15 PF00069 0.391
MOD_NEK2_2 202 207 PF00069 0.380
MOD_PIKK_1 40 46 PF00454 0.709
MOD_PIKK_1 500 506 PF00454 0.457
MOD_PIKK_1 542 548 PF00454 0.709
MOD_PIKK_1 568 574 PF00454 0.783
MOD_PIKK_1 580 586 PF00454 0.640
MOD_PK_1 665 671 PF00069 0.457
MOD_PKA_1 55 61 PF00069 0.560
MOD_PKA_2 155 161 PF00069 0.427
MOD_PKA_2 294 300 PF00069 0.523
MOD_PKA_2 3 9 PF00069 0.628
MOD_PKA_2 686 692 PF00069 0.582
MOD_PKA_2 702 708 PF00069 0.678
MOD_PKA_2 718 724 PF00069 0.694
MOD_Plk_1 512 518 PF00069 0.508
MOD_Plk_1 599 605 PF00069 0.518
MOD_Plk_1 65 71 PF00069 0.508
MOD_Plk_2-3 445 451 PF00069 0.587
MOD_Plk_4 110 116 PF00069 0.342
MOD_Plk_4 124 130 PF00069 0.305
MOD_Plk_4 174 180 PF00069 0.348
MOD_Plk_4 202 208 PF00069 0.332
MOD_Plk_4 324 330 PF00069 0.494
MOD_Plk_4 34 40 PF00069 0.663
MOD_Plk_4 367 373 PF00069 0.391
MOD_Plk_4 486 492 PF00069 0.421
MOD_Plk_4 60 66 PF00069 0.452
MOD_Plk_4 697 703 PF00069 0.666
MOD_Plk_4 718 724 PF00069 0.738
MOD_ProDKin_1 102 108 PF00069 0.241
MOD_ProDKin_1 283 289 PF00069 0.442
MOD_ProDKin_1 298 304 PF00069 0.420
MOD_ProDKin_1 336 342 PF00069 0.538
MOD_ProDKin_1 478 484 PF00069 0.619
MOD_ProDKin_1 547 553 PF00069 0.667
MOD_ProDKin_1 554 560 PF00069 0.676
MOD_ProDKin_1 646 652 PF00069 0.509
MOD_ProDKin_1 692 698 PF00069 0.675
MOD_SUMO_for_1 263 266 PF00179 0.552
MOD_SUMO_rev_2 101 111 PF00179 0.268
MOD_SUMO_rev_2 234 244 PF00179 0.383
MOD_SUMO_rev_2 265 270 PF00179 0.391
MOD_SUMO_rev_2 275 281 PF00179 0.330
MOD_SUMO_rev_2 41 51 PF00179 0.693
MOD_SUMO_rev_2 532 537 PF00179 0.539
TRG_DiLeu_BaEn_1 243 248 PF01217 0.331
TRG_DiLeu_BaEn_1 266 271 PF01217 0.359
TRG_DiLeu_BaEn_1 718 723 PF01217 0.664
TRG_DiLeu_BaEn_3 387 393 PF01217 0.418
TRG_DiLeu_BaEn_4 233 239 PF01217 0.427
TRG_DiLeu_BaLyEn_6 611 616 PF01217 0.516
TRG_ENDOCYTIC_2 23 26 PF00928 0.494
TRG_ENDOCYTIC_2 449 452 PF00928 0.613
TRG_ENDOCYTIC_2 458 461 PF00928 0.534
TRG_ENDOCYTIC_2 488 491 PF00928 0.532
TRG_ENDOCYTIC_2 526 529 PF00928 0.334
TRG_ENDOCYTIC_2 62 65 PF00928 0.416
TRG_ENDOCYTIC_2 679 682 PF00928 0.375
TRG_ENDOCYTIC_2 74 77 PF00928 0.368
TRG_ER_diArg_1 153 156 PF00400 0.427
TRG_ER_diArg_1 313 316 PF00400 0.413
TRG_ER_diLys_1 742 745 PF00400 0.478
TRG_Pf-PMV_PEXEL_1 671 675 PF00026 0.502

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK76 Leptomonas seymouri 66% 99%
A0A0S4JDJ1 Bodo saltans 39% 79%
A0A0S4JGZ5 Bodo saltans 31% 90%
A0A1X0P6Q5 Trypanosomatidae 43% 100%
A0A1X0P7K4 Trypanosomatidae 29% 100%
A0A3Q8IL77 Leishmania donovani 30% 100%
A0A3R7M693 Trypanosoma rangeli 27% 100%
A0A3S7WUR9 Leishmania donovani 100% 100%
A0A3S7WUS2 Leishmania donovani 32% 100%
A0A422NWG4 Trypanosoma rangeli 40% 100%
A4H9B8 Leishmania braziliensis 31% 96%
A4H9B9 Leishmania braziliensis 79% 100%
A4HXN9 Leishmania infantum 32% 100%
A4IA41 Leishmania infantum 30% 100%
C9ZM59 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
D0A017 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9ARF0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9ARF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q2T0 Leishmania major 31% 100%
Q4QE28 Leishmania major 94% 100%
Q4QE29 Leishmania major 32% 100%
V5B9W6 Trypanosoma cruzi 40% 100%
V5BEH2 Trypanosoma cruzi 29% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS