LeishMANIAdb
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CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CNNM transmembrane domain-containing protein
Gene product:
Domain of unknown function DUF21/CBS domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HXN9_LEIIN
TriTrypDb:
LINF_180006300
Length:
703

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 11, no: 10
NetGPI no yes: 0, no: 21
Cellular components
TermNameLevelCount
GO:0005886 plasma membrane 3 6
GO:0016020 membrane 2 22
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 22
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Expansion

Sequence features

A4HXN9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXN9

Function

Biological processes
TermNameLevelCount
GO:0010960 magnesium ion homeostasis 8 22
GO:0042592 homeostatic process 3 22
GO:0048878 chemical homeostasis 4 22
GO:0050801 monoatomic ion homeostasis 5 22
GO:0055065 obsolete metal ion homeostasis 7 22
GO:0055080 monoatomic cation homeostasis 6 22
GO:0065007 biological regulation 1 22
GO:0065008 regulation of biological quality 2 22
GO:0072507 obsolete divalent inorganic cation homeostasis 7 22
GO:0098771 inorganic ion homeostasis 6 22
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Could not find GO molecular_function term for this entry.

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 299 303 PF00656 0.309
CLV_NRD_NRD_1 271 273 PF00675 0.454
CLV_NRD_NRD_1 362 364 PF00675 0.739
CLV_NRD_NRD_1 377 379 PF00675 0.608
CLV_NRD_NRD_1 686 688 PF00675 0.763
CLV_NRD_NRD_1 95 97 PF00675 0.237
CLV_PCSK_KEX2_1 271 273 PF00082 0.488
CLV_PCSK_KEX2_1 362 364 PF00082 0.592
CLV_PCSK_KEX2_1 376 378 PF00082 0.610
CLV_PCSK_KEX2_1 698 700 PF00082 0.679
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I5K6 Leptomonas seymouri 60% 96%
A0A0N1IK76 Leptomonas seymouri 31% 93%
A0A0S4JDJ1 Bodo saltans 32% 74%
A0A0S4JGZ5 Bodo saltans 33% 84%
A0A1X0P6Q5 Trypanosomatidae 33% 94%
A0A1X0P7K4 Trypanosomatidae 38% 100%
A0A3R7M693 Trypanosoma rangeli 38% 100%
A0A3S7WUR9 Leishmania donovani 32% 94%
A0A3S7WUS2 Leishmania donovani 99% 100%
A0A422NWG4 Trypanosoma rangeli 32% 96%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS