Diphosphomevalonate decarboxylase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ontology term:GO:0005524

Species:

Leishmania infantum

UniProt:

A4HXM8_LEIIN

TriTrypDb:

LINF_180005200

Length:

383

Annotations

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, mevalonate-diphosphate decarboxylase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HXM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXM8

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	12
GO:0006084	acetyl-CoA metabolic process	5	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006629	lipid metabolic process	3	13
GO:0006637	acyl-CoA metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006694	steroid biosynthetic process	5	12
GO:0006695	cholesterol biosynthetic process	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006790	sulfur compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	13
GO:0008202	steroid metabolic process	4	12
GO:0008203	cholesterol metabolic process	5	12
GO:0008610	lipid biosynthetic process	4	13
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	13
GO:0009117	nucleotide metabolic process	5	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009240	isopentenyl diphosphate biosynthetic process	6	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009987	cellular process	1	13
GO:0016125	sterol metabolic process	4	12
GO:0016126	sterol biosynthetic process	5	12
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	6	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0033865	nucleoside bisphosphate metabolic process	5	12
GO:0033875	ribonucleoside bisphosphate metabolic process	6	12
GO:0034032	purine nucleoside bisphosphate metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0035383	thioester metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044255	cellular lipid metabolic process	3	13
GO:0044281	small molecule metabolic process	2	12
GO:0044283	small molecule biosynthetic process	3	12
GO:0046165	alcohol biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0046490	isopentenyl diphosphate metabolic process	5	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	13
GO:0072521	purine-containing compound metabolic process	4	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	13
GO:1901615	organic hydroxy compound metabolic process	3	12
GO:1901617	organic hydroxy compound biosynthetic process	4	12
GO:1902652	secondary alcohol metabolic process	4	12
GO:1902653	secondary alcohol biosynthetic process	5	12
GO:0006720	isoprenoid metabolic process	4	1
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0044249	cellular biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004163	diphosphomevalonate decarboxylase activity	5	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016829	lyase activity	2	13
GO:0016830	carbon-carbon lyase activity	3	13
GO:0016831	carboxy-lyase activity	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.430
CLV_NRD_NRD_1	55	57	PF00675	0.408
CLV_PCSK_KEX2_1	23	25	PF00082	0.386
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.386
CLV_PCSK_SKI1_1	29	33	PF00082	0.484
CLV_PCSK_SKI1_1	95	99	PF00082	0.505
DOC_CKS1_1	74	79	PF01111	0.533
DOC_CYCLIN_yCln2_LP_2	378	381	PF00134	0.460
DOC_MAPK_DCC_7	305	313	PF00069	0.473
DOC_MAPK_gen_1	129	137	PF00069	0.431
DOC_MAPK_gen_1	354	361	PF00069	0.450
DOC_MAPK_gen_1	45	55	PF00069	0.394
DOC_MAPK_MEF2A_6	132	139	PF00069	0.431
DOC_MAPK_MEF2A_6	179	186	PF00069	0.458
DOC_MAPK_MEF2A_6	305	313	PF00069	0.473
DOC_PP2B_LxvP_1	30	33	PF13499	0.368
DOC_PP2B_LxvP_1	378	381	PF13499	0.465
DOC_USP7_MATH_1	148	152	PF00917	0.365
DOC_USP7_MATH_1	353	357	PF00917	0.531
DOC_USP7_MATH_1	46	50	PF00917	0.386
DOC_USP7_UBL2_3	19	23	PF12436	0.343
DOC_USP7_UBL2_3	192	196	PF12436	0.484
DOC_WW_Pin1_4	208	213	PF00397	0.428
DOC_WW_Pin1_4	360	365	PF00397	0.450
DOC_WW_Pin1_4	73	78	PF00397	0.431
LIG_14-3-3_CanoR_1	132	136	PF00244	0.423
LIG_14-3-3_CanoR_1	257	261	PF00244	0.511
LIG_14-3-3_CanoR_1	48	54	PF00244	0.371
LIG_14-3-3_CanoR_1	6	10	PF00244	0.463
LIG_14-3-3_CanoR_1	78	83	PF00244	0.389
LIG_BIR_II_1	1	5	PF00653	0.492
LIG_EH1_1	270	278	PF00400	0.450
LIG_eIF4E_1	271	277	PF01652	0.450
LIG_FHA_1	132	138	PF00498	0.450
LIG_FHA_1	166	172	PF00498	0.406
LIG_FHA_1	74	80	PF00498	0.449
LIG_FHA_2	319	325	PF00498	0.468
LIG_FHA_2	49	55	PF00498	0.411
LIG_LIR_Gen_1	118	128	PF02991	0.450
LIG_LIR_Gen_1	237	246	PF02991	0.461
LIG_LIR_Gen_1	268	279	PF02991	0.450
LIG_LIR_Gen_1	321	331	PF02991	0.471
LIG_LIR_Nem_3	118	123	PF02991	0.466
LIG_LIR_Nem_3	151	156	PF02991	0.348
LIG_LIR_Nem_3	178	184	PF02991	0.392
LIG_LIR_Nem_3	237	241	PF02991	0.443
LIG_LIR_Nem_3	268	274	PF02991	0.450
LIG_LIR_Nem_3	345	349	PF02991	0.471
LIG_NRBOX	356	362	PF00104	0.404
LIG_Pex14_2	17	21	PF04695	0.343
LIG_Pex14_2	319	323	PF04695	0.499
LIG_SH2_CRK	120	124	PF00017	0.465
LIG_SH2_CRK	271	275	PF00017	0.450
LIG_SH2_CRK	340	344	PF00017	0.543
LIG_SH2_STAP1	291	295	PF00017	0.450
LIG_SH2_STAT5	100	103	PF00017	0.390
LIG_SH2_STAT5	120	123	PF00017	0.450
LIG_SH2_STAT5	291	294	PF00017	0.447
LIG_SH2_STAT5	371	374	PF00017	0.380
LIG_SH3_3	6	12	PF00018	0.335
LIG_SUMO_SIM_anti_2	310	315	PF11976	0.498
LIG_SUMO_SIM_par_1	133	138	PF11976	0.541
LIG_UBA3_1	301	305	PF00899	0.460
MOD_CDK_SPK_2	73	78	PF00069	0.454
MOD_CK1_1	115	121	PF00069	0.450
MOD_CK1_1	138	144	PF00069	0.541
MOD_CK1_1	207	213	PF00069	0.435
MOD_CK1_1	49	55	PF00069	0.370
MOD_CK1_1	81	87	PF00069	0.513
MOD_CK2_1	48	54	PF00069	0.427
MOD_Cter_Amidation	21	24	PF01082	0.346
MOD_Cter_Amidation	67	70	PF01082	0.563
MOD_GlcNHglycan	1	4	PF01048	0.618
MOD_GlcNHglycan	115	118	PF01048	0.244
MOD_GlcNHglycan	144	147	PF01048	0.234
MOD_GlcNHglycan	150	153	PF01048	0.333
MOD_GSK3_1	131	138	PF00069	0.450
MOD_GSK3_1	144	151	PF00069	0.470
MOD_GSK3_1	204	211	PF00069	0.450
MOD_GSK3_1	34	41	PF00069	0.356
MOD_N-GLC_1	34	39	PF02516	0.358
MOD_NEK2_1	113	118	PF00069	0.450
MOD_NEK2_1	204	209	PF00069	0.450
MOD_NEK2_1	300	305	PF00069	0.518
MOD_NEK2_1	38	43	PF00069	0.354
MOD_PIKK_1	170	176	PF00454	0.381
MOD_PK_1	217	223	PF00069	0.556
MOD_PK_1	78	84	PF00069	0.443
MOD_PKA_2	131	137	PF00069	0.431
MOD_PKA_2	256	262	PF00069	0.519
MOD_PKA_2	5	11	PF00069	0.470
MOD_Plk_1	135	141	PF00069	0.450
MOD_Plk_1	267	273	PF00069	0.450
MOD_Plk_1	34	40	PF00069	0.357
MOD_Plk_4	135	141	PF00069	0.460
MOD_Plk_4	217	223	PF00069	0.513
MOD_Plk_4	374	380	PF00069	0.396
MOD_Plk_4	78	84	PF00069	0.428
MOD_ProDKin_1	208	214	PF00069	0.428
MOD_ProDKin_1	360	366	PF00069	0.450
MOD_ProDKin_1	73	79	PF00069	0.423
MOD_SUMO_for_1	191	194	PF00179	0.495
MOD_SUMO_rev_2	330	339	PF00179	0.488
MOD_SUMO_rev_2	93	99	PF00179	0.423
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.518
TRG_ENDOCYTIC_2	120	123	PF00928	0.446
TRG_ENDOCYTIC_2	153	156	PF00928	0.407
TRG_ENDOCYTIC_2	271	274	PF00928	0.450
TRG_ENDOCYTIC_2	286	289	PF00928	0.556
TRG_ER_diArg_1	233	236	PF00400	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ7	Leptomonas seymouri	87%	99%
A0A0S4JH23	Bodo saltans	65%	99%
A0A1D8PC43	Candida albicans (strain SC5314 / ATCC MYA-2876)	41%	100%
A0A1X0P6N9	Trypanosomatidae	72%	100%
A0A3S7WUN8	Leishmania donovani	100%	100%
A0A422NWH3	Trypanosoma rangeli	69%	100%
A4H9A8	Leishmania braziliensis	88%	100%
C9ZZY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D0A068	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D0EAP4	Panax ginseng	37%	92%
D4GXZ3	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	29%	100%
E9ARD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
F4JCU3	Arabidopsis thaliana	39%	91%
F8QQQ7	Panax ginseng	36%	91%
G9BIY1	Ganoderma lucidum	39%	96%
I1S130	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	42%	100%
O13963	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	97%
O23722	Arabidopsis thaliana	37%	93%
P32377	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	97%
P53602	Homo sapiens	45%	96%
Q0P570	Bos taurus	40%	96%
Q4QE40	Leishmania major	92%	100%
Q4WNV9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	39%	95%
Q54YQ9	Dictyostelium discoideum	44%	98%
Q5U403	Danio rerio	44%	96%
Q62967	Rattus norvegicus	45%	96%
Q6BY07	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	36%	99%
Q751D8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	38%	96%
Q97UL5	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	35%	100%
Q99JF5	Mus musculus	44%	96%
V5BEI4	Trypanosoma cruzi	67%	100%