LeishMANIAdb
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Putative zinc-finger protein ZPR1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative zinc-finger protein ZPR1
Gene product:
zinc-finger protein ZPR1 - putative
Species:
Leishmania infantum
UniProt:
A4HXL9_LEIIN
TriTrypDb:
LINF_170021500
Length:
497

Annotations

Annotations by Jardim et al.

Metal Binding, zinc-finger ZPR1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HXL9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXL9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 12
GO:0008270 zinc ion binding 6 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0046914 transition metal ion binding 5 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 483 487 PF00656 0.467
CLV_NRD_NRD_1 163 165 PF00675 0.243
CLV_NRD_NRD_1 272 274 PF00675 0.313
CLV_NRD_NRD_1 32 34 PF00675 0.495
CLV_PCSK_KEX2_1 272 274 PF00082 0.254
CLV_PCSK_KEX2_1 32 34 PF00082 0.494
CLV_PCSK_KEX2_1 331 333 PF00082 0.224
CLV_PCSK_KEX2_1 99 101 PF00082 0.301
CLV_PCSK_PC1ET2_1 331 333 PF00082 0.224
CLV_PCSK_PC1ET2_1 99 101 PF00082 0.301
CLV_PCSK_SKI1_1 232 236 PF00082 0.405
CLV_PCSK_SKI1_1 332 336 PF00082 0.246
CLV_PCSK_SKI1_1 393 397 PF00082 0.266
DEG_APCC_DBOX_1 370 378 PF00400 0.415
DOC_MAPK_gen_1 316 324 PF00069 0.441
DOC_MAPK_gen_1 99 107 PF00069 0.427
DOC_MAPK_JIP1_4 273 279 PF00069 0.397
DOC_MAPK_MEF2A_6 232 239 PF00069 0.420
DOC_MAPK_MEF2A_6 316 324 PF00069 0.441
DOC_PP2B_LxvP_1 132 135 PF13499 0.440
DOC_PP2B_LxvP_1 342 345 PF13499 0.415
DOC_PP2B_LxvP_1 432 435 PF13499 0.481
DOC_USP7_MATH_1 200 204 PF00917 0.427
DOC_USP7_MATH_1 384 388 PF00917 0.454
DOC_USP7_UBL2_3 247 251 PF12436 0.437
LIG_14-3-3_CanoR_1 319 323 PF00244 0.443
LIG_14-3-3_CanoR_1 61 70 PF00244 0.468
LIG_BIR_II_1 1 5 PF00653 0.647
LIG_FHA_1 122 128 PF00498 0.425
LIG_FHA_1 191 197 PF00498 0.425
LIG_FHA_1 260 266 PF00498 0.436
LIG_FHA_1 319 325 PF00498 0.433
LIG_FHA_1 32 38 PF00498 0.495
LIG_FHA_1 337 343 PF00498 0.391
LIG_FHA_1 411 417 PF00498 0.425
LIG_FHA_1 57 63 PF00498 0.427
LIG_FHA_2 193 199 PF00498 0.455
LIG_FHA_2 219 225 PF00498 0.416
LIG_FHA_2 226 232 PF00498 0.416
LIG_FHA_2 244 250 PF00498 0.511
LIG_FHA_2 392 398 PF00498 0.454
LIG_FHA_2 446 452 PF00498 0.554
LIG_LIR_Apic_2 203 207 PF02991 0.447
LIG_LIR_Apic_2 210 214 PF02991 0.449
LIG_LIR_Gen_1 120 130 PF02991 0.427
LIG_LIR_Gen_1 170 180 PF02991 0.422
LIG_LIR_Gen_1 255 265 PF02991 0.441
LIG_LIR_Gen_1 410 420 PF02991 0.513
LIG_LIR_Nem_3 120 125 PF02991 0.427
LIG_LIR_Nem_3 151 157 PF02991 0.546
LIG_LIR_Nem_3 170 175 PF02991 0.323
LIG_LIR_Nem_3 255 261 PF02991 0.485
LIG_LIR_Nem_3 298 302 PF02991 0.415
LIG_LIR_Nem_3 410 415 PF02991 0.513
LIG_MYND_1 214 218 PF01753 0.485
LIG_NRBOX 401 407 PF00104 0.427
LIG_Pex14_2 92 96 PF04695 0.427
LIG_SH2_CRK 154 158 PF00017 0.454
LIG_SH2_NCK_1 172 176 PF00017 0.501
LIG_SH2_PTP2 204 207 PF00017 0.512
LIG_SH2_SRC 204 207 PF00017 0.415
LIG_SH2_STAP1 103 107 PF00017 0.415
LIG_SH2_STAT3 103 106 PF00017 0.481
LIG_SH2_STAT3 286 289 PF00017 0.512
LIG_SH2_STAT5 204 207 PF00017 0.415
LIG_SH2_STAT5 286 289 PF00017 0.409
LIG_SH2_STAT5 299 302 PF00017 0.427
LIG_SH2_STAT5 36 39 PF00017 0.511
LIG_SH2_STAT5 424 427 PF00017 0.415
LIG_SH2_STAT5 447 450 PF00017 0.437
LIG_SH3_5 207 211 PF00018 0.559
LIG_SUMO_SIM_par_1 123 129 PF11976 0.512
LIG_SUMO_SIM_par_1 192 198 PF11976 0.481
LIG_SUMO_SIM_par_1 337 346 PF11976 0.477
LIG_SUMO_SIM_par_1 403 411 PF11976 0.454
LIG_TRAF2_1 246 249 PF00917 0.597
LIG_TRAF2_1 489 492 PF00917 0.611
LIG_UBA3_1 46 53 PF00899 0.417
LIG_WRC_WIRS_1 182 187 PF05994 0.489
LIG_WRC_WIRS_1 75 80 PF05994 0.419
MOD_CK1_1 184 190 PF00069 0.495
MOD_CK1_1 259 265 PF00069 0.584
MOD_CK2_1 200 206 PF00069 0.419
MOD_CK2_1 218 224 PF00069 0.486
MOD_CK2_1 243 249 PF00069 0.532
MOD_CK2_1 358 364 PF00069 0.415
MOD_CK2_1 391 397 PF00069 0.510
MOD_CK2_1 445 451 PF00069 0.553
MOD_CK2_1 471 477 PF00069 0.526
MOD_CK2_1 73 79 PF00069 0.413
MOD_GlcNHglycan 154 157 PF01048 0.264
MOD_GlcNHglycan 186 189 PF01048 0.302
MOD_GlcNHglycan 386 389 PF01048 0.242
MOD_GSK3_1 117 124 PF00069 0.425
MOD_GSK3_1 334 341 PF00069 0.415
MOD_GSK3_1 359 366 PF00069 0.415
MOD_NEK2_1 150 155 PF00069 0.485
MOD_NEK2_1 287 292 PF00069 0.425
MOD_NEK2_1 318 323 PF00069 0.461
MOD_NEK2_1 46 51 PF00069 0.509
MOD_NEK2_1 57 62 PF00069 0.397
MOD_NEK2_1 63 68 PF00069 0.364
MOD_NEK2_1 92 97 PF00069 0.481
MOD_NEK2_2 458 463 PF00069 0.496
MOD_PIKK_1 135 141 PF00454 0.415
MOD_PIKK_1 259 265 PF00454 0.555
MOD_PIKK_1 365 371 PF00454 0.481
MOD_PKA_2 31 37 PF00069 0.555
MOD_PKA_2 318 324 PF00069 0.443
MOD_Plk_1 150 156 PF00069 0.499
MOD_Plk_1 259 265 PF00069 0.517
MOD_Plk_1 410 416 PF00069 0.512
MOD_Plk_4 200 206 PF00069 0.415
MOD_Plk_4 287 293 PF00069 0.415
MOD_Plk_4 338 344 PF00069 0.484
MOD_Plk_4 391 397 PF00069 0.461
MOD_SUMO_for_1 118 121 PF00179 0.440
MOD_SUMO_for_1 180 183 PF00179 0.443
MOD_SUMO_for_1 295 298 PF00179 0.454
MOD_SUMO_for_1 324 327 PF00179 0.457
MOD_SUMO_for_1 440 443 PF00179 0.532
MOD_SUMO_rev_2 244 253 PF00179 0.543
MOD_SUMO_rev_2 304 309 PF00179 0.415
MOD_SUMO_rev_2 436 442 PF00179 0.503
TRG_DiLeu_BaEn_1 401 406 PF01217 0.433
TRG_DiLeu_BaEn_2 409 415 PF01217 0.454
TRG_DiLeu_BaEn_3 410 416 PF01217 0.454
TRG_ENDOCYTIC_2 154 157 PF00928 0.536
TRG_ENDOCYTIC_2 172 175 PF00928 0.332
TRG_ER_diArg_1 100 103 PF00400 0.501
TRG_ER_diArg_1 272 274 PF00400 0.497
TRG_NLS_MonoExtC_3 98 104 PF00514 0.512
TRG_NLS_MonoExtN_4 98 103 PF00514 0.512
TRG_Pf-PMV_PEXEL_1 400 404 PF00026 0.278

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I6X5 Leptomonas seymouri 78% 93%
A0A0S4J2U4 Bodo saltans 58% 100%
A0A1X0NSX4 Trypanosomatidae 70% 100%
A0A3Q8IB01 Leishmania donovani 99% 100%
A0A3S5IQV9 Trypanosoma rangeli 68% 100%
A4H998 Leishmania braziliensis 83% 100%
A9CB27 Papio anubis 41% 100%
C9ZPB5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9ARB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O13724 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 100%
O16999 Caenorhabditis elegans 41% 100%
O75312 Homo sapiens 40% 100%
P53303 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40% 100%
Q2TBX0 Bos taurus 41% 100%
Q4QE48 Leishmania major 94% 100%
Q55E13 Dictyostelium discoideum 42% 100%
Q62384 Mus musculus 41% 100%
Q9W379 Drosophila melanogaster 39% 100%
V5BJH3 Trypanosoma cruzi 64% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS