Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

IQ calmodulin-binding motif containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HXL6_LEIIN

TriTrypDb:

LINF_170021200

Length:

802

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HXL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	421	425	PF00656	0.495
CLV_C14_Caspase3-7	443	447	PF00656	0.449
CLV_C14_Caspase3-7	554	558	PF00656	0.695
CLV_NRD_NRD_1	292	294	PF00675	0.771
CLV_NRD_NRD_1	520	522	PF00675	0.524
CLV_NRD_NRD_1	531	533	PF00675	0.527
CLV_NRD_NRD_1	579	581	PF00675	0.503
CLV_NRD_NRD_1	592	594	PF00675	0.505
CLV_NRD_NRD_1	623	625	PF00675	0.486
CLV_NRD_NRD_1	641	643	PF00675	0.421
CLV_NRD_NRD_1	669	671	PF00675	0.494
CLV_NRD_NRD_1	675	677	PF00675	0.473
CLV_NRD_NRD_1	752	754	PF00675	0.570
CLV_NRD_NRD_1	765	767	PF00675	0.522
CLV_NRD_NRD_1	795	797	PF00675	0.556
CLV_PCSK_KEX2_1	520	522	PF00082	0.526
CLV_PCSK_KEX2_1	592	594	PF00082	0.544
CLV_PCSK_KEX2_1	641	643	PF00082	0.531
CLV_PCSK_KEX2_1	669	671	PF00082	0.522
CLV_PCSK_KEX2_1	675	677	PF00082	0.497
CLV_PCSK_KEX2_1	737	739	PF00082	0.546
CLV_PCSK_KEX2_1	752	754	PF00082	0.571
CLV_PCSK_KEX2_1	765	767	PF00082	0.512
CLV_PCSK_KEX2_1	776	778	PF00082	0.471
CLV_PCSK_KEX2_1	794	796	PF00082	0.213
CLV_PCSK_PC1ET2_1	737	739	PF00082	0.431
CLV_PCSK_PC1ET2_1	776	778	PF00082	0.602
CLV_PCSK_PC7_1	791	797	PF00082	0.249
CLV_PCSK_SKI1_1	199	203	PF00082	0.603
CLV_PCSK_SKI1_1	294	298	PF00082	0.775
CLV_PCSK_SKI1_1	344	348	PF00082	0.528
CLV_PCSK_SKI1_1	521	525	PF00082	0.576
CLV_PCSK_SKI1_1	58	62	PF00082	0.429
CLV_PCSK_SKI1_1	669	673	PF00082	0.515
CLV_PCSK_SKI1_1	766	770	PF00082	0.517
CLV_PCSK_SKI1_1	796	800	PF00082	0.569
CLV_PCSK_SKI1_1	89	93	PF00082	0.458
DEG_APCC_DBOX_1	239	247	PF00400	0.565
DEG_SPOP_SBC_1	419	423	PF00917	0.505
DOC_CKS1_1	92	97	PF01111	0.490
DOC_CYCLIN_yCln2_LP_2	152	158	PF00134	0.636
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.712
DOC_MAPK_gen_1	532	542	PF00069	0.594
DOC_MAPK_gen_1	604	612	PF00069	0.461
DOC_MAPK_gen_1	791	801	PF00069	0.665
DOC_MAPK_MEF2A_6	535	544	PF00069	0.595
DOC_MAPK_RevD_3	610	625	PF00069	0.533
DOC_PP1_RVXF_1	559	566	PF00149	0.486
DOC_PP2B_LxvP_1	205	208	PF13499	0.689
DOC_PP2B_LxvP_1	277	280	PF13499	0.713
DOC_PP2B_LxvP_1	463	466	PF13499	0.776
DOC_PP2B_LxvP_1	7	10	PF13499	0.390
DOC_PP4_FxxP_1	204	207	PF00568	0.595
DOC_PP4_FxxP_1	225	228	PF00568	0.636
DOC_USP7_MATH_1	180	184	PF00917	0.563
DOC_USP7_MATH_1	236	240	PF00917	0.581
DOC_USP7_MATH_1	330	334	PF00917	0.723
DOC_WW_Pin1_4	102	107	PF00397	0.676
DOC_WW_Pin1_4	112	117	PF00397	0.617
DOC_WW_Pin1_4	203	208	PF00397	0.614
DOC_WW_Pin1_4	294	299	PF00397	0.719
DOC_WW_Pin1_4	310	315	PF00397	0.615
DOC_WW_Pin1_4	401	406	PF00397	0.756
DOC_WW_Pin1_4	454	459	PF00397	0.532
DOC_WW_Pin1_4	5	10	PF00397	0.548
DOC_WW_Pin1_4	59	64	PF00397	0.472
DOC_WW_Pin1_4	91	96	PF00397	0.521
LIG_14-3-3_CanoR_1	134	138	PF00244	0.671
LIG_14-3-3_CanoR_1	194	199	PF00244	0.618
LIG_14-3-3_CanoR_1	220	226	PF00244	0.722
LIG_14-3-3_CanoR_1	232	238	PF00244	0.578
LIG_14-3-3_CanoR_1	371	380	PF00244	0.583
LIG_14-3-3_CanoR_1	50	56	PF00244	0.432
LIG_14-3-3_CanoR_1	609	618	PF00244	0.586
LIG_14-3-3_CanoR_1	741	749	PF00244	0.524
LIG_14-3-3_CanoR_1	777	782	PF00244	0.635
LIG_APCC_ABBA_1	21	26	PF00400	0.410
LIG_BRCT_BRCA1_1	14	18	PF00533	0.400
LIG_BRCT_BRCA1_1	374	378	PF00533	0.558
LIG_BRCT_BRCA1_1	38	42	PF00533	0.424
LIG_BRCT_BRCA1_1	61	65	PF00533	0.431
LIG_BRCT_BRCA1_1	83	87	PF00533	0.489
LIG_CaM_IQ_9	497	512	PF13499	0.490
LIG_CaM_IQ_9	596	611	PF13499	0.490
LIG_CaM_IQ_9	633	649	PF13499	0.437
LIG_CaM_IQ_9	656	672	PF13499	0.433
LIG_CaM_IQ_9	717	732	PF13499	0.510
LIG_CtBP_PxDLS_1	37	41	PF00389	0.422
LIG_CtBP_PxDLS_1	9	13	PF00389	0.384
LIG_deltaCOP1_diTrp_1	480	486	PF00928	0.628
LIG_FHA_1	137	143	PF00498	0.666
LIG_FHA_1	233	239	PF00498	0.739
LIG_FHA_1	295	301	PF00498	0.779
LIG_FHA_1	352	358	PF00498	0.626
LIG_FHA_2	286	292	PF00498	0.687
LIG_FHA_2	428	434	PF00498	0.545
LIG_FHA_2	441	447	PF00498	0.491
LIG_FHA_2	92	98	PF00498	0.489
LIG_Integrin_RGD_1	408	410	PF01839	0.774
LIG_LIR_Apic_2	223	228	PF02991	0.633
LIG_LIR_Gen_1	219	228	PF02991	0.673
LIG_LIR_Gen_1	241	251	PF02991	0.555
LIG_LIR_Nem_3	102	107	PF02991	0.597
LIG_LIR_Nem_3	15	21	PF02991	0.580
LIG_LIR_Nem_3	197	201	PF02991	0.535
LIG_LIR_Nem_3	219	225	PF02991	0.777
LIG_LIR_Nem_3	241	247	PF02991	0.550
LIG_LIR_Nem_3	638	643	PF02991	0.499
LIG_LIR_Nem_3	696	702	PF02991	0.587
LIG_MLH1_MIPbox_1	14	18	PF16413	0.400
LIG_MYND_1	10	14	PF01753	0.385
LIG_MYND_1	203	207	PF01753	0.596
LIG_PCNA_yPIPBox_3	185	199	PF02747	0.582
LIG_Pex14_2	17	21	PF04695	0.411
LIG_Rb_LxCxE_1	47	64	PF01857	0.425
LIG_REV1ctd_RIR_1	563	573	PF16727	0.525
LIG_RPA_C_Fungi	588	600	PF08784	0.415
LIG_RPA_C_Fungi	748	760	PF08784	0.366
LIG_SH2_CRK	699	703	PF00017	0.325
LIG_SH2_SRC	472	475	PF00017	0.628
LIG_SH2_SRC	72	75	PF00017	0.436
LIG_SH2_STAT3	643	646	PF00017	0.565
LIG_SH2_STAT5	379	382	PF00017	0.548
LIG_SH2_STAT5	415	418	PF00017	0.684
LIG_SH2_STAT5	472	475	PF00017	0.628
LIG_SH3_2	207	212	PF14604	0.650
LIG_SH3_3	204	210	PF00018	0.616
LIG_SH3_3	315	321	PF00018	0.726
LIG_SH3_3	60	66	PF00018	0.461
LIG_SUMO_SIM_anti_2	385	391	PF11976	0.637
LIG_SUMO_SIM_anti_2	716	721	PF11976	0.389
LIG_SUMO_SIM_par_1	36	41	PF11976	0.425
LIG_SUMO_SIM_par_1	414	427	PF11976	0.498
LIG_TRAF2_1	308	311	PF00917	0.661
LIG_TRAF2_1	356	359	PF00917	0.505
LIG_TRAF2_1	382	385	PF00917	0.622
LIG_TRAF2_1	432	435	PF00917	0.628
LIG_WRC_WIRS_1	137	142	PF05994	0.675
LIG_WRC_WIRS_1	198	203	PF05994	0.551
LIG_WRC_WIRS_1	222	227	PF05994	0.567
LIG_WRC_WIRS_1	332	337	PF05994	0.591
LIG_WRPW_2	201	204	PF00400	0.598
MOD_CDC14_SPxK_1	105	108	PF00782	0.509
MOD_CDK_SPK_2	454	459	PF00069	0.532
MOD_CDK_SPxK_1	102	108	PF00069	0.507
MOD_CDK_SPxxK_3	401	408	PF00069	0.697
MOD_CK1_1	132	138	PF00069	0.618
MOD_CK1_1	164	170	PF00069	0.629
MOD_CK1_1	223	229	PF00069	0.684
MOD_CK1_1	234	240	PF00069	0.642
MOD_CK1_1	351	357	PF00069	0.408
MOD_CK1_1	422	428	PF00069	0.486
MOD_CK1_1	8	14	PF00069	0.626
MOD_CK2_1	285	291	PF00069	0.736
MOD_CK2_1	420	426	PF00069	0.750
MOD_CK2_1	427	433	PF00069	0.680
MOD_CK2_1	454	460	PF00069	0.761
MOD_CK2_1	49	55	PF00069	0.426
MOD_CK2_1	91	97	PF00069	0.497
MOD_GlcNHglycan	225	228	PF01048	0.670
MOD_GlcNHglycan	272	275	PF01048	0.630
MOD_GlcNHglycan	285	288	PF01048	0.680
MOD_GlcNHglycan	32	35	PF01048	0.450
MOD_GlcNHglycan	338	341	PF01048	0.628
MOD_GlcNHglycan	350	353	PF01048	0.545
MOD_GlcNHglycan	494	497	PF01048	0.483
MOD_GlcNHglycan	528	531	PF01048	0.602
MOD_GlcNHglycan	553	556	PF01048	0.703
MOD_GlcNHglycan	682	686	PF01048	0.572
MOD_GlcNHglycan	743	746	PF01048	0.618
MOD_GlcNHglycan	83	86	PF01048	0.753
MOD_GSK3_1	129	136	PF00069	0.652
MOD_GSK3_1	157	164	PF00069	0.671
MOD_GSK3_1	190	197	PF00069	0.547
MOD_GSK3_1	232	239	PF00069	0.696
MOD_GSK3_1	279	286	PF00069	0.712
MOD_GSK3_1	302	309	PF00069	0.742
MOD_GSK3_1	326	333	PF00069	0.700
MOD_GSK3_1	38	45	PF00069	0.461
MOD_GSK3_1	418	425	PF00069	0.616
MOD_GSK3_1	448	455	PF00069	0.736
MOD_GSK3_1	545	552	PF00069	0.609
MOD_GSK3_1	681	688	PF00069	0.547
MOD_GSK3_1	737	744	PF00069	0.482
MOD_GSK3_1	8	15	PF00069	0.590
MOD_LATS_1	218	224	PF00433	0.560
MOD_LATS_1	230	236	PF00433	0.498
MOD_N-GLC_1	102	107	PF02516	0.668
MOD_NEK2_1	129	134	PF00069	0.614
MOD_NEK2_1	251	256	PF00069	0.632
MOD_NEK2_1	267	272	PF00069	0.580
MOD_NEK2_1	326	331	PF00069	0.654
MOD_NEK2_1	42	47	PF00069	0.439
MOD_NEK2_1	440	445	PF00069	0.627
MOD_NEK2_1	482	487	PF00069	0.642
MOD_NEK2_1	524	529	PF00069	0.574
MOD_NEK2_1	635	640	PF00069	0.577
MOD_NEK2_2	170	175	PF00069	0.558
MOD_OFUCOSY	46	53	PF10250	0.419
MOD_OFUCOSY	632	639	PF10250	0.533
MOD_PIKK_1	181	187	PF00454	0.586
MOD_PIKK_1	27	33	PF00454	0.416
MOD_PKA_1	737	743	PF00069	0.594
MOD_PKA_1	81	87	PF00069	0.443
MOD_PKA_2	133	139	PF00069	0.636
MOD_PKA_2	144	150	PF00069	0.692
MOD_PKA_2	231	237	PF00069	0.728
MOD_PKA_2	372	378	PF00069	0.586
MOD_PKA_2	458	464	PF00069	0.646
MOD_PKA_2	49	55	PF00069	0.469
MOD_PKA_2	737	743	PF00069	0.591
MOD_Plk_1	251	257	PF00069	0.668
MOD_Plk_1	556	562	PF00069	0.542
MOD_Plk_2-3	306	312	PF00069	0.663
MOD_Plk_4	12	18	PF00069	0.396
MOD_Plk_4	285	291	PF00069	0.774
MOD_Plk_4	38	44	PF00069	0.455
MOD_Plk_4	411	417	PF00069	0.520
MOD_Plk_4	658	664	PF00069	0.489
MOD_Plk_4	698	704	PF00069	0.525
MOD_ProDKin_1	102	108	PF00069	0.677
MOD_ProDKin_1	112	118	PF00069	0.618
MOD_ProDKin_1	203	209	PF00069	0.620
MOD_ProDKin_1	294	300	PF00069	0.719
MOD_ProDKin_1	310	316	PF00069	0.617
MOD_ProDKin_1	401	407	PF00069	0.756
MOD_ProDKin_1	454	460	PF00069	0.532
MOD_ProDKin_1	5	11	PF00069	0.547
MOD_ProDKin_1	59	65	PF00069	0.474
MOD_ProDKin_1	91	97	PF00069	0.521
MOD_SUMO_for_1	107	110	PF00179	0.508
MOD_SUMO_rev_2	527	534	PF00179	0.502
TRG_ENDOCYTIC_2	198	201	PF00928	0.539
TRG_ENDOCYTIC_2	699	702	PF00928	0.586
TRG_ER_diArg_1	149	152	PF00400	0.771
TRG_ER_diArg_1	507	510	PF00400	0.363
TRG_ER_diArg_1	591	593	PF00400	0.554
TRG_ER_diArg_1	607	610	PF00400	0.209
TRG_ER_diArg_1	640	642	PF00400	0.543
TRG_ER_diArg_1	669	671	PF00400	0.423
TRG_ER_diArg_1	675	677	PF00400	0.488
TRG_ER_diArg_1	752	754	PF00400	0.584
TRG_ER_diArg_1	793	796	PF00400	0.398
TRG_Pf-PMV_PEXEL_1	670	674	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	747	751	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8D9	Leptomonas seymouri	45%	100%
A0A0S4J9A9	Bodo saltans	29%	90%
A0A1X0NSM4	Trypanosomatidae	27%	100%
A0A3R7K6T1	Trypanosoma rangeli	28%	100%
A0A3S7WUM7	Leishmania donovani	99%	100%
A4H995	Leishmania braziliensis	66%	100%
E9ARB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QE51	Leishmania major	91%	100%