Protein SDA1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein SDA1

Gene product:

NUC130/3NT domain/SDA1 - putative

Species:

Leishmania infantum

UniProt:

A4HXL4_LEIIN

TriTrypDb:

LINF_170021000

Length:

874

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HXL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXL4

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	11
GO:0000055	ribosomal large subunit export from nucleus	4	11
GO:0006810	transport	3	11
GO:0006913	nucleocytoplasmic transport	5	11
GO:0006996	organelle organization	4	11
GO:0007010	cytoskeleton organization	5	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016043	cellular component organization	3	11
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0030029	actin filament-based process	2	11
GO:0030036	actin cytoskeleton organization	3	11
GO:0031503	protein-containing complex localization	2	11
GO:0033036	macromolecule localization	2	11
GO:0033750	ribosome localization	3	11
GO:0042273	ribosomal large subunit biogenesis	5	11
GO:0044085	cellular component biogenesis	3	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051168	nuclear export	6	11
GO:0051169	nuclear transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051640	organelle localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0051656	establishment of organelle localization	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	395	399	PF00656	0.346
CLV_C14_Caspase3-7	512	516	PF00656	0.295
CLV_C14_Caspase3-7	523	527	PF00656	0.243
CLV_C14_Caspase3-7	532	536	PF00656	0.208
CLV_C14_Caspase3-7	540	544	PF00656	0.169
CLV_C14_Caspase3-7	573	577	PF00656	0.632
CLV_C14_Caspase3-7	612	616	PF00656	0.383
CLV_C14_Caspase3-7	692	696	PF00656	0.339
CLV_NRD_NRD_1	130	132	PF00675	0.297
CLV_NRD_NRD_1	142	144	PF00675	0.327
CLV_NRD_NRD_1	18	20	PF00675	0.377
CLV_NRD_NRD_1	189	191	PF00675	0.335
CLV_NRD_NRD_1	275	277	PF00675	0.470
CLV_NRD_NRD_1	580	582	PF00675	0.708
CLV_NRD_NRD_1	752	754	PF00675	0.323
CLV_NRD_NRD_1	801	803	PF00675	0.277
CLV_NRD_NRD_1	811	813	PF00675	0.214
CLV_NRD_NRD_1	839	841	PF00675	0.214
CLV_PCSK_FUR_1	16	20	PF00082	0.366
CLV_PCSK_FUR_1	750	754	PF00082	0.411
CLV_PCSK_FUR_1	837	841	PF00082	0.231
CLV_PCSK_FUR_1	867	871	PF00082	0.240
CLV_PCSK_KEX2_1	158	160	PF00082	0.332
CLV_PCSK_KEX2_1	18	20	PF00082	0.378
CLV_PCSK_KEX2_1	188	190	PF00082	0.330
CLV_PCSK_KEX2_1	262	264	PF00082	0.420
CLV_PCSK_KEX2_1	268	270	PF00082	0.432
CLV_PCSK_KEX2_1	275	277	PF00082	0.479
CLV_PCSK_KEX2_1	412	414	PF00082	0.326
CLV_PCSK_KEX2_1	582	584	PF00082	0.634
CLV_PCSK_KEX2_1	752	754	PF00082	0.357
CLV_PCSK_KEX2_1	762	764	PF00082	0.259
CLV_PCSK_KEX2_1	786	788	PF00082	0.240
CLV_PCSK_KEX2_1	811	813	PF00082	0.257
CLV_PCSK_KEX2_1	827	829	PF00082	0.230
CLV_PCSK_KEX2_1	836	838	PF00082	0.293
CLV_PCSK_KEX2_1	839	841	PF00082	0.315
CLV_PCSK_KEX2_1	869	871	PF00082	0.240
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.332
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.413
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.411
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.414
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.326
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.634
CLV_PCSK_PC1ET2_1	752	754	PF00082	0.350
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.291
CLV_PCSK_PC1ET2_1	786	788	PF00082	0.240
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.256
CLV_PCSK_PC1ET2_1	836	838	PF00082	0.293
CLV_PCSK_PC1ET2_1	869	871	PF00082	0.319
CLV_PCSK_PC7_1	408	414	PF00082	0.305
CLV_PCSK_SKI1_1	132	136	PF00082	0.346
CLV_PCSK_SKI1_1	214	218	PF00082	0.341
CLV_PCSK_SKI1_1	255	259	PF00082	0.425
CLV_PCSK_SKI1_1	265	269	PF00082	0.368
CLV_PCSK_SKI1_1	272	276	PF00082	0.420
CLV_PCSK_SKI1_1	726	730	PF00082	0.332
CLV_PCSK_SKI1_1	791	795	PF00082	0.360
CLV_PCSK_SKI1_1	862	866	PF00082	0.249
CLV_PCSK_SKI1_1	94	98	PF00082	0.249
CLV_Separin_Metazoa	79	83	PF03568	0.305
DEG_APCC_DBOX_1	217	225	PF00400	0.308
DEG_APCC_DBOX_1	6	14	PF00400	0.355
DEG_APCC_DBOX_1	827	835	PF00400	0.280
DEG_Kelch_Keap1_1	515	520	PF01344	0.354
DEG_SPOP_SBC_1	514	518	PF00917	0.261
DEG_SPOP_SBC_1	716	720	PF00917	0.364
DOC_ANK_TNKS_1	571	578	PF00023	0.606
DOC_CDC14_PxL_1	483	491	PF14671	0.236
DOC_CYCLIN_RxL_1	126	136	PF00134	0.423
DOC_MAPK_DCC_7	290	298	PF00069	0.354
DOC_MAPK_gen_1	126	135	PF00069	0.308
DOC_MAPK_HePTP_8	174	186	PF00069	0.285
DOC_MAPK_MEF2A_6	177	186	PF00069	0.279
DOC_MAPK_MEF2A_6	68	76	PF00069	0.325
DOC_PP1_RVXF_1	860	867	PF00149	0.240
DOC_PP2B_LxvP_1	222	225	PF13499	0.382
DOC_PP2B_LxvP_1	340	343	PF13499	0.387
DOC_PP4_MxPP_1	373	376	PF00568	0.354
DOC_SPAK_OSR1_1	319	323	PF12202	0.320
DOC_USP7_MATH_1	522	526	PF00917	0.428
DOC_USP7_MATH_1	542	546	PF00917	0.277
DOC_USP7_MATH_1	702	706	PF00917	0.298
DOC_USP7_UBL2_3	128	132	PF12436	0.390
DOC_USP7_UBL2_3	249	253	PF12436	0.405
DOC_USP7_UBL2_3	255	259	PF12436	0.412
DOC_USP7_UBL2_3	813	817	PF12436	0.219
DOC_USP7_UBL2_3	857	861	PF12436	0.242
DOC_USP7_UBL2_3	865	869	PF12436	0.243
DOC_WW_Pin1_4	207	212	PF00397	0.448
LIG_14-3-3_CanoR_1	189	198	PF00244	0.440
LIG_14-3-3_CanoR_1	226	231	PF00244	0.545
LIG_14-3-3_CanoR_1	332	340	PF00244	0.361
LIG_14-3-3_CanoR_1	36	43	PF00244	0.458
LIG_14-3-3_CanoR_1	394	402	PF00244	0.458
LIG_14-3-3_CanoR_1	726	733	PF00244	0.270
LIG_14-3-3_CanoR_1	802	810	PF00244	0.373
LIG_Actin_WH2_2	69	84	PF00022	0.373
LIG_APCC_ABBA_1	116	121	PF00400	0.308
LIG_APCC_ABBA_1	446	451	PF00400	0.259
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_BIR_III_1	1	5	PF00653	0.511
LIG_BIR_III_2	554	558	PF00653	0.207
LIG_BIR_III_3	1	5	PF00653	0.511
LIG_BIR_III_4	574	578	PF00653	0.605
LIG_BRCT_BRCA1_1	316	320	PF00533	0.374
LIG_BRCT_BRCA1_1	804	808	PF00533	0.373
LIG_CtBP_PxDLS_1	90	94	PF00389	0.239
LIG_FAT_LD_1	306	314	PF03623	0.323
LIG_FHA_1	113	119	PF00498	0.374
LIG_FHA_1	134	140	PF00498	0.441
LIG_FHA_1	195	201	PF00498	0.306
LIG_FHA_1	208	214	PF00498	0.308
LIG_FHA_1	358	364	PF00498	0.320
LIG_FHA_1	399	405	PF00498	0.294
LIG_FHA_1	471	477	PF00498	0.396
LIG_FHA_1	7	13	PF00498	0.342
LIG_FHA_1	717	723	PF00498	0.377
LIG_FHA_1	805	811	PF00498	0.442
LIG_FHA_2	15	21	PF00498	0.347
LIG_FHA_2	226	232	PF00498	0.429
LIG_FHA_2	331	337	PF00498	0.345
LIG_FHA_2	404	410	PF00498	0.290
LIG_FHA_2	521	527	PF00498	0.437
LIG_FHA_2	571	577	PF00498	0.803
LIG_FHA_2	605	611	PF00498	0.369
LIG_FHA_2	650	656	PF00498	0.389
LIG_FHA_2	727	733	PF00498	0.283
LIG_FHA_2	819	825	PF00498	0.274
LIG_Integrin_RGD_1	433	435	PF01839	0.240
LIG_LIR_Apic_2	349	354	PF02991	0.327
LIG_LIR_Gen_1	490	500	PF02991	0.293
LIG_LIR_Gen_1	535	546	PF02991	0.319
LIG_LIR_Gen_1	688	697	PF02991	0.320
LIG_LIR_Gen_1	730	739	PF02991	0.240
LIG_LIR_Nem_3	113	119	PF02991	0.316
LIG_LIR_Nem_3	33	38	PF02991	0.252
LIG_LIR_Nem_3	451	456	PF02991	0.286
LIG_LIR_Nem_3	490	496	PF02991	0.293
LIG_LIR_Nem_3	535	541	PF02991	0.319
LIG_LIR_Nem_3	688	693	PF02991	0.320
LIG_LIR_Nem_3	730	736	PF02991	0.240
LIG_LRP6_Inhibitor_1	402	408	PF00058	0.291
LIG_LYPXL_S_1	452	456	PF13949	0.259
LIG_LYPXL_yS_3	453	456	PF13949	0.259
LIG_MYND_1	454	458	PF01753	0.240
LIG_MYND_1	557	561	PF01753	0.616
LIG_PALB2_WD40_1	685	693	PF16756	0.305
LIG_Pex14_2	116	120	PF04695	0.299
LIG_PTB_Apo_2	46	53	PF02174	0.329
LIG_SH2_GRB2like	326	329	PF00017	0.368
LIG_SH2_NCK_1	483	487	PF00017	0.236
LIG_SH2_SRC	326	329	PF00017	0.319
LIG_SH2_SRC	493	496	PF00017	0.251
LIG_SH2_STAT3	278	281	PF00017	0.448
LIG_SH2_STAT3	429	432	PF00017	0.214
LIG_SH2_STAT5	326	329	PF00017	0.368
LIG_SH2_STAT5	483	486	PF00017	0.253
LIG_SH2_STAT5	58	61	PF00017	0.263
LIG_SH3_3	536	542	PF00018	0.250
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.283
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.314
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.334
LIG_SUMO_SIM_par_1	180	185	PF11976	0.277
LIG_SUMO_SIM_par_1	193	202	PF11976	0.309
LIG_SUMO_SIM_par_1	360	366	PF11976	0.328
LIG_SUMO_SIM_par_1	590	596	PF11976	0.711
LIG_TRAF2_1	545	548	PF00917	0.444
LIG_TRAF2_1	627	630	PF00917	0.206
LIG_TRAF2_1	668	671	PF00917	0.333
LIG_TYR_ITIM	324	329	PF00017	0.321
LIG_TYR_ITIM	491	496	PF00017	0.283
LIG_UBA3_1	101	107	PF00899	0.314
LIG_UBA3_1	309	315	PF00899	0.296
LIG_UBA3_1	422	430	PF00899	0.259
LIG_UBA3_1	831	836	PF00899	0.240
MOD_CDK_SPxxK_3	207	214	PF00069	0.440
MOD_CK1_1	207	213	PF00069	0.330
MOD_CK1_1	392	398	PF00069	0.391
MOD_CK1_1	44	50	PF00069	0.488
MOD_CK1_1	507	513	PF00069	0.274
MOD_CK1_1	593	599	PF00069	0.614
MOD_CK1_1	603	609	PF00069	0.456
MOD_CK1_1	710	716	PF00069	0.316
MOD_CK1_1	718	724	PF00069	0.358
MOD_CK1_1	745	751	PF00069	0.259
MOD_CK2_1	258	264	PF00069	0.475
MOD_CK2_1	330	336	PF00069	0.342
MOD_CK2_1	403	409	PF00069	0.291
MOD_CK2_1	502	508	PF00069	0.329
MOD_CK2_1	514	520	PF00069	0.242
MOD_CK2_1	522	528	PF00069	0.285
MOD_CK2_1	541	547	PF00069	0.137
MOD_CK2_1	604	610	PF00069	0.319
MOD_CK2_1	624	630	PF00069	0.330
MOD_CK2_1	633	639	PF00069	0.260
MOD_CK2_1	650	656	PF00069	0.325
MOD_CK2_1	661	667	PF00069	0.348
MOD_CK2_1	803	809	PF00069	0.253
MOD_CK2_1	818	824	PF00069	0.206
MOD_Cter_Amidation	750	753	PF01082	0.360
MOD_GlcNHglycan	365	368	PF01048	0.444
MOD_GlcNHglycan	38	41	PF01048	0.447
MOD_GlcNHglycan	395	398	PF01048	0.470
MOD_GlcNHglycan	503	507	PF01048	0.318
MOD_GlcNHglycan	517	520	PF01048	0.372
MOD_GlcNHglycan	543	547	PF01048	0.372
MOD_GlcNHglycan	567	570	PF01048	0.680
MOD_GlcNHglycan	676	679	PF01048	0.247
MOD_GlcNHglycan	684	687	PF01048	0.354
MOD_GSK3_1	108	115	PF00069	0.364
MOD_GSK3_1	133	140	PF00069	0.355
MOD_GSK3_1	190	197	PF00069	0.410
MOD_GSK3_1	389	396	PF00069	0.336
MOD_GSK3_1	502	509	PF00069	0.284
MOD_GSK3_1	520	527	PF00069	0.408
MOD_GSK3_1	600	607	PF00069	0.701
MOD_GSK3_1	638	645	PF00069	0.378
MOD_GSK3_1	691	698	PF00069	0.229
MOD_GSK3_1	707	714	PF00069	0.304
MOD_GSK3_1	716	723	PF00069	0.361
MOD_GSK3_1	738	745	PF00069	0.271
MOD_GSK3_1	813	820	PF00069	0.284
MOD_LATS_1	34	40	PF00433	0.374
MOD_N-GLC_1	14	19	PF02516	0.342
MOD_N-GLC_1	570	575	PF02516	0.545
MOD_N-GLC_1	700	705	PF02516	0.348
MOD_N-GLC_1	818	823	PF02516	0.291
MOD_NEK2_1	133	138	PF00069	0.354
MOD_NEK2_1	163	168	PF00069	0.370
MOD_NEK2_1	267	272	PF00069	0.442
MOD_NEK2_1	357	362	PF00069	0.334
MOD_NEK2_1	363	368	PF00069	0.294
MOD_NEK2_1	38	43	PF00069	0.319
MOD_NEK2_1	382	387	PF00069	0.432
MOD_NEK2_1	461	466	PF00069	0.342
MOD_NEK2_1	6	11	PF00069	0.344
MOD_NEK2_1	602	607	PF00069	0.797
MOD_NEK2_1	717	722	PF00069	0.349
MOD_NEK2_1	81	86	PF00069	0.277
MOD_NEK2_1	818	823	PF00069	0.267
MOD_NEK2_1	832	837	PF00069	0.240
MOD_NEK2_1	845	850	PF00069	0.217
MOD_NEK2_1	97	102	PF00069	0.265
MOD_NEK2_2	403	408	PF00069	0.287
MOD_NEK2_2	702	707	PF00069	0.185
MOD_PIKK_1	352	358	PF00454	0.341
MOD_PIKK_1	41	47	PF00454	0.471
MOD_PIKK_1	593	599	PF00454	0.718
MOD_PIKK_1	738	744	PF00454	0.270
MOD_PK_1	226	232	PF00069	0.429
MOD_PK_1	707	713	PF00069	0.364
MOD_PKA_1	258	264	PF00069	0.425
MOD_PKA_1	786	792	PF00069	0.263
MOD_PKA_1	802	808	PF00069	0.289
MOD_PKA_1	813	819	PF00069	0.193
MOD_PKA_2	225	231	PF00069	0.539
MOD_PKA_2	393	399	PF00069	0.477
MOD_PKA_2	461	467	PF00069	0.354
MOD_PKA_2	6	12	PF00069	0.362
MOD_PKA_2	786	792	PF00069	0.354
MOD_PKA_2	81	87	PF00069	0.380
MOD_PKA_2	851	857	PF00069	0.375
MOD_PKB_1	188	196	PF00069	0.447
MOD_Plk_1	112	118	PF00069	0.318
MOD_Plk_1	126	132	PF00069	0.355
MOD_Plk_1	194	200	PF00069	0.310
MOD_Plk_2-3	194	200	PF00069	0.389
MOD_Plk_2-3	20	26	PF00069	0.437
MOD_Plk_2-3	520	526	PF00069	0.310
MOD_Plk_2-3	549	555	PF00069	0.384
MOD_Plk_2-3	604	610	PF00069	0.343
MOD_Plk_2-3	633	639	PF00069	0.241
MOD_Plk_2-3	650	656	PF00069	0.352
MOD_Plk_4	38	44	PF00069	0.366
MOD_Plk_4	6	12	PF00069	0.363
MOD_Plk_4	97	103	PF00069	0.373
MOD_ProDKin_1	207	213	PF00069	0.441
MOD_SUMO_for_1	668	671	PF00179	0.185
MOD_SUMO_for_1	793	796	PF00179	0.354
MOD_SUMO_rev_2	858	866	PF00179	0.240
TRG_DiLeu_BaEn_4	671	677	PF01217	0.421
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.316
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.304
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.318
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.430
TRG_DiLeu_BaLyEn_6	723	728	PF01217	0.373
TRG_ENDOCYTIC_2	326	329	PF00928	0.347
TRG_ENDOCYTIC_2	345	348	PF00928	0.312
TRG_ENDOCYTIC_2	449	452	PF00928	0.247
TRG_ENDOCYTIC_2	453	456	PF00928	0.233
TRG_ENDOCYTIC_2	483	486	PF00928	0.256
TRG_ENDOCYTIC_2	493	496	PF00928	0.263
TRG_ER_diArg_1	16	19	PF00400	0.367
TRG_ER_diArg_1	187	190	PF00400	0.316
TRG_ER_diArg_1	580	583	PF00400	0.724
TRG_ER_diArg_1	810	812	PF00400	0.256
TRG_ER_diArg_1	837	840	PF00400	0.231
TRG_NLS_Bipartite_1	802	818	PF00514	0.257
TRG_NLS_MonoCore_2	811	816	PF00514	0.233
TRG_NLS_MonoExtC_3	580	585	PF00514	0.620
TRG_NLS_MonoExtC_3	812	817	PF00514	0.235
TRG_NLS_MonoExtC_3	835	840	PF00514	0.231
TRG_NLS_MonoExtN_4	580	586	PF00514	0.652
TRG_NLS_MonoExtN_4	811	818	PF00514	0.239
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.259
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.240
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	726	730	PF00026	0.240

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R9	Leptomonas seymouri	73%	100%
A0A0S4J2U0	Bodo saltans	57%	98%
A0A1X0NT40	Trypanosomatidae	70%	100%
A0A3S5H720	Leishmania donovani	99%	100%
A4H993	Leishmania braziliensis	84%	99%
A7S6A5	Nematostella vectensis	33%	100%
C9ZPA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ARB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
P53313	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q4QE53	Leishmania major	94%	99%
V5AZE5	Trypanosoma cruzi	60%	100%