Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXL0_LEIIN

TriTrypDb:

LINF_170020600

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HXL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.362
CLV_PCSK_KEX2_1	12	14	PF00082	0.381
CLV_PCSK_SKI1_1	116	120	PF00082	0.336
DEG_APCC_DBOX_1	79	87	PF00400	0.637
DEG_MDM2_SWIB_1	4	11	PF02201	0.519
DEG_SPOP_SBC_1	58	62	PF00917	0.639
DOC_AGCK_PIF_2	103	108	PF00069	0.585
DOC_CDC14_PxL_1	50	58	PF14671	0.640
DOC_MAPK_MEF2A_6	49	58	PF00069	0.585
DOC_PP2B_LxvP_1	144	147	PF13499	0.388
DOC_PP2B_LxvP_1	203	206	PF13499	0.585
DOC_WW_Pin1_4	109	114	PF00397	0.589
DOC_WW_Pin1_4	130	135	PF00397	0.417
LIG_14-3-3_CanoR_1	59	68	PF00244	0.726
LIG_CtBP_PxDLS_1	232	236	PF00389	0.629
LIG_eIF4E_1	152	158	PF01652	0.248
LIG_FHA_1	139	145	PF00498	0.255
LIG_FHA_1	198	204	PF00498	0.617
LIG_FHA_2	74	80	PF00498	0.575
LIG_LIR_Apic_2	150	155	PF02991	0.357
LIG_LIR_Gen_1	107	113	PF02991	0.606
LIG_LIR_Gen_1	76	86	PF02991	0.594
LIG_LIR_Nem_3	101	106	PF02991	0.572
LIG_LIR_Nem_3	107	111	PF02991	0.630
LIG_LIR_Nem_3	213	219	PF02991	0.587
LIG_LIR_Nem_3	6	11	PF02991	0.612
LIG_LIR_Nem_3	76	81	PF02991	0.592
LIG_PCNA_TLS_4	180	187	PF02747	0.522
LIG_Pex14_2	4	8	PF04695	0.518
LIG_SH2_CRK	152	156	PF00017	0.248
LIG_SH2_CRK	97	101	PF00017	0.604
LIG_SH2_NCK_1	108	112	PF00017	0.588
LIG_SH2_SRC	108	111	PF00017	0.599
LIG_SH2_SRC	219	222	PF00017	0.672
LIG_SH2_STAP1	22	26	PF00017	0.580
LIG_SH2_STAT3	22	25	PF00017	0.705
LIG_SH2_STAT5	194	197	PF00017	0.562
LIG_SH2_STAT5	219	222	PF00017	0.672
LIG_SH2_STAT5	75	78	PF00017	0.580
LIG_SH3_2	85	90	PF14604	0.558
LIG_SH3_3	203	209	PF00018	0.585
LIG_SH3_3	222	228	PF00018	0.730
LIG_SH3_3	82	88	PF00018	0.581
LIG_TRAF2_1	112	115	PF00917	0.538
LIG_TRAF2_1	70	73	PF00917	0.628
MOD_CDK_SPxxK_3	109	116	PF00069	0.580
MOD_CK1_1	61	67	PF00069	0.716
MOD_CK2_1	109	115	PF00069	0.582
MOD_CK2_1	73	79	PF00069	0.568
MOD_GlcNHglycan	14	17	PF01048	0.401
MOD_GlcNHglycan	51	54	PF01048	0.441
MOD_GlcNHglycan	63	66	PF01048	0.394
MOD_GSK3_1	57	64	PF00069	0.697
MOD_NEK2_1	138	143	PF00069	0.361
MOD_NEK2_1	174	179	PF00069	0.627
MOD_NEK2_2	147	152	PF00069	0.451
MOD_PIKK_1	174	180	PF00454	0.602
MOD_PKA_1	12	18	PF00069	0.703
MOD_PKA_2	12	18	PF00069	0.681
MOD_PKA_2	58	64	PF00069	0.626
MOD_Plk_2-3	73	79	PF00069	0.571
MOD_Plk_4	147	153	PF00069	0.452
MOD_Plk_4	3	9	PF00069	0.613
MOD_Plk_4	73	79	PF00069	0.571
MOD_ProDKin_1	109	115	PF00069	0.582
MOD_ProDKin_1	130	136	PF00069	0.417
MOD_SUMO_for_1	29	32	PF00179	0.562
MOD_SUMO_rev_2	109	118	PF00179	0.575
TRG_DiLeu_BaEn_1	79	84	PF01217	0.640
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.237
TRG_ENDOCYTIC_2	108	111	PF00928	0.617
TRG_ENDOCYTIC_2	97	100	PF00928	0.607
TRG_ER_diArg_1	11	13	PF00400	0.556
TRG_ER_diArg_1	209	212	PF00400	0.666
TRG_ER_diArg_1	91	94	PF00400	0.609
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILZ4	Leptomonas seymouri	76%	100%
A0A0S4J5W5	Bodo saltans	50%	100%
A0A1X0NSN8	Trypanosomatidae	61%	98%
A0A3Q8I9U7	Leishmania donovani	100%	100%
A0A422NB46	Trypanosoma rangeli	68%	100%
A4H989	Leishmania braziliensis	92%	100%
C9ZPA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9ARA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QE57	Leishmania major	94%	100%
V5AZF8	Trypanosoma cruzi	68%	100%