Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Secreted protein

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4HXK9_LEIIN

TriTrypDb:

Length:

120

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HXK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.360
CLV_NRD_NRD_1	8	10	PF00675	0.377
CLV_PCSK_FUR_1	5	9	PF00082	0.383
CLV_PCSK_KEX2_1	107	109	PF00082	0.360
CLV_PCSK_KEX2_1	7	9	PF00082	0.380
DEG_ODPH_VHL_1	37	48	PF01847	0.199
DOC_MAPK_MEF2A_6	52	61	PF00069	0.526
DOC_MAPK_MEF2A_6	9	18	PF00069	0.557
DOC_PP1_RVXF_1	26	32	PF00149	0.199
DOC_PP4_FxxP_1	47	50	PF00568	0.199
DOC_USP7_MATH_1	12	16	PF00917	0.556
DOC_USP7_MATH_1	50	54	PF00917	0.406
DOC_USP7_MATH_1	75	79	PF00917	0.545
DOC_WW_Pin1_4	10	15	PF00397	0.559
DOC_WW_Pin1_4	109	114	PF00397	0.555
DOC_WW_Pin1_4	46	51	PF00397	0.199
DOC_WW_Pin1_4	71	76	PF00397	0.526
DOC_WW_Pin1_4	88	93	PF00397	0.553
LIG_14-3-3_CanoR_1	28	32	PF00244	0.199
LIG_14-3-3_CanoR_1	52	58	PF00244	0.534
LIG_14-3-3_CanoR_1	7	16	PF00244	0.566
LIG_BRCT_BRCA1_1	14	18	PF00533	0.400
LIG_BRCT_BRCA1_1	23	27	PF00533	0.199
LIG_BRCT_BRCA1_1	67	71	PF00533	0.507
LIG_BRCT_BRCA1_1	90	94	PF00533	0.555
LIG_FHA_1	11	17	PF00498	0.553
LIG_FHA_1	54	60	PF00498	0.524
LIG_FHA_1	94	100	PF00498	0.564
LIG_LIR_Apic_2	45	50	PF02991	0.199
LIG_LIR_Gen_1	33	42	PF02991	0.199
LIG_LIR_Nem_3	112	117	PF02991	0.559
LIG_LIR_Nem_3	30	34	PF02991	0.199
LIG_LIR_Nem_3	49	54	PF02991	0.400
LIG_NRP_CendR_1	118	120	PF00754	0.364
LIG_Pex14_1	19	23	PF04695	0.199
LIG_Pex14_2	23	27	PF04695	0.199
LIG_Pex14_2	47	51	PF04695	0.199
LIG_SH2_CRK	34	38	PF00017	0.199
LIG_SH2_STAP1	34	38	PF00017	0.199
LIG_SH2_STAT5	34	37	PF00017	0.199
LIG_SH3_1	107	113	PF00018	0.555
LIG_SH3_3	107	113	PF00018	0.555
LIG_SH3_3	60	66	PF00018	0.508
LIG_TYR_ITIM	32	37	PF00017	0.199
MOD_CDC14_SPxK_1	49	52	PF00782	0.199
MOD_CDK_SPxK_1	46	52	PF00069	0.199
MOD_CK1_1	53	59	PF00069	0.525
MOD_CK1_1	78	84	PF00069	0.527
MOD_GSK3_1	23	30	PF00069	0.199
MOD_GSK3_1	42	49	PF00069	0.199
MOD_GSK3_1	65	72	PF00069	0.508
MOD_GSK3_1	74	81	PF00069	0.540
MOD_GSK3_1	8	15	PF00069	0.565
MOD_LATS_1	6	12	PF00433	0.575
MOD_NEK2_1	23	28	PF00069	0.199
MOD_NEK2_1	32	37	PF00069	0.199
MOD_NEK2_1	42	47	PF00069	0.199
MOD_NEK2_1	69	74	PF00069	0.514
MOD_PKA_1	8	14	PF00069	0.567
MOD_PKA_2	27	33	PF00069	0.199
MOD_PKA_2	8	14	PF00069	0.567
MOD_Plk_4	27	33	PF00069	0.199
MOD_Plk_4	37	43	PF00069	0.199
MOD_Plk_4	78	84	PF00069	0.527
MOD_ProDKin_1	10	16	PF00069	0.559
MOD_ProDKin_1	109	115	PF00069	0.556
MOD_ProDKin_1	46	52	PF00069	0.199
MOD_ProDKin_1	71	77	PF00069	0.531
MOD_ProDKin_1	88	94	PF00069	0.553
TRG_ENDOCYTIC_2	34	37	PF00928	0.199
TRG_ER_diArg_1	106	108	PF00400	0.556
TRG_ER_diArg_1	117	120	PF00400	0.565
TRG_ER_diArg_1	5	8	PF00400	0.584