Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Methyltransferase domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HXK8_LEIIN

TriTrypDb:

LINF_170020400

Length:

1048

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HXK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXK8

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.640
CLV_C14_Caspase3-7	57	61	PF00656	0.468
CLV_MEL_PAP_1	343	349	PF00089	0.402
CLV_NRD_NRD_1	1041	1043	PF00675	0.347
CLV_NRD_NRD_1	160	162	PF00675	0.395
CLV_NRD_NRD_1	168	170	PF00675	0.363
CLV_NRD_NRD_1	185	187	PF00675	0.457
CLV_NRD_NRD_1	517	519	PF00675	0.638
CLV_NRD_NRD_1	562	564	PF00675	0.739
CLV_NRD_NRD_1	799	801	PF00675	0.509
CLV_NRD_NRD_1	854	856	PF00675	0.522
CLV_NRD_NRD_1	893	895	PF00675	0.437
CLV_PCSK_FUR_1	166	170	PF00082	0.400
CLV_PCSK_FUR_1	560	564	PF00082	0.569
CLV_PCSK_KEX2_1	1041	1043	PF00082	0.347
CLV_PCSK_KEX2_1	160	162	PF00082	0.388
CLV_PCSK_KEX2_1	168	170	PF00082	0.368
CLV_PCSK_KEX2_1	185	187	PF00082	0.444
CLV_PCSK_KEX2_1	504	506	PF00082	0.589
CLV_PCSK_KEX2_1	517	519	PF00082	0.618
CLV_PCSK_KEX2_1	560	562	PF00082	0.747
CLV_PCSK_KEX2_1	674	676	PF00082	0.494
CLV_PCSK_KEX2_1	799	801	PF00082	0.509
CLV_PCSK_KEX2_1	893	895	PF00082	0.404
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.661
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.541
CLV_PCSK_PC7_1	795	801	PF00082	0.409
CLV_PCSK_SKI1_1	161	165	PF00082	0.483
CLV_PCSK_SKI1_1	505	509	PF00082	0.541
CLV_PCSK_SKI1_1	539	543	PF00082	0.496
CLV_PCSK_SKI1_1	583	587	PF00082	0.494
CLV_PCSK_SKI1_1	723	727	PF00082	0.389
CLV_PCSK_SKI1_1	774	778	PF00082	0.265
CLV_PCSK_SKI1_1	800	804	PF00082	0.434
CLV_PCSK_SKI1_1	832	836	PF00082	0.352
CLV_PCSK_SKI1_1	837	841	PF00082	0.321
CLV_PCSK_SKI1_1	92	96	PF00082	0.433
CLV_PCSK_SKI1_1	947	951	PF00082	0.502
CLV_PCSK_SKI1_1	99	103	PF00082	0.403
DEG_MDM2_SWIB_1	840	847	PF02201	0.452
DOC_ANK_TNKS_1	517	524	PF00023	0.665
DOC_ANK_TNKS_1	626	633	PF00023	0.565
DOC_CKS1_1	619	624	PF01111	0.653
DOC_CKS1_1	736	741	PF01111	0.528
DOC_CKS1_1	925	930	PF01111	0.512
DOC_CYCLIN_RxL_1	89	96	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.371
DOC_MAPK_gen_1	217	224	PF00069	0.411
DOC_MAPK_gen_1	324	332	PF00069	0.560
DOC_MAPK_gen_1	403	412	PF00069	0.601
DOC_MAPK_gen_1	580	590	PF00069	0.400
DOC_MAPK_gen_1	673	679	PF00069	0.447
DOC_MAPK_gen_1	721	730	PF00069	0.416
DOC_MAPK_gen_1	893	904	PF00069	0.398
DOC_MAPK_MEF2A_6	324	332	PF00069	0.627
DOC_MAPK_MEF2A_6	580	588	PF00069	0.443
DOC_MAPK_MEF2A_6	721	730	PF00069	0.457
DOC_MAPK_MEF2A_6	747	754	PF00069	0.362
DOC_MAPK_NFAT4_5	723	731	PF00069	0.487
DOC_PP1_RVXF_1	348	354	PF00149	0.445
DOC_PP1_RVXF_1	830	837	PF00149	0.416
DOC_PP1_RVXF_1	839	845	PF00149	0.375
DOC_PP2B_LxvP_1	460	463	PF13499	0.581
DOC_PP2B_LxvP_1	7	10	PF13499	0.306
DOC_USP7_MATH_1	1016	1020	PF00917	0.452
DOC_USP7_MATH_1	3	7	PF00917	0.422
DOC_USP7_MATH_1	445	449	PF00917	0.628
DOC_USP7_MATH_1	593	597	PF00917	0.606
DOC_USP7_MATH_1	603	607	PF00917	0.591
DOC_USP7_MATH_1	72	76	PF00917	0.556
DOC_USP7_MATH_1	734	738	PF00917	0.595
DOC_USP7_UBL2_3	431	435	PF12436	0.428
DOC_WW_Pin1_4	1029	1034	PF00397	0.360
DOC_WW_Pin1_4	139	144	PF00397	0.685
DOC_WW_Pin1_4	458	463	PF00397	0.756
DOC_WW_Pin1_4	534	539	PF00397	0.624
DOC_WW_Pin1_4	561	566	PF00397	0.645
DOC_WW_Pin1_4	599	604	PF00397	0.749
DOC_WW_Pin1_4	605	610	PF00397	0.742
DOC_WW_Pin1_4	618	623	PF00397	0.745
DOC_WW_Pin1_4	735	740	PF00397	0.546
DOC_WW_Pin1_4	78	83	PF00397	0.503
DOC_WW_Pin1_4	784	789	PF00397	0.522
DOC_WW_Pin1_4	820	825	PF00397	0.518
DOC_WW_Pin1_4	921	926	PF00397	0.502
LIG_14-3-3_CanoR_1	242	248	PF00244	0.570
LIG_14-3-3_CanoR_1	286	291	PF00244	0.377
LIG_14-3-3_CanoR_1	530	538	PF00244	0.704
LIG_14-3-3_CanoR_1	539	544	PF00244	0.671
LIG_14-3-3_CanoR_1	568	574	PF00244	0.601
LIG_14-3-3_CanoR_1	651	655	PF00244	0.475
LIG_14-3-3_CanoR_1	70	78	PF00244	0.575
LIG_14-3-3_CanoR_1	747	751	PF00244	0.489
LIG_14-3-3_CanoR_1	769	778	PF00244	0.508
LIG_14-3-3_CanoR_1	799	809	PF00244	0.427
LIG_14-3-3_CanoR_1	828	836	PF00244	0.411
LIG_14-3-3_CanoR_1	947	956	PF00244	0.404
LIG_Actin_WH2_2	35	52	PF00022	0.394
LIG_APCC_ABBA_1	883	888	PF00400	0.425
LIG_APCC_ABBA_1	995	1000	PF00400	0.440
LIG_BRCT_BRCA1_1	74	78	PF00533	0.467
LIG_Clathr_ClatBox_1	587	591	PF01394	0.412
LIG_Clathr_ClatBox_1	988	992	PF01394	0.310
LIG_deltaCOP1_diTrp_1	69	78	PF00928	0.586
LIG_EH1_1	581	589	PF00400	0.456
LIG_EH1_1	982	990	PF00400	0.315
LIG_eIF4E_1	582	588	PF01652	0.496
LIG_FHA_1	157	163	PF00498	0.354
LIG_FHA_1	33	39	PF00498	0.476
LIG_FHA_1	407	413	PF00498	0.498
LIG_FHA_1	424	430	PF00498	0.366
LIG_FHA_1	455	461	PF00498	0.657
LIG_FHA_1	674	680	PF00498	0.498
LIG_FHA_1	736	742	PF00498	0.564
LIG_FHA_1	747	753	PF00498	0.413
LIG_FHA_1	802	808	PF00498	0.370
LIG_FHA_1	811	817	PF00498	0.385
LIG_FHA_1	89	95	PF00498	0.560
LIG_FHA_1	903	909	PF00498	0.391
LIG_FHA_2	179	185	PF00498	0.415
LIG_FHA_2	226	232	PF00498	0.359
LIG_FHA_2	34	40	PF00498	0.447
LIG_FHA_2	361	367	PF00498	0.472
LIG_FHA_2	383	389	PF00498	0.518
LIG_FHA_2	402	408	PF00498	0.556
LIG_FHA_2	498	504	PF00498	0.543
LIG_FHA_2	938	944	PF00498	0.442
LIG_Integrin_RGD_1	405	407	PF01839	0.586
LIG_Integrin_RGD_1	552	554	PF01839	0.501
LIG_LIR_Apic_2	710	714	PF02991	0.449
LIG_LIR_Gen_1	311	321	PF02991	0.497
LIG_LIR_Gen_1	352	361	PF02991	0.421
LIG_LIR_Gen_1	537	547	PF02991	0.622
LIG_LIR_Gen_1	60	69	PF02991	0.459
LIG_LIR_Gen_1	646	655	PF02991	0.482
LIG_LIR_Gen_1	780	791	PF02991	0.445
LIG_LIR_Gen_1	901	912	PF02991	0.419
LIG_LIR_Gen_1	965	976	PF02991	0.457
LIG_LIR_LC3C_4	207	210	PF02991	0.515
LIG_LIR_Nem_3	21	26	PF02991	0.349
LIG_LIR_Nem_3	311	316	PF02991	0.500
LIG_LIR_Nem_3	352	356	PF02991	0.428
LIG_LIR_Nem_3	493	499	PF02991	0.485
LIG_LIR_Nem_3	537	543	PF02991	0.631
LIG_LIR_Nem_3	60	66	PF02991	0.354
LIG_LIR_Nem_3	646	650	PF02991	0.481
LIG_LIR_Nem_3	780	786	PF02991	0.445
LIG_LIR_Nem_3	838	843	PF02991	0.393
LIG_LIR_Nem_3	877	883	PF02991	0.402
LIG_LIR_Nem_3	901	907	PF02991	0.429
LIG_LIR_Nem_3	96	101	PF02991	0.395
LIG_LIR_Nem_3	965	971	PF02991	0.364
LIG_MYND_1	885	889	PF01753	0.390
LIG_NRBOX	838	844	PF00104	0.438
LIG_Pex14_2	836	840	PF04695	0.447
LIG_Rb_pABgroove_1	1021	1029	PF01858	0.336
LIG_REV1ctd_RIR_1	833	841	PF16727	0.442
LIG_SH2_CRK	1036	1040	PF00017	0.382
LIG_SH2_CRK	582	586	PF00017	0.460
LIG_SH2_CRK	647	651	PF00017	0.538
LIG_SH2_SRC	915	918	PF00017	0.508
LIG_SH2_STAT5	283	286	PF00017	0.337
LIG_SH2_STAT5	41	44	PF00017	0.344
LIG_SH2_STAT5	488	491	PF00017	0.487
LIG_SH2_STAT5	540	543	PF00017	0.593
LIG_SH2_STAT5	577	580	PF00017	0.549
LIG_SH2_STAT5	62	65	PF00017	0.422
LIG_SH2_STAT5	647	650	PF00017	0.524
LIG_SH2_STAT5	915	918	PF00017	0.379
LIG_SH2_STAT5	926	929	PF00017	0.398
LIG_SH2_STAT5	996	999	PF00017	0.354
LIG_SH3_1	922	928	PF00018	0.532
LIG_SH3_3	459	465	PF00018	0.741
LIG_SH3_3	478	484	PF00018	0.425
LIG_SH3_3	616	622	PF00018	0.747
LIG_SH3_3	727	733	PF00018	0.422
LIG_SH3_3	738	744	PF00018	0.384
LIG_SH3_3	857	863	PF00018	0.621
LIG_SH3_3	878	884	PF00018	0.411
LIG_SH3_3	922	928	PF00018	0.501
LIG_SH3_4	99	106	PF00018	0.377
LIG_SUMO_SIM_anti_2	1017	1025	PF11976	0.377
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.409
LIG_SUMO_SIM_anti_2	204	211	PF11976	0.584
LIG_SUMO_SIM_anti_2	722	728	PF11976	0.446
LIG_SUMO_SIM_anti_2	806	811	PF11976	0.352
LIG_SUMO_SIM_anti_2	986	992	PF11976	0.312
LIG_SUMO_SIM_par_1	569	574	PF11976	0.404
LIG_SUMO_SIM_par_1	692	699	PF11976	0.438
LIG_SUMO_SIM_par_1	775	780	PF11976	0.445
LIG_SUMO_SIM_par_1	986	992	PF11976	0.312
LIG_TRAF2_1	151	154	PF00917	0.419
LIG_TRAF2_1	589	592	PF00917	0.440
LIG_TRAF2_1	940	943	PF00917	0.494
LIG_UBA3_1	205	212	PF00899	0.301
LIG_WRC_WIRS_1	968	973	PF05994	0.392
MOD_CDK_SPK_2	1029	1034	PF00069	0.360
MOD_CDK_SPK_2	534	539	PF00069	0.584
MOD_CDK_SPxxK_3	561	568	PF00069	0.578
MOD_CDK_SPxxK_3	618	625	PF00069	0.656
MOD_CK1_1	137	143	PF00069	0.644
MOD_CK1_1	145	151	PF00069	0.456
MOD_CK1_1	194	200	PF00069	0.591
MOD_CK1_1	31	37	PF00069	0.512
MOD_CK1_1	320	326	PF00069	0.553
MOD_CK1_1	534	540	PF00069	0.661
MOD_CK1_1	602	608	PF00069	0.582
MOD_CK1_1	820	826	PF00069	0.474
MOD_CK1_1	861	867	PF00069	0.500
MOD_CK1_1	918	924	PF00069	0.488
MOD_CK2_1	178	184	PF00069	0.433
MOD_CK2_1	312	318	PF00069	0.539
MOD_CK2_1	382	388	PF00069	0.609
MOD_CK2_1	389	395	PF00069	0.559
MOD_CK2_1	497	503	PF00069	0.548
MOD_CK2_1	561	567	PF00069	0.720
MOD_CK2_1	78	84	PF00069	0.550
MOD_CK2_1	937	943	PF00069	0.441
MOD_Cter_Amidation	853	856	PF01082	0.473
MOD_GlcNHglycan	1017	1021	PF01048	0.518
MOD_GlcNHglycan	1044	1047	PF01048	0.568
MOD_GlcNHglycan	11	14	PF01048	0.403
MOD_GlcNHglycan	137	140	PF01048	0.638
MOD_GlcNHglycan	193	196	PF01048	0.649
MOD_GlcNHglycan	243	246	PF01048	0.659
MOD_GlcNHglycan	28	31	PF01048	0.524
MOD_GlcNHglycan	380	383	PF01048	0.711
MOD_GlcNHglycan	447	450	PF01048	0.654
MOD_GlcNHglycan	50	53	PF01048	0.485
MOD_GlcNHglycan	554	558	PF01048	0.823
MOD_GlcNHglycan	605	608	PF01048	0.771
MOD_GlcNHglycan	635	638	PF01048	0.619
MOD_GlcNHglycan	771	774	PF01048	0.262
MOD_GlcNHglycan	829	832	PF01048	0.378
MOD_GlcNHglycan	863	866	PF01048	0.563
MOD_GlcNHglycan	917	920	PF01048	0.420
MOD_GlcNHglycan	95	98	PF01048	0.421
MOD_GSK3_1	135	142	PF00069	0.605
MOD_GSK3_1	190	197	PF00069	0.513
MOD_GSK3_1	21	28	PF00069	0.407
MOD_GSK3_1	282	289	PF00069	0.355
MOD_GSK3_1	312	319	PF00069	0.473
MOD_GSK3_1	378	385	PF00069	0.763
MOD_GSK3_1	454	461	PF00069	0.742
MOD_GSK3_1	530	537	PF00069	0.711
MOD_GSK3_1	599	606	PF00069	0.653
MOD_GSK3_1	669	676	PF00069	0.525
MOD_GSK3_1	742	749	PF00069	0.434
MOD_GSK3_1	801	808	PF00069	0.381
MOD_GSK3_1	898	905	PF00069	0.545
MOD_GSK3_1	917	924	PF00069	0.353
MOD_GSK3_1	999	1006	PF00069	0.474
MOD_N-GLC_1	454	459	PF02516	0.758
MOD_N-GLC_1	479	484	PF02516	0.570
MOD_N-GLC_1	769	774	PF02516	0.255
MOD_N-GLC_2	763	765	PF02516	0.258
MOD_NEK2_1	208	213	PF00069	0.595
MOD_NEK2_1	225	230	PF00069	0.244
MOD_NEK2_1	25	30	PF00069	0.509
MOD_NEK2_1	316	321	PF00069	0.572
MOD_NEK2_1	371	376	PF00069	0.519
MOD_NEK2_1	401	406	PF00069	0.676
MOD_NEK2_1	48	53	PF00069	0.364
MOD_NEK2_1	529	534	PF00069	0.685
MOD_NEK2_1	54	59	PF00069	0.341
MOD_NEK2_1	633	638	PF00069	0.643
MOD_NEK2_1	768	773	PF00069	0.450
MOD_NEK2_1	777	782	PF00069	0.455
MOD_NEK2_1	810	815	PF00069	0.360
MOD_NEK2_1	835	840	PF00069	0.375
MOD_NEK2_1	88	93	PF00069	0.457
MOD_NEK2_1	902	907	PF00069	0.346
MOD_NEK2_1	972	977	PF00069	0.333
MOD_NEK2_1	984	989	PF00069	0.297
MOD_NEK2_2	406	411	PF00069	0.603
MOD_NEK2_2	72	77	PF00069	0.419
MOD_OFUCOSY	27	32	PF10250	0.387
MOD_OFUCOSY	368	375	PF10250	0.443
MOD_PIKK_1	194	200	PF00454	0.448
MOD_PIKK_1	645	651	PF00454	0.483
MOD_PIKK_1	810	816	PF00454	0.366
MOD_PIKK_1	902	908	PF00454	0.274
MOD_PIKK_1	948	954	PF00454	0.378
MOD_PK_1	856	862	PF00069	0.480
MOD_PKA_1	673	679	PF00069	0.482
MOD_PKA_1	893	899	PF00069	0.517
MOD_PKA_2	184	190	PF00069	0.544
MOD_PKA_2	225	231	PF00069	0.372
MOD_PKA_2	241	247	PF00069	0.558
MOD_PKA_2	529	535	PF00069	0.760
MOD_PKA_2	650	656	PF00069	0.342
MOD_PKA_2	746	752	PF00069	0.370
MOD_PKA_2	768	774	PF00069	0.538
MOD_PKA_2	827	833	PF00069	0.345
MOD_PKA_2	861	867	PF00069	0.594
MOD_PKA_2	893	899	PF00069	0.517
MOD_Plk_1	1016	1022	PF00069	0.438
MOD_Plk_1	317	323	PF00069	0.592
MOD_Plk_1	406	412	PF00069	0.655
MOD_Plk_1	479	485	PF00069	0.518
MOD_Plk_2-3	184	190	PF00069	0.416
MOD_Plk_2-3	389	395	PF00069	0.526
MOD_Plk_4	175	181	PF00069	0.397
MOD_Plk_4	270	276	PF00069	0.300
MOD_Plk_4	312	318	PF00069	0.539
MOD_Plk_4	352	358	PF00069	0.540
MOD_Plk_4	650	656	PF00069	0.397
MOD_Plk_4	746	752	PF00069	0.365
MOD_Plk_4	967	973	PF00069	0.355
MOD_Plk_4	984	990	PF00069	0.239
MOD_ProDKin_1	1029	1035	PF00069	0.356
MOD_ProDKin_1	139	145	PF00069	0.677
MOD_ProDKin_1	458	464	PF00069	0.754
MOD_ProDKin_1	534	540	PF00069	0.616
MOD_ProDKin_1	561	567	PF00069	0.643
MOD_ProDKin_1	599	605	PF00069	0.748
MOD_ProDKin_1	618	624	PF00069	0.744
MOD_ProDKin_1	735	741	PF00069	0.532
MOD_ProDKin_1	78	84	PF00069	0.504
MOD_ProDKin_1	784	790	PF00069	0.522
MOD_ProDKin_1	820	826	PF00069	0.509
MOD_ProDKin_1	921	927	PF00069	0.492
TRG_DiLeu_BaEn_1	722	727	PF01217	0.417
TRG_DiLeu_BaEn_1	986	991	PF01217	0.312
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.491
TRG_ENDOCYTIC_2	1036	1039	PF00928	0.382
TRG_ENDOCYTIC_2	434	437	PF00928	0.548
TRG_ENDOCYTIC_2	540	543	PF00928	0.593
TRG_ENDOCYTIC_2	582	585	PF00928	0.467
TRG_ENDOCYTIC_2	62	65	PF00928	0.475
TRG_ENDOCYTIC_2	647	650	PF00928	0.476
TRG_ER_diArg_1	160	162	PF00400	0.392
TRG_ER_diArg_1	166	169	PF00400	0.362
TRG_ER_diArg_1	327	330	PF00400	0.567
TRG_ER_diArg_1	516	518	PF00400	0.639
TRG_ER_diArg_1	560	563	PF00400	0.669
TRG_ER_diArg_1	680	683	PF00400	0.445
TRG_ER_diArg_1	892	894	PF00400	0.445
TRG_NES_CRM1_1	204	219	PF08389	0.453
TRG_NES_CRM1_1	986	1000	PF08389	0.318
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R1	Leptomonas seymouri	56%	100%
A0A0S4J6V1	Bodo saltans	34%	100%
A0A3Q8IE30	Leishmania donovani	99%	100%
A0A3R7LJI9	Trypanosoma rangeli	37%	100%
A4H976	Leishmania braziliensis	73%	100%
C9ZP99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ARA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QE60	Leishmania major	91%	100%
V5BET6	Trypanosoma cruzi	34%	100%