LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative translation initiation factor

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative translation initiation factor
Gene product:
translation initiation factor - putative
Species:
Leishmania infantum
UniProt:
A4HXK6_LEIIN
TriTrypDb:
LINF_170020200
Length:
709

Annotations

Annotations by Jardim et al.

Translation, translation initiation factor

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005852 eukaryotic translation initiation factor 3 complex 2 12
GO:0032991 protein-containing complex 1 12
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HXK6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXK6

Function

Biological processes
Term Name Level Count
GO:0006413 translational initiation 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0044237 cellular metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003743 translation initiation factor activity 4 12
GO:0005488 binding 1 12
GO:0005515 protein binding 2 12
GO:0008135 translation factor activity, RNA binding 3 12
GO:0031369 translation initiation factor binding 3 12
GO:0045182 translation regulator activity 1 12
GO:0090079 translation regulator activity, nucleic acid binding 2 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 128 132 PF00656 0.496
CLV_NRD_NRD_1 163 165 PF00675 0.400
CLV_NRD_NRD_1 33 35 PF00675 0.418
CLV_NRD_NRD_1 632 634 PF00675 0.430
CLV_NRD_NRD_1 699 701 PF00675 0.523
CLV_NRD_NRD_1 99 101 PF00675 0.395
CLV_PCSK_KEX2_1 162 164 PF00082 0.467
CLV_PCSK_KEX2_1 23 25 PF00082 0.375
CLV_PCSK_KEX2_1 33 35 PF00082 0.326
CLV_PCSK_KEX2_1 436 438 PF00082 0.231
CLV_PCSK_KEX2_1 458 460 PF00082 0.231
CLV_PCSK_KEX2_1 642 644 PF00082 0.410
CLV_PCSK_KEX2_1 699 701 PF00082 0.524
CLV_PCSK_PC1ET2_1 23 25 PF00082 0.375
CLV_PCSK_PC1ET2_1 436 438 PF00082 0.231
CLV_PCSK_PC1ET2_1 458 460 PF00082 0.231
CLV_PCSK_PC1ET2_1 642 644 PF00082 0.389
CLV_PCSK_PC7_1 29 35 PF00082 0.476
CLV_PCSK_PC7_1 432 438 PF00082 0.231
CLV_PCSK_SKI1_1 24 28 PF00082 0.305
CLV_PCSK_SKI1_1 262 266 PF00082 0.353
CLV_PCSK_SKI1_1 322 326 PF00082 0.407
CLV_PCSK_SKI1_1 387 391 PF00082 0.180
CLV_PCSK_SKI1_1 511 515 PF00082 0.222
CLV_PCSK_SKI1_1 577 581 PF00082 0.213
CLV_PCSK_SKI1_1 642 646 PF00082 0.398
DOC_CKS1_1 250 255 PF01111 0.420
DOC_MAPK_gen_1 265 275 PF00069 0.321
DOC_PP1_RVXF_1 225 231 PF00149 0.436
DOC_PP4_FxxP_1 334 337 PF00568 0.376
DOC_PP4_FxxP_1 496 499 PF00568 0.390
DOC_USP7_MATH_1 222 226 PF00917 0.429
DOC_USP7_MATH_1 288 292 PF00917 0.278
DOC_USP7_MATH_1 302 306 PF00917 0.393
DOC_USP7_UBL2_3 479 483 PF12436 0.393
DOC_USP7_UBL2_3 576 580 PF12436 0.448
DOC_WW_Pin1_4 17 22 PF00397 0.372
DOC_WW_Pin1_4 239 244 PF00397 0.253
DOC_WW_Pin1_4 249 254 PF00397 0.270
LIG_14-3-3_CanoR_1 285 293 PF00244 0.396
LIG_14-3-3_CanoR_1 92 97 PF00244 0.397
LIG_APCC_ABBA_1 226 231 PF00400 0.437
LIG_APCC_ABBA_1 273 278 PF00400 0.460
LIG_BIR_III_2 131 135 PF00653 0.332
LIG_CSL_BTD_1 398 401 PF09270 0.380
LIG_deltaCOP1_diTrp_1 145 153 PF00928 0.268
LIG_deltaCOP1_diTrp_1 278 286 PF00928 0.290
LIG_deltaCOP1_diTrp_1 396 405 PF00928 0.482
LIG_deltaCOP1_diTrp_1 540 548 PF00928 0.385
LIG_FHA_1 231 237 PF00498 0.379
LIG_FHA_1 318 324 PF00498 0.339
LIG_FHA_1 467 473 PF00498 0.405
LIG_FHA_1 52 58 PF00498 0.386
LIG_FHA_2 250 256 PF00498 0.331
LIG_FHA_2 391 397 PF00498 0.431
LIG_FHA_2 446 452 PF00498 0.470
LIG_FHA_2 48 54 PF00498 0.477
LIG_FHA_2 522 528 PF00498 0.445
LIG_FHA_2 535 541 PF00498 0.339
LIG_FHA_2 568 574 PF00498 0.482
LIG_FHA_2 594 600 PF00498 0.361
LIG_FHA_2 657 663 PF00498 0.484
LIG_LIR_Apic_2 103 109 PF02991 0.446
LIG_LIR_Apic_2 333 337 PF02991 0.378
LIG_LIR_Apic_2 493 499 PF02991 0.390
LIG_LIR_Gen_1 245 253 PF02991 0.277
LIG_LIR_Gen_1 404 411 PF02991 0.458
LIG_LIR_Gen_1 451 457 PF02991 0.482
LIG_LIR_Gen_1 692 702 PF02991 0.570
LIG_LIR_Gen_1 90 99 PF02991 0.340
LIG_LIR_LC3C_4 289 294 PF02991 0.400
LIG_LIR_Nem_3 145 151 PF02991 0.265
LIG_LIR_Nem_3 245 250 PF02991 0.272
LIG_LIR_Nem_3 343 347 PF02991 0.294
LIG_LIR_Nem_3 404 408 PF02991 0.458
LIG_LIR_Nem_3 416 421 PF02991 0.306
LIG_LIR_Nem_3 451 456 PF02991 0.482
LIG_LIR_Nem_3 544 550 PF02991 0.459
LIG_LIR_Nem_3 667 672 PF02991 0.423
LIG_LIR_Nem_3 692 697 PF02991 0.568
LIG_LIR_Nem_3 90 96 PF02991 0.322
LIG_Pex14_2 144 148 PF04695 0.277
LIG_Pex14_2 27 31 PF04695 0.416
LIG_SH2_CRK 694 698 PF00017 0.567
LIG_SH2_PTP2 106 109 PF00017 0.523
LIG_SH2_PTP2 247 250 PF00017 0.348
LIG_SH2_SRC 106 109 PF00017 0.573
LIG_SH2_SRC 247 250 PF00017 0.383
LIG_SH2_STAT5 106 109 PF00017 0.523
LIG_SH2_STAT5 247 250 PF00017 0.260
LIG_SH2_STAT5 316 319 PF00017 0.497
LIG_SH2_STAT5 354 357 PF00017 0.404
LIG_SH2_STAT5 418 421 PF00017 0.447
LIG_SH2_STAT5 439 442 PF00017 0.468
LIG_SH2_STAT5 547 550 PF00017 0.482
LIG_SH2_STAT5 569 572 PF00017 0.482
LIG_SH2_STAT5 640 643 PF00017 0.410
LIG_SH3_3 102 108 PF00018 0.568
LIG_SH3_3 193 199 PF00018 0.374
LIG_SH3_3 247 253 PF00018 0.345
LIG_SH3_3 586 592 PF00018 0.358
LIG_SUMO_SIM_anti_2 255 260 PF11976 0.393
LIG_SUMO_SIM_anti_2 289 296 PF11976 0.400
LIG_TRAF2_1 635 638 PF00917 0.512
LIG_TRAF2_1 659 662 PF00917 0.485
LIG_TRAF2_1 681 684 PF00917 0.441
LIG_TRAF2_1 95 98 PF00917 0.418
LIG_TYR_ITSM 690 697 PF00017 0.561
LIG_UBA3_1 258 266 PF00899 0.444
LIG_UBA3_1 474 479 PF00899 0.489
MOD_CDK_SPK_2 249 254 PF00069 0.363
MOD_CDK_SPxK_1 17 23 PF00069 0.373
MOD_CDK_SPxxK_3 17 24 PF00069 0.371
MOD_CDK_SPxxK_3 239 246 PF00069 0.274
MOD_CK1_1 140 146 PF00069 0.364
MOD_CK1_1 330 336 PF00069 0.347
MOD_CK1_1 532 538 PF00069 0.416
MOD_CK1_1 63 69 PF00069 0.334
MOD_CK2_1 209 215 PF00069 0.426
MOD_CK2_1 239 245 PF00069 0.253
MOD_CK2_1 47 53 PF00069 0.403
MOD_CK2_1 534 540 PF00069 0.482
MOD_CK2_1 551 557 PF00069 0.374
MOD_CK2_1 567 573 PF00069 0.427
MOD_CK2_1 632 638 PF00069 0.570
MOD_CK2_1 656 662 PF00069 0.466
MOD_CK2_1 91 97 PF00069 0.414
MOD_CMANNOS 150 153 PF00535 0.397
MOD_GlcNHglycan 139 142 PF01048 0.438
MOD_GlcNHglycan 186 189 PF01048 0.422
MOD_GlcNHglycan 191 194 PF01048 0.406
MOD_GlcNHglycan 286 289 PF01048 0.374
MOD_GlcNHglycan 329 332 PF01048 0.402
MOD_GlcNHglycan 490 493 PF01048 0.204
MOD_GlcNHglycan 531 534 PF01048 0.213
MOD_GlcNHglycan 57 60 PF01048 0.426
MOD_GlcNHglycan 84 87 PF01048 0.426
MOD_GSK3_1 201 208 PF00069 0.372
MOD_GSK3_1 284 291 PF00069 0.398
MOD_GSK3_1 326 333 PF00069 0.345
MOD_GSK3_1 409 416 PF00069 0.404
MOD_GSK3_1 47 54 PF00069 0.427
MOD_GSK3_1 82 89 PF00069 0.318
MOD_N-GLC_1 17 22 PF02516 0.391
MOD_N-GLC_1 521 526 PF02516 0.203
MOD_NEK2_1 137 142 PF00069 0.379
MOD_NEK2_1 189 194 PF00069 0.390
MOD_NEK2_1 209 214 PF00069 0.283
MOD_NEK2_1 390 395 PF00069 0.482
MOD_NEK2_1 466 471 PF00069 0.466
MOD_NEK2_1 509 514 PF00069 0.417
MOD_NEK2_1 567 572 PF00069 0.459
MOD_NEK2_1 606 611 PF00069 0.530
MOD_NEK2_1 82 87 PF00069 0.430
MOD_NEK2_2 222 227 PF00069 0.436
MOD_NEK2_2 551 556 PF00069 0.482
MOD_PIKK_1 209 215 PF00454 0.282
MOD_PIKK_1 347 353 PF00454 0.365
MOD_PIKK_1 593 599 PF00454 0.498
MOD_PK_1 254 260 PF00069 0.353
MOD_PKA_1 164 170 PF00069 0.496
MOD_PKA_1 183 189 PF00069 0.501
MOD_PKA_2 173 179 PF00069 0.495
MOD_PKA_2 284 290 PF00069 0.393
MOD_PKA_2 326 332 PF00069 0.475
MOD_PKA_2 431 437 PF00069 0.482
MOD_PKA_2 632 638 PF00069 0.433
MOD_PKA_2 91 97 PF00069 0.387
MOD_PKB_1 162 170 PF00069 0.531
MOD_Plk_1 230 236 PF00069 0.356
MOD_Plk_1 254 260 PF00069 0.292
MOD_Plk_1 288 294 PF00069 0.290
MOD_Plk_1 509 515 PF00069 0.403
MOD_Plk_1 521 527 PF00069 0.404
MOD_Plk_1 556 562 PF00069 0.450
MOD_Plk_2-3 274 280 PF00069 0.458
MOD_Plk_2-3 521 527 PF00069 0.482
MOD_Plk_4 205 211 PF00069 0.359
MOD_Plk_4 288 294 PF00069 0.271
MOD_Plk_4 401 407 PF00069 0.482
MOD_Plk_4 509 515 PF00069 0.404
MOD_Plk_4 590 596 PF00069 0.479
MOD_Plk_4 606 612 PF00069 0.346
MOD_ProDKin_1 17 23 PF00069 0.373
MOD_ProDKin_1 239 245 PF00069 0.253
MOD_ProDKin_1 249 255 PF00069 0.271
MOD_SUMO_rev_2 176 185 PF00179 0.461
MOD_SUMO_rev_2 598 603 PF00179 0.385
MOD_SUMO_rev_2 627 635 PF00179 0.483
TRG_DiLeu_BaEn_1 118 123 PF01217 0.574
TRG_DiLeu_BaEn_1 319 324 PF01217 0.391
TRG_DiLeu_BaEn_1 386 391 PF01217 0.277
TRG_ENDOCYTIC_2 206 209 PF00928 0.387
TRG_ENDOCYTIC_2 247 250 PF00928 0.254
TRG_ENDOCYTIC_2 300 303 PF00928 0.444
TRG_ENDOCYTIC_2 418 421 PF00928 0.380
TRG_ENDOCYTIC_2 547 550 PF00928 0.476
TRG_ENDOCYTIC_2 564 567 PF00928 0.366
TRG_ENDOCYTIC_2 694 697 PF00928 0.570
TRG_ER_diArg_1 161 164 PF00400 0.486
TRG_ER_diArg_1 33 35 PF00400 0.455
TRG_NES_CRM1_1 231 245 PF08389 0.412
TRG_NLS_MonoExtN_4 262 269 PF00514 0.319
TRG_Pf-PMV_PEXEL_1 24 28 PF00026 0.519
TRG_Pf-PMV_PEXEL_1 33 37 PF00026 0.410
TRG_Pf-PMV_PEXEL_1 382 386 PF00026 0.380
TRG_Pf-PMV_PEXEL_1 483 487 PF00026 0.231

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P842 Leptomonas seymouri 80% 100%
A0A0S4JDX9 Bodo saltans 33% 97%
A0A1X0NUD9 Trypanosomatidae 45% 100%
A0A3R7NH08 Trypanosoma rangeli 46% 100%
A0A3S7WUM3 Leishmania donovani 100% 100%
A1CS92 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 21% 96%
A1D558 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 21% 96%
A2Q908 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 21% 96%
A3LY29 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 21% 100%
A4H988 Leishmania braziliensis 94% 100%
A4QZL9 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 23% 95%
A5E5Y8 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 25% 100%
A6SFQ6 Botryotinia fuckeliana (strain B05.10) 22% 95%
A6ZPJ1 Saccharomyces cerevisiae (strain YJM789) 24% 93%
A7EHM8 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 22% 95%
A7TKF2 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 25% 98%
B0W562 Culex quinquefasciatus 23% 100%
B0XRG7 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 21% 96%
B3ME25 Drosophila ananassae 22% 100%
B3NMI5 Drosophila erecta 22% 100%
B4GAY7 Drosophila persimilis 23% 100%
B4HMV9 Drosophila sechellia 22% 100%
B4J6D5 Drosophila grimshawi 22% 100%
B4KNN9 Drosophila mojavensis 22% 100%
B4LM71 Drosophila virilis 22% 100%
B4MQL8 Drosophila willistoni 22% 100%
B4P5F7 Drosophila yakuba 22% 100%
B4QB88 Drosophila simulans 22% 100%
B5E081 Drosophila pseudoobscura pseudoobscura 23% 100%
C9ZP96 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9ARA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
P06103 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 93%
P0CN44 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 24% 94%
P0CN45 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 24% 94%
P56821 Nicotiana tabacum 22% 99%
Q0CN46 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 21% 96%
Q0E940 Drosophila melanogaster 22% 100%
Q0IEY3 Aedes aegypti 23% 100%
Q10425 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 98%
Q1DI97 Coccidioides immitis (strain RS) 23% 96%
Q1HDZ5 Bombyx mori 25% 100%
Q2GM53 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 22% 95%
Q2URB7 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 22% 96%
Q4P6G4 Ustilago maydis (strain 521 / FGSC 9021) 24% 95%
Q4QE62 Leishmania major 99% 100%
Q4WKL7 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 21% 96%
Q54QW1 Dictyostelium discoideum 22% 100%
Q569Z1 Xenopus laevis 24% 100%
Q5AGV4 Candida albicans (strain SC5314 / ATCC MYA-2876) 24% 96%
Q5BGH1 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 22% 96%
Q6BLY5 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 24% 99%
Q6C1H8 Yarrowia lipolytica (strain CLIB 122 / E 150) 24% 99%
Q6CY34 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 24% 97%
Q6FM92 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 22% 99%
Q758X9 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 23% 96%
Q7PZY1 Anopheles gambiae 23% 100%
Q7S464 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 22% 95%
Q9C5Z1 Arabidopsis thaliana 23% 100%
Q9XWI6 Caenorhabditis elegans 25% 98%
V5AZD7 Trypanosoma cruzi 46% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS