Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HXK5_LEIIN

TriTrypDb:

LINF_170020100

Length:

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HXK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	43	45	PF00082	0.432
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.432
CLV_PCSK_SKI1_1	32	36	PF00082	0.364
CLV_PCSK_SKI1_1	61	65	PF00082	0.293
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.364
DOC_MAPK_MEF2A_6	15	24	PF00069	0.289
DOC_PP2B_LxvP_1	24	27	PF13499	0.364
LIG_BIR_II_1	1	5	PF00653	0.341
LIG_FHA_1	4	10	PF00498	0.310
LIG_LIR_Gen_1	53	63	PF02991	0.523
LIG_LIR_Nem_3	53	58	PF02991	0.520
LIG_PTB_Apo_2	7	14	PF02174	0.334
LIG_PTB_Phospho_1	7	13	PF10480	0.359
LIG_REV1ctd_RIR_1	27	36	PF16727	0.403
LIG_SH2_NCK_1	38	42	PF00017	0.578
LIG_SH2_SRC	38	41	PF00017	0.577
LIG_SH2_STAP1	38	42	PF00017	0.578
LIG_SH2_STAT5	11	14	PF00017	0.323
LIG_SH2_STAT5	33	36	PF00017	0.460
MOD_CK2_1	61	67	PF00069	0.580
MOD_N-GLC_1	9	14	PF02516	0.540
MOD_NEK2_1	9	14	PF00069	0.325
MOD_Plk_1	9	15	PF00069	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R6	Leptomonas seymouri	77%	96%
A0A0S4JAP6	Bodo saltans	58%	100%
A0A3Q8IAT0	Leishmania donovani	98%	100%
A4H987	Leishmania braziliensis	94%	100%
C9ZP95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	92%
E9ARA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QE63	Leishmania major	94%	100%
V5DFS3	Trypanosoma cruzi	65%	92%