Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Organic solute transport protein 1 - putative

Species:

Leishmania infantum

UniProt:

A4HXK3_LEIIN

TriTrypDb:

LINF_170019900

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HXK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.247
CLV_NRD_NRD_1	238	240	PF00675	0.592
CLV_NRD_NRD_1	87	89	PF00675	0.304
CLV_PCSK_KEX2_1	157	159	PF00082	0.346
CLV_PCSK_SKI1_1	131	135	PF00082	0.364
CLV_PCSK_SKI1_1	158	162	PF00082	0.236
CLV_PCSK_SKI1_1	191	195	PF00082	0.489
CLV_PCSK_SKI1_1	264	268	PF00082	0.486
CLV_PCSK_SKI1_1	409	413	PF00082	0.476
DEG_APCC_DBOX_1	105	113	PF00400	0.273
DEG_SPOP_SBC_1	73	77	PF00917	0.238
DOC_CKS1_1	310	315	PF01111	0.620
DOC_CKS1_1	55	60	PF01111	0.293
DOC_CYCLIN_RxL_1	155	165	PF00134	0.282
DOC_CYCLIN_RxL_1	406	413	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.254
DOC_MAPK_gen_1	157	163	PF00069	0.241
DOC_MAPK_gen_1	167	175	PF00069	0.236
DOC_MAPK_MEF2A_6	167	175	PF00069	0.239
DOC_PP2B_LxvP_1	288	291	PF13499	0.478
DOC_PP4_FxxP_1	187	190	PF00568	0.375
DOC_PP4_FxxP_1	194	197	PF00568	0.372
DOC_PP4_FxxP_1	218	221	PF00568	0.554
DOC_PP4_FxxP_1	418	421	PF00568	0.617
DOC_USP7_MATH_1	132	136	PF00917	0.260
DOC_USP7_MATH_1	232	236	PF00917	0.538
DOC_USP7_MATH_1	259	263	PF00917	0.483
DOC_USP7_MATH_1	370	374	PF00917	0.655
DOC_USP7_MATH_1	382	386	PF00917	0.632
DOC_USP7_MATH_1	73	77	PF00917	0.270
DOC_WW_Pin1_4	193	198	PF00397	0.388
DOC_WW_Pin1_4	309	314	PF00397	0.603
DOC_WW_Pin1_4	374	379	PF00397	0.647
DOC_WW_Pin1_4	388	393	PF00397	0.680
DOC_WW_Pin1_4	417	422	PF00397	0.492
DOC_WW_Pin1_4	54	59	PF00397	0.274
LIG_14-3-3_CanoR_1	131	141	PF00244	0.399
LIG_14-3-3_CanoR_1	143	149	PF00244	0.319
LIG_14-3-3_CanoR_1	157	161	PF00244	0.223
LIG_14-3-3_CanoR_1	244	252	PF00244	0.371
LIG_14-3-3_CanoR_1	264	269	PF00244	0.486
LIG_14-3-3_CanoR_1	285	289	PF00244	0.478
LIG_14-3-3_CanoR_1	34	39	PF00244	0.324
LIG_14-3-3_CanoR_1	398	404	PF00244	0.532
LIG_14-3-3_CanoR_1	81	87	PF00244	0.311
LIG_APCC_ABBA_1	171	176	PF00400	0.366
LIG_APCC_ABBA_1	352	357	PF00400	0.403
LIG_APCC_ABBAyCdc20_2	170	176	PF00400	0.366
LIG_BIR_II_1	1	5	PF00653	0.359
LIG_BIR_III_4	428	432	PF00653	0.570
LIG_BRCT_BRCA1_1	183	187	PF00533	0.363
LIG_BRCT_BRCA1_1	246	250	PF00533	0.349
LIG_eIF4E_1	349	355	PF01652	0.309
LIG_EVH1_1	225	229	PF00568	0.519
LIG_FHA_1	263	269	PF00498	0.596
LIG_FHA_1	47	53	PF00498	0.352
LIG_FHA_1	63	69	PF00498	0.181
LIG_LIR_Apic_2	184	190	PF02991	0.301
LIG_LIR_Apic_2	192	197	PF02991	0.385
LIG_LIR_Apic_2	217	221	PF02991	0.477
LIG_LIR_Apic_2	417	421	PF02991	0.606
LIG_LIR_Gen_1	5	15	PF02991	0.277
LIG_LIR_Gen_1	92	103	PF02991	0.353
LIG_LIR_Nem_3	247	253	PF02991	0.346
LIG_LIR_Nem_3	5	11	PF02991	0.279
LIG_LIR_Nem_3	92	98	PF02991	0.393
LIG_MAD2	124	132	PF02301	0.260
LIG_PDZ_Class_3	446	451	PF00595	0.590
LIG_Pex14_2	47	51	PF04695	0.309
LIG_PTB_Apo_2	50	57	PF02174	0.249
LIG_Rb_pABgroove_1	85	93	PF01858	0.298
LIG_REV1ctd_RIR_1	161	171	PF16727	0.298
LIG_SH2_CRK	91	95	PF00017	0.353
LIG_SH2_NCK_1	91	95	PF00017	0.378
LIG_SH2_STAP1	253	257	PF00017	0.435
LIG_SH2_STAP1	327	331	PF00017	0.408
LIG_SH2_STAP1	91	95	PF00017	0.385
LIG_SH2_STAT3	333	336	PF00017	0.474
LIG_SH2_STAT5	188	191	PF00017	0.465
LIG_SH2_STAT5	208	211	PF00017	0.271
LIG_SH2_STAT5	333	336	PF00017	0.382
LIG_SH2_STAT5	349	352	PF00017	0.399
LIG_SH3_3	209	215	PF00018	0.541
LIG_SH3_3	223	229	PF00018	0.382
LIG_SH3_3	276	282	PF00018	0.579
LIG_SH3_3	290	296	PF00018	0.574
LIG_SH3_3	307	313	PF00018	0.744
LIG_SH3_3	366	372	PF00018	0.694
LIG_SH3_3	389	395	PF00018	0.659
LIG_SUMO_SIM_anti_2	443	450	PF11976	0.524
LIG_SUMO_SIM_par_1	107	113	PF11976	0.249
LIG_SUMO_SIM_par_1	443	450	PF11976	0.491
LIG_TRAF2_1	136	139	PF00917	0.249
LIG_TRAF2_1	403	406	PF00917	0.468
LIG_TYR_ITIM	347	352	PF00017	0.330
LIG_TYR_ITIM	93	98	PF00017	0.401
MOD_CDK_SPK_2	417	422	PF00069	0.492
MOD_CDK_SPxxK_3	195	202	PF00069	0.354
MOD_CK1_1	262	268	PF00069	0.661
MOD_CK1_1	302	308	PF00069	0.568
MOD_CK1_1	37	43	PF00069	0.352
MOD_CK1_1	63	69	PF00069	0.304
MOD_CK1_1	75	81	PF00069	0.118
MOD_CK1_1	83	89	PF00069	0.207
MOD_CK2_1	132	138	PF00069	0.409
MOD_CK2_1	358	364	PF00069	0.653
MOD_GlcNHglycan	134	137	PF01048	0.282
MOD_GlcNHglycan	183	186	PF01048	0.354
MOD_GlcNHglycan	255	258	PF01048	0.381
MOD_GlcNHglycan	301	304	PF01048	0.674
MOD_GlcNHglycan	361	364	PF01048	0.730
MOD_GlcNHglycan	372	375	PF01048	0.569
MOD_GlcNHglycan	401	404	PF01048	0.521
MOD_GlcNHglycan	425	428	PF01048	0.658
MOD_GSK3_1	152	159	PF00069	0.405
MOD_GSK3_1	260	267	PF00069	0.634
MOD_GSK3_1	305	312	PF00069	0.672
MOD_GSK3_1	37	44	PF00069	0.294
MOD_GSK3_1	370	377	PF00069	0.688
MOD_GSK3_1	433	440	PF00069	0.575
MOD_GSK3_1	56	63	PF00069	0.225
MOD_GSK3_1	69	76	PF00069	0.311
MOD_NEK2_1	112	117	PF00069	0.278
MOD_NEK2_1	144	149	PF00069	0.385
MOD_NEK2_1	179	184	PF00069	0.303
MOD_NEK2_1	337	342	PF00069	0.525
MOD_NEK2_1	399	404	PF00069	0.492
MOD_NEK2_1	61	66	PF00069	0.392
MOD_NEK2_1	74	79	PF00069	0.293
MOD_PK_1	34	40	PF00069	0.354
MOD_PK_1	410	416	PF00069	0.362
MOD_PKA_1	294	300	PF00069	0.511
MOD_PKA_2	156	162	PF00069	0.333
MOD_PKA_2	169	175	PF00069	0.241
MOD_PKA_2	243	249	PF00069	0.343
MOD_PKA_2	284	290	PF00069	0.505
MOD_PKA_2	397	403	PF00069	0.500
MOD_PKA_2	80	86	PF00069	0.296
MOD_Plk_1	112	118	PF00069	0.239
MOD_Plk_1	83	89	PF00069	0.262
MOD_Plk_4	169	175	PF00069	0.237
MOD_Plk_4	34	40	PF00069	0.283
MOD_Plk_4	410	416	PF00069	0.624
MOD_Plk_4	63	69	PF00069	0.400
MOD_Plk_4	75	81	PF00069	0.144
MOD_ProDKin_1	193	199	PF00069	0.395
MOD_ProDKin_1	309	315	PF00069	0.604
MOD_ProDKin_1	374	380	PF00069	0.647
MOD_ProDKin_1	388	394	PF00069	0.676
MOD_ProDKin_1	417	423	PF00069	0.500
MOD_ProDKin_1	54	60	PF00069	0.274
MOD_SUMO_rev_2	172	179	PF00179	0.249
TRG_DiLeu_BaEn_1	5	10	PF01217	0.261
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.434
TRG_ENDOCYTIC_2	100	103	PF00928	0.207
TRG_ENDOCYTIC_2	349	352	PF00928	0.315
TRG_ENDOCYTIC_2	91	94	PF00928	0.269
TRG_ENDOCYTIC_2	95	98	PF00928	0.243
TRG_ER_diArg_1	236	239	PF00400	0.355
TRG_NES_CRM1_1	5	16	PF08389	0.302
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P0	Leptomonas seymouri	50%	98%
A0A0S4JB79	Bodo saltans	31%	100%
A0A1X0NSP8	Trypanosomatidae	33%	100%
A0A3R7MAW0	Trypanosoma rangeli	36%	100%
A0A3S7WUM8	Leishmania donovani	98%	100%
A4H985	Leishmania braziliensis	71%	99%
C9ZP93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AR98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q29S00	Bos taurus	29%	100%
Q4QE65	Leishmania major	88%	100%
Q4QQS3	Rattus norvegicus	27%	100%
Q8BHW2	Mus musculus	28%	100%
Q8WVF1	Homo sapiens	27%	100%
V5BNX0	Trypanosoma cruzi	35%	100%